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Bovine Rumen Metabolome Database



Showing metabocard for Glycine (RMDB00123)

Legend: metabolite field enzyme field

Version 1.0
Creation Date 2005-11-16 15:48:42
Update Date 2010-01-22 09:50:25
Accession Number RMDB00123
Common Name Glycine
Description Glycine is a simple, nonessential amino acid, although experimental animals show reduced growth on low-glycine diets. The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. Glycine levels are effectively measured in plasma in both normal patients and those with inborn errors of glycine metabolism. (http://www.dcnutrition.com/AminoAcids/) Nonketotic hyperglycinaemia (OMIM 606899) is an autosomal recessive condition caused by deficient enzyme activity of the glycine cleavage enzyme system (EC 2.1.1.10). The glycine cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins). Mutations have been described in the GLDC (OMIM 238300), AMT (OMIM 238310), and GCSH (OMIM 238330) genes encoding the P-, T-, and H-proteins respectively. The glycine cleavage system catalyses the oxidative conversion of glycine into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate. It is the main catabolic pathway for glycine and it also contributes to one-carbon metabolism. Patients with a deficiency of this enzyme system have increased glycine in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma glycine ratio. (PMID 16151895)
Synonyms
  1. 2-Aminoacetate
  2. 2-Aminoacetic acid
  3. Aciport
  4. Aminoacetate
  5. Aminoacetic acid
  6. Aminoethanoate
  7. Aminoethanoic acid
  8. Glicoamin
  9. Glycocoll
  10. Glycolixir
  11. Glycosthene
  12. Gyn-Hydralin
  13. Padil
  14. amino-Acetate
  15. amino-Acetic acid
Chemical IUPAC Name 2-aminoacetic acid
Chemical Formula C2H5NO2
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Amino acids and Amino Acid conjugates
Class
  • Amino Acids
Sub Class
  • NA
Family
  • Mammalian_Metabolite
Species
  • primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid
Biofunction
  • Non-essential amino acid
Application
Source
  • Endogenous
Average Molecular Weight 75.067
Monoisotopic Molecular Weight 75.032028
Isomeric SMILES NCC(O)=O
Canonical SMILES NCC(O)=O
KEGG Compound ID C00037 Link Image
BioCyc ID GLY Link Image
BiGG ID 33610 Link Image
Wikipedia Link Glycine Link Image
METLIN ID 20 Link Image
PubChem Compound 750 Link Image
PubChem Substance 836139 Link Image
ChEBI ID 15428 Link Image
CAS Registry Number 56-40-6
InChI Identifier InChI=1/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
Synthesis Reference Anslow, Winston K.; King, Harold. Synthesis of glycine. Journal of the Chemical Society (1929), 2163-6.
Melting Point (Experimental) 504 deg F
Experimental Water Solubility 249.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)] Source: PhysProp
Predicted Water Solubility 552.0 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 0
State Solid
Experimental LogP/Hydrophobicity -3.21 [HANSCH,C ET AL. (1995)] Source: PhysProp
Predicted LogP/Hydrophobicity -3.34 [Predicted by ALOGPS]; -3.4 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show Link Image
SDF File Show Link Image
PDB File Show Link Image
2D Structure
3D Structure
Experimental PDB ID 1CVI Link Image
Experimental PDB File Show
Experimental PDB Structure
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum
Low Energy
Download File
Show Experimental Conditions Link Image
Medium Energy
Download File
Show Experimental Conditions Link Image
High Energy
Download File
Show Experimental Conditions Link Image
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Cytoplasm (Predicted from LogP)
  • Extracellular
  • lysosome
  • mitochondria
  • peroxisome
Biofluid Location
  • Blood
  • Cow_Milk
  • Rumen
Tissue Location
Concentrations (Normal)
Biofluid Rumen
Value 112.5 +/- 27.2 uM
Age 4-5 years old
Sex Female (lactating)
Condition Normal (0% barley grain in dry matter (DM) basis)
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 104.5 +/- 0.7 uM
Age N/A
Sex Female
Condition Normal
Breed Not Available
Experimental Condition Not Available
Comments Not Available
References
  • Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows. Burim N. Ametaj, Qendrim Zebeli, Fozia Saleem, Nikolaos Psychogios, Michael J. Lewis, Suzanna M. Dunn, Jianguo Xia and David S. Wishart Metabolomics 2010;6(4):583-594
Concentrations (Abnormal)
Biofluid Rumen
Value 129 +/- 17 uM
Age 4-5 years old
Sex Female (lactating)
Condition 15% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 165 +/- 55 uM
Age 4-5 years old
Sex Female (lactating)
Condition 30% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 168 +/- 70 uM
Age 4-5 years old
Sex Female (lactating)
Condition 45% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Pathway Names Not Available
HMDB Pathways Not Available
KEGG Pathways Not Available
SimCell Pathways Not Available
General References
  1. Wikipedia Link Image
Metabolic Enzymes
  1. Serine hydroxymethyltransferase, mitochondrial
  2. Serine hydroxymethyltransferase, cytosolic
  3. Glutathione synthetase
  4. 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
  5. Glycine amidinotransferase, mitochondrial
  6. Trifunctional purine biosynthetic protein adenosine-3
  7. 5-aminolevulinate synthase, nonspecific, mitochondrial
  8. 5-aminolevulinate synthase, erythroid-specific, mitochondrial
  9. Alanine--glyoxylate aminotransferase 2, mitochondrial
  10. Peroxisomal sarcosine oxidase
  11. Arylacetyl-CoA N-acyltransferase
  12. Glycine N-acyltransferase
Enzyme 1 [top]
Enzyme 1 ID 83
Enzyme 1 Name Serine hydroxymethyltransferase, mitochondrial
Enzyme 1 Synonyms
  1. SHMT
  2. Serine methylase
  3. Glycine hydroxymethyltransferase
Enzyme 1 Gene Name SHMT2
Enzyme 1 Protein Sequence >Serine hydroxymethyltransferase, mitochondrial
MLSFSFIWATRPLRRCGQLVGMAVRCQHSEAAQTQTGEASKGWSGQESLSDSDPEMWELL
RREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ
RRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPQTGLIDYDQLALTARLFKPRLIIAGTSAYARLIDYARMREV
CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVQAVD
PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQILKNAQA
MANALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT
PGGLRLGAPALTSRGFLEDDFRKVVGFIDEGVNIGLEVKSKTTKLQDFKSFLLKDPETSH
QLADLRQRVEQFARAFPMPGFDDH
Enzyme 1 Number of Residues 504
Enzyme 1 Molecular Weight 55604.9
Enzyme 1 Theoretical pI 7.78
Enzyme 1 GO Classification
Function
Process
Component
Enzyme 1 General Function Amino acid transport and metabolism
Enzyme 1 Specific Function Interconversion of serine and glycine
Enzyme 1 Pathways
  • One-carbon metabolism
  • tetrahydrofolate interconversion
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 74268173 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q3SZ20 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name GLYM_BOVIN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >1515 bp
ATGTTGTCCTTCTCTTTTATTTGGGCGACTCGGCCTCTGCGGAGATGTGGTCAGCTGGTT
GGGATGGCCGTACGGTGCCAGCACAGTGAGGCGGCCCAGACTCAGACTGGAGAAGCAAGC
AAGGGCTGGTCAGGCCAGGAGAGTCTATCAGACAGTGACCCTGAGATGTGGGAGCTGCTG
CGGAGAGAGAAGGACAGGCAGTGTCGCGGCCTGGAGCTCATTGCTTCAGAGAACTTCTGC
AGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTAT
CCTGGCAAGAGATACTACGGAGGAGCAGAGGTAGTGGATGAGATAGAGCTGCTGTGTCAG
CGCCGGGCCTTGGAGGCCTTTGACCTGGATCCTGCTCAGTGGGGAGTCAATGTCCAACCC
TACTCCGGATCCCCAGCCAATCTGGCTGCCTACACAGCCCTTCTGCAGCCTCACGACCGA
ATCATGGGGCTGGACTTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGATGTC
AAGCGGATCTCAGCTACATCTATCTTCTTCGAGTCTATGCCTTATAAGCTGAACCCCCAA
ACCGGCCTCATTGACTATGACCAGCTGGCACTCACTGCTCGGCTCTTCAAACCACGACTC
ATCATAGCTGGTACCAGTGCCTATGCTCGTCTCATTGACTACGCCCGCATGAGAGAAGTG
TGTGACGAGGTCAAGGCACACCTCTTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCT
GCCAAGGTGATCCCCTCACCCTTCAAGCACGCGGATATTGTCACCACGACCACTCACAAG
ACCCTTCGAGGGGCCAGGTCAGGACTCATCTTCTACCGGAAGGGGGTGCAGGCTGTGGAC
CCCAAAACTGGCCGAGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCTGTGTTC
CCATCCCTGCAGGGGGGCCCCCACAACCATGCCATTGCTGCAGTGGCTGTGGCCCTAAAG
CAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGATTCTAAAGAACGCTCAGGCC
ATGGCTAATGCCCTGCTGGAGCGAGGCTACTCCCTGGTGTCTGGTGGCACTGACAACCAC
CTAGTGCTGGTAGACCTTCGGCCAAAGGGCCTGGACGGAGCTCGAGCAGAACGGGTGTTG
GAACTTGTATCCATCACGGCCAACAAGAACACCTGTCCTGGAGATCGAAGTGCCATCACC
CCTGGGGGCCTGAGGCTGGGGGCCCCAGCCCTGACTTCTCGAGGGTTCCTTGAAGATGAC
TTCCGGAAAGTTGTAGGCTTTATAGATGAAGGTGTCAACATTGGCTTGGAAGTGAAGAGC
AAGACCACCAAACTCCAGGATTTCAAATCTTTCCTGCTCAAAGACCCAGAAACAAGTCAT
CAGCTGGCCGACCTTAGGCAACGGGTGGAGCAGTTCGCCAGGGCCTTCCCCATGCCTGGT
TTTGATGATCACTGA
Enzyme 1 GenBank Gene ID BC103242 Link Image
Enzyme 1 GeneCard ID SHMT2 Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Chromosome:1
Enzyme 1 Locus 12q12-q14
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References Not Available
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 87
Enzyme 2 Name Serine hydroxymethyltransferase, cytosolic
Enzyme 2 Synonyms
  1. SHMT
  2. Serine methylase
  3. Glycine hydroxymethyltransferase
Enzyme 2 Gene Name SHMT1
Enzyme 2 Protein Sequence >Serine hydroxymethyltransferase, cytosolic
MAAPVNKAPRDANLWSLHEKMLAQPLKDNDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEVLCQKRALQVYGLDSQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPRLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHVSGLVAAGV
VPSPFEHCHVVSTTTHKTLRGCRAGMIFYRKGVRSVDPKTGRETRYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTPEFRAYQRQVVANCRALAEALMGLGYRVVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQK
VAHFIHRGIELTLQIQDAVGVKATLKEFMEKLAGAEEHHRAVAALRAEVESFATLFPLPG
LPGF
Enzyme 2 Number of Residues 484
Enzyme 2 Molecular Weight 52977.1
Enzyme 2 Theoretical pI 8.11
Enzyme 2 GO Classification
Function
Process
Component
Enzyme 2 General Function Amino acid transport and metabolism
Enzyme 2 Specific Function Interconversion of serine and glycine
Enzyme 2 Pathways
  • One-carbon metabolism
  • tetrahydrofolate interconversion
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 59858107 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q5E9P9 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name GLYC_BOVIN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1455 bp
ATGGCAGCTCCAGTCAACAAGGCACCCAGAGATGCCAATTTGTGGTCCTTGCACGAGAAG
ATGCTGGCACAGCCCCTGAAGGACAACGATGTCGAGGTTTACAACATCATTAAGAAGGAG
AGTAACCGGCAGAGGGTTGGACTGGAGCTGATCGCCTCCGAGAACTTTGCCAGCCGGGCT
GTTCTGGAGGCCCTAGGCTCTTGCCTGAACAACAAGTACTCTGAGGGGTACCCAGGCCAG
AGGTACTATGGTGGGACGGAGTTCATCGACGAGCTAGAGGTCCTCTGTCAGAAGCGAGCG
CTGCAGGTCTATGGCCTGGACTCCCAGTGCTGGGGGGTTAACGTCCAGCCTTACTCAGGC
TCCCCAGCAAACTTCGCAGTGTACACGGCCCTGGTGGAGCCCCATGGCCGCATCATGGGC
CTGGACCTGCCAGATGGGGGCCACCTGACCCATGGGTTCATGACTGACAAGAAGAAGATT
TCTGCCACGTCCATCTTTTTTGAATCTATGCCCTACAAGGTGAATCCCGATACCGGCTAC
ATCAACTACGACCAGCTGGAGGAGAACGCCCGCCTCTTCCACCCGAGGCTGATCATTGCT
GGGACTAGCTGCTACTCCCGGAACCTGGACTACGCTCGGCTGCGCAAGATCGCTGATGAC
AACGGGGCGTACCTCATGGCCGACATGGCACATGTCAGTGGGCTGGTGGCGGCCGGCGTG
GTGCCTTCGCCCTTCGAGCACTGCCACGTGGTGTCCACCACCACCCACAAGACCCTGCGG
GGCTGCCGCGCCGGCATGATCTTCTACAGGAAGGGAGTGCGCAGTGTGGACCCCAAGACA
GGCAGAGAGACTCGCTACAACCTGGAGTCGCTCATCAACTCTGCTGTGTTCCCAGGCCTG
CAAGGGGGACCCCACAACCACGCCATTGCTGGGGTCGCGGTTGCTCTGAAGCAGGCCATG
ACTCCAGAATTCAGAGCCTACCAGCGCCAGGTGGTGGCCAACTGCAGGGCTCTGGCCGAG
GCCTTGATGGGACTGGGCTACAGAGTGGTCACAGGGGGTTCTGACAACCACTTGATCCTC
GTGGACCTCCGCTCCAAAGGCACAGATGGCGGCAGGGCAGAGAAAGTGCTGGAAGCCTGC
TCCATTGCCTGCAATAAGAACACCTGCCCAGGTGATAAAAGCGCGCTACGGCCCAGTGGG
CTGCGCCTGGGGACCCCAGCATTGACCTCCCGAGGGCTCTTGGAAGAAGATTTCCAAAAG
GTCGCCCATTTCATTCACAGAGGCATAGAGCTGACCCTGCAGATCCAGGACGCCGTAGGG
GTGAAGGCCACCCTGAAGGAGTTCATGGAGAAGCTGGCAGGGGCCGAGGAGCACCATCGG
GCCGTGGCGGCCCTCAGGGCAGAGGTGGAGAGCTTCGCCACCCTATTCCCGCTGCCTGGC
CTGCCTGGCTTCTAG
Enzyme 2 GenBank Gene ID BT020871 Link Image
Enzyme 2 GeneCard ID SHMT1 Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Chromosome:1
Enzyme 2 Locus 17p11.2
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 197
Enzyme 3 Name Glutathione synthetase
Enzyme 3 Synonyms
  1. Glutathione synthase
  2. GSH synthetase
  3. GSH-S
Enzyme 3 Gene Name GSS
Enzyme 3 Protein Sequence >Glutathione synthetase
MATGWGSLLQDEQQLEELARQAVDRALAEGVLLRTSQAPSSSHVVSYAPFTLFPSPVPSA
LLEQAYAVQADFNLLVDAVSQNAVFLEQTLSSTIKRDSFTARLFDIHKQVLKEGIAQTVF
LGLNRSDYMFQCNPDGSAALKQIEINTVSASFGGLASRTPAVHRHVLSVLGKTKEAAKIL
SNNPSKGLAMGIAKAWELYGSANAQVLLIAQEKERNIFDQRAIENELLARNIHVIRRKFE
DVSEKGSLDQDRRLFMDGQEIAVVYFRDGYMPGHYSLQNWEARLLLERSCAVKCPDIATQ
LAGTKKVQQELSRVGVLESFLPGQPEAVARLRATFAGLYSLDLGEEGDQAITKAIAAPSC
FVLKPQREGGGNNLYGEEMVQALERLKDSEERASYILMEKIEPEPFRNCLLRPGSPARVI
QCISELGIFGVYVREGKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV
Enzyme 3 Number of Residues 474
Enzyme 3 Molecular Weight 52065.0
Enzyme 3 Theoretical pI 6.44
Enzyme 3 GO Classification
Function
Process
Component
Enzyme 3 General Function Involved in ATP binding
Enzyme 3 Specific Function ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
Enzyme 3 Pathways
  • Sulfur metabolism
  • glutathione biosynthesis
  • glutathione from L-cysteine and L-glutamate:step 2/2
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 59857659 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q5EAC2 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name GSHB_BOVIN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1425 bp
ATGGCCACCGGCTGGGGGAGCCTCTTGCAGGATGAACAGCAGCTGGAGGAGCTAGCAAGG
CAGGCTGTGGACCGGGCTCTGGCTGAGGGTGTGTTGCTGAGGACCTCACAGGCACCCAGC
TCCTCTCATGTGGTGAGCTATGCTCCATTCACACTCTTCCCTTCACCGGTCCCAAGTGCC
CTGCTGGAGCAGGCCTATGCTGTGCAGGCGGACTTCAACCTCCTGGTGGATGCGGTCAGC
CAAAATGCTGTCTTTCTGGAGCAGACTCTCTCCAGCACCATCAAAAGAGACAGCTTTACT
GCTCGTCTCTTTGACATCCACAAGCAAGTCTTAAAAGAAGGCATTGCCCAGACCGTGTTC
CTGGGCTTGAATCGCTCAGACTACATGTTCCAGTGCAATCCGGATGGCTCCGCAGCCCTG
AAACAGATTGAAATCAACACCGTCTCTGCCAGCTTTGGGGGCCTAGCCTCCCGGACCCCA
GCTGTGCATCGACATGTTCTCAGTGTCCTGGGTAAGACCAAAGAAGCTGCCAAGATCCTC
TCCAATAATCCCAGCAAGGGACTGGCCATGGGGATTGCCAAAGCCTGGGAGCTCTACGGC
TCAGCCAATGCTCAGGTGCTACTGATTGCTCAAGAGAAGGAAAGGAACATATTTGACCAG
CGTGCCATAGAGAATGAGCTACTGGCCAGGAATATCCATGTAATCCGACGAAAGTTCGAA
GATGTCTCTGAAAAGGGGTCTCTAGACCAAGACCGAAGACTATTTATGGACGGCCAGGAG
ATTGCTGTGGTTTACTTCCGGGATGGCTACATGCCAGGCCATTACAGCCTACAGAACTGG
GAAGCACGCCTGCTCCTGGAGAGGTCATGTGCTGTCAAGTGCCCGGATATTGCCACCCAG
CTGGCCGGGACCAAGAAGGTGCAGCAGGAGCTGAGCAGAGTGGGCGTGCTGGAGTCCTTT
CTCCCAGGGCAGCCTGAGGCTGTGGCCCGCCTCCGTGCCACCTTTGCTGGCCTCTACTCA
CTAGACCTGGGTGAAGAAGGGGACCAGGCTATCACCAAGGCCATTGCTGCTCCTAGCTGC
TTTGTGCTAAAGCCTCAAAGAGAGGGTGGAGGTAACAACCTATACGGGGAGGAGATGGTA
CAAGCCCTGGAGCGGCTGAAGGACAGTGAGGAGAGAGCCTCCTACATCCTCATGGAGAAG
ATCGAACCCGAGCCTTTTAGGAATTGTCTACTACGACCCGGCAGCCCTGCCCGAGTGATC
CAATGCATTTCAGAGCTGGGCATCTTCGGGGTCTATGTCAGGGAGGGAAAGACACTTGTG
ATGAACAAGCACGTGGGACATCTGCTTCGAACCAAAGCCATCGAGCATGCAGATGGCGGT
GTGGCGGCTGGAGTGGCAGTCCTGGACAACCCGTACCCTGTGTGA
Enzyme 3 GenBank Gene ID BT020647 Link Image
Enzyme 3 GeneCard ID GSS Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Chromosome:2
Enzyme 3 Locus 20q11.2
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 366
Enzyme 4 Name 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Enzyme 4 Synonyms
  1. AKB ligase
  2. Glycine acetyltransferase
  3. Aminoacetone synthetase
Enzyme 4 Gene Name GCAT
Enzyme 4 Protein Sequence >2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
MWAGRVLHAALSRAPRESRAQSALAQLRGILEEELESIRGAGTWKSERVITSRQGPHIHV
DGAPGGIINFCANNYLGLSSHPEVIQAGLRTLKEFGAGLSSVRFICGTQSIHKDLEAKIA
RFHQREDAILYPSCFDANTGLFEALLTSEDAVLSDELNHASIIDGIRLCKAHKYRYRHLD
MADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICRLASQYGALVFVDESHATGFLG
ATGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGALVSLLRQRARPYLFSNSLPP
AAVGCASKALDLLMESNAIVQSMAAKTLRFRSQMEAAGFTISGANHPICPVMLGDARLAL
NIADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP
Enzyme 4 Number of Residues 419
Enzyme 4 Molecular Weight 45165.2
Enzyme 4 Theoretical pI 7.38
Enzyme 4 GO Classification
Function
Process
Component
Enzyme 4 General Function Coenzyme transport and metabolism
Enzyme 4 Specific Function Acetyl-CoA + glycine = CoA + 2-amino-3- oxobutanoate
Enzyme 4 Pathways
  • Amino-acid degradation
  • L-threonine degradation via oxydo-reductase pathway
  • glycine from L-threonine:step 2/2
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 112362358 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q0P5L8 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name KBL_BOVIN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >1260 bp
ATGTGGGCTGGCCGCGTCCTGCATGCTGCGCTCTCCCGGGCCCCCCGCGAGAGCCGGGCG
CAGTCAGCGCTGGCTCAGCTGCGTGGCATCCTGGAGGAGGAGCTGGAAAGCATCCGCGGA
GCTGGCACCTGGAAGAGCGAGCGGGTCATCACGTCCCGTCAGGGGCCGCACATCCACGTG
GACGGCGCCCCGGGAGGAATTATTAACTTCTGTGCCAACAACTACCTGGGCCTGAGCAGC
CACCCTGAGGTCATTCAGGCAGGTCTGCGGACCCTAAAGGAGTTTGGAGCCGGCCTTAGC
TCAGTCCGCTTCATCTGTGGCACCCAGAGCATCCACAAAGACCTAGAAGCAAAGATAGCC
CGCTTTCACCAAAGGGAGGATGCCATCCTCTATCCCAGCTGTTTTGATGCCAACACCGGC
CTCTTTGAGGCACTGCTGACTTCGGAGGACGCAGTCCTGTCGGATGAGCTGAACCATGCC
TCCATCATCGATGGCATCCGTCTGTGCAAGGCCCACAAGTACCGCTACCGCCACCTGGAT
ATGGCTGATCTGGAGGCCAAGCTGCAGGAGGCCCAGAAGCATCGGCTGCGCCTGGTGGCC
ACTGATGGGGCCTTTTCCATGGATGGTGACATCGCACCCCTGCAGGAGATCTGCCGCCTT
GCCTCTCAATATGGTGCCTTAGTCTTTGTGGACGAAAGCCACGCCACTGGCTTCCTGGGG
GCCACAGGACGGGGCACAGATGAGCTGCTGGGCGTGATGGACCAAGTCACCATCATCAAC
TCCACACTGGGGAAGGCCCTGGGTGGAGCATCAGGGGGCTACACGACTGGGCCTGGGGCC
CTGGTATCCCTGCTACGGCAGCGTGCCCGGCCCTACCTCTTCTCCAACAGCCTGCCCCCT
GCTGCTGTCGGCTGTGCCTCCAAGGCCCTGGACCTGCTCATGGAGAGCAACGCCATCGTC
CAGTCTATGGCGGCCAAGACCCTGCGATTCCGCAGTCAGATGGAGGCTGCTGGCTTCACC
ATCTCAGGAGCCAATCACCCCATCTGCCCTGTGATGCTGGGTGACGCTCGGCTGGCCTTA
AACATAGCGGATGACATGCTTAAGAGAGGCATCTTTGTCATTGGGTTCAGCTACCCTGTG
GTCCCCAAAGGCAAGGCCCGGATCCGAGTCCAGATCTCAGCAGTGCACAGTGAGGAGGAC
ATTGACCGCTGTGTGGAGGCCTTCGTGGAGGTGGGGCGACTGCACGGCGCGCTGCCTTGA
Enzyme 4 GenBank Gene ID BC119870 Link Image
Enzyme 4 GeneCard ID GCAT Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Chromosome:2
Enzyme 4 Locus 22q13.1
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References
  1. [PubMed Link Image]
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 556
Enzyme 5 Name Glycine amidinotransferase, mitochondrial
Enzyme 5 Synonyms
  1. L-arginine:glycine amidinotransferase
  2. Transamidinase
  3. AT
Enzyme 5 Gene Name GATM
Enzyme 5 Protein Sequence >Glycine amidinotransferase, mitochondrial
MLRVRCLRGGSRGAEALHYIGSRLGRTVTGWVQRTFQSTQAATASSRNSCAADDKATDPL
PKDCPVSSFNEWDPLEEVIVGRAENACVPPFTVEVKANTYDKHWPFYQKYGGSYFPKDHL
QKAVAEIEEMCNILKMEGVTVRRPDPIDWSLKYKTPDFESTGLYGAMPRDILIVVGNEII
EAPMAWRARFFEYRAYRTIIKDYFRRGAKWTTAPKPTMADELYDQDYPIHSVEDRHKLAA
QGKFVTTEFEPCFDAADFIRAGRDIFVQRSQVTNYMGIEWMRKHLAPDYRVHIVSFKDPN
PMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPIIPDDHPLWMSSKWLSM
NVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVSIRNANSLGGGFHCWTCDVRRRGTLQS
YFD
Enzyme 5 Number of Residues 423
Enzyme 5 Molecular Weight 48357.0
Enzyme 5 Theoretical pI 7.97
Enzyme 5 GO Classification
Function
Process
Component
Enzyme 5 General Function Amino acid transport and metabolism
Enzyme 5 Specific Function L-arginine + glycine = L-ornithine + guanidinoacetate
Enzyme 5 Pathways
  • Amine and polyamine biosynthesis
  • creatine biosynthesis
  • creatine from L-arginine and glycine:step 1/2
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 87578309 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q2HJ74 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name GATM_BOVIN Link Image
Enzyme 5 PDB ID 3JDW Link Image
Enzyme 5 PDB File Show
Enzyme 5 3D Structure
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >1272 bp
ATGCTGCGGGTGCGGTGTCTGCGCGGCGGGAGCCGCGGTGCCGAAGCGCTGCACTACATC
GGGTCTCGGCTTGGAAGAACTGTAACGGGATGGGTGCAGCGAACTTTCCAGAGCACCCAG
GCAGCTACGGCTTCCTCCCGGAATTCCTGTGCAGCTGATGACAAGGCCACTGATCCTCTG
CCCAAGGACTGCCCTGTCTCCTCTTTCAACGAATGGGACCCCTTAGAGGAAGTGATCGTG
GGCAGAGCAGAAAATGCCTGTGTTCCACCGTTCACTGTGGAGGTGAAGGCCAACACATAT
GACAAGCACTGGCCTTTTTACCAAAAGTATGGGGGCAGTTATTTTCCCAAAGATCATTTG
CAAAAGGCTGTTGCTGAAATTGAAGAAATGTGCAATATTTTAAAAATGGAAGGAGTGACA
GTGAGGAGGCCTGACCCCATTGACTGGTCACTGAAGTATAAAACTCCTGATTTTGAGTCT
ACGGGTTTATATGGCGCGATGCCTCGAGACATCCTGATAGTTGTGGGAAATGAGATTATC
GAGGCTCCCATGGCCTGGCGCGCTCGCTTCTTTGAGTACCGTGCATACAGAACAATTATC
AAAGACTACTTCCGCCGTGGGGCCAAGTGGACAACGGCTCCTAAGCCCACAATGGCTGAT
GAGCTTTATGACCAAGATTACCCCATCCATTCTGTAGAAGACAGACACAAATTGGCTGCT
CAGGGAAAGTTTGTGACAACTGAGTTTGAGCCATGCTTTGATGCTGCTGATTTCATTCGA
GCTGGAAGAGATATCTTCGTACAAAGAAGCCAGGTTACAAACTACATGGGCATTGAATGG
ATGCGTAAGCATCTGGCTCCAGACTACAGAGTGCACATTGTTTCCTTTAAAGACCCCAAT
CCAATGCACATTGATGCCACCTTCAATATCATTGGGCCTGGTCTTGTGCTTTCCAACCCT
GACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACCATAGTTACTCCT
CCAACACCAATCATCCCAGATGATCACCCACTCTGGATGTCCTCCAAATGGCTTTCCATG
AATGTCTTAATGCTAGATGAAAAGCGTGTTATGGTGGATGCCAACGAGGTCCCAATTCAG
AAGATGTTTGAAAAGCTGGGTATCAGTACCATTAAGGTTAGCATTCGTAACGCCAATTCC
CTGGGAGGAGGCTTCCACTGCTGGACCTGCGATGTCCGTCGCCGGGGCACCCTGCAGTCC
TACTTTGACTGA
Enzyme 5 GenBank Gene ID BC113272 Link Image
Enzyme 5 GeneCard ID GATM Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Chromosome:1
Enzyme 5 Locus 15q21.1
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References Not Available
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 600
Enzyme 6 Name Trifunctional purine biosynthetic protein adenosine-3
Enzyme 6 Synonyms
  1. Phosphoribosylamine--glycine ligase
  2. Glycinamide ribonucleotide synthetase
  3. GARS
  4. Phosphoribosylglycinamide synthetase
  5. Phosphoribosylformylglycinamidine cyclo-ligase
  6. Phosphoribosyl-aminoimidazole synthetase
  7. AIR synthase
  8. AIRS
  9. Phosphoribosylglycinamide formyltransferase
  10. 5'-phosphoribosylglycinamide transformylase
  11. GAR transformylase
  12. GART
Enzyme 6 Gene Name GART
Enzyme 6 Protein Sequence >Trifunctional purine biosynthetic protein adenosine-3
MAARVLVIGNGGREHTLAWKLAQSTHVKQVLVTPGNAGTACSEKISNTDISISDHTALAQ
FCKDEKIEFVVVGPEAPLAAGIVGNLNSVGVRCFGPTAQAAQLESSKRFAKEFMDRHGIS
TARWRAFTKPKEACDFIMSADFPALVVKASGLAAGKGVIVAKSKEEACEAVREIMQGKAF
GEAGETVVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDEGPNTGGMGAYCPAP
QVSKDLLLKIKNNILQRTVDGMQEEGMPYTGVLYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSILDGLLCTSLPVWLDNCAAVTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFQAGTALKDGKVVTNGGRVLTVTAIRENLISALEEARKGLAAIKFEGAVYRKD
IGFRAIAFLQQPRGLTYKESGVDIAAGNMLVQKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFTDPLLACGTDGVGTKLKIAQQCSKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLRTTEAVITGIAKACKKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
QLERITEGDAVIGIASSGLHSNGFSLVRKIVAKSSLEYSSPAPGGCGDQTLGDLLLTPTK
IYSRSLLPVLRSGRVKAVAHITGGGLLENIPRVLPQKLGVNLDAQTWRVPRIFSWLQQEG
HLSEEEMARTFNCGIGAALVVSEDLVKQTLQDIEQHQEEACVIGRVVACPKGSPRVKVEH
LIETMQINGSVLENGTLRNHFSVQPKKARVAVLISGTGSNLQALIDSTREPSSLAHIVIV
ISNKAAVAGLDKAEKAGIPTRVINHKLYKNRAAFDTAIDEVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLDAGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVETLSERVKLAEHKIFPSALQLVASGAVRLGENGRICWVTED
Enzyme 6 Number of Residues 1010
Enzyme 6 Molecular Weight 107906.5
Enzyme 6 Theoretical pI 6.34
Enzyme 6 GO Classification
Function
Process
Component
Enzyme 6 General Function Nucleotide transport and metabolism
Enzyme 6 Specific Function ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide
Enzyme 6 Pathways
  • Purine metabolism
  • IMP biosynthesis via de novo pathway
  • N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5- phospho-D-ribosyl)glycinamide (10-formyl THF route):step 1/1
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 113912153 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID Q59A32 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name PUR2_BOVIN Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >3033 bp
ATGGCAGCCCGAGTACTTGTCATTGGCAATGGAGGACGAGAACACACGCTGGCCTGGAAA
CTTGCACAGTCTACTCATGTCAAACAAGTGTTGGTTACCCCAGGAAATGCAGGCACTGCC
TGCTCTGAGAAGATTTCAAATACTGACATCTCAATCAGTGATCATACTGCCCTTGCGCAG
TTCTGCAAAGATGAGAAAATTGAATTCGTAGTTGTTGGACCAGAGGCACCTCTAGCTGCT
GGAATTGTTGGGAACCTGAACTCTGTGGGAGTTCGGTGCTTTGGCCCCACAGCACAAGCA
GCTCAGTTAGAGTCCAGCAAGAGATTTGCCAAAGAGTTTATGGACCGACATGGAATCTCA
ACTGCAAGATGGAGAGCTTTCACTAAACCTAAAGAAGCCTGTGACTTCATTATGAGTGCA
GACTTCCCTGCTTTGGTTGTGAAGGCCAGTGGTCTTGCAGCTGGGAAAGGGGTAATTGTT
GCCAAGAGCAAAGAGGAGGCCTGTGAAGCTGTCAGAGAGATTATGCAGGGTAAAGCTTTC
GGAGAAGCAGGAGAAACAGTTGTCATTGAAGAACTTCTTGAAGGAGAAGAGGTGTCTTGT
CTGTGCTTCACTGATGGACGGACTGTGGCCCCCATGCCCCCAGCACAGGACCATAAGCGA
TTGCTGGAGGGCGATGAGGGCCCCAACACGGGAGGAATGGGAGCCTATTGTCCAGCCCCT
CAGGTTTCTAAGGATTTGTTGCTAAAAATTAAAAATAATATTCTTCAGAGGACAGTGGAT
GGCATGCAGGAGGAGGGTATGCCATACACAGGTGTCCTCTATGCTGGTATAATGCTGACC
AAGAACGGCCCCAAAGTTCTGGAATTTAATTGCCGTTTCGGTGATCCAGAGTGCCAAGTG
ATCCTCCCACTTCTTAAAAGTGATCTTTATGAAGTGATTCAGTCTATCTTAGATGGCTTG
CTCTGCACTTCTCTGCCTGTTTGGCTGGACAACTGTGCTGCCGTAACTGTGGTCATGGCA
AGTAAAGGTTATCCAGGAGACTACACCAAGGGTGTAGAGATAACAGGGTTTCCTGAGGCT
CAGGCTTTAGGACTGGAGGTGTTCCAAGCAGGCACTGCCCTAAAAGATGGCAAGGTGGTG
ACTAACGGGGGTAGGGTCCTTACTGTCACGGCCATCAGGGAAAATCTCATCTCAGCTCTT
GAAGAAGCCAGGAAAGGACTTGCCGCCATAAAGTTTGAGGGAGCTGTTTATAGGAAAGAC
ATCGGCTTTCGAGCCATAGCTTTCCTCCAGCAGCCCAGGGGCCTGACTTACAAGGAATCT
GGGGTAGACATTGCAGCTGGTAATATGCTGGTCCAGAAAATTAAACCTTTAGCGAAGGCC
ACCTCCAGACCAGGCTGTGATGTTGATCTTGGAGGTTTTGCTGGTCTTTTTGATTTGAAA
GCAGCTGGTTTCACTGATCCTCTTCTGGCTTGTGGAACAGATGGTGTTGGGACGAAACTG
AAGATTGCCCAGCAGTGCAGTAAACATGACACCATTGGTCAGGATTTGGTTGCGATGTGT
GTAAATGACATTCTGGCACAAGGAGCAGAGCCCCTCTTTTTCCTCGATTACTTTTCCTGT
GGAAAACTTGACCTCCGTACTACTGAAGCTGTTATCACTGGGATCGCCAAAGCTTGTAAA
AAGGCTGGATGTGCTCTCCTCGGAGGTGAAACGGCAGAGATGCCTGACATGTACCCTCCT
GGAGAGTATGATCTAGCTGGTTTTGCCGTTGGCGCCATGGAGCGGGATCAGAAACTTCCT
CAACTGGAAAGAATCACGGAAGGAGACGCTGTTATTGGAATCGCTTCATCTGGTCTTCAC
AGCAACGGATTCAGCCTTGTGAGGAAAATTGTAGCAAAATCTTCTCTCGAGTACTCTTCT
CCAGCACCTGGTGGCTGTGGTGACCAGACCTTAGGTGACTTACTTCTAACCCCAACCAAA
ATCTACAGCCGCTCACTGTTACCTGTCCTGCGTTCAGGACGTGTTAAGGCCGTTGCACAT
ATTACTGGTGGAGGATTACTGGAAAACATCCCCAGAGTCCTCCCTCAGAAATTGGGGGTG
AATTTAGATGCCCAGACCTGGAGGGTCCCCAGGATCTTCTCATGGTTACAGCAGGAAGGC
CACCTCTCTGAAGAGGAGATGGCCAGAACATTTAACTGTGGGATTGGGGCTGCCCTCGTG
GTATCAGAGGACCTGGTGAAGCAGACTCTGCAGGATATTGAGCAGCACCAGGAAGAAGCC
TGCGTGATCGGCAGAGTGGTTGCATGTCCCAAGGGTTCTCCTCGTGTGAAAGTCGAGCAT
CTGATTGAAACCATGCAAATAAATGGATCAGTATTGGAGAATGGAACCCTGAGAAATCAT
TTCTCTGTTCAACCAAAAAAGGCAAGAGTAGCTGTCTTAATTTCTGGGACAGGATCAAAC
CTCCAAGCTCTCATAGACAGCACTAGGGAGCCAAGTAGCTTGGCACACATTGTCATTGTG
ATCTCCAACAAAGCTGCAGTGGCTGGGTTAGATAAAGCAGAAAAAGCCGGGATTCCCACG
AGAGTAATTAATCATAAATTATATAAAAATCGTGCAGCATTTGACACTGCAATTGACGAA
GTCCTTGAAGAGTTCTCCACAGACATAGTCTGTCTTGCAGGATTCATGAGAATTTTGTCT
GGCCCCTTCGTCAGAAAATGGAATGGGAAAATGCTCAATATCCACCCATCCTTGCTCCCT
TCGTTTAAGGGTTCAAATGCCCATGAACAAGTCCTGGATGCTGGGGTCACAGTCACCGGG
TGCACCGTGCACTTTGTAGCTGAAGATGTAGATGCCGGTCAAATTATCTTACAGGAAGCC
GTTCCAGTGAAGAGGGGTGACACTGTTGAAACTCTATCTGAGAGAGTAAAATTAGCAGAA
CATAAAATATTTCCCTCAGCCCTCCAGCTGGTGGCCAGTGGAGCTGTACGGCTTGGAGAA
AATGGCAGAATCTGTTGGGTCACAGAGGACTGA
Enzyme 6 GenBank Gene ID BC122573 Link Image
Enzyme 6 GeneCard ID GART Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Chromosome:2
Enzyme 6 Locus 21q22.1|21q22.11
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References
  1. [PubMed Link Image]
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 624
Enzyme 7 Name 5-aminolevulinate synthase, nonspecific, mitochondrial
Enzyme 7 Synonyms
  1. 5-aminolevulinic acid synthase
  2. Delta-aminolevulinate synthase
  3. Delta-ALA synthetase
  4. ALAS-H
Enzyme 7 Gene Name ALAS1
Enzyme 7 Protein Sequence >5-aminolevulinate synthase, nonspecific, mitochondrial
METVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEIGAKPAPRALSTSAVLCQQVTE
TPPANEKDKAAKAEVQQAPDGSQQAPDGSQQTADGTQLPSGHPSLASSQGTGSKCPFLAA
EMSQGGSSVFRKASLALQEDVQEMHAVREEVAQTSVNPSVINVKTEGGELNGLLKNFQDI
MRKQRPERVSHLLQDNLPKSVCTFQYDRFFEKKIDEKKNDHSYRVFKTVNRKAQCFPMAD
DYSDSLISKKQVSVWCSNDYLGMSRHPRVCGAVIDTLKQHGTGAGGTRNISGTSKFHVDL
EQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDAGNHASMIQGIRNSGVPK
YIFRHNDVSHLRELLQRSDPAVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEV
HAVGLYGLQGGGIGDRDGVMPKMDIISGTLGKAIGCVGGYIASTSSLIDTVRSYAAGFIF
TTSLPPMLLAGALESVRILRSTEGRTLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVR
VADAAKNTEVCDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMSYFVDNLLAT
WKRVGLELKPHSSAECNFCRRPLHFEMMSEREKSYFSGMSKLVSAQA
Enzyme 7 Number of Residues 647
Enzyme 7 Molecular Weight 71061.7
Enzyme 7 Theoretical pI 7.92
Enzyme 7 GO Classification
Function
Process
Component
Enzyme 7 General Function Coenzyme transport and metabolism
Enzyme 7 Specific Function Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)
Enzyme 7 Pathways
  • Porphyrin metabolism
  • protoporphyrin-IX biosynthesis
  • 5- aminolevulinate from glycine:step 1/1
Enzyme 7 Reactions Not Available
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • None
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein 151554736 Link Image
Enzyme 7 UniProtKB/Swiss-Prot ID A6QLI6 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name HEM1_BOVIN Link Image
Enzyme 7 PDB ID Not Available
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence >1944 bp
ATGGAGACTGTTGTTCGTCGCTGCCCATTCTTATCCCGAGTGCCTCAAGCCTTTCTGCAG
AAGGCAGGCAAATCTCTATTGTTCTATGCCCAAAACTGCCCTAAGATGATGGAAATTGGG
GCCAAGCCAGCCCCTCGGGCCCTGTCCACTTCAGCAGTACTCTGCCAGCAGGTCACAGAA
ACCCCTCCAGCTAATGAGAAGGACAAAGCCGCCAAAGCCGAAGTGCAGCAGGCTCCTGAT
GGATCCCAGCAGGCTCCTGATGGGTCCCAGCAGACTGCAGATGGCACGCAGCTTCCGTCT
GGACACCCTTCCCTCGCCTCGAGCCAGGGCACTGGGAGCAAATGCCCTTTCCTGGCAGCC
GAGATGAGCCAGGGCGGCAGCAGTGTCTTCCGCAAAGCCAGCCTGGCGCTTCAGGAAGAT
GTGCAGGAGATGCATGCCGTGAGGGAAGAGGTTGCCCAAACTTCAGTGAATCCCAGTGTG
ATTAACGTGAAGACCGAAGGAGGGGAGCTGAATGGACTGTTGAAGAACTTTCAGGATATC
ATGCGAAAGCAGCGACCAGAAAGAGTGTCCCACCTTCTTCAAGATAACTTGCCAAAATCT
GTTTGCACTTTTCAGTATGATCGTTTCTTTGAGAAGAAAATTGATGAGAAAAAAAATGAC
CATAGCTATCGAGTTTTCAAAACTGTGAACCGGAAGGCTCAATGCTTCCCCATGGCAGAT
GACTATTCGGACTCTCTCATCAGCAAAAAGCAGGTGTCTGTCTGGTGTAGCAATGACTAC
CTAGGAATGAGTCGCCACCCACGGGTGTGTGGAGCCGTCATAGACACTTTGAAACAGCAT
GGTACTGGAGCAGGGGGTACTAGAAATATTTCTGGAACTAGTAAATTCCACGTGGACCTG
GAGCAGGAGCTGGCTGACCTCCATGGAAAAGATGCTGCACTCTTGTTCTCCTCGTGCTTT
GTGGCCAATGACTCGACCCTCTTCACTCTGGCTAAGATGATGCCAGGCTGTGAGATTTAC
TCTGACGCTGGGAACCATGCCTCCATGATCCAAGGGATTCGAAACAGTGGAGTGCCAAAG
TACATCTTCCGCCACAACGATGTCAGCCACCTCCGGGAACTGCTGCAGAGGTCTGACCCT
GCCGTCCCCAAGATTGTCGCCTTTGAAACTGTCCACTCAATGGACGGGGCAGTGTGCCCG
CTGGAAGAGCTGTGTGACGTGGCCCACGAGTTTGGAGCAATCACCTTCGTGGATGAGGTC
CACGCAGTGGGGCTCTACGGGCTGCAAGGCGGAGGGATTGGCGATCGGGATGGAGTTATG
CCAAAAATGGACATCATTTCTGGAACACTTGGCAAAGCCATTGGCTGCGTTGGAGGGTAC
ATCGCCAGCACGAGTTCCCTGATCGACACCGTCCGGTCCTACGCAGCGGGCTTCATTTTC
ACCACCTCCCTGCCGCCCATGCTGCTGGCTGGAGCACTGGAGTCTGTGCGGATCCTGAGG
AGCACTGAGGGCCGAACACTTCGCCGCCAACACCAGCGCAACGTGAAGCTCATGAGGCAG
ATGCTGATGGACGCTGGCCTGCCAGTGGTCCACTGCCCCAGTCACATCATCCCCGTCCGG
GTGGCAGATGCTGCTAAAAACACGGAGGTCTGTGATGAACTAATGACTAGACATAATATC
TACGTCCAAGCGATCAATTACCCCACAGTGCCCCGGGGTGAGGAGCTGCTGCGCATCGCC
CCCACGCCCCACCACACACCACAGATGATGAGCTACTTTGTGGATAACCTGCTGGCCACG
TGGAAGCGAGTTGGGCTGGAACTCAAGCCACATTCCTCAGCCGAGTGCAACTTCTGCAGG
AGGCCACTGCATTTTGAAATGATGAGTGAAAGAGAGAAATCCTACTTCTCTGGTATGAGC
AAGCTGGTGTCTGCTCAGGCCTGA
Enzyme 7 GenBank Gene ID BC147978 Link Image
Enzyme 7 GeneCard ID ALAS1 Link Image
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Chromosome:3
Enzyme 7 Locus 3p21.1
Enzyme 7 SNPs SNPJam Report Link Image
Enzyme 7 General References Not Available
Enzyme 7 Metabolite References Not Available
Enzyme 8 [top]
Enzyme 8 ID 629
Enzyme 8 Name 5-aminolevulinate synthase, erythroid-specific, mitochondrial
Enzyme 8 Synonyms
  1. 5-aminolevulinic acid synthase
  2. Delta-aminolevulinate synthase
  3. Delta-ALA synthetase
  4. ALAS-E
Enzyme 8 Gene Name ALAS2
Enzyme 8 Protein Sequence >5-aminolevulinate synthase, erythroid-specific, mitochondrial
MVTAAMLLQRCPVLIRSPTGLLGKMIKTHQFLFGIGRCPILATQGPSFSQIHLKATKAGG
DSPSWAKSHCPFMLLELQDGKSKIVQKAAPEVQEDVKTFKTDLPTSLASTSLKKTFSSPQ
EPEKNSEKVTHLIQNNMAGDHVFGYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAEH
FFEASVASKDVSVWCSNDYLGMSRHPRVLQATQEILQRHGAGAGGTRNISGTSKFHVELE
QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF
VFRHNDPDHLKKLLKKSNPETPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVH
AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT
TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV
GDAMLNTRICDLLLSKYGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLEAW
TEVGLPLQDISIAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA
Enzyme 8 Number of Residues 587
Enzyme 8 Molecular Weight 65136.4
Enzyme 8 Theoretical pI 7.90
Enzyme 8 GO Classification
Function
Process
Component
Enzyme 8 General Function Coenzyme transport and metabolism
Enzyme 8 Specific Function Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)
Enzyme 8 Pathways
  • Porphyrin metabolism
  • protoporphyrin-IX biosynthesis
  • 5- aminolevulinate from glycine:step 1/1
Enzyme 8 Reactions Not Available
Enzyme 8 Pfam Domain Function
Enzyme 8 Signals
  • None
Enzyme 8 Transmembrane Regions
  • None
Enzyme 8 Essentiality Not Available
Enzyme 8 GenBank ID Protein 73587019 Link Image
Enzyme 8 UniProtKB/Swiss-Prot ID Q3ZC31 Link Image
Enzyme 8 UniProtKB/Swiss-Prot Entry Name HEM0_BOVIN Link Image
Enzyme 8 PDB ID Not Available
Enzyme 8 Cellular Location Not Available
Enzyme 8 Gene Sequence >1764 bp
ATGGTGACAGCAGCCATGTTGCTACAGCGTTGCCCAGTGCTTATCCGGAGCCCCACAGGC
CTCCTGGGCAAGATGATTAAGACTCACCAGTTCCTGTTTGGTATTGGACGTTGTCCCATT
CTGGCCACCCAAGGACCAAGTTTTTCTCAAATCCACCTTAAGGCAACCAAGGCTGGAGGG
GATTCTCCATCTTGGGCCAAGAGCCACTGTCCCTTCATGCTGTTGGAACTCCAGGATGGG
AAGAGTAAAATTGTGCAAAAAGCAGCCCCAGAAGTCCAGGAAGATGTGAAGACTTTCAAG
ACAGACTTGCCCACCTCTCTGGCCTCAACCAGCCTGAAGAAGACATTCTCCAGTCCCCAA
GAGCCAGAGAAAAATTCGGAGAAGGTCACACACCTGATTCAGAACAACATGGCTGGAGAC
CATGTCTTTGGTTATGACCAGTTTTTTAGGGACAAAATCATGGAGAAGAAACAGGACCAC
ACCTATCGTGTTTTCAAGACTGTGAATCGCTGGGCTGATGCATACCCCTTTGCTGAACAC
TTCTTTGAGGCATCTGTGGCCTCAAAGGATGTGTCTGTCTGGTGCAGTAATGACTACCTG
GGCATGAGCCGGCACCCTCGGGTCTTGCAAGCCACACAAGAGATCCTGCAGCGCCATGGA
GCTGGAGCTGGTGGCACCCGCAACATCTCGGGTACCAGTAAGTTCCATGTCGAGCTGGAG
CAAGAGCTGGCTGAGCTGCACCAGAAGGACTCAGCCCTGCTCTTCTCTTCCTGCTTTGTG
GCCAATGACTCCACTCTCTTCACCTTGGCCAAGATCTTGCCAGGGTGTGAGATTTACTCA
GATGCAGGCAACCATGCTTCCATGATCCAAGGTATCCGCAACAGTGGAGCAGCTAAGTTT
GTCTTCAGGCACAATGATCCTGACCACCTGAAGAAACTTCTAAAGAAGTCCAACCCTGAG
ACACCCAAAATCGTGGCCTTCGAGACTGTTCACTCCATGGACGGTGCCATCTGTCCCCTT
GAGGAATTGTGTGATGTGGCCCATCAGTATGGGGCTCTGACCTTCGTGGATGAAGTTCAT
GCTGTAGGACTGTATGGGTCCCGGGGTGCTGGGATTGGGGAGCGTGATGGAATTATGCAC
AAGATTGACATCATCTCTGGAACTCTTGGCAAAGCCTTTGGCTGTGTGGGTGGCTACATT
GCCAGCACCCGTGACTTGGTGGACATGGTACGTTCCTATGCTGCTGGCTTCATCTTCACC
ACTTCACTGCCTCCCATGGTGCTCTCTGGGGCTCTGGAATCCGTGCGACTGCTCAAAGGA
GAGGAGGGCCAAGCCCTGAGGAGGGCCCACCAACGCAATGTCAAGCACATGCGTCAGCTA
CTAATGGACAGGGGCCTTCCTGTCATTCCATGCCCCAGCCACATCATCCCCATTCGGGTG
GGTGATGCAATGCTGAACACCAGGATCTGTGATCTCCTGCTCTCCAAGTATGGCATCTAT
GTGCAGGCCATCAACTACCCAACTGTCCCCCGGGGTGAGGAGCTGCTGCGCTTGGCACCC
TCCCCCCACCACAGCCCTCAGATGATGGAAGACTTTGTGGAGAAGCTGCTAGAAGCCTGG
ACTGAGGTGGGACTCCCCCTCCAGGATATATCTATAGCTGCCTGCAATTTCTGCCGCCGT
CCTGTACACTTCGAGCTCATGAGTGAGTGGGAACGTTCCTACTTTGGGAACATGGGGCCC
CAGTATGTCACCACTTATGCCTAA
Enzyme 8 GenBank Gene ID BC102938 Link Image
Enzyme 8 GeneCard ID ALAS2 Link Image
Enzyme 8 GenAtlas ID Not Available
Enzyme 8 HGNC ID Not Available
Enzyme 8 Chromosome Location Not Available
Enzyme 8 Locus Xp11.21
Enzyme 8 SNPs SNPJam Report Link Image
Enzyme 8 General References Not Available
Enzyme 8 Metabolite References Not Available
Enzyme 9 [top]
Enzyme 9 ID 793
Enzyme 9 Name Alanine--glyoxylate aminotransferase 2, mitochondrial
Enzyme 9 Synonyms
  1. AGT 2
  2. (R)-3-amino-2-methylpropionate--pyruvate transaminase
  3. Beta-alanine-pyruvate aminotransferase
  4. Beta-ALAAT II
  5. D-AIBAT
Enzyme 9 Gene Name AGXT2
Enzyme 9 Protein Sequence >Alanine--glyoxylate aminotransferase 2, mitochondrial
MTGAWGHLLRSLHLKTLSLWIPKTCFSLKARAFWTSVTRCGLHTKPSMPPCDFTPERYQS
LAYSRVLEIHKQHLSPVHTAYFPEPLLLHQGHVEWLFDHEGNRYLDFFSGIVTVSVGHCH
PKVNAAAQRQLGRLWHTSSVFFHPLIHEYAEKLSALLPEPLKVVFLVNSGSEANDLAMLM
ARAHSNSTDIISFRGAYHGCSPYTLGLTNVGIYKMDLPHGMGCQPTMCPDIFHGPWGGSH
CRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAKSIAGFFAEPIQGVNGVVQYPK
GFLKEAFELVRERGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAA
VVTTPDIAKSLTKRMLHFNTFGGNPMACAVGSAVLEVIKEENLQENSQEVGTYMLLKLAK
LRDEFEIVGDVRGKGLMIGIEMVKDKESRQPLPREEVNQIHHDCKCMGLLIGRGGLFSQT
FRIAPSMCITKPEVDFAVEVFRSALIQHMERRAK
Enzyme 9 Number of Residues 514
Enzyme 9 Molecular Weight 57225.8
Enzyme 9 Theoretical pI 7.93
Enzyme 9 GO Classification
Function
Process
Component
Enzyme 9 General Function Amino acid transport and metabolism
Enzyme 9 Specific Function L-alanine + glyoxylate = pyruvate + glycine
Enzyme 9 Pathways Not Available
Enzyme 9 Reactions Not Available
Enzyme 9 Pfam Domain Function
Enzyme 9 Signals
  • None
Enzyme 9 Transmembrane Regions
  • None
Enzyme 9 Essentiality Not Available
Enzyme 9 GenBank ID Protein 109659373 Link Image
Enzyme 9 UniProtKB/Swiss-Prot ID Q17QF0 Link Image
Enzyme 9 UniProtKB/Swiss-Prot Entry Name AGT2_BOVIN Link Image
Enzyme 9 PDB ID Not Available
Enzyme 9 Cellular Location Not Available
Enzyme 9 Gene Sequence >1545 bp
ATGACAGGAGCCTGGGGACATTTGCTGAGATCTTTGCACCTGAAAACCTTATCTCTCTGG
ATCCCCAAGACGTGCTTTTCCCTTAAGGCCCGTGCTTTCTGGACATCTGTGACCAGGTGC
GGTCTTCATACAAAGCCCAGCATGCCGCCATGTGACTTCACACCCGAAAGATACCAGTCC
CTGGCCTATAGCCGAGTCCTGGAGATCCATAAGCAACATCTCTCTCCTGTGCACACCGCC
TATTTCCCGGAGCCCCTGTTGCTCCACCAGGGACACGTGGAGTGGCTCTTTGATCATGAG
GGAAACAGATACCTGGATTTCTTTTCTGGGATTGTCACTGTCAGTGTTGGTCACTGCCAC
CCAAAAGTAAACGCAGCGGCGCAAAGGCAGCTGGGCCGCCTGTGGCATACAAGTTCTGTC
TTCTTCCACCCTCTGATCCACGAATATGCAGAGAAGCTTTCAGCACTTCTTCCTGAGCCT
TTGAAGGTCGTTTTCTTGGTGAACAGTGGTTCAGAAGCCAATGACCTAGCCATGCTGATG
GCCAGAGCACACTCAAACAGCACAGACATCATTTCTTTCAGAGGAGCCTACCATGGATGC
AGTCCTTACACACTTGGCTTGACAAATGTAGGCATCTATAAGATGGACCTCCCTCATGGG
ATGGGCTGCCAACCAACAATGTGCCCAGACATTTTCCATGGCCCTTGGGGAGGAAGCCAC
TGCCGAGATTCTCCAGTGCAAACAATTAGGAAGTGCAGCTGTGCGCCAGACTGCTGTCAA
GCTAAAGACCAGTATATTGAACAATTCAAAGATACTCTGAGCACTTCTGTGGCCAAATCA
ATTGCTGGATTTTTTGCAGAGCCAATTCAAGGGGTGAATGGCGTTGTTCAGTACCCGAAG
GGGTTTCTAAAGGAAGCCTTCGAGCTGGTGCGCGAGCGGGGAGGCGTGTGCATTGCAGAT
GAAGTGCAGACAGGATTTGGAAGGCTGGGCTCTCACTTCTGGGGCTTCCAAACACACGAT
GTCCTGCCAGATATTGTTACCATGGCTAAAGGGATTGGGAATGGCTTTCCCATGGCAGCA
GTCGTGACAACTCCAGATATTGCCAAGTCCTTAACCAAGCGCATGCTTCACTTCAATACC
TTTGGAGGGAACCCCATGGCCTGCGCCGTTGGTTCAGCAGTGCTTGAGGTGATTAAAGAA
GAAAATCTACAAGAAAATAGCCAAGAAGTTGGCACCTATATGTTGCTGAAGTTGGCTAAG
CTGCGGGATGAATTTGAAATTGTAGGAGATGTCCGAGGCAAAGGTCTCATGATAGGAATA
GAAATGGTGAAGGATAAGGAGAGCCGCCAGCCTCTTCCCCGTGAAGAAGTAAATCAAATC
CACCACGACTGCAAATGCATGGGGCTTCTGATTGGCAGAGGCGGCCTTTTCTCTCAGACT
TTCCGCATTGCGCCCTCAATGTGCATCACTAAACCAGAAGTTGATTTTGCAGTGGAAGTG
TTTCGCTCTGCCTTAATTCAACACATGGAGAGAAGAGCTAAATAA
Enzyme 9 GenBank Gene ID BC118402 Link Image
Enzyme 9 GeneCard ID AGXT2 Link Image
Enzyme 9 GenAtlas ID Not Available
Enzyme 9 HGNC ID Not Available
Enzyme 9 Chromosome Location Chromosome:5
Enzyme 9 Locus 5p13
Enzyme 9 SNPs SNPJam Report Link Image
Enzyme 9 General References Not Available
Enzyme 9 Metabolite References Not Available
Enzyme 10 [top]
Enzyme 10 ID 895
Enzyme 10 Name Peroxisomal sarcosine oxidase
Enzyme 10 Synonyms
  1. PSO
  2. L-pipecolate oxidase
  3. L-pipecolic acid oxidase
Enzyme 10 Gene Name PIPOX
Enzyme 10 Protein Sequence >Peroxisomal sarcosine oxidase
MAAQRELYDAIVIGAGIQGCFTAYHLAKHSKKVLLLEQFFLPHSRGSSHGQSRIIRRAYP
EDFYTQMMAECYSLWAQLEHEAGTQLYRQTGLLLLGMKENPELKIIQATLSRQGVEHQCL
SSEELKQRFPNIRLARGEVGLLEVSGGVLYADKALRALQDAIRQLGGIVHDGEKVVEIKS
GLPVMVKTTSRSYQAKSLIITAGPWTNRLLRPLGAELPLQTLRINVCYWQEKVPGSYSVS
QAFPCFMGLGLSLAPHHIYGLPSREYPGLMKVCYHHGNNADPEERDCPAAFSDIQDVHIL
SGFVRDHLPDLQPEPAVMEHCMYTNTPDGHFVLDRHPKYDNIVIGAGFSGHGFKLSPVVG
KILYELSMKLTPSYDLTPFRISRFPSLGKAHL
Enzyme 10 Number of Residues 392
Enzyme 10 Molecular Weight 43819.2
Enzyme 10 Theoretical pI 8.05
Enzyme 10 GO Classification
Function
Process
Component
Enzyme 10 General Function Amino acid transport and metabolism
Enzyme 10 Specific Function Metabolizes sarcosine, L-pipecolic acid and L-proline
Enzyme 10 Pathways Not Available
Enzyme 10 Reactions Not Available
Enzyme 10 Pfam Domain Function
Enzyme 10 Signals
  • None
Enzyme 10 Transmembrane Regions
  • None
Enzyme 10 Essentiality Not Available
Enzyme 10 GenBank ID Protein 59858253 Link Image
Enzyme 10 UniProtKB/Swiss-Prot ID Q29RU9 Link Image
Enzyme 10 UniProtKB/Swiss-Prot Entry Name SOX_BOVIN Link Image
Enzyme 10 PDB ID Not Available
Enzyme 10 Cellular Location Not Available
Enzyme 10 Gene Sequence >1179 bp
ATGGCTGCTCAGAGGGAGCTCTATGACGCCATTGTGATCGGGGCAGGCATCCAGGGCTGC
TTCACGGCGTACCACCTGGCCAAACACAGCAAGAAAGTCCTCCTGCTGGAGCAGTTCTTT
CTCCCGCACTCCCGAGGAAGCTCCCATGGGCAGAGCCGGATCATCCGAAGGGCATACCCA
GAAGATTTCTACACCCAGATGATGGCTGAGTGCTACTCCCTGTGGGCCCAGCTGGAGCAT
GAGGCGGGAACCCAATTATACAGGCAGACTGGACTACTGCTGCTGGGAATGAAGGAGAAC
CCAGAATTAAAGATAATCCAGGCTACTTTGTCGAGGCAGGGAGTGGAGCACCAGTGTCTT
TCATCTGAGGAACTGAAGCAACGTTTCCCCAATATTCGGTTGGCCAGGGGAGAAGTGGGG
CTCTTGGAGGTGTCCGGAGGAGTTCTCTATGCCGACAAGGCACTCAGAGCCCTCCAGGAT
GCAATTCGACAGCTAGGTGGCATAGTGCATGATGGAGAGAAGGTAGTGGAGATAAAATCA
GGGCTACCAGTCATGGTGAAAACTACCTCCAGGAGCTACCAAGCCAAGAGCTTGATCATC
ACGGCAGGTCCTTGGACCAACCGGCTCCTCCGTCCCTTGGGAGCTGAGCTACCTCTCCAG
ACCCTGCGGATCAACGTGTGTTACTGGCAAGAGAAGGTTCCTGGAAGCTACAGTGTGTCC
CAGGCCTTTCCGTGTTTCATGGGCCTGGGCCTCAGCCTGGCTCCTCACCACATCTACGGG
CTGCCCTCCAGAGAGTACCCAGGGCTGATGAAGGTCTGCTATCACCACGGCAACAATGCA
GATCCCGAGGAGCGGGACTGCCCAGCAGCTTTCTCAGACATCCAAGATGTCCACATCCTG
AGCGGTTTTGTCAGAGATCACTTACCTGACCTGCAGCCCGAGCCTGCTGTGATGGAGCAT
TGCATGTACACGAACACCCCCGATGGGCACTTCGTTCTTGATAGACACCCAAAGTACGAC
AACATTGTCATTGGTGCTGGATTCTCTGGGCATGGGTTCAAGTTGTCCCCTGTCGTGGGG
AAGATCCTGTACGAATTAAGCATGAAATTAACGCCATCCTATGACTTGACACCTTTTCGA
ATCAGCCGCTTTCCCAGCCTGGGCAAAGCCCACCTTTGA
Enzyme 10 GenBank Gene ID BT020944 Link Image
Enzyme 10 GeneCard ID PIPOX Link Image
Enzyme 10 GenAtlas ID Not Available
Enzyme 10 HGNC ID Not Available
Enzyme 10 Chromosome Location Chromosome:1
Enzyme 10 Locus 17q11.2
Enzyme 10 SNPs SNPJam Report Link Image
Enzyme 10 General References
  1. [PubMed Link Image]
Enzyme 10 Metabolite References Not Available
Enzyme 11 [top]
Enzyme 11 ID 955
Enzyme 11 Name Arylacetyl-CoA N-acyltransferase
Enzyme 11 Synonyms
  1. Arylacetyltransferase
  2. Arylacetyl-CoA:amino acid N-acyltransferase
  3. ArAlk
Enzyme 11 Gene Name Not Available
Enzyme 11 Protein Sequence >Arylacetyl-CoA N-acyltransferase
MFHLQGPQLLQMLEKSLRKSLPESLKVYGTVFHMNQGNPFNLKALVDKWPDFKTVVIRPQ
EQEMADDFDHYTNTYQIYSKDLNNCQESLATSDVINWKQHLQIQSSQSSLNEVVQNLAAT
KFVKVEHTQCILYVMPETARKLLPSLPETKNLPVGYGAPKAINQEMFKLSSMDPTHAALV
NKFWHFGGNERSQRFIERCIRAFPTFCLLGPEGTPASWSLMDQTGEIRMGATLPEYRGHG
LISHMLAVHTRALDQLGIPVYNHTDKANKIVQKVSHNLHHIAIPHGWNQWNCEPL
Enzyme 11 Number of Residues 295
Enzyme 11 Molecular Weight 33683.4
Enzyme 11 Theoretical pI 7.99
Enzyme 11 GO Classification
Function
Process
Component
Enzyme 11 General Function Involved in glycine N-acyltransferase activity
Enzyme 11 Specific Function Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines. Catalyzes the conjugation of arylacetic acids with glycine but does not have activity towards any alkyl-CoA
Enzyme 11 Pathways Not Available
Enzyme 11 Reactions Not Available
Enzyme 11 Pfam Domain Function
Enzyme 11 Signals
  • None
Enzyme 11 Transmembrane Regions
  • None
Enzyme 11 Essentiality Not Available
Enzyme 11 GenBank ID Protein 3492930 Link Image
Enzyme 11 UniProtKB/Swiss-Prot ID O77512 Link Image
Enzyme 11 UniProtKB/Swiss-Prot Entry Name GLYAL_BOVIN Link Image
Enzyme 11 PDB ID Not Available
Enzyme 11 Cellular Location Not Available
Enzyme 11 Gene Sequence >891 bp
ATGTTCCATTTACAAGGCCCACAACTGCTGCAGATGTTAGAGAAATCCTTGAGGAAGAGT
CTCCCCGAGTCCTTAAAGGTTTACGGGACCGTCTTCCACATGAACCAGGGAAACCCATTC
AATCTAAAGGCCCTGGTGGACAAGTGGCCTGATTTTAAGACCGTGGTCATCCGCCCTCAG
GAGCAGGAGATGGCAGATGACTTTGATCATTATACCAACACCTACCAAATCTATTCCAAG
GATCTCAACAACTGTCAAGAGTCCSHHCTTGCCACATCAGATGTCATCAACTGGAAACAA
CATTTGCAGATCCAAAGTTCACAGTCCAGTCTGAATGAGGTGGTACAGAATCTTGCAGCC
ACTAAATTTGTTAAGGTCGAGCACACACAGTGCATTCTGTATGTGATGCCGGAGACAGCG
AGGAAACTTCTTCCTTCCCTGCCAGAGACAAAGAACTTACCTGTTGGATATGGCGCACCC
AAAGCCATTAACCAGGAGATGTTTAAGCTCTCATCAATGGATCCTACCCATGCCGCTTTG
GTGAATAAATTCTGGCATTTTGGTGGCAACGAGAGGAGCCAGAGGTTCATCGAGCGCTGT
ATCCGGGCCTTCCCCACCTTCTGCCTTCTGGGGCCTGAGGGGACCCCTGCCTCCTGGTCC
CTGATGGACCAGACGGGAGAGATCCGGATGGGGGCCACGCTGCCCGAGTACCGTGGCCAC
GGGCTCATCTCCCACATGCTGGCTGTCCACACCCGGGCTCTGGACCAGCTCGGCATCCCC
GTGTATAACCACACGGACAAAGCCAACAAAATCGTGCAGAAAGTCAGTCACAACCTGCAT
CACATCGCCATCCCCCATGGGTGGAACCAGTGGAACTGTGAGCCCCTGTAA
Enzyme 11 GenBank Gene ID AF022073 Link Image
Enzyme 11 GeneCard ID Not Available
Enzyme 11 GenAtlas ID Not Available
Enzyme 11 HGNC ID Not Available
Enzyme 11 Chromosome Location Not Available
Enzyme 11 Locus Not Available
Enzyme 11 SNPs SNPJam Report Link Image
Enzyme 11 General References
  1. [PubMed Link Image]
Enzyme 11 Metabolite References Not Available
Enzyme 12 [top]
Enzyme 12 ID 956
Enzyme 12 Name Glycine N-acyltransferase
Enzyme 12 Synonyms
  1. Acyl-CoA:glycine N-acyltransferase
  2. AAc
  3. Aralkyl acyl-CoA N-acyltransferase
  4. Aralkyl acyl-CoA:amino acid N-acyltransferase
Enzyme 12 Gene Name GLYAT
Enzyme 12 Protein Sequence >Glycine N-acyltransferase
MFLLQGAQMLQMLEKSLRKSLPMSLKVYGTVMHMNHGNPFNLKALVDKWPDFQTVVIRPQ
EQDMKDDLDHYTNTYHVYSEDLKNCQEFLDLPEVINWKQHLQIQSTQSSLNEVIQNLAAT
KSFKVKRSKNILYMASETIKELTPSLLDVKNLPVGDGKPKAIDPEMFKLSSVDPSHAAVV
NRFWLFGGNERSLRFIERCIQSFPNFCLLGTEGTPVSWSLMDQTGEMRMAGTLPEYRAQG
LVTHAIYQQAQCLLKRGFPVYSHVDPKNQIMQKMSQSLNHVPMPSDWNQWNCEPL
Enzyme 12 Number of Residues 295
Enzyme 12 Molecular Weight 33906.9
Enzyme 12 Theoretical pI 7.59
Enzyme 12 GO Classification
Function
Process
Component
Enzyme 12 General Function Involved in glycine N-acyltransferase activity
Enzyme 12 Specific Function Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines
Enzyme 12 Pathways Not Available
Enzyme 12 Reactions Not Available
Enzyme 12 Pfam Domain Function
Enzyme 12 Signals
  • None
Enzyme 12 Transmembrane Regions
  • None
Enzyme 12 Essentiality Not Available
Enzyme 12 GenBank ID Protein 2865607 Link Image
Enzyme 12 UniProtKB/Swiss-Prot ID Q2KIR7 Link Image
Enzyme 12 UniProtKB/Swiss-Prot Entry Name GLYAT_BOVIN Link Image
Enzyme 12 PDB ID Not Available
Enzyme 12 Cellular Location Not Available
Enzyme 12 Gene Sequence >888 bp
ATGTTCCTGCTGCAAGGTGCCCAGATGCTGCAGATGCTGGAGAAATCCTTGAGGAAGAGC
CTTCCTATGTCCTTAAAGGTTTATGGGACCGTCATGCACATGAACCATGGAAACCCATTC
AATCTAAAGGCCCTGGTGGACAAGTGGCCTGATTTTCAGACCGTGGTTATCCGCCCTCAG
GAGCAGGACATGAAAGATGACCTTGATCACTACACTAATACTTACCATGTCTACTCTGAA
GATCTTAAGAATTGTCAGGAATTCCTTGACTTACCAGAAGTCATCAATTGGAAACAGCAT
CTGCAGATCCAAAGTACACAGTCCAGCCTGAATGAAGTAATACAAAATCTTGCAGCCACG
AAATCCTTCAAAGTCAAGCGATCAAAAAACATTCTCTACATGGCATCTGAGACAATAAAG
GAACTGACTCCGTCCTTGCTGGATGTAAAGAACTTACCAGTTGGCGATGGCAAACCAAAG
GCCATCGACCCAGAGATGTTTAAGCTCTCATCTGTGGATCCTAGCCACGCAGCTGTGGTG
AACAGATTCTGGCTTTTCGGTGGCAACGAGAGGAGCCTGAGGTTCATCGAGCGCTGTATC
CAGAGCTTCCCCAACTTCTGCCTGCTGGGGCCCGAGGGGACCCCTGTGTCTTGGTCCCTG
ATGGACCAGACGGGAGAGATGCGGATGGCAGGCACCCTGCCTGAGTACCGGGCCCAGGGG
CTCGTCACCCACGCCATCTACCAGCAGGCCCAGTGTCTGCTCAAGCGGGGCTTCCCTGTG
TACTCTCATGTGGACCCCAAGAACCAGATCATGCAGAAGATGAGTCAGAGCCTCAACCAC
GTGCCAATGCCCTCTGACTGGAACCAGTGGAACTGTGAGCCTCTGTGA
Enzyme 12 GenBank Gene ID AF045032 Link Image
Enzyme 12 GeneCard ID GLYAT Link Image
Enzyme 12 GenAtlas ID Not Available
Enzyme 12 HGNC ID Not Available
Enzyme 12 Chromosome Location Chromosome:1
Enzyme 12 Locus 11q12.1
Enzyme 12 SNPs SNPJam Report Link Image
Enzyme 12 General References
  1. [PubMed Link Image]
Enzyme 12 Metabolite References Not Available