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Bovine Rumen Metabolome Database



Showing metabocard for L-Lysine (RMDB00182)

Legend: metabolite field enzyme field

Version 1.0
Creation Date 2005-11-16 15:48:42
Update Date 2009-10-28 13:47:18
Accession Number RMDB00182
Common Name L-Lysine
Description L-lysine is an essential amino acid. Normal requirements for lysine have been found to be about 8 g per day or 12 mg/kg in adults. Children and infants need more- 44 mg/kg per day for an eleven to-twelve-year old, and 97 mg/kg per day for three-to six-month old. Lysine is highly concentrated in muscle compared to most other amino acids. Lysine is high in foods such as wheat germ, cottage cheese and chicken. Of meat products, wild game and pork have the highest concentration of lysine. Fruits and vegetables contain little lysine, except avocados. Normal lysine metabolism is dependent upon many nutrients including niacin, vitamin B6, riboflavin, vitamin C, glutamic acid and iron. Excess arginine antagonizes lysine. Several inborn errors of lysine metabolism are known. Most are marked by mental retardation with occasional diverse symptoms such as absence of secondary sex characteristics, undescended testes, abnormal facial structure, anemia, obesity, enlarged liver and spleen, and eye muscle imbalance. Lysine also may be a useful adjunct in the treatment of osteoporosis. Although high protein diets result in loss of large amounts of calcium in urine, so does lysine deficiency. Lysine may be an adjunct therapy because it reduces calcium losses in urine. Lysine deficiency also may result in immunodeficiency. Requirements for this amino acid are probably increased by stress. Lysine toxicity has not occurred with oral doses in humans. Lysine dosages are presently too small and may fail to reach the concentrations necessary to prove potential therapeutic applications. Lysine metabolites, amino caproic acid and carnitine have already shown their therapeutic potential. Thirty grams daily of amino caproic acid has been used as an initial daily dose in treating blood clotting disorders, indicating that the proper doses of lysine, its precursor, have yet to be used in medicine. Low lysine levels have been found in patients with Parkinson's, hypothyroidism, kidney disease, asthma and depression. The exact significance of these levels is unclear, yet lysine therapy can normalize the level and has been associated with improvement of some patients with these conditions. Abnormally elevated hydroxylysines have been found in virtually all chronic degenerative diseases and coumadin therapy. The levels of this stress marker may be improved by high doses of vitamin C. Lysine is particularly useful in therapy for marasmus (wasting) and herpes simplex. It stops the growth of herpes simplex in culture, and has helped to reduce the number and occurrence of cold sores in clinical studies. Dosing has not been adequately studied, but beneficial clinical effects occur in doses ranging from 100 mg to 4 g a day. Higher doses may also be useful, and toxicity has not been reported in doses as high as 8 g per day. Diets high in lysine and low in arginine can be useful in the prevention and treatment of herpes. Some researchers think herpes simplex virus is involved in many other diseases related to cranial nerves such as migraines, Bell's palsy and Meniere's disease. Herpes blister fluid will produce fatal encephalitis in the rabbit. (http://www.dcnutrition.com)
Synonyms
  1. (+)-S-Lysine
  2. (S)-2,6-Diaminohexanoate
  3. (S)-2,6-Diaminohexanoic acid
  4. (S)-2,6-diamino-Hexanoate
  5. (S)-2,6-diamino-Hexanoic acid
  6. (S)-Lysine
  7. (S)-a,e-Diaminocaproate
  8. (S)-a,e-Diaminocaproic acid
  9. 2,6-Diaminohexanoate
  10. 2,6-Diaminohexanoic acid
  11. 6-amino-Aminutrin
  12. 6-amino-L-Norleucine
  13. Aminutrin
  14. L-(+)-Lysine
  15. L-2,6-Diainohexanoate
  16. L-2,6-Diainohexanoic acid
  17. L-2,6-Diaminocaproate
  18. L-2,6-Diaminocaproic acid
  19. L-Lys
  20. Lys
  21. Lysine
  22. Lysine acid
  23. a-Lysine
  24. h-Lys-oh
  25. alpha-Lysine
Chemical IUPAC Name 2,6-diaminohexanoic acid
Chemical Formula C6H14N2O2
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Amino acids and Amino Acid conjugates
Class
  • Amino Acids
Sub Class
  • NA
Family
  • Mammalian_Metabolite
Species
  • primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid
Biofunction
  • Essential amino acids; Component of Aminoacyl-tRNA biosynthesis; Component of Lysine biosynthesis
Application
Source
  • Exogenous
Average Molecular Weight 146.188
Monoisotopic Molecular Weight 146.105530
Isomeric SMILES NCCCC[C@H](N)C(O)=O
Canonical SMILES NCCCCC(N)C(O)=O
KEGG Compound ID C00047 Link Image
BioCyc ID LYS Link Image
BiGG ID 33655 Link Image
Wikipedia Link L-Lysine Link Image
METLIN ID 5200 Link Image
PubChem Compound 5962 Link Image
PubChem Substance 819792 Link Image
ChEBI ID 18019 Link Image
CAS Registry Number 56-87-1
InChI Identifier InChI=1/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1
Synthesis Reference Rothstein, Morton. DL-Lysine-6-C14 and DL-a-aminoadipic acid-6-C14. Biochemical Preparations (1961), 8 85-8.
Melting Point (Experimental) 224.5 oC
Experimental Water Solubility 1000.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)] Source: PhysProp
Predicted Water Solubility 104.99999 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 1
State Solid
Experimental LogP/Hydrophobicity -3.05 [HANSCH,C ET AL. (1995)] Source: PhysProp
Predicted LogP/Hydrophobicity -3.76 [Predicted by ALOGPS]; -2.9 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show Link Image
SDF File Show Link Image
PDB File Show Link Image
2D Structure
3D Structure
Experimental PDB ID 1BBU Link Image
Experimental PDB File Show
Experimental PDB Structure
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum
Low Energy
Download File
Show Experimental Conditions Link Image
Medium Energy
Download File
Show Experimental Conditions Link Image
High Energy
Download File
Show Experimental Conditions Link Image
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Cytoplasm
  • Extracellular
  • mitochondria
  • nucleus
  • peroxisome
Biofluid Location
  • Rumen
  • Urine
  • Blood
  • Cow_Milk
Tissue Location
Concentrations (Normal)
Biofluid Rumen
Value 135 (46.0 -224) uM
Age N/A
Sex Both
Condition Normal
Breed Not Available
Experimental Condition Not Available
Comments This concentration measured after 1 hour of feeding.; The three amino acids (AA), threonine, methionine and Lysine were administered intraruminally in mixtures at dosages of 100, 200, 300, and 400 mmol of each,together with polyethylene glycol (PEG) as a liquid marker.
References
Biofluid Rumen
Value 177.2 +/- 78.7 uM
Age 4-5 years old
Sex Female (lactating)
Condition Normal (0% barley grain in dry matter (DM) basis)
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 110.5 +/- 7.8 uM
Age N/A
Sex Female
Condition Normal
Breed Not Available
Experimental Condition Not Available
Comments Not Available
References
  • Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows. Burim N. Ametaj, Qendrim Zebeli, Fozia Saleem, Nikolaos Psychogios, Michael J. Lewis, Suzanna M. Dunn, Jianguo Xia and David S. Wishart Metabolomics 2010;6(4):583-594
Concentrations (Abnormal)
Biofluid Rumen
Value 122 +/- 26 uM
Age 4-5 years old
Sex Female (lactating)
Condition 15% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 165 +/- 30 uM
Age 4-5 years old
Sex Female (lactating)
Condition 30% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 232 +/- 67 uM
Age 4-5 years old
Sex Female (lactating)
Condition 45% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Pathway Names Not Available
HMDB Pathways Not Available
KEGG Pathways Not Available
SimCell Pathways Not Available
General References
  1. Wikipedia Link Image
Metabolic Enzymes
  1. Histone-lysine N-methyltransferase SUV39H2
  2. Histone-lysine N-methyltransferase SETD8
  3. Putative histone-lysine N-methyltransferase PRDM6
  4. EHMT1 protein
  5. Histone-lysine N-methyltransferase SUV39H1
  6. Histone-lysine N-methyltransferase EZH1
  7. Histone-lysine N-methyltransferase SUV420H1
  8. Histone-lysine N-methyltransferase SETMAR
  9. Carboxypeptidase E
  10. Carboxypeptidase B
  11. Alpha-aminoadipic semialdehyde synthase, mitochondrial
  12. Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
  13. Ubiquitin-conjugating enzyme E2 E3
  14. Ubiquitin/ISG15-conjugating enzyme E2 L6
  15. NEDD8-conjugating enzyme UBE2F
  16. Ubiquitin-conjugating enzyme E2 L3
  17. Ubiquitin-conjugating enzyme E2 N
  18. Ubiquitin-conjugating enzyme E2 D3
  19. NEDD8-conjugating enzyme Ubc12
  20. Ubiquitin-conjugating enzyme E2 H
  21. Carboxypeptidase N catalytic chain
  22. Ubiquitin-conjugating enzyme E2 C
  23. Ubiquitin-conjugating enzyme E2 Q2
  24. Ubiquitin-conjugating enzyme E2 B
  25. Ubiquitin-conjugating enzyme E2 D2
  26. Ubiquitin-conjugating enzyme E2 J2
  27. Lysyl-tRNA synthetase
  28. Ubiquitin-conjugating enzyme E2 G2
  29. Ubiquitin-conjugating enzyme E2 D1
  30. Ubiquitin-conjugating enzyme E2 T
  31. Ubiquitin-conjugating enzyme E2 K
  32. Ubiquitin-conjugating enzyme E2 S
Enzyme 1 [top]
Enzyme 1 ID 395
Enzyme 1 Name Histone-lysine N-methyltransferase SUV39H2
Enzyme 1 Synonyms
  1. Suppressor of variegation 3-9 homolog 2
  2. Su(var)3-9 homolog 2
Enzyme 1 Gene Name SUV39H2
Enzyme 1 Protein Sequence >Histone-lysine N-methyltransferase SUV39H2
MAAAGAEAPGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFFNDKHNYLSQVKKGKAITLKENHRALK
PAVAEYIVKKAKQRIALQRWQDELNRRKTHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFEKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQLYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDVSSDSIDHSPAKKRARTVCKCGAVTCRGYLN
Enzyme 1 Number of Residues 410
Enzyme 1 Molecular Weight 46550.9
Enzyme 1 Theoretical pI 7.97
Enzyme 1 GO Classification
Function
Process
Component
Enzyme 1 General Function Involved in histone-lysine N-methyltransferase activity
Enzyme 1 Specific Function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis
Enzyme 1 Pathways Not Available
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 81294232 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q32PH7 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name SUV92_BOVIN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >1233 bp
ATGGCGGCGGCCGGGGCCGAGGCGCCAGGAGCTTGGTGTGTGCCTTGCCTAGTTTCACTT
GATACTCTTCAGGAATTATGTAGAAAAGAAAAGCTCACATGTAAATCGATTGGAATCACC
AAAAGGAATCTAAACAATTATGAGGTGGAATACTTGTGTGACTACAAGGTAGTAAAGGAT
ATGGAATATTATCTTGTAAAATGGAAAGGATGGCCAGATTCTACAAATACTTGGGAACCT
TTGCAAAATCTCAAGTGCCCATTACTACTTCAGCAGTTCTTTAATGACAAGCATAATTAT
TTATCTCAGGTAAAGAAAGGCAAAGCAATAACTCTAAAAGAAAATCACAGAGCCTTGAAA
CCTGCTGTTGCTGAATACATTGTAAAGAAGGCTAAACAAAGGATAGCCCTGCAGAGATGG
CAGGATGAACTCAACAGAAGGAAGACTCACAAAGGAATGATTTTTGTTGAAAATACTGTG
GACTTAGAGGGGCCCCCTTCAGACTTCTACTACATTAATGAATACAAACCAGCTCCTGGA
ATCAGCTTAGTAAATGAAGCTACCTTTGGTTGTTCATGCACAGATTGCTTCTTTGAAAAA
TGTTGTCCTGCTGAAGCTGGAGTTCTTTTGGCTTATAATAAAAATCAACAAATTAAAATC
CCACCTGGTACCCCCATTTATGAGTGCAACTCAAGATGTCAATGTGGACCCGACTGTCCC
AACAGGATCGTACAAAAAGGCACACAGTATTCACTTTGCATCTTTCGAACTAGCAATGGC
TGTGGCTGGGGTGTAAAAACCCTTGTGAAGATTAAAAGAATGAGTTTTGTCATGGAATAT
GTTGGAGAGGTGATCACCAGTGAGGAAGCTGAGAGACGTGGCCAGTTATATGACAACAAA
GGAATCACGTATCTCTTTGATCTGGACTATGAATCTGATGAATTCACAGTGGATGCAGCT
CGATATGGAAATGTGTCTCATTTTGTGAATCACAGTTGTGACCCAAACCTTCAGGTGTTC
AATGTTTTCATTGATAACCTCGATACCCGTCTTCCCCGAATAGCATTATTTTCCACGAGA
ACTATCAATGCTGGAGAAGAGCTCACTTTTGATTATCAAATGAAAGGTTCTGGAGATGTA
TCTTCAGATTCTATTGACCACAGCCCAGCCAAAAAGAGGGCCAGAACTGTGTGCAAATGT
GGAGCTGTGACTTGCAGAGGTTACCTCAACTGA
Enzyme 1 GenBank Gene ID BC108111 Link Image
Enzyme 1 GeneCard ID SUV39H2 Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Chromosome:1
Enzyme 1 Locus 10p13
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References Not Available
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 398
Enzyme 2 Name Histone-lysine N-methyltransferase SETD8
Enzyme 2 Synonyms
  1. H4-K20-HMTase SETD8
  2. SET domain-containing protein 8
  3. PR/SET domain-containing protein 07
  4. PR/SET07
  5. PR-Set7
Enzyme 2 Gene Name SETD8
Enzyme 2 Protein Sequence >Histone-lysine N-methyltransferase SETD8
MARGRKMSKPRAVEAAAAAAAVAATAPGPEMVERRGPGRPRTNGENVFTGQSKIYTYMSP
NKCSGMRSPLQEENSVAQYEVKCQGKPLAGIYRKRDEKRNSGNAIRSSMKAEEQKIKDAR
RGPLAPFPNQKSEAAEPPKTPTSSCDTPNAAAAKQGLKKPVRGKQAPRKKAQGKTQQNRK
LTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGE
FVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHS
KCGNCQTKLHDIDGVPHLILIASRDIEAGEELLYDYGDRSRASIEAYPWLKH
Enzyme 2 Number of Residues 352
Enzyme 2 Molecular Weight 39276.2
Enzyme 2 Theoretical pI 10.10
Enzyme 2 GO Classification
Function
Process
Component
Enzyme 2 General Function Involved in histone-lysine N-methyltransferase activity
Enzyme 2 Specific Function Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones
Enzyme 2 Pathways Not Available
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 82571632 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q2YDJ8 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name SETD8_BOVIN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1059 bp
ATGGCTAGAGGCAGGAAGATGTCCAAGCCCCGCGCGGTGGAGGCGGCGGCGGCGGCGGCG
GCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGCCCGGGGAGGCCC
CGCACCAACGGGGAGAATGTATTTACCGGGCAATCAAAGATCTATACCTACATGAGCCCG
AACAAATGCTCTGGAATGCGTTCCCCCCTTCAGGAAGAGAACTCAGTTGCACAATACGAA
GTCAAATGCCAGGGGAAGCCATTAGCCGGAATCTACAGGAAACGCGACGAGAAAAGAAAC
TCTGGGAATGCAATACGAAGCTCCATGAAGGCCGAGGAACAGAAGATCAAAGACGCCAGG
AGAGGTCCCCTGGCACCTTTTCCAAACCAAAAATCTGAAGCTGCAGAACCTCCCAAAACC
CCAACCTCGTCTTGTGATACTCCCAATGCAGCCGCTGCCAAGCAGGGCCTGAAAAAGCCT
GTGAGGGGCAAACAGGCCCCCAGGAAAAAAGCTCAAGGAAAAACACAGCAGAATCGCAAG
CTCACAGATTTCTACCCTGTGCGAAGGAGCTCAAGGAAGAGCAAGGCTGAGCTGCAGTCT
GAAGAAAGGAAAAGAATAGATGAGTTGATTGAAAGCGGGAAGGAAGAAGGAATGAAGATC
GACCTCATCGACGGCAAAGGCAGGGGCGTCATCGCCACCAAGCAGTTCTCCCGGGGTGAG
TTTGTGGTGGAATACCACGGGGACCTCATCGAGATCACCGACGCCAAGAAGCGGGAGGCT
CTGTACGCACAAGACCCCTCCACGGGCTGCTACATGTACTATTTTCAGTATCTGAGCAAA
ACCTACTGCGTGGATGCAACCCGAGAGACAAATCGCCTGGGAAGACTGATCAATCACAGT
AAATGTGGGAACTGCCAAACCAAACTGCACGACATCGACGGCGTGCCTCACCTCATCCTC
ATCGCCTCCCGTGACATCGAGGCCGGGGAGGAGCTTCTGTATGACTATGGGGACCGCAGC
CGGGCTTCCATTGAAGCCTACCCCTGGCTGAAGCATTAA
Enzyme 2 GenBank Gene ID BC110189 Link Image
Enzyme 2 GeneCard ID SETD8 Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Chromosome:1
Enzyme 2 Locus 12q24.31
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References Not Available
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 400
Enzyme 3 Name Putative histone-lysine N-methyltransferase PRDM6
Enzyme 3 Synonyms
  1. PR domain zinc finger protein 6
  2. PR domain-containing protein 6
Enzyme 3 Gene Name PRDM6
Enzyme 3 Protein Sequence >Putative histone-lysine N-methyltransferase PRDM6
MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGGGPLKGGGAAGPLGAPQPLQPPPPPERAE
PQPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAAAAALAGLSALPVAQLPVFA
PLATVAAEPLPPKDLCLGATSGPGPSKCGGSGGDGRGVPRFRCSAEELDYYLYGQQRMEI
IPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEWLRDLP
REVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQD
GTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYN
DSYTSFFGIPLQCIAQDENLNVPSTVMEAMCRQDALQPFNKSSKLSQAPQQRSVVFPQTP
CGRNFSLLDKSGPLESGFNQISVKNQRVLASPTSTSQLHSEFSDWHLWKCGQCFKTFTQR
ILLQMHVCTQNPDRPYQCGHCSQSFSQPSELRNHVVTHSSDRPFKCGYCGRAFAGATTLN
NHIRTHTGEKPFKCERCERSFTQATQLSRHQRMPNECKPITESPESIEVD
Enzyme 3 Number of Residues 590
Enzyme 3 Molecular Weight 63988.7
Enzyme 3 Theoretical pI 7.73
Enzyme 3 GO Classification
Function
Process
Component
Enzyme 3 General Function Involved in histone-lysine N-methyltransferase activity
Enzyme 3 Specific Function Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 151556864 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID A6QPM3 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name PRDM6_BOVIN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1773 bp
ATGCTGAAGCCCGGAGACCCCGGCGGCTCGGCCTTCCTCAAAGTGGACCCAGCTTATCTG
CAACACTGGCAGCAACTCTTCCCGCACGGGGGCGGAGGCCCGCTCAAGGGCGGCGGTGCC
GCGGGTCCCCTGGGCGCACCACAGCCTCTCCAGCCACCGCCACCACCGGAGCGCGCTGAG
CCCCAGCCAGACAGCCTGCGGCCGCGGCCGGCCTCGCTCTCCTCCGCCTCGTCCACTCCG
GCTTCCTCCTCCACCTCGGCCTCCTCTGCCTCCTCCTGCGCTGCTGCTGCCGCCGCTGCC
GCCGCCGCCGCGCTGGCCGGTCTCTCGGCCCTGCCGGTGGCGCAGCTGCCGGTGTTCGCG
CCTCTGGCCACCGTCGCCGCGGAGCCTCTGCCCCCCAAGGACCTGTGCCTCGGCGCCACC
TCGGGCCCGGGGCCCTCCAAGTGCGGAGGCAGTGGCGGGGACGGCCGGGGTGTCCCGCGC
TTCCGCTGCAGCGCGGAGGAGCTGGACTATTACCTGTACGGCCAGCAGCGCATGGAGATC
ATCCCGCTCAACCAGCACACCAGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAAC
CGCAACGGCGAGTGCCCCATGCACGGGCCGCTGCACTCGCTGCGCCGGCTCGTGGGCACC
AGCAGCGCCGCGGCCGCCGCGCCCCCGCCGGAGCTACCCGAGTGGCTGCGGGACCTGCCC
AGGGAGGTGTGCCTGTGCACCAGCACCGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCG
CAGAGGATCCAGCAGGGCACCTGGATCGGGCCCTTCCAGGGCGTGCTCCTGCCCCCGGAA
AAGGTGCAGGCCGGAGCCGTGAGGAACACGCAGCATCTCTGGGAGATATATGACCAAGAT
GGGACACTACAGCACTTTATTGATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTAT
ATCCGATGTGCAAGGCACTGCGGAGAACAGAATCTAACAGTAGTTCAGTACAGGTCGAAT
ATATTCTACCGAGCCTGTATAGATATTCCCAGGGGTACCGAGCTTCTCGTGTGGTACAAT
GACAGCTATACGTCTTTCTTTGGGATCCCTTTACAATGCATTGCCCAGGATGAAAACTTA
AATGTCCCCTCGACAGTCATGGAAGCCATGTGCAGACAGGACGCCCTGCAGCCCTTCAAC
AAGAGCAGCAAACTCTCCCAGGCTCCCCAGCAGCGCTCTGTTGTCTTCCCCCAGACTCCG
TGCGGCAGGAACTTCTCCCTCCTGGATAAGTCAGGGCCCCTGGAATCTGGATTTAATCAA
ATCAGCGTGAAGAACCAGCGCGTCCTGGCGAGCCCCACCTCCACCAGCCAGCTCCACTCG
GAGTTCAGTGACTGGCACCTCTGGAAATGTGGGCAGTGCTTTAAGACTTTTACGCAGCGG
ATCCTGCTACAGATGCACGTGTGCACACAGAACCCTGACAGACCTTACCAATGCGGCCAC
TGCTCCCAGTCCTTTTCCCAGCCTTCAGAACTGAGGAACCACGTGGTCACTCACTCCAGT
GACCGGCCTTTCAAATGCGGCTACTGTGGTCGTGCCTTTGCTGGGGCCACCACTCTCAAC
AACCACATCCGAACCCACACTGGAGAAAAGCCCTTCAAGTGTGAGAGGTGTGAGAGGAGC
TTCACGCAGGCCACCCAGCTGAGCCGACACCAGCGGATGCCCAATGAGTGCAAGCCAATA
ACCGAGAGCCCAGAATCAATCGAAGTGGATTAA
Enzyme 3 GenBank Gene ID BC149387 Link Image
Enzyme 3 GeneCard ID PRDM6 Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Chromosome:5
Enzyme 3 Locus 5q23.2
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References Not Available
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 402
Enzyme 4 Name EHMT1 protein
Enzyme 4 Synonyms Not Available
Enzyme 4 Gene Name EHMT1
Enzyme 4 Protein Sequence >EHMT1 protein
MAAADAEAVPAKGETKQDCGLGAELPSEGSPMAADDGSAEQQGGEAPVAADGETNGSCDQ
SDASGHAAAVKHPQESTRGSPQEGAGPGSRIAENGILDRDPEVGKQNHIRSDGFPQNPVI
GSNGYFLGKAPLSEPPLRVASALASSLPGHAAKTLPGGAGKGRTPGAFPQPPAAVPAKPG
EGSKDTEDKKAPAPGADVKVHRARKTMPKSIPGLHAASKDPREGRDARDHEEPKEELSRG
ASEFARQQLSPPFPSLHQSLPQNQCYVATAKAQTAAAVSRKKKRRMGTYSLVPKKKTKVL
KQRTVIEMFKSITHSTGGSKGEKDLSDGSLHVNGESLDLDSEEDDSEELDEDEDQGGPPA
AAFPTEDGRASKDGVLAPDCSQKVDGESEEEQESAGTADEEEDGDESDLSSESSVKKKFL
KRKGKPDSPWIKPARKRRRRSKKKPCSVLGSEASASSSGSVEPTAPGDGGGYMEVPLDSL
NLHVQGALTSDTEGLANGPDAGETDGLQEVPLCSCRMETPKSREITTLANNQCRATESVD
HQLGRCTNSVVKHELMRPSSKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPES
SISHRFHKACASRVNNASYCPHCGEETSKAKEVTIAKADTTSTVTLAPGQEKSCAAEGRA
DTTTGSAAGPLLSEEDKPQSLAPQVPEGFDPTGPAGLGKPAPGLSQGPGKETLESALIAL
DSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEVGHVD
ICHMLIQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGALVDPKDAEGSTCLHLAA
KKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEEN
ICLHWAAFSGCVDIAEILLAARCDLHAVNIHGDSPLHIAAREDRYACVVLFLSRDSDVTL
KNKEGETPLQCASLNSQVWSALQVSQALRDAAPDRPTPVEKTVSRDIARGYERIPIPCVN
GVDGEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKD
GRLLPEFNMAEPPLLFECNHACSCWRTCRNRVVQNGLRARLQLYRTQNMGWGVRSLQDIP
LGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGELYCIDARFYGNVSRFINHHCEPNL
VPVRVFMSHQDLRFPRIAFFSTRLIEAGEQLGFDYGQRFWDIKGKLFSCRCGSPKCRHSG
AALAQRQAGAQEDGLPDTSSSPADPL
Enzyme 4 Number of Residues 1286
Enzyme 4 Molecular Weight 138732.8
Enzyme 4 Theoretical pI 5.57
Enzyme 4 GO Classification
Function
Process
Component
Enzyme 4 General Function Involved in histone-lysine N-methyltransferase activity
Enzyme 4 Specific Function S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 148745496 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID A5PK11 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name A5PK11_BOVIN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >3861 bp
ATGGCCGCCGCCGATGCCGAGGCGGTTCCGGCGAAGGGGGAGACCAAGCAGGACTGCGGC
CTGGGAGCTGAGCTGCCGAGCGAAGGGTCACCCATGGCTGCTGATGACGGCTCAGCGGAA
CAGCAGGGAGGGGAGGCCCCGGTGGCTGCAGACGGGGAGACCAACGGGTCCTGTGACCAG
AGCGATGCCAGTGGCCACGCGGCTGCTGTGAAGCACCCTCAGGAGAGCACACGAGGCAGC
CCTCAGGAAGGGGCCGGCCCGGGGTCCCGGATAGCGGAAAATGGGATTTTGGACAGAGAC
CCCGAGGTGGGGAAGCAGAACCACATCCGCTCTGATGGCTTCCCCCAGAATCCTGTCATT
GGGAGCAACGGCTACTTCCTTGGCAAGGCCCCCTTGTCTGAGCCACCACTGCGGGTGGCC
AGCGCCCTGGCTTCCTCCCTGCCTGGCCACGCGGCGAAGACCCTCCCTGGCGGGGCTGGC
AAAGGGAGGACTCCCGGTGCTTTTCCCCAGCCGCCGGCTGCTGTGCCGGCCAAGCCTGGG
GAGGGCAGCAAGGACACAGAGGACAAGAAGGCCCCGGCCCCGGGCGCCGACGTCAAGGTC
CACAGGGCTCGGAAGACCATGCCGAAGTCCATCCCGGGCCTGCACGCGGCGAGTAAGGAC
CCCAGGGAAGGCCGGGACGCCCGCGACCACGAGGAGCCGAAGGAGGAGCTGAGCAGGGGC
GCCTCGGAGTTCGCACGCCAGCAGCTTTCACCCCCCTTCCCGTCCCTTCACCAGTCGCTA
CCTCAGAACCAATGCTACGTGGCCACCGCGAAGGCCCAGACAGCAGCTGCAGTATCTCGG
AAGAAAAAGCGAAGAATGGGAACCTATAGCCTGGTTCCTAAGAAGAAGACCAAAGTGTTA
AAGCAGAGGACGGTGATTGAGATGTTTAAGAGCATAACTCATTCCACGGGGGGTTCCAAG
GGTGAGAAGGATCTGAGCGATGGCTCCCTCCATGTGAACGGTGAGAGCCTGGATCTGGAC
TCGGAGGAGGATGACTCGGAGGAGCTGGACGAGGATGAGGACCAGGGCGGCCCACCAGCA
GCTGCGTTCCCTACTGAGGATGGCAGGGCCTCCAAGGATGGCGTGTTGGCGCCTGACTGC
AGCCAGAAGGTGGACGGCGAGTCTGAAGAGGAGCAGGAGTCGGCCGGCACCGCGGACGAG
GAGGAGGACGGAGACGAGTCCGACTTGAGTTCTGAGTCCAGCGTCAAGAAGAAGTTCCTC
AAGAGGAAGGGGAAGCCTGACAGCCCTTGGATCAAGCCAGCGAGGAAGAGGAGGCGGAGA
AGCAAAAAGAAGCCCTGCTCTGTGTTAGGTTCTGAAGCCTCTGCGTCGTCTTCGGGCAGT
GTGGAGCCAACGGCGCCTGGCGACGGCGGGGGGTACATGGAGGTGCCGCTGGACTCCTTG
AATCTCCATGTCCAGGGTGCGCTGACCTCTGACACAGAAGGGCTGGCCAACGGTCCTGAT
GCAGGCGAGACGGATGGCCTCCAGGAGGTGCCCCTCTGCAGCTGCCGGATGGAGACCCCA
AAGAGCCGGGAGATCACCACTCTGGCCAACAACCAGTGCAGGGCCACAGAGAGTGTGGAC
CACCAGCTGGGCAGGTGCACGAACAGCGTGGTGAAGCATGAGCTGATGCGTCCGTCCAGC
AAGGCACCGCTGCTGGTGCTGTGTGAGGACCACCGGGGCCGGATGGTGAAGCACCAGTGC
TGCCCCGGCTGCGGCTACTTCTGCACGGCCGGTAATTTTATGGAATGTCAGCCTGAGAGC
AGCATTTCTCATCGTTTCCACAAAGCCTGTGCCTCTCGAGTCAATAATGCCAGCTACTGT
CCCCACTGTGGGGAGGAGACCTCCAAGGCCAAAGAGGTGACCATTGCAAAGGCAGACACG
ACGTCCACGGTGACCCTGGCCCCTGGGCAGGAGAAGAGCTGTGCAGCAGAGGGCAGGGCC
GACACCACCACGGGCAGCGCTGCTGGCCCCCTGCTCTCAGAGGAGGACAAGCCGCAGAGC
CTGGCCCCCCAGGTGCCGGAGGGCTTCGACCCCACAGGGCCGGCTGGGCTGGGGAAGCCG
GCGCCAGGCCTCTCCCAGGGCCCTGGGAAGGAGACCCTGGAGAGCGCACTCATCGCCCTG
GATTCCGAGAAACCCAAGAAGCTCCGCTTCCACCCGAAGCAGCTGTACTTCTCGGCGCGG
CAAGGGGAGCTGCAGAAGGTGCTGCTCATGTTGGTTGACGGGATCGACCCCAACTTCAAG
ATGGAGCATCAGAACAAGCGCTCGCCCCTGCACGCCGCGGCGGAGGTTGGCCACGTGGAC
ATCTGCCACATGCTGATCCAGGCGGGCGCCAACATCGACACCTGCTCTGAGGACCAGAGG
ACCCCGCTGATGGAGGCCGCGGAGAACAACCACTTGGACGCGGTGAAGTACCTCATCAAG
GCCGGGGCCCTCGTGGATCCCAAGGACGCAGAGGGCTCGACCTGTTTGCACCTGGCTGCC
AAGAAAGGCCACTACGACGTGGTTCAGTACTTGCTCTCAAACGGACAGATGGACGTCAAC
TGTCAGGATGATGGTGGCTGGACGCCCATGATCTGGGCCACTGAGTACAAGCACGTGGAC
CTCGTGAAGCTGTTGCTCTCCAAGGGGTCTGACATCAACATCCGGGACAACGAGGAAAAC
ATCTGCCTGCACTGGGCGGCCTTCTCAGGCTGTGTGGACATCGCTGAGATCCTGCTGGCC
GCCAGGTGCGACCTGCACGCGGTGAACATCCACGGGGACTCGCCCCTGCACATCGCGGCC
CGGGAGGACCGCTACGCCTGTGTCGTCCTCTTCCTGTCCCGGGACTCGGATGTCACTCTG
AAGAACAAGGAGGGGGAGACTCCCCTGCAGTGCGCCAGCCTCAACTCACAGGTGTGGAGC
GCCCTGCAGGTGAGCCAGGCGCTGCGGGACGCGGCCCCTGACAGGCCCACCCCGGTGGAG
AAGACGGTGAGCAGGGACATTGCTCGGGGCTACGAGCGGATCCCCATCCCCTGCGTCAAT
GGTGTGGACGGCGAGCCGTGCCCCAGCAACTACAAGTACGTGTCTCAGAACTGTGTGACG
TCCCCCATGAACATCGATAGGAACATCACCCACCTGCAGTACTGCGTGTGCATCGACGAC
TGCTCCTCCAGCAACTGCATGTGTGGCCAGCTCAGCATGCGCTGCTGGTACGACAAGGAC
GGTCGGCTGCTGCCAGAGTTCAACATGGCAGAGCCGCCCCTGCTGTTCGAGTGCAACCAC
GCCTGCTCCTGCTGGAGGACGTGCCGCAACCGCGTGGTGCAGAATGGCCTCAGGGCGAGG
CTGCAGCTCTATCGGACACAGAACATGGGCTGGGGCGTCCGGTCCCTGCAGGACATCCCA
CTGGGCACCTTTGTTTGCGAGTACGTTGGGGAGCTTATTTCTGACTCGGAAGCTGATGTG
CGGGAAGAAGACTCTTATCTCTTTGATCTTGACAACAAGGACGGAGAGCTGTACTGCATC
GACGCGCGTTTCTATGGCAACGTCAGCCGCTTCATCAACCACCACTGTGAGCCCAATCTG
GTGCCCGTGCGTGTGTTCATGTCCCACCAGGACCTGCGCTTCCCGCGGATCGCCTTCTTC
AGCACCCGCCTGATTGAGGCCGGGGAGCAGCTGGGCTTCGACTATGGGCAGCGCTTCTGG
GACATCAAGGGCAAGCTGTTCAGCTGCCGCTGCGGCTCCCCCAAGTGCCGGCACTCCGGG
GCCGCGCTGGCCCAGCGGCAGGCCGGTGCCCAGGAGGACGGGCTGCCCGACACCAGCTCC
TCGCCTGCCGACCCGCTATGA
Enzyme 4 GenBank Gene ID BC142313 Link Image
Enzyme 4 GeneCard ID EHMT1 Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Chromosome:9
Enzyme 4 Locus 9q34.3
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 417
Enzyme 5 Name Histone-lysine N-methyltransferase SUV39H1
Enzyme 5 Synonyms
  1. Suppressor of variegation 3-9 homolog 1
  2. Su(var)3-9 homolog 1
Enzyme 5 Gene Name SUV39H1
Enzyme 5 Protein Sequence >Histone-lysine N-methyltransferase SUV39H1
MAESLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYY
LVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKPPRHLDPSLANYLVQ
KAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVG
CECQDCLWAPAGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKG
IRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFD
LDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEE
LTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
Enzyme 5 Number of Residues 412
Enzyme 5 Molecular Weight 47846.0
Enzyme 5 Theoretical pI 8.07
Enzyme 5 GO Classification
Function
Process
Component
Enzyme 5 General Function Involved in chromatin binding
Enzyme 5 Specific Function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1- stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiaton, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length
Enzyme 5 Pathways Not Available
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 84708731 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q2NL30 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name SUV91_BOVIN Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >1239 bp
ATGGCGGAAAGTTTAAAAGGCTGCAGTGTGTGTTGCAAATCTTCTTGGAATCAGCTACAG
GACCTGTGCCGCCTGGCCAAGCTCTCCTGCCCTGCCCTTGGCATCTCCAAGAGGAACCTC
TATGACTTTGAAGTCGAGTACCTGTGCGATTACAAAAAGATCCGCGAACAGGAGTATTAC
CTGGTAAAATGGCGTGGGTACCCAGACTCCGAGAGCACTTGGGAACCACGGCAGAATCTC
AAGTGTGTGCGCATTCTCAAGCAGTTCCACAAGGACTTGGAAAGGGAGCTGCTCCGGCGG
CACCACCGGTCAAAGCCACCCCGGCACCTGGACCCAAGCCTGGCCAACTACCTGGTGCAG
AAGGCCAAGCAGAGGCGGGCACTCCGGCGCTGGGAGCAGGAGCTCAATGCCAAGCGCAGC
CACCTGGGACGCATCACCGTGGAGAACGAAGTGGACCTGGATGGCCCCCCACGGGCCTTC
GTGTACATCAACGAGTACCGTGTTGGTGAGGGCATCACCCTCAACCAGGTGGCTGTGGGC
TGCGAGTGCCAGGACTGTCTGTGGGCACCGGCCGGAGGCTGCTGCCCTGGGGCGTCACTG
CACAAGTTTGCCTACAATGACCAGGGCCAGGTGCGCCTGCGAGCCGGGCTGCCCATCTAT
GAGTGCAACTCCCGCTGCCGCTGTGGCTATGACTGCCCCAACCGCGTGGTACAGAAGGGC
ATCCGCTACGACCTCTGCATCTTCCGCACGGATGATGGACGCGGCTGGGGTGTCCGCACG
CTGGAGAAGATCCGCAAGAACAGTTTCGTCATGGAGTACGTGGGCGAGATCATTACCTCA
GAGGAGGCAGAGCGGCGGGGCCAGATCTATGACCGCCAGGGTGCCACCTACCTCTTCGAC
CTGGACTACGTGGAGGATGTGTACACTGTGGACGCCGCCTATTACGGCAACATCTCTCAC
TTTGTCAACCACAGTTGTGACCCCAACCTCCAGGTGTACAACGTCTTCATAGACAACCTT
GATGAGCGGCTGCCCCGCATTGCTTTCTTTGCCACCAGAACCATCCGGGCAGGCGAGGAG
CTCACCTTTGATTACAACATGCAAGTGGACCCGGTGGACATGGAGAGCACACGCATGGAC
TCCAACTTTGGCCTGGCTGGGCTCCCCGGCTCTCCCAAGAAGCGGGTCCGCATTGAATGC
AAGTGTGGGACTGAATCCTGCCGCAAATACCTCTTCTAG
Enzyme 5 GenBank Gene ID BC111156 Link Image
Enzyme 5 GeneCard ID SUV39H1 Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Not Available
Enzyme 5 Locus Xp11.23
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References Not Available
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 418
Enzyme 6 Name Histone-lysine N-methyltransferase EZH1
Enzyme 6 Synonyms
  1. Enhancer of zeste homolog 1
Enzyme 6 Gene Name EZH1
Enzyme 6 Protein Sequence >Histone-lysine N-methyltransferase EZH1
MDIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
KKLRVQPVQLMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
DALNQYSDEDEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGSKKSSKKQFPNDMIFSAI
ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
RRRRHHVVNASCSNTSASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
EELFFDYRYSQADALKYVGIERETDVL
Enzyme 6 Number of Residues 747
Enzyme 6 Molecular Weight 85284.4
Enzyme 6 Theoretical pI 7.77
Enzyme 6 GO Classification
Function
Process
Component
Enzyme 6 General Function Involved in DNA binding
Enzyme 6 Specific Function Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation
Enzyme 6 Pathways Not Available
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function Not Available
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 154757656 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID A7E2Z2 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name EZH1_BOVIN Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >2124 bp
ATGGATATACCAAATCCCCCGACGTCCAAATGTATCACTTACTGGAAGAGGAAAGTTAAG
TCTGAATACATGCGACTTCGGCAGCTTAAACGGCTTCAGGCGAATATGGGTGCAAAGGCT
CTCTATGTAGCAAATTTTGCAAAAGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG
AAGAAGCTTCGTGTCCAACCTGTTCAGTTAATGAAGCCTGTGAGTGGGCATCCTTTTCTC
AAAAAGTGTACCATAGAGAGCATTTTCCCGGGATTTGCAAGCCAGCACATGTTAATGAGG
TCTCTGAACACAGTTGCCTTGGTTCCCATCATGTACTCGTGGTCCCCTCTCCAGCAGAAC
TTCATGGTGGAAGATGAGACAGTTTTGTGCAATATCCCCTACATGGGAGATGAGGTGAAA
GAGGAAGATGAGACTTTCATTGAGGAGCTGATCAATAACTACGATGGCAAAGTCCACGGT
GAAGAAGAGATGATTCCTGGCTCTGTCCTGATCAGTGATGCTGTTTTCCTGGAGTTGGTA
GATGCTCTGAATCAATACTCAGATGAAGATGAAGAAGGGCACAACGACACCTCAGATGGA
AAGCAAGATGACAGCAAAGAGGATCTGCCAGTAACAAGAAAGAGGAAACGACATGCTATT
GAAGGCAGCAAAAAGAGTTCCAAGAAACAATTCCCAAACGACATGATCTTCAGTGCGATC
GCCTCGATGTTCCCTGAGAACGGTGTCCCAGACGACATGAAGGAGAGGTACCGAGAGCTC
ACAGAGATGTCAGACCCCAATGCGCTCCCCCCGCAGTGCACACCCAACATCGACGGCCCC
AACGCCAAGTCTGTGCAGCGGGAACAGTCTCTGCACTCCTTCCACACACTCTTCTGCCGG
CGCTGCTTCAAATACGACTGCTTCCTTCACCCTTTCCATGCCACCCCTAATGTGTATAAA
CGCAAGAACAAAGAAATCAAGATTGAGCCAGAACCGTGTGGCACAGACTGCTTCCTTCTG
CTGGAAGGAGCAAAGGAGTACGCCATGCTGCACAACCCTCGCTCCAAGTGCTCTGGGCGT
CGCCGGCGAAGGCACCACGTGGTCAATGCCTCCTGCTCCAACACTTCAGCCTCTGCTGTG
GCTGAGACCAAAGAAGGGGACAGCGACAGGGACACTGGCAATGACTGGGCCTCCAGTTCT
TCAGAGGCAAACTCACGCTGTCAGACGCCCACGAAACAGAAGGCGAGTCCAGCCCCACCT
CAGCTCTGTGTCGTGGAAGCACCCTCAGAACCTGTGGAGTGGACTGGGGCTGAAGAATCT
CTTTTTCGAGTCTTTCATGGCACCTACTTCAACAACTTCTGTTCAATAGCCAGACTTCTG
GGGACTAAGACATGCAAGCAGGTCTTCCAGTTTGCAGTCAAAGAGTCACTTATCCTGAAG
CTGCCCACAGATGAGCTTATGAACCCCTCGCAGAAGAAGAAGAGAAAGCACAGGTTGTGG
GCTGCACACTGCCGGAAAATTCAGCTGAAGAAAGATAACTCCTCCACCCAGGTGTACAAC
TACCAGCCCTGCGACCACCCGGACCGCCCCTGTGACAGCACGTGCCCCTGCATCATGACT
CAGAATTTCTGTGAGAAGTTCTGCCAGTGCAACCCCGACTGTCAGAATCGCTTTCCCGGC
TGTCGCTGTAAGACCCAGTGCAATACCAAGCAGTGCCCGTGCTACCTGGCGGTGCGCGAG
TGTGACCCTGACCTGTGCCTCACCTGTGGGGCCTCGGAGCACTGGGACTGCAAGGTGGTT
TCCTGTAAGAACTGCAGCATTCAACGTGGCCTCAAAAAGCACCTGCTGCTGGCCCCCTCA
GATGTGGCCGGATGGGGCACCTTCATTAAGGAGTCTGTGCAGAAGAATGAATTCATTTCT
GAATACTGTGGTGAGCTCATCTCTCAGGATGAGGCCGATCGACGAGGGAAGGTCTATGAC
AAGTACATGTCCAGCTTCCTCTTCAACCTCAATAACGATTTTGTAGTGGATGCTACCCGG
AAAGGAAACAAAATTCGATTTGCAAACCATTCGGTGAACCCCAACTGTTATGCCAAAGCC
AAAATAACAGATCTAAAAGCATAG
Enzyme 6 GenBank Gene ID BC151626 Link Image
Enzyme 6 GeneCard ID EZH1 Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Chromosome:1
Enzyme 6 Locus 17q21.1-q21.3
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References Not Available
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 419
Enzyme 7 Name Histone-lysine N-methyltransferase SUV420H1
Enzyme 7 Synonyms
  1. Suppressor of variegation 4-20 homolog 1
  2. Su(var)4-20 homolog 1
  3. Suv4-20h1
Enzyme 7 Gene Name SUV420H1
Enzyme 7 Protein Sequence >Histone-lysine N-methyltransferase SUV420H1
MKWLGESKNMVVNGRRHGGKLSNDHQQNQSKLQHSGKDNVKAGRNAGERRSSRCNGNSGF
EGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPPRSSRHFSKSDSFS
HNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKE
HVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEEN
MLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPG
EEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNR
LKKLGDSSKNSDSQSVSSNTDADTTQGRNDASK
Enzyme 7 Number of Residues 393
Enzyme 7 Molecular Weight 44551.6
Enzyme 7 Theoretical pI 8.91
Enzyme 7 GO Classification
Function
Process
Component
Enzyme 7 General Function Involved in histone-lysine N-methyltransferase activity
Enzyme 7 Specific Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2)
Enzyme 7 Pathways Not Available
Enzyme 7 Reactions Not Available
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • None
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein 88954113 Link Image
Enzyme 7 UniProtKB/Swiss-Prot ID Q29RP8 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name SUV41_BOVIN Link Image
Enzyme 7 PDB ID Not Available
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence >1182 bp
ATGAAGTGGTTGGGAGAATCCAAGAACATGGTGGTGAATGGCAGGAGACATGGAGGCAAG
TTGTCTAATGACCATCAGCAGAATCAATCAAAGTTACAGCACTCGGGAAAGGACAACGTG
AAGGCTGGCAGAAACGCAGGCGAGAGGAGGTCGAGCAGATGTAATGGGAACTCAGGCTTT
GAGGGACAGAGTCGATATGTACCATCTTCTGGAATGTCTGCCAAGGAACTCTGTGAAAAT
GATGACCTAGCGACCAGTTTGGTTCTTGATCCCTATTTAGGTTTTCAAACACACAAAATG
AATACTAGCGCCTTTCCTCCGAGGAGCTCAAGGCATTTTTCAAAATCTGACAGTTTTTCT
CACAACAACCCTGTAAGATTTCGGCCTATTAAAGGAAGGCAGGAAGAACTCAAAGAAGTA
ATTGAACGTTTTAAGAAAGATGAGCACTTGGAGAAAGCCTTCAAATGTCTGACTTCAGGA
GAATGGGCACGGCACTATTTTCTCAACAAGAACAAAATGCAGGAGAAATTATTCAAGGAA
CATGTATTTATTTATTTGCGAATGTTTGCAACTGACAGTGGATTTGAAATATTGCCTTGT
AATAGATACTCTTCAGAACAAAATGGAGCCAAAATAGTTGCAACGAAAGAGTGGAAACGA
AATGACAAAATAGAATTACTGGTGGGTTGTATTGCCGAACTTTCAGAAATTGAGGAGAAC
ATGCTGCTTAGACATGGAGAAAACGACTTCAGTGTCATGTATTCCACAAGGAAAAACTGT
GCTCAGCTCTGGCTTGGTCCTGCTGCATTTATAAACCATGATTGCAGACCTAACTGTAAG
TTTGTGTCAACTGGTCGAGATACAGCATGTGTGAAGGCCCTAAGAGATATTGAACCTGGA
GAAGAAATTTCTTGTTATTATGGAGATGGGTTTTTTGGAGAAAACAATGAGTTCTGCGAG
TGTTACACTTGTGAAAGACGGGGAACTGGTGCTTTTAAATCCAGAGTGGGACTGCCTGCG
CCTGCTCCTGTTATCAATAGCAAATACGGACTCAGAGAAACAGATAAACGTTTAAATAGG
CTTAAAAAGTTAGGTGACAGCAGCAAAAACTCAGACAGTCAGTCTGTCAGCTCCAACACT
GACGCAGACACCACTCAGGGAAGAAACGACGCAAGTAAGTAG
Enzyme 7 GenBank Gene ID BC114079 Link Image
Enzyme 7 GeneCard ID SUV420H1 Link Image
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Chromosome:1
Enzyme 7 Locus 11q13.2
Enzyme 7 SNPs SNPJam Report Link Image
Enzyme 7 General References Not Available
Enzyme 7 Metabolite References Not Available
Enzyme 8 [top]
Enzyme 8 ID 422
Enzyme 8 Name Histone-lysine N-methyltransferase SETMAR
Enzyme 8 Synonyms
  1. SET domain and mariner transposase fusion gene-containing protein homolog
Enzyme 8 Gene Name SETMAR
Enzyme 8 Protein Sequence >Histone-lysine N-methyltransferase SETMAR
MATCEEVPEALKGQLDVARGLENLPVSAWPPGAEPEPFQYTPDHVAGPGADADPSQITFP
GCACLKTPCLPGTCSCLRHENNYDDRSCLRDIGSEAKCTEPVFECNVLCQCSERCRNRVV
QWGLQFHLQVFKTDHKGWGLRTLDFIPKGRFVCEYAGEVLGISEVQRRVQLQTIHDSNYI
IAIREHVYNGQVMETFVDPASIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAARDIL
PEEELSYDYSGRFLNLMHSEDKERLDNGKLRKPCYCGARSCAAFLPYDSSLYCPTEKPDT
SEEGRA
Enzyme 8 Number of Residues 306
Enzyme 8 Molecular Weight 34253.5
Enzyme 8 Theoretical pI 4.99
Enzyme 8 GO Classification
Function
Process
Component
Enzyme 8 General Function Involved in histone-lysine N-methyltransferase activity
Enzyme 8 Specific Function Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'
Enzyme 8 Pathways Not Available
Enzyme 8 Reactions Not Available
Enzyme 8 Pfam Domain Function
Enzyme 8 Signals
  • None
Enzyme 8 Transmembrane Regions
  • None
Enzyme 8 Essentiality Not Available
Enzyme 8 GenBank ID Protein 111304572 Link Image
Enzyme 8 UniProtKB/Swiss-Prot ID Q0VD24 Link Image
Enzyme 8 UniProtKB/Swiss-Prot Entry Name SETMR_BOVIN Link Image
Enzyme 8 PDB ID Not Available
Enzyme 8 Cellular Location Not Available
Enzyme 8 Gene Sequence >921 bp
ATGGCAACGTGTGAGGAGGTGCCTGAGGCCTTGAAGGGCCAGCTGGACGTTGCGCGTGGC
CTTGAAAATCTGCCTGTGAGCGCCTGGCCCCCAGGGGCGGAGCCTGAGCCCTTTCAGTAT
ACTCCTGATCATGTAGCTGGGCCTGGAGCAGATGCAGATCCCTCTCAAATAACCTTTCCT
GGATGTGCTTGTCTCAAAACTCCCTGCCTCCCTGGTACTTGTTCCTGTCTCCGTCATGAG
AATAACTATGATGATCGTTCATGCCTCAGAGATATAGGATCCGAAGCAAAGTGCACTGAG
CCAGTTTTCGAGTGCAATGTCCTGTGCCAGTGCAGCGAGCGCTGCAGGAACAGAGTGGTC
CAGTGGGGTCTGCAGTTCCACCTCCAGGTGTTCAAGACGGATCACAAAGGCTGGGGACTT
CGTACCCTGGACTTCATACCAAAAGGACGGTTTGTCTGTGAATATGCCGGTGAGGTGTTA
GGAATCTCTGAAGTGCAGAGAAGAGTTCAGTTACAAACAATACATGATTCGAATTACATT
ATAGCCATCAGGGAGCATGTCTATAATGGGCAGGTAATGGAAACATTTGTGGATCCTGCC
TCTATAGGAAATATTGGAAGATTCCTTAACCATTCTTGTGAGCCAAACCTGTTGATGATT
CCTGTCCGAATAGACTCGATGGTACCAAAGTTGGCACTTTTTGCAGCCAGAGACATTCTG
CCAGAAGAAGAACTCTCTTATGACTACTCAGGAAGATTTCTTAATCTAATGCATAGTGAA
GACAAAGAAAGGTTAGATAATGGGAAATTAAGGAAACCTTGTTATTGTGGTGCCAGATCA
TGTGCTGCGTTCCTGCCCTATGACAGCTCCCTGTACTGCCCCACAGAAAAGCCAGACACG
AGTGAGGAAGGAAGAGCATAG
Enzyme 8 GenBank Gene ID BC119874 Link Image
Enzyme 8 GeneCard ID SETMAR Link Image
Enzyme 8 GenAtlas ID Not Available
Enzyme 8 HGNC ID Not Available
Enzyme 8 Chromosome Location Chromosome:3
Enzyme 8 Locus 3p26.2
Enzyme 8 SNPs SNPJam Report Link Image
Enzyme 8 General References Not Available
Enzyme 8 Metabolite References Not Available
Enzyme 9 [top]
Enzyme 9 ID 552
Enzyme 9 Name Carboxypeptidase E
Enzyme 9 Synonyms
  1. CPE
  2. Carboxypeptidase H
  3. CPH
  4. Enkephalin convertase
  5. Prohormone-processing carboxypeptidase
Enzyme 9 Gene Name CPE
Enzyme 9 Protein Sequence >Carboxypeptidase E
MARRGGCALLVLCGSLAACAWLLGAEARGPGGPVAGARRRRRPQEDGISFEYHRYPELRE
ALVSVWLQCAAVSRIYTVGRSFEGRELLVLELSDNPGVHEPGEPEFKYIGNMHGNEAVGR
ELLIFLAQYLCNEYQKGNETIVQLIHNTRIHIMPSLNPDGFEKAASQLGELKDWFVGRSN
AQGIDLNRNFPDLDRIVYINEKEGGPNNHLLKNLKKIVDQNTKLAPETKAVIHWIMDIPF
VLSANLHGGDLVANYPYDETRSGSAHEYSSCPDDDIFQSLARAYSSFNPPMSDPDRPPCR
KNDDDSSFVEGTTNGAAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKNYWEDN
KNSLISYIQQIHRGVKGFVRDLQGNPIANATLSVEGIDHDVTSAKDGDYWRLLVPGNYKL
TASAPGYLAIAKKVAVPYSPAVRVDFELESFSERKEEEKEELMEWWKMMSETLNF
Enzyme 9 Number of Residues 475
Enzyme 9 Molecular Weight 53308.5
Enzyme 9 Theoretical pI 4.94
Enzyme 9 GO Classification
Function
Process
Component
Enzyme 9 General Function Amino acid transport and metabolism
Enzyme 9 Specific Function Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing
Enzyme 9 Pathways Not Available
Enzyme 9 Reactions Not Available
Enzyme 9 Pfam Domain Function
Enzyme 9 Signals
  • 1-27
Enzyme 9 Transmembrane Regions
  • None
Enzyme 9 Essentiality Not Available
Enzyme 9 GenBank ID Protein 148743816 Link Image
Enzyme 9 UniProtKB/Swiss-Prot ID P04836 Link Image
Enzyme 9 UniProtKB/Swiss-Prot Entry Name CBPE_BOVIN Link Image
Enzyme 9 PDB ID Not Available
Enzyme 9 Cellular Location Not Available
Enzyme 9 Gene Sequence >1428 bp
ATGGCCCGGCGAGGGGGCTGCGCGCTGCTGGTGCTGTGCGGCTCGCTGGCCGCCTGTGCC
TGGCTGCTGGGCGCCGAGGCCCGGGGGCCTGGGGGCCCTGTGGCGGGCGCAAGGCGGCGC
CGGCGGCCCCAGGAGGACGGCATCTCCTTTGAGTACCACCGCTACCCAGAGCTTCGTGAA
GCGCTCGTGTCCGTGTGGCTGCAGTGCGCCGCGGTCAGCAGGATCTACACGGTGGGGCGC
AGCTTCGAGGGCCGCGAGCTGCTGGTGCTCGAGCTGTCCGACAACCCCGGCGTCCACGAG
CCGGGTGAGCCTGAATTTAAATACATCGGGAATATGCATGGCAATGAAGCTGTCGGACGG
GAGCTGCTCATTTTTCTGGCCCAGTACCTGTGCAATGAGTACCAAAAAGGGAATGAGACA
ATTGTCCAGCTGATCCACAACACCCGAATCCACATCATGCCTTCTCTGAACCCTGATGGC
TTTGAAAAGGCAGCATCTCAGCTTGGTGAGCTGAAGGACTGGTTCGTGGGTCGAAGCAAT
GCCCAGGGAATAGATCTGAACCGGAACTTTCCCGACCTGGACAGAATAGTTTATATTAAT
GAGAAAGAAGGTGGTCCAAATAATCATCTGTTGAAAAATCTGAAGAAAATTGTGGATCAA
AACACAAAGCTTGCTCCTGAGACGAAGGCTGTCATTCATTGGATTATGGATATTCCTTTT
GTGCTCTCTGCCAATCTTCACGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACG
AGGAGTGGTAGTGCTCATGAATACAGCTCCTGCCCAGATGACGACATCTTCCAAAGCTTA
GCTCGGGCATACTCATCCTTCAACCCCCCAATGTCGGACCCAGATCGGCCCCCATGTCGC
AAGAATGATGATGACAGCAGCTTTGTAGAAGGAACGACCAATGGTGCTGCATGGTACAGC
GTGCCTGGAGGAATGCAAGATTTCAATTACCTCAGCAGCAACTGCTTTGAGATTACTGTG
GAGCTTAGCTGTGAAAAGTTTCCACCTGAAGAGACTTTGAAGAACTACTGGGAGGATAAC
AAAAACTCCCTCATTAGCTACATTCAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGA
GATCTTCAGGGTAACCCAATTGCTAATGCCACCCTCTCTGTGGAAGGAATAGACCATGAT
GTCACATCTGCAAAGGATGGTGATTACTGGAGATTGCTCGTCCCTGGAAACTATAAACTT
ACAGCCTCAGCACCGGGCTATCTGGCAATAGCAAAGAAAGTGGCAGTTCCTTATAGCCCT
GCTGTCAGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAAGAAGAAGAGAAGGAA
GAATTAATGGAATGGTGGAAGATGATGTCAGAAACTTTAAACTTTTAA
Enzyme 9 GenBank Gene ID BC142181 Link Image
Enzyme 9 GeneCard ID CPE Link Image
Enzyme 9 GenAtlas ID Not Available
Enzyme 9 HGNC ID Not Available
Enzyme 9 Chromosome Location Chromosome:4
Enzyme 9 Locus 4q32.3
Enzyme 9 SNPs SNPJam Report Link Image
Enzyme 9 General References
  1. [PubMed Link Image]
Enzyme 9 Metabolite References Not Available
Enzyme 10 [top]
Enzyme 10 ID 554
Enzyme 10 Name Carboxypeptidase B
Enzyme 10 Synonyms Not Available
Enzyme 10 Gene Name CPB1
Enzyme 10 Protein Sequence >Carboxypeptidase B
MLAFLILVTVTLASAHHSGEHFEGDKVFRVHVEDENHISLLHELASTRQMDFWKPDSVTQ
VKPHSTVDFRVKAEDTVAVEDFLGQNGLRYEVLISNLRSMLEAQFDSRVRTTGHSYEKYN
NWETIEAWTEQVASENPDLISRSAIGTTFLGNTIYLLKVGKPGSNKPAVFMDCGFHAREW
ISPAFCQWFVREAVRTYGREIHMTEFLDKLDFYVLPVVNIDGYIYTWTTNRMWRKTRSTR
AGSSCTGTDLNRNFDAGWCSIGASNNPCSETYCGSAAESEKESKAVADFIRNHLSSIKAY
LTIHSYSQMMLYPYSYDYKLPKNNVELNTLAKGAVKKLASLHGTTYTYGPGASTIYPASG
GSDDWAYDQGIKYSFTFELRDKGRYGFVLPESQIQPTCEETMLAIKYVTSYVLEHLY
Enzyme 10 Number of Residues 417
Enzyme 10 Molecular Weight 47347.9
Enzyme 10 Theoretical pI 6.39
Enzyme 10 GO Classification
Function
Process
Component
Enzyme 10 General Function Amino acid transport and metabolism
Enzyme 10 Specific Function Preferential release of a C-terminal lysine or arginine amino acid
Enzyme 10 Pathways Not Available
Enzyme 10 Reactions Not Available
Enzyme 10 Pfam Domain Function
Enzyme 10 Signals
  • 1-16
Enzyme 10 Transmembrane Regions
  • None
Enzyme 10 Essentiality Not Available
Enzyme 10 GenBank ID Protein Not Available
Enzyme 10 UniProtKB/Swiss-Prot ID P00732 Link Image
Enzyme 10 UniProtKB/Swiss-Prot Entry Name CBPB1_BOVIN Link Image
Enzyme 10 PDB ID Not Available
Enzyme 10 Cellular Location Not Available
Enzyme 10 Gene Sequence Not Available
Enzyme 10 GenBank Gene ID Not Available
Enzyme 10 GeneCard ID CPB1 Link Image
Enzyme 10 GenAtlas ID Not Available
Enzyme 10 HGNC ID Not Available
Enzyme 10 Chromosome Location Chromosome:3
Enzyme 10 Locus 3q24
Enzyme 10 SNPs SNPJam Report Link Image
Enzyme 10 General References
  1. [PubMed Link Image]
Enzyme 10 Metabolite References Not Available
Enzyme 11 [top]
Enzyme 11 ID 631
Enzyme 11 Name Alpha-aminoadipic semialdehyde synthase, mitochondrial
Enzyme 11 Synonyms
  1. LKR/SDH
  2. Lysine ketoglutarate reductase
  3. LKR
  4. LOR
  5. Saccharopine dehydrogenase
  6. SDH
Enzyme 11 Gene Name AASS
Enzyme 11 Protein Sequence >Alpha-aminoadipic semialdehyde synthase, mitochondrial
MLRVSRTKLGRLSPSLSRGLHHKAVMALRREDVNAWERRAPLAPRHVKGITNLGYKVLIQ
PSNRRAIHDKEYVKAGGILQEDISEACLILGVKRPPEEKLMPKKTYAFFSHTIKAQEANM
GLLDEILKQEIRLIDYEKMVDHRGIRVVAFGQWAGVAGIINILHGMGLRLLALGHHTPFM
HIGMAHNYRNSGQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEIFNELPC
EYVEPHELKEVSQNGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYDKYPERYISRFNTDIA
PYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKSPVAGVEGCPALPHKLVAICDISADTG
GSIEFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIESTEYFGDMLY
PYVEEMILSDATQPLESQNFSPVVRDAVIASNGMLSNKYKYIQKLRENREHAQSLSMGTK
KKVLVLGSGYVSEPVLEYLLRDDSIEITVGSDMKNQIEQLGKKYNINPVSLHVGKQEEKL
SSLVATQDLVISLLPYVLHPLVAKACIASKVNMITASYITPALKELEKSVEDAGITVIGE
LGLDPGLDHMLAMETIDKAKEVGATIESYVSYCGGLPAPECSDNPLRYKFSWSPVGVLMN
IMQPATYLLNGKVVNAVGGVSFLDSVTPMDYFPGLNLEGYPNRDSTKYAEIYGIPSAHTL
LRGTLRYKGYAKALSGFVKLGLINRDAFPALQPDANPLTWKELLCDLVGISSSSKCDVLK
EAVFKKLGGDTTQLEALEWLGLLGDEQVPQAESLVDALSKHLAVKLSYGPGEKDMIVMRD
SFGIRHPSGHLENKTIDLVVYGDVNGFSAMAKTVGLPTAMAAKMLLDGEIQAKGLMGPFS
KEIYGPILERIKAEGIMYTTQSTIKL
Enzyme 11 Number of Residues 926
Enzyme 11 Molecular Weight 102083.0
Enzyme 11 Theoretical pI 6.70
Enzyme 11 GO Classification
Function
Process
Component
Enzyme 11 General Function Amino acid transport and metabolism
Enzyme 11 Specific Function Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-oxoglutarate reductase and saccharopine dehydrogenase activity, respectively
Enzyme 11 Pathways
  • Amino-acid degradation
  • L-lysine degradation via saccharopine pathway
  • glutaryl-CoA from L-lysine:step 2/6
Enzyme 11 Reactions Not Available
Enzyme 11 Pfam Domain Function
Enzyme 11 Signals
  • None
Enzyme 11 Transmembrane Regions
  • None
Enzyme 11 Essentiality Not Available
Enzyme 11 GenBank ID Protein 157743061 Link Image
Enzyme 11 UniProtKB/Swiss-Prot ID A8E657 Link Image
Enzyme 11 UniProtKB/Swiss-Prot Entry Name AASS_BOVIN Link Image
Enzyme 11 PDB ID Not Available
Enzyme 11 Cellular Location Not Available
Enzyme 11 Gene Sequence >2781 bp
ATGCTGCGAGTGTCCAGAACCAAACTGGGCAGGCTGAGCCCCAGCCTCTCCAGAGGGCTT
CACCACAAGGCGGTGATGGCCTTGAGGCGGGAGGATGTGAATGCCTGGGAAAGGCGGGCT
CCTCTGGCTCCCCGGCACGTCAAAGGGATCACCAACCTGGGATACAAGGTCTTAATACAG
CCTTCCAATCGGCGAGCCATTCACGATAAGGAATATGTCAAAGCTGGTGGCATTCTCCAA
GAGGATATTTCTGAAGCTTGTCTAATTTTGGGAGTTAAAAGACCGCCAGAGGAAAAATTA
ATGCCCAAGAAGACTTATGCATTCTTCTCCCACACAATAAAGGCTCAGGAGGCCAATATG
GGTTTGCTGGATGAGATCCTAAAACAGGAAATCCGACTTATTGATTATGAGAAAATGGTG
GATCATAGAGGAATACGGGTGGTGGCATTCGGACAGTGGGCAGGTGTGGCAGGAATAATC
AACATTCTTCATGGGATGGGTTTAAGGCTCCTTGCTTTGGGACATCACACACCTTTTATG
CACATTGGCATGGCTCATAACTACAGGAACAGTGGTCAGGCTGTGCAAGCTGTCCGCGAT
GCTGGCTATGAAATATCTTTGGGTTTGATGCCGAAGTCAATAGGGCCCTTAACATTTGTG
TTCACAGGGACTGGTAATGTATCTAAGGGAGCCCAAGAAATCTTCAATGAATTACCTTGT
GAGTATGTGGAGCCACATGAATTAAAAGAAGTTTCCCAAAATGGAGACCTGAGAAAAGTG
TACGGGACAGTGTTAAGTCGCCATCATCATCTTGTCAGGAAAACAGATGGTGTATATGAC
CCTGTAGAGTATGACAAATACCCCGAGCGCTACATTAGCCGTTTTAATACTGATATTGCA
CCCTATACAACTTGTTTAATTAACGGGATCTACTGGGAACAGAACACCCCTCGTCTACTC
ACCCGCCAAGATGCTCAGAGTCTCCTGGCTCCAGGCAAGTCCCCAGTTGCTGGTGTTGAA
GGCTGCCCTGCATTGCCACACAAACTTGTGGCAATATGTGACATTTCAGCGGACACAGGA
GGATCCATTGAGTTTATGACTGAGTGTACGACCATAGAGCGTCCCTTTTGCATGTATGAT
GCAGATCAGCATATTATTCATGACAGTGTGGAAGGCTCTGGGATTCTGATGTGTTCCATT
GACAATTTGCCAGCACAGCTTCCAATTGAATCTACAGAATACTTTGGAGACATGCTTTAC
CCTTATGTTGAAGAAATGATACTATCAGATGCGACACAGCCTCTTGAAAGTCAGAATTTT
TCTCCTGTGGTGCGAGATGCAGTGATTGCATCTAATGGCATGCTGTCTAACAAGTATAAA
TATATCCAGAAACTCCGAGAGAACAGGGAACATGCTCAGTCACTTTCAATGGGCACCAAG
AAAAAGGTCTTGGTTCTTGGATCTGGTTACGTTTCTGAGCCTGTATTGGAATACCTGTTG
AGAGATGACAGTATTGAAATAACAGTAGGTTCTGACATGAAGAATCAAATTGAACAATTA
GGCAAGAAATATAATATTAATCCTGTTAGCCTGCACGTTGGTAAACAAGAAGAGAAGTTG
AGCTCCTTGGTGGCAACACAGGATCTTGTCATCAGCTTATTGCCTTATGTATTGCATCCT
CTTGTGGCCAAGGCATGCATCGCAAGCAAAGTTAACATGATCACTGCAAGCTACATCACC
CCAGCGCTAAAAGAATTAGAAAAGAGTGTGGAAGATGCTGGCATCACAGTCATTGGTGAA
TTGGGATTGGACCCTGGTCTTGATCATATGTTGGCAATGGAAACAATAGATAAGGCCAAA
GAAGTGGGAGCCACGATTGAATCTTATGTTTCCTACTGCGGTGGCCTTCCAGCTCCTGAA
TGTTCAGACAATCCTTTGAGATACAAATTTAGCTGGAGTCCAGTGGGAGTTCTGATGAAC
ATAATGCAGCCCGCTACCTACCTGCTCAACGGAAAGGTTGTGAATGCTGTAGGAGGTGTC
TCCTTTCTGGATTCAGTCACTCCCATGGATTATTTCCCTGGATTAAATTTGGAAGGTTAT
CCTAACAGAGACAGTACGAAGTATGCTGAGATTTATGGCATTCCATCTGCTCACACTTTA
TTACGAGGGACACTGAGGTACAAGGGGTATGCCAAAGCTTTGAGTGGATTTGTGAAGTTG
GGTCTCATAAACAGAGATGCGTTTCCTGCCCTTCAACCTGATGCCAATCCGCTCACCTGG
AAAGAACTCCTCTGTGATCTAGTTGGGATTTCATCCTCTTCCAAATGTGATGTGCTTAAG
GAAGCTGTCTTTAAGAAACTGGGAGGAGACACAACCCAGTTGGAGGCTCTCGAATGGTTA
GGGCTACTCGGGGATGAACAAGTCCCTCAGGCCGAGTCTCTCGTGGATGCCCTCTCCAAG
CATCTGGCCGTGAAACTTTCCTATGGTCCTGGAGAGAAAGATATGATTGTGATGAGAGAC
AGCTTTGGAATCAGACATCCTTCTGGACATTTGGAAAATAAAACTATTGATCTTGTGGTT
TATGGGGATGTCAATGGTTTTTCAGCCATGGCTAAAACTGTGGGGTTACCCACTGCTATG
GCAGCCAAGATGTTACTTGATGGTGAAATTCAAGCTAAAGGCCTGATGGGACCCTTTTCA
AAGGAGATCTATGGACCAATATTGGAGCGAATTAAAGCAGAAGGCATTATGTATACTACA
CAGAGCACAATCAAACTATAA
Enzyme 11 GenBank Gene ID BC153851 Link Image
Enzyme 11 GeneCard ID AASS Link Image
Enzyme 11 GenAtlas ID Not Available
Enzyme 11 HGNC ID Not Available
Enzyme 11 Chromosome Location Chromosome:7
Enzyme 11 Locus 7q31.3
Enzyme 11 SNPs SNPJam Report Link Image
Enzyme 11 General References Not Available
Enzyme 11 Metabolite References Not Available
Enzyme 12 [top]
Enzyme 12 ID 682
Enzyme 12 Name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Enzyme 12 Synonyms
  1. Lysyl hydroxylase 1
  2. LH1
Enzyme 12 Gene Name PLOD1
Enzyme 12 Protein Sequence >Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
MRLLLLLAPLGWLLLAETKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGL
GEDWPGEAMLAGGGLKVRLLKKALEKHADKENLVILFTDSYDVVFASGPRELLKKFRQAR
SQVVFSAEELIYPDRRLEAKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQL
FYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEVVLKFEMGQVRARNLAYDTLPVLIH
GNGPTKLQLNYLGNYIPRFWTFETGCAVCDEGLRSLKGIGDEALPAVLVGVFIEQPTPFL
SLFFQRLLRLHYPQKRLRLFIHNHEQHHKAQVEQFLAEHGDEYQSVKLVGPEVRVANADA
RNMGADLCRQDRGCTYYFSVDADVALTEPKTLRLLIEQNKNVIAPLMTRHGRLWSNFWGA
LSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRAELQETDLFHHSKLDPDM
AFCANIRQQDVFMFLTNRHSFGHLLSLDSYQTTHLHNDLWEVFSNPEDWKEKYIHENYTK
ALAGKMVEMPCPDVYWFPIFTETACDELVEEMEHYGQWSLGDNKDNRIQGGYENVPTIDI
HMNQINFEREWHKFLVEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLVPHHDAST
FTINIALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTKGTRYIA
VSFVDP
Enzyme 12 Number of Residues 726
Enzyme 12 Molecular Weight 83486.6
Enzyme 12 Theoretical pI 6.61
Enzyme 12 GO Classification
Function
Process
Component
Enzyme 12 General Function Involved in iron ion binding
Enzyme 12 Specific Function Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links
Enzyme 12 Pathways Not Available
Enzyme 12 Reactions Not Available
Enzyme 12 Pfam Domain Function
Enzyme 12 Signals
  • 1-18
Enzyme 12 Transmembrane Regions
  • None
Enzyme 12 Essentiality Not Available
Enzyme 12 GenBank ID Protein 3283055 Link Image
Enzyme 12 UniProtKB/Swiss-Prot ID O77588 Link Image
Enzyme 12 UniProtKB/Swiss-Prot Entry Name PLOD1_BOVIN Link Image
Enzyme 12 PDB ID Not Available
Enzyme 12 Cellular Location Not Available
Enzyme 12 Gene Sequence >2181 bp
ATGCGGCTCCTGCTGCTCCTGGCCCCGTTGGGCTGGCTGCTTCTAGCCGAAACGAAGGGT
GACGCCAAGCCGGAGGACAACCTTTTGGTCCTCACTGTGGCTACGAAGGAGACCGAGGGG
TTCCGACGCTTTAAGCGCTCAGCTCAGTTCTTCAACTACAAGATCCAGGCGCTGGGGCTG
GGGGAGGACTGGCCTGGGGAGGCGATGTTGGCAGGCGGTGGGCTGAAGGTCCGGCTATTG
AAGAAAGCCCTGGAGAAGCACGCCGACAAGGAGAACCTGGTCATTCTCTTCACAGACAGC
TATGATGTGGTATTTGCCTCGGGGCCCCGAGAGCTCCTGAAGAAGTTCCGGCAGGCCAGG
AGCCAGGTGGTCTTCTCGGCCGAGGAGCTCATCTACCCGGACCGCAGGCTGGAGGCCAAT
TACCCGGTGGTGTCCGACGGCAAGAGGTTCCTGGGCTCTGGAGGCTTCATCGGTTATGCT
CCCAACCTTATCAAACTGGTGGCAGAGTGGGAAGGCCAGGACAGCGACAGCGATCAGCTC
TTTTACACCAAGATCTTCTTGGACCCAGAGAAGAGGGAGCAGATCAATATCACCCTGGAC
CACCGTTGCCGAATCTTCCAGAATTTCCATGGAGCCTTGGATGAGGTCGTGCTCAAGTTT
GAAATGGGCCAAGTGAGAGCGAGGAACCTGGCCTACGACACCCTCCCAGTCCTGATTCAT
GGCAACGGGCCCACCAAGCTGCAGCTGAACTACTTGGGCAACTACATCCCGCGCTTCTGG
ACCTTCGAGACGGGGTGCGCTGTGTGTGACGAGGGCCTGCGCAGCCTCAAGGGCATCGGG
GATGAAGCTCTGCCTGCTGTTCTGGTCGGCGTGTTCATCGAACAGCCCACCCCGTTCCTG
TCCCTGTTCTTCCAGCGGCTCTTGCTCCTCCACTACCCCCAAAAACGGTTCAGGCTTTTC
ATTCACAACCACGAGCAGCACCACAAGGCTCAGGTGGAGCAGTTCCTGGCAGAGCACGGC
GATGAGTACCAGTCTGTGAAACTGGTGGGCCCCGAGGTGCGGGTGGCCAACGCAGACGCC
AGGAACATGGGCGCGGACTTGTGCCGGCAGGACCGTGGCTGCACTTACTACTTCAGCGTG
GATGCCGACGTGGCCCTGACTGAGCCCAAAACCCTGCGGCTGCTGATCGAGCAGAACAAG
AACGTTATCACCCCATTGATGACCCGCCATGGGAGGCTGTGGTCGAACTTCTGGGGGGCA
CTGAGTGCAGATGGCTACTACGCCCGCTCCGAGGACTACGTGGACATCGTGCAGGGGCGG
CGTGTGGGTGTCTGGAATGTACCCTACATCTCAAACATCTACCTGATCAAGGGTAGCGCC
CTGCGGGCTGAGTTGCAGGAGACAGACCTGTTCCACCACAGCAAGCTGGACCCCGACATG
GCCTTCTGTGCCAACATCCGGCAGCAGGATGTGTTCATGTTCCTGACCAACCGGCACTCC
TTTGGCCACCTGCTCTCCCTGGACAGCTACCAGACCACCCACCTCCACAACGACCTCTGG
GAGGTGTTCAGCAACCCCGAGGACTGGAAGGAGAAATACATCCATGAGAACTACACCAAG
GCCTTGGCGGGGAAGATGGTGGAGATGCCTTGCCCGGACGTCTACTGGTTCCCCATCTTC
ACGGAGACGGCCTGTGATGAGCTGGTGGAAGAGATGGAGCACTACGGCCAGTGGTCCCTG
GGAGATAACAAGGACAACCGCATCCAGGGTGGCTACGAAAACGTGCCAACCATCGACATC
CACATGAACCAGATCAACTATGAGCGGGAGTGGCACAAGTTCCTGGTGGAGTACATCGCC
CCCATGACGGAGAAACTCTACCCGGGCTACTACACCAGGGCCCAATTCGACCTGGCCTTT
GTCGTCCGCTACAAGCCTGATGAGCAGCCCTCGCTGGTGCCACACCACGACGCCTCCACC
TTCACCATCAACATCGGCCTGAACCGGGTTGGAGTGGATTATGAGGGCGGGGGGTGTCGG
TTCCTGCGCTACAACTGCTCCATCCGAGCCCCACGGAAGGGCTGGACCCTGATGCACCCC
GGGCGACTCACGCACTACCACGAGGGGGTCCCCACCACCAAAGGCACCCGCTACATCGCA
GTCTCCTTCGTCGATCCCTAA
Enzyme 12 GenBank Gene ID AF054274 Link Image
Enzyme 12 GeneCard ID PLOD1 Link Image
Enzyme 12 GenAtlas ID Not Available
Enzyme 12 HGNC ID Not Available
Enzyme 12 Chromosome Location Chromosome:1
Enzyme 12 Locus 1p36.22
Enzyme 12 SNPs SNPJam Report Link Image
Enzyme 12 General References
  1. [PubMed Link Image]
Enzyme 12 Metabolite References Not Available
Enzyme 13 [top]
Enzyme 13 ID 966
Enzyme 13 Name Ubiquitin-conjugating enzyme E2 E3
Enzyme 13 Synonyms
  1. Ubiquitin-protein ligase E3
  2. Ubiquitin carrier protein E3
Enzyme 13 Gene Name UBE2E3
Enzyme 13 Protein Sequence >Ubiquitin-conjugating enzyme E2 E3
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLS
TSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDY
PFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLV
GSIATQYLTNRAEHDRIARQWTKRYAT
Enzyme 13 Number of Residues 207
Enzyme 13 Molecular Weight 22912.3
Enzyme 13 Theoretical pI 7.25
Enzyme 13 GO Classification
Function
Process
Component
Enzyme 13 General Function Involved in ATP binding
Enzyme 13 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest
Enzyme 13 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 13 Reactions Not Available
Enzyme 13 Pfam Domain Function
Enzyme 13 Signals
  • None
Enzyme 13 Transmembrane Regions
  • None
Enzyme 13 Essentiality Not Available
Enzyme 13 GenBank ID Protein 83405477 Link Image
Enzyme 13 UniProtKB/Swiss-Prot ID Q2T9X7 Link Image
Enzyme 13 UniProtKB/Swiss-Prot Entry Name UB2E3_BOVIN Link Image
Enzyme 13 PDB ID 1Y6L Link Image
Enzyme 13 PDB File Show
Enzyme 13 3D Structure
Enzyme 13 Cellular Location Not Available
Enzyme 13 Gene Sequence >624 bp
ATGTCCAGTGATCGGCAGAGATCCGATGATGAGAGTCCCAGCACCAGCAGCGGTAGCTCA
GATGCAGACCAGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAAGAAAGAAAACCG
TCTGCCACCCAGCAGAAGAAAAACACCAAACTCTCTAGCAAAACCACTGCTAAATTATCC
ACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCTAAC
TGCAGTGCTGGGCCTAAAGGAGATAACATTTATGAATGGAGATCGACTATACTTGGTCCA
CCAGGTTCTGTATATGAAGGTGGTGTGTTTTTTCTGGATATCACATTTTCATCCGATTAT
CCATTTAAGCCACCAAAGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAATAGT
CAGGGAGTCATCTGCCTGGACATCCTTAAAGACAACTGGAGTCCTGCTTTGACTATTTCA
AAGGTTTTGCTGTCAATTTGTTCTCTTTTGACAGACTGCAACCCTGCGGATCCTCTGGTT
GGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACATGACAGGATAGCCAGACAG
TGGACCAAGCGATACGCAACATAA
Enzyme 13 GenBank Gene ID BC111218 Link Image
Enzyme 13 GeneCard ID UBE2E3 Link Image
Enzyme 13 GenAtlas ID Not Available
Enzyme 13 HGNC ID Not Available
Enzyme 13 Chromosome Location Chromosome:2
Enzyme 13 Locus 2q32.1
Enzyme 13 SNPs SNPJam Report Link Image
Enzyme 13 General References Not Available
Enzyme 13 Metabolite References Not Available
Enzyme 14 [top]
Enzyme 14 ID 967
Enzyme 14 Name Ubiquitin/ISG15-conjugating enzyme E2 L6
Enzyme 14 Synonyms
  1. Ubiquitin-protein ligase L6
  2. Ubiquitin carrier protein L6
  3. UbcM8
Enzyme 14 Gene Name UBE2L6
Enzyme 14 Protein Sequence >Ubiquitin/ISG15-conjugating enzyme E2 L6
MTASKRVAKELEDLQKELPKYLRNLCSEEDNVLVWHALLLPERPPYNLKAFRLCISFPRE
YPFQPPTVKFTTRIYHPNVDRDGRVCLPIISKKNWKASTRTCQVLEALNMLVNQPEPGQP
VRLELAEQLTQDPELFDQMAQEFTLQFGVDRPS
Enzyme 14 Number of Residues 153
Enzyme 14 Molecular Weight 17824.4
Enzyme 14 Theoretical pI 7.29
Enzyme 14 GO Classification
Function
Process
Component
Enzyme 14 General Function Involved in ATP binding
Enzyme 14 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53
Enzyme 14 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 14 Reactions Not Available
Enzyme 14 Pfam Domain Function
Enzyme 14 Signals
  • None
Enzyme 14 Transmembrane Regions
  • None
Enzyme 14 Essentiality Not Available
Enzyme 14 GenBank ID Protein 148743936 Link Image
Enzyme 14 UniProtKB/Swiss-Prot ID A5PJC4 Link Image
Enzyme 14 UniProtKB/Swiss-Prot Entry Name UB2L6_BOVIN Link Image
Enzyme 14 PDB ID Not Available
Enzyme 14 Cellular Location Not Available
Enzyme 14 Gene Sequence >462 bp
ATGACGGCGAGCAAGCGGGTGGCGAAGGAGCTGGAAGACCTGCAGAAGGAGCTTCCCAAG
TACCTGCGGAACCTGTGCAGCGAGGAGGACAACGTGCTGGTGTGGCATGCGCTCCTGCTG
CCTGAGAGGCCACCCTACAACCTCAAGGCCTTCAGGCTGTGCATCAGCTTCCCCAGGGAG
TACCCGTTCCAGCCCCCGACGGTGAAATTCACCACTAGGATCTACCACCCCAACGTGGAC
AGGGACGGGAGGGTGTGCCTGCCCATCATCAGCAAGAAGAACTGGAAAGCCAGCACCAGG
ACCTGCCAAGTCTTGGAGGCCCTCAACATGCTGGTGAATCAACCGGAGCCGGGACAGCCC
GTTCGGCTGGAGCTCGCGGAGCAGCTGACACAGGACCCAGAGCTGTTTGACCAGATGGCC
CAAGAGTTCACCCTCCAGTTTGGAGTGGACCGGCCCTCCTAA
Enzyme 14 GenBank Gene ID BC142048 Link Image
Enzyme 14 GeneCard ID UBE2L6 Link Image
Enzyme 14 GenAtlas ID Not Available
Enzyme 14 HGNC ID Not Available
Enzyme 14 Chromosome Location Chromosome:1
Enzyme 14 Locus 11q12
Enzyme 14 SNPs SNPJam Report Link Image
Enzyme 14 General References Not Available
Enzyme 14 Metabolite References Not Available
Enzyme 15 [top]
Enzyme 15 ID 968
Enzyme 15 Name NEDD8-conjugating enzyme UBE2F
Enzyme 15 Synonyms
  1. Ubiquitin-conjugating enzyme E2 F
  2. NEDD8 protein ligase UBE2F
  3. NEDD8 carrier protein UBE2F
  4. NEDD8-conjugating enzyme 2
Enzyme 15 Gene Name UBE2F
Enzyme 15 Protein Sequence >NEDD8-conjugating enzyme UBE2F
MLTLASKLKRDDGLKGSRASATASDSTRRVSVRDRLLVKEVAELEANLPCTCKVHFPDPN
KLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTRIWHPNITETGEICLSLL
REHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVEDYI
KRYAR
Enzyme 15 Number of Residues 185
Enzyme 15 Molecular Weight 21132.8
Enzyme 15 Theoretical pI 6.78
Enzyme 15 GO Classification
Function
Process
Component
Enzyme 15 General Function Involved in ATP binding
Enzyme 15 Specific Function Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5
Enzyme 15 Pathways
  • Protein modification
  • protein neddylation
Enzyme 15 Reactions Not Available
Enzyme 15 Pfam Domain Function
Enzyme 15 Signals
  • None
Enzyme 15 Transmembrane Regions
  • None
Enzyme 15 Essentiality Not Available
Enzyme 15 GenBank ID Protein 92096626 Link Image
Enzyme 15 UniProtKB/Swiss-Prot ID Q1RMW1 Link Image
Enzyme 15 UniProtKB/Swiss-Prot Entry Name UBE2F_BOVIN Link Image
Enzyme 15 PDB ID Not Available
Enzyme 15 Cellular Location Not Available
Enzyme 15 Gene Sequence >558 bp
ATGCTGACGCTGGCAAGCAAGCTGAAGCGGGATGATGGTCTCAAAGGGTCCCGGGCGTCA
GCCACAGCCTCTGACTCCACTCGGCGGGTGTCTGTGAGGGACAGGCTGCTTGTTAAAGAG
GTTGCAGAACTTGAAGCTAATTTACCTTGTACGTGTAAAGTGCATTTTCCTGATCCAAAC
AAGCTTCATTGCTTTCAGCTAACTGTCACCCCAGATGAGGGTTACTACCAGGGTGGAAAA
TTTCAGTTTGAAACTGAAGTTCCTGACGCATACAACATGGTGCCTCCCAAAGTGAAATGC
TTGACCAGGATCTGGCACCCCAACATCACCGAGACTGGTGAGATATGTCTCAGCTTACTG
AGAGAACACTCGATCGACGGCACCGGCTGGGCCCCCACAAGGACGCTGAAGGATGTTGTT
TGGGGATTAAACTCTTTGTTTACTGATCTGTTGAATTTTGATGATCCACTGAATATTGAA
GCTGCGGAACATCATTTGCGAGACAAGGAGGACTTCCGGAATAAAGTGGAGGACTACATT
AAGCGCTACGCCAGATGA
Enzyme 15 GenBank Gene ID BC114675 Link Image
Enzyme 15 GeneCard ID UBE2F Link Image
Enzyme 15 GenAtlas ID Not Available
Enzyme 15 HGNC ID Not Available
Enzyme 15 Chromosome Location Chromosome:2
Enzyme 15 Locus 2q37.3
Enzyme 15 SNPs SNPJam Report Link Image
Enzyme 15 General References Not Available
Enzyme 15 Metabolite References Not Available
Enzyme 16 [top]
Enzyme 16 ID 969
Enzyme 16 Name Ubiquitin-conjugating enzyme E2 L3
Enzyme 16 Synonyms
  1. Ubiquitin-protein ligase L3
  2. Ubiquitin carrier protein L3
Enzyme 16 Gene Name UBE2L3
Enzyme 16 Protein Sequence >Ubiquitin-conjugating enzyme E2 L3
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE
YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP
LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD
Enzyme 16 Number of Residues 154
Enzyme 16 Molecular Weight 17861.4
Enzyme 16 Theoretical pI 8.79
Enzyme 16 GO Classification
Function
Process
Component
Enzyme 16 General Function Involved in ATP binding
Enzyme 16 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53
Enzyme 16 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 16 Reactions Not Available
Enzyme 16 Pfam Domain Function
Enzyme 16 Signals
  • None
Enzyme 16 Transmembrane Regions
  • None
Enzyme 16 Essentiality Not Available
Enzyme 16 GenBank ID Protein 75947622 Link Image
Enzyme 16 UniProtKB/Swiss-Prot ID Q3MHP1 Link Image
Enzyme 16 UniProtKB/Swiss-Prot Entry Name UB2L3_BOVIN Link Image
Enzyme 16 PDB ID 1FBV Link Image
Enzyme 16 PDB File Show
Enzyme 16 3D Structure
Enzyme 16 Cellular Location Not Available
Enzyme 16 Gene Sequence >465 bp
ATGGCGGCCAGCAGGAGGCTGATGAAGGAGCTTGAAGAAATCCGCAAGTGTGGGATGAAA
AACTTCCGTAACATCCAGGTCGATGAAGCTAATTTGCTGACTTGGCAAGGGCTCATTGTT
CCCGACAACCCTCCCTATGATAAGGGGGCCTTCAGAATCGAAATCAACTTTCCAGCAGAG
TACCCCTTCAAACCACCGAAGATCACGTTCAAAACGAAGATCTACCACCCGAACATCGAC
GAGAAGGGGCAGGTGTGTCTGCCTGTAATTAGTGCTGAAAACTGGAAGCCAGCAACCAAA
ACCGACCAAGTCATCCAGTCCCTCATAGCACTGGTGAACGACCCCCAGCCGGAGCACCCG
CTCCGGGCTGACCTAGCCGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCT
GAAGAATTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAA
Enzyme 16 GenBank Gene ID BC105164 Link Image
Enzyme 16 GeneCard ID UBE2L3 Link Image
Enzyme 16 GenAtlas ID Not Available
Enzyme 16 HGNC ID Not Available
Enzyme 16 Chromosome Location Chromosome:2
Enzyme 16 Locus 22q11.21
Enzyme 16 SNPs SNPJam Report Link Image
Enzyme 16 General References
  1. [PubMed Link Image]
Enzyme 16 Metabolite References Not Available
Enzyme 17 [top]
Enzyme 17 ID 970
Enzyme 17 Name Ubiquitin-conjugating enzyme E2 N
Enzyme 17 Synonyms
  1. Ubiquitin-protein ligase N
  2. Ubiquitin carrier protein N
Enzyme 17 Gene Name UBE2N
Enzyme 17 Protein Sequence >Ubiquitin-conjugating enzyme E2 N
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE
EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP
LANDVAEQWKTNEAQAIETARAWTRLYAMNNI
Enzyme 17 Number of Residues 152
Enzyme 17 Molecular Weight 17137.6
Enzyme 17 Theoretical pI 6.53
Enzyme 17 GO Classification
Function
Process
Component
Enzyme 17 General Function Involved in ATP binding
Enzyme 17 Specific Function The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys- 63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF or SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair
Enzyme 17 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 17 Reactions Not Available
Enzyme 17 Pfam Domain Function
Enzyme 17 Signals
  • None
Enzyme 17 Transmembrane Regions
  • None
Enzyme 17 Essentiality Not Available
Enzyme 17 GenBank ID Protein 112362019 Link Image
Enzyme 17 UniProtKB/Swiss-Prot ID Q0P5K3 Link Image
Enzyme 17 UniProtKB/Swiss-Prot Entry Name UBE2N_BOVIN Link Image
Enzyme 17 PDB ID 1J7D Link Image
Enzyme 17 PDB File Show
Enzyme 17 3D Structure
Enzyme 17 Cellular Location Not Available
Enzyme 17 Gene Sequence >459 bp
ATGGCCGGGCTGCCCCGCAGGATTATCAAGGAAACCCAGCGTTTGCTGGCAGAACCAGTT
CCCGGCATTAAAGCAGAACCAGATGAGAGCAACGCCCGTTATTTTCATGTGGTCATTGCC
GGCCCTCAGGATTCCCCCTTTGAGGGAGGGACTTTTAAACTTGAACTATTCCTTCCAGAA
GAATACCCAATGGCAGCCCCTAAAGTACGTTTCATGACCAAAATTTATCATCCTAATGTA
GACAAGTTGGGAAGAATATGTTTAGATATTTTGAAAGATAAGTGGTCCCCAGCACTGCAG
ATCCGCACAGTTCTGCTATCGATCCAGGCTTTGTTAAGTGCTCCCAATCCAGATGATCCA
TTAGCAAATGATGTAGCGGAGCAATGGAAGACCAATGAAGCCCAAGCCATAGAAACAGCT
AGAGCATGGACTAGGCTATATGCCATGAATAATATTTAA
Enzyme 17 GenBank Gene ID BC119931 Link Image
Enzyme 17 GeneCard ID UBE2N Link Image
Enzyme 17 GenAtlas ID Not Available
Enzyme 17 HGNC ID Not Available
Enzyme 17 Chromosome Location Chromosome:1
Enzyme 17 Locus 12q22
Enzyme 17 SNPs SNPJam Report Link Image
Enzyme 17 General References Not Available
Enzyme 17 Metabolite References Not Available
Enzyme 18 [top]
Enzyme 18 ID 971
Enzyme 18 Name Ubiquitin-conjugating enzyme E2 D3
Enzyme 18 Synonyms
  1. Ubiquitin-protein ligase D3
  2. Ubiquitin carrier protein D3
Enzyme 18 Gene Name UBE2D3
Enzyme 18 Protein Sequence >Ubiquitin-conjugating enzyme E2 D3
MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTRIYHPNINSNDSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV
PEIARIYKTDRDKYNRISREWTQKYAM
Enzyme 18 Number of Residues 147
Enzyme 18 Molecular Weight 16745.0
Enzyme 18 Theoretical pI 7.38
Enzyme 18 GO Classification
Function
Process
Component
Enzyme 18 General Function Involved in ATP binding
Enzyme 18 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53
Enzyme 18 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 18 Reactions Not Available
Enzyme 18 Pfam Domain Function
Enzyme 18 Signals
  • None
Enzyme 18 Transmembrane Regions
  • None
Enzyme 18 Essentiality Not Available
Enzyme 18 GenBank ID Protein 73586555 Link Image
Enzyme 18 UniProtKB/Swiss-Prot ID Q3ZCF7 Link Image
Enzyme 18 UniProtKB/Swiss-Prot Entry Name UB2D3_BOVIN Link Image
Enzyme 18 PDB ID 1X23 Link Image
Enzyme 18 PDB File Show
Enzyme 18 3D Structure
Enzyme 18 Cellular Location Not Available
Enzyme 18 Gene Sequence >444 bp
ATGGCGCTGAAACGGATTAATAAGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAA
TGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCT
AATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTAC
CCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGT
AATGACAGCATTTGTCTCGATATTCTAAGATCACAGTGGTCTCCTGCTTTAACTATTTCT
AAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTG
CCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAA
TGGACTCAGAAGTATGCCATGTGA
Enzyme 18 GenBank Gene ID BC102425 Link Image
Enzyme 18 GeneCard ID UBE2D3 Link Image
Enzyme 18 GenAtlas ID Not Available
Enzyme 18 HGNC ID Not Available
Enzyme 18 Chromosome Location Chromosome:4
Enzyme 18 Locus 4q24
Enzyme 18 SNPs SNPJam Report Link Image
Enzyme 18 General References Not Available
Enzyme 18 Metabolite References Not Available
Enzyme 19 [top]
Enzyme 19 ID 972
Enzyme 19 Name NEDD8-conjugating enzyme Ubc12
Enzyme 19 Synonyms
  1. Ubiquitin-conjugating enzyme E2 M
  2. NEDD8 protein ligase
  3. NEDD8 carrier protein
Enzyme 19 Gene Name UBE2M
Enzyme 19 Protein Sequence >NEDD8-conjugating enzyme Ubc12
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNF
KLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWK
PVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFER
CLK
Enzyme 19 Number of Residues 183
Enzyme 19 Molecular Weight 20899.8
Enzyme 19 Theoretical pI 7.84
Enzyme 19 GO Classification
Function
Process
Component
Enzyme 19 General Function Involved in ATP binding
Enzyme 19 Specific Function Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation
Enzyme 19 Pathways
  • Protein modification
  • protein neddylation
Enzyme 19 Reactions Not Available
Enzyme 19 Pfam Domain Function
Enzyme 19 Signals
  • None
Enzyme 19 Transmembrane Regions
  • None
Enzyme 19 Essentiality Not Available
Enzyme 19 GenBank ID Protein 126920920 Link Image
Enzyme 19 UniProtKB/Swiss-Prot ID A3KN22 Link Image
Enzyme 19 UniProtKB/Swiss-Prot Entry Name UBC12_BOVIN Link Image
Enzyme 19 PDB ID 1Y8X Link Image
Enzyme 19 PDB File Show
Enzyme 19 3D Structure
Enzyme 19 Cellular Location Not Available
Enzyme 19 Gene Sequence >552 bp
ATGATCAAGCTGTTCTCGCTGAAGCAGCAGAAGAAGGAGGAGGAGTCGGCGGGCGGCACC
AAGGGCAGCAGCAAGAAGGCGTCGGCGGCGCAGCTGCGGATCCAGAAGGACATAAACGAG
CTGAATCTGCCCAAGACGTGTGACATCAGTTTCTCAGATCCAGACGACCTCCTCAACTTC
AAGCTGGTTATCTGTCCTGATGAGGGCTTCTACAAGAGCGGGAAGTTTGTGTTCAGTTTT
AAGGTGGGCCAGGGTTACCCGCATGACCCCCCCAAGGTGAAGTGTGAGACGATGGTTTAT
CACCCCAACATTGACCTCGAGGGCAACGTCTGCCTCAACATCCTCAGAGAGGACTGGAAG
CCAGTCCTTACGATAAACTCCATAATTTATGGCTTGCAGTATCTCTTCTTGGAGCCCAAC
CCTGAAGACCCACTGAACAAGGAAGCCGCCGAGGTCCTGCAGAACAACCGGAGGCTGTTT
GAGCAGAATGTCCAGCGCTCCATGCGGGGTGGCTATATCGGCTCCACTTACTTCGAGCGC
TGCCTGAAATAG
Enzyme 19 GenBank Gene ID BC133501 Link Image
Enzyme 19 GeneCard ID UBE2M Link Image
Enzyme 19 GenAtlas ID Not Available
Enzyme 19 HGNC ID Not Available
Enzyme 19 Chromosome Location Chromosome:1
Enzyme 19 Locus 19q13.43
Enzyme 19 SNPs SNPJam Report Link Image
Enzyme 19 General References Not Available
Enzyme 19 Metabolite References Not Available
Enzyme 20 [top]
Enzyme 20 ID 973
Enzyme 20 Name Ubiquitin-conjugating enzyme E2 H
Enzyme 20 Synonyms
  1. Ubiquitin-protein ligase H
  2. Ubiquitin carrier protein H
Enzyme 20 Gene Name UBE2H
Enzyme 20 Protein Sequence >Ubiquitin-conjugating enzyme E2 H
MSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPDK
YPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPID
PLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQD
MEL
Enzyme 20 Number of Residues 183
Enzyme 20 Molecular Weight 20655.0
Enzyme 20 Theoretical pI 4.29
Enzyme 20 GO Classification
Function
Process
Component
Enzyme 20 General Function Involved in ATP binding
Enzyme 20 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Capable, in vitro, to ubiquitinate histone H2A
Enzyme 20 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 20 Reactions Not Available
Enzyme 20 Pfam Domain Function
Enzyme 20 Signals
  • None
Enzyme 20 Transmembrane Regions
  • None
Enzyme 20 Essentiality Not Available
Enzyme 20 GenBank ID Protein 81673740 Link Image
Enzyme 20 UniProtKB/Swiss-Prot ID Q32LN1 Link Image
Enzyme 20 UniProtKB/Swiss-Prot Entry Name UBE2H_BOVIN Link Image
Enzyme 20 PDB ID 1YH6 Link Image
Enzyme 20 PDB File Show
Enzyme 20 3D Structure
Enzyme 20 Cellular Location Not Available
Enzyme 20 Gene Sequence >552 bp
ATGTCATCCCCTAGTCCGGGCAAGAGGCGGATGGACACGGACGTGGTCAAGCTTATTGAG
AGTAAGCATGAGGTTACTATCCTAGGAGGACTCAATGAATTTGTAGTGAAGTTTTATGGA
CCACAAGGAACACCGTATGAAGGCGGAGTATGGAAAGTTAGAGTGGATCTTCCTGATAAA
TACCCTTTCAAATCTCCTTCTATAGGATTCATGAATAAAATTTTCCATCCCAACATTGAT
GAAGCGTCAGGAACTGTGTGTCTAGATGTAATTAATCAAACTTGGACAGCTCTCTATGAT
CTTACCAATATATTTGAGTCCTTCCTGCCCCAGTTGTTGGCCTATCCCAACCCCATAGAT
CCTCTCAATGGTGACGCTGCAGCTATGTACCTCCATCGACCAGAAGAATACAAGCAGAAA
ATTAAAGAGTACATCCAGAAATATGCAACGGAGGAGGCACTGAAAGAGCAGGAAGAGGGC
ACTGGAGACAGCTCATCGGAGAGTTCTATGTCTGACTTTTCGGAAGACGAGGCCCAGGAT
ATGGAGTTGTAG
Enzyme 20 GenBank Gene ID BC109502 Link Image
Enzyme 20 GeneCard ID UBE2H Link Image
Enzyme 20 GenAtlas ID Not Available
Enzyme 20 HGNC ID Not Available
Enzyme 20 Chromosome Location Chromosome:7
Enzyme 20 Locus 7q32
Enzyme 20 SNPs SNPJam Report Link Image
Enzyme 20 General References Not Available
Enzyme 20 Metabolite References Not Available
Enzyme 21 [top]
Enzyme 21 ID 974
Enzyme 21 Name Carboxypeptidase N catalytic chain
Enzyme 21 Synonyms
  1. CPN
  2. Carboxypeptidase N polypeptide 1
  3. Carboxypeptidase N small subunit
Enzyme 21 Gene Name CPN1
Enzyme 21 Protein Sequence >Carboxypeptidase N catalytic chain
MSDLVSIFLHLLLFKLVAPVTFRHHRYDDLVRMLYKVHNECPHITRVYSIGRSVKGRHLY
VLEFSDYPGIHEPLEPEVKYVGNMHGNEVLGRELLLQLSEFLCEEFRNRNQRIVRLVEDT
RIHIMPSMNPDGYEVAAAAQERDISGYLVGRNNANGVDLNRNFPDLNTYIYYNEKNGGPN
HHFPLPDNWKSQVEPETQAVIQWIRSFNFVLSANLHGGAVVANYPYDKSLGHRVRGFRRT
ANTPTPDDKLFQKLAKIYSYAHGWMHQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHT
NCFEITLELSCDKFPLQGELQREWLGNREALIQFLEQVHQGIKGMVRDENYNNLADAVIS
VGGINHDVTSGAHGDYFRLLLPGTYTVTATAPGFDPETVSVTVGPAEPKLVNFQLKRSTP
QAAPKRRIPNSGHRGRVLPKKVQPRAARKKETMMKQPQRGPA
Enzyme 21 Number of Residues 462
Enzyme 21 Molecular Weight 52668.5
Enzyme 21 Theoretical pI 8.79
Enzyme 21 GO Classification
Function
Process
Component
Enzyme 21 General Function Amino acid transport and metabolism
Enzyme 21 Specific Function Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation
Enzyme 21 Pathways Not Available
Enzyme 21 Reactions Not Available
Enzyme 21 Pfam Domain Function
Enzyme 21 Signals
  • 1-19
Enzyme 21 Transmembrane Regions
  • None
Enzyme 21 Essentiality Not Available
Enzyme 21 GenBank ID Protein 86821877 Link Image
Enzyme 21 UniProtKB/Swiss-Prot ID Q2KJ83 Link Image
Enzyme 21 UniProtKB/Swiss-Prot Entry Name CBPN_BOVIN Link Image
Enzyme 21 PDB ID Not Available
Enzyme 21 Cellular Location Not Available
Enzyme 21 Gene Sequence >1389 bp
ATGTCAGACCTGGTCTCAATCTTCCTCCACCTCCTTCTCTTCAAGTTGGTTGCCCCAGTG
ACCTTTCGCCACCACCGCTATGATGACCTCGTGCGGATGCTGTACAAGGTGCACAACGAA
TGTCCCCACATCACTCGGGTTTACAGCATTGGGCGCAGTGTGAAGGGGAGACACCTCTAT
GTGCTGGAATTCAGCGACTACCCTGGAATCCACGAACCCTTGGAACCGGAAGTCAAGTAC
GTGGGGAATATGCACGGCAATGAGGTGCTAGGCCGTGAGCTGCTGCTGCAGCTGTCGGAG
TTCCTGTGTGAGGAATTCCGCAACAGGAACCAGCGCATCGTCCGGCTGGTGGAGGACACG
CGCATCCACATCATGCCGTCCATGAACCCTGACGGCTACGAGGTGGCCGCTGCTGCCCAG
GAACGGGACATCTCTGGGTATCTGGTTGGCAGGAACAATGCAAATGGGGTGGACCTGAAC
CGCAACTTCCCCGATCTCAATACCTACATCTACTACAATGAGAAGAACGGAGGCCCCAAC
CACCACTTCCCCCTTCCAGACAACTGGAAAAGTCAGGTGGAACCCGAGACCCAGGCTGTG
ATACAGTGGATCCGATCCTTCAACTTTGTCCTTTCAGCCAATCTCCACGGAGGGGCAGTG
GTAGCCAATTATCCATATGACAAGTCCCTTGGGCACCGGGTCCGAGGTTTCCGCCGCACT
GCCAATACCCCCACGCCTGATGACAAGCTTTTCCAGAAGCTGGCGAAGATCTACTCCTAT
GCACATGGATGGATGCACCAAGGTTGGAACTGTGGGGATTACTTCCCAGACGGCATCACC
AATGGGGCTTCCTGGTATTCCCTCAGCAAGGGAATGCAAGACTTCAATTATCTCCATACC
AATTGCTTTGAGATCACGCTGGAACTTAGTTGTGACAAGTTTCCGCTGCAAGGGGAATTA
CAGCGCGAGTGGCTGGGTAATAGGGAAGCCCTCATCCAATTCTTGGAACAGGTCCACCAG
GGCATCAAGGGAATGGTGAGGGATGAGAATTATAATAATCTTGCGGATGCTGTCATTTCT
GTCGGTGGGATTAATCATGATGTCACTTCGGGTGCCCATGGCGATTACTTCCGGCTGCTG
CTTCCGGGTACCTACACGGTCACTGCCACAGCACCTGGGTTCGACCCAGAGACCGTGAGT
GTGACCGTGGGTCCTGCGGAACCCAAGCTGGTTAATTTCCAACTCAAAAGAAGCACCCCT
CAAGCAGCCCCTAAGAGGAGAATTCCCAACTCAGGGCATAGAGGCAGAGTCTTACCAAAG
AAAGTGCAGCCCCGGGCAGCTAGGAAAAAAGAAACGATGATGAAGCAACCCCAGAGAGGC
CCTGCCTGA
Enzyme 21 GenBank Gene ID BC105475 Link Image
Enzyme 21 GeneCard ID CPN1 Link Image
Enzyme 21 GenAtlas ID Not Available
Enzyme 21 HGNC ID Not Available
Enzyme 21 Chromosome Location Chromosome:1
Enzyme 21 Locus 10q24.2
Enzyme 21 SNPs SNPJam Report Link Image
Enzyme 21 General References Not Available
Enzyme 21 Metabolite References Not Available
Enzyme 22 [top]
Enzyme 22 ID 975
Enzyme 22 Name Ubiquitin-conjugating enzyme E2 C
Enzyme 22 Synonyms
  1. Ubiquitin-protein ligase C
  2. Ubiquitin carrier protein C
Enzyme 22 Gene Name UBE2C
Enzyme 22 Protein Sequence >Ubiquitin-conjugating enzyme E2 C
MASQNRDPVAASVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF
KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKD
KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVSSQDP
Enzyme 22 Number of Residues 179
Enzyme 22 Molecular Weight 19608.1
Enzyme 22 Theoretical pI 7.50
Enzyme 22 GO Classification
Function
Process
Component
Enzyme 22 General Function Involved in ATP binding
Enzyme 22 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Required for the destruction of mitotic cyclins
Enzyme 22 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 22 Reactions Not Available
Enzyme 22 Pfam Domain Function
Enzyme 22 Signals
  • None
Enzyme 22 Transmembrane Regions
  • None
Enzyme 22 Essentiality Not Available
Enzyme 22 GenBank ID Protein 79158783 Link Image
Enzyme 22 UniProtKB/Swiss-Prot ID Q32PA5 Link Image
Enzyme 22 UniProtKB/Swiss-Prot Entry Name UBE2C_BOVIN Link Image
Enzyme 22 PDB ID 1I7K Link Image
Enzyme 22 PDB File Show
Enzyme 22 3D Structure
Enzyme 22 Cellular Location Not Available
Enzyme 22 Gene Sequence >540 bp
ATGGCTTCCCAGAACCGCGACCCAGTCGCCGCCAGCGTCGCCGCCGCCCGTAAAGGAGCC
GAGCCCAGCGGGGGTGCTGCCCGGGGCCCTGTGGGCAAGAGGCTACAACAGGAGCTGATG
ACTCTCATGATGTCTGGCGATAAAGGAATTTCTGCCTTCCCTGAATCCGACAACCTCTTC
AAATGGGTGGGGACCATCCATGGAGCCGCTGGCACAGTATATGAAGACCTGAGGTATAAA
CTGTCCCTGGAGTTCCCCAGTGGCTACCCTTACAACGCGCCCACGGTGAAGTTCCTCACA
CCCTGCTACCATCCCAATGTGGACACCCAGGGTAACATCTGTCTGGACATCCTGAAAGAC
AAGTGGTCCGCCCTGTATGACGTCAGGACCATCCTGCTCTCCATCCAGAGTCTGCTCGGA
GAGCCCAACATTGATAGCCCTTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACA
GCCTTTAAGAAGTACCTGCAAGAAACCTACTCAAAGCAGGTCTCCAGCCAAGACCCCTGA
Enzyme 22 GenBank Gene ID BC108195 Link Image
Enzyme 22 GeneCard ID UBE2C Link Image
Enzyme 22 GenAtlas ID Not Available
Enzyme 22 HGNC ID Not Available
Enzyme 22 Chromosome Location Chromosome:2
Enzyme 22 Locus 20q13.12
Enzyme 22 SNPs SNPJam Report Link Image
Enzyme 22 General References Not Available
Enzyme 22 Metabolite References Not Available
Enzyme 23 [top]
Enzyme 23 ID 976
Enzyme 23 Name Ubiquitin-conjugating enzyme E2 Q2
Enzyme 23 Synonyms
  1. Ubiquitin-protein ligase Q2
  2. Ubiquitin carrier protein Q2
Enzyme 23 Gene Name UBE2Q2
Enzyme 23 Protein Sequence >Ubiquitin-conjugating enzyme E2 Q2
MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPPPAPPGSPHSPPPPLTLHC
NITESYPSSSPIWFVDSDDPNLTSVLERLEDTKNNNSNGTTEEVTSEEEEEEEMAEDIED
LDHYEMKEEEPISGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKEL
RDIYRSQSYKTGIYSVELINDSLYDWHVKLQKVDPDSPLHSDLQILKEKEGIEYILLNFS
FKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKG
KARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG
Enzyme 23 Number of Residues 342
Enzyme 23 Molecular Weight 38717.1
Enzyme 23 Theoretical pI 4.59
Enzyme 23 GO Classification
Function
Process
Component
Enzyme 23 General Function Involved in ATP binding
Enzyme 23 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins
Enzyme 23 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 23 Reactions Not Available
Enzyme 23 Pfam Domain Function
Enzyme 23 Signals
  • None
Enzyme 23 Transmembrane Regions
  • None
Enzyme 23 Essentiality Not Available
Enzyme 23 GenBank ID Protein 81674350 Link Image
Enzyme 23 UniProtKB/Swiss-Prot ID Q32L27 Link Image
Enzyme 23 UniProtKB/Swiss-Prot Entry Name UB2Q2_BOVIN Link Image
Enzyme 23 PDB ID Not Available
Enzyme 23 Cellular Location Not Available
Enzyme 23 Gene Sequence >1029 bp
ATGTCCGTATCAGGGCTCAAGGCCGAGCTGAAGTTCCTGGCGTCCATCTTCGACAAGAAC
CACGAGCGATTCCGCATCGTCAGCTGGAAGCTGGACGAACTGCATTGCCAGTTCCTGGTG
CCGCCACCGGCGCCGCCGGGCAGCCCGCACTCCCCGCCGCCGCCGCTCACACTCCACTGC
AACATCACGGAATCTTATCCATCTTCTTCACCAATATGGTTTGTGGACTCTGATGATCCA
AACCTGACTTCAGTTCTGGAACGTCTCGAAGACACTAAGAACAACAATTCGAATGGGACA
ACAGAAGAGGTGACTTCAGAAGAGGAGGAAGAGGAAGAGATGGCTGAAGATATAGAAGAC
TTGGATCATTATGAGATGAAGGAAGAAGAGCCCATTAGTGGGAAAAAGTCAGAGGATGAA
GGAATTGAAAAAGAAAATTTGGCAATATTAGAGAAAATTAGGAAGACTCAAAGGCAAGAC
CATCTAAATGGTGCAGTGTCTGGGTCTGTACAAGCTTCAGATAGACTTATGAAAGAGCTC
AGGGACATATACAGATCACAGAGTTATAAAACAGGGATTTATTCAGTGGAACTCATAAAT
GACAGTTTATATGACTGGCATGTTAAACTGCAGAAGGTGGATCCTGATAGTCCTTTGCAC
AGTGATCTTCAGATTTTAAAAGAAAAAGAAGGCATAGAATATATTTTGCTTAACTTCTCT
TTTAAGGATAACTTTCCATTTGATCCTCCATTTGTTCGAGTGGTATTACCTGTTCTCTCA
GGAGGGTACGTGTTGGGTGGTGGAGCACTGTGCATGGAACTACTCACAAAACAGGGCTGG
AGCAGTGCCTATTCAATAGAATCGGTCATCATGCAGATCAATGCCACCTTAGTTAAAGGC
AAAGCCAGAGTGCAGTTTGGAGCAAATAAGAATCAATATAATCTAGCAAGAGCCCAGCAA
TCTTATAATTCCATTGTACAGATACATGAGAAAAATGGCTGGTACACCCCTCCAAAGGAA
GATGGCTAA
Enzyme 23 GenBank Gene ID BC109798 Link Image
Enzyme 23 GeneCard ID UBE2Q2 Link Image
Enzyme 23 GenAtlas ID Not Available
Enzyme 23 HGNC ID Not Available
Enzyme 23 Chromosome Location Chromosome:1
Enzyme 23 Locus 15q24.2
Enzyme 23 SNPs SNPJam Report Link Image
Enzyme 23 General References Not Available
Enzyme 23 Metabolite References Not Available
Enzyme 24 [top]
Enzyme 24 ID 977
Enzyme 24 Name Ubiquitin-conjugating enzyme E2 B
Enzyme 24 Synonyms
  1. Ubiquitin-protein ligase B
  2. Ubiquitin carrier protein B
Enzyme 24 Gene Name UBE2B
Enzyme 24 Protein Sequence >Ubiquitin-conjugating enzyme E2 B
MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFS
EEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNS
PANSQAAQLYQENKREYEKRVSAIVEQSWNDS
Enzyme 24 Number of Residues 152
Enzyme 24 Molecular Weight 17312.2
Enzyme 24 Theoretical pI 4.64
Enzyme 24 GO Classification
Function
Process
Component
Enzyme 24 General Function Involved in ATP binding
Enzyme 24 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on 'Lys-164'. May be involved in neurite outgrowth
Enzyme 24 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 24 Reactions Not Available
Enzyme 24 Pfam Domain Function
Enzyme 24 Signals
  • None
Enzyme 24 Transmembrane Regions
  • None
Enzyme 24 Essentiality Not Available
Enzyme 24 GenBank ID Protein 79158792 Link Image
Enzyme 24 UniProtKB/Swiss-Prot ID Q32P99 Link Image
Enzyme 24 UniProtKB/Swiss-Prot Entry Name UBE2B_BOVIN Link Image
Enzyme 24 PDB ID 1JAS Link Image
Enzyme 24 PDB File Show
Enzyme 24 3D Structure
Enzyme 24 Cellular Location Not Available
Enzyme 24 Gene Sequence >459 bp
ATGTCGACCCCGGCCCGGAGGAGGCTTATGCGGGATTTCAAGCGATTGCAAGAGGACCCA
CCTGTGGGTGTCAGTGGCGCACCATCTGAAAACAACATCATGCAGTGGAATGCAGTTATA
TTTGGACCAGAAGGGACACCCTTTGAAGATGGAACTTTTAAACTAGTAATAGAATTTTCT
GAAGAATATCCAAATAAGCCGCCAACTGTTAGGTTTTTATCCAAAATGTTTCATCCAAAT
GTGTATGCTGATGGTAGCATATGTTTAGATATCCTTCAGAATAGATGGAGTCCAACATAC
GATGTATCTTCTATCTTAACATCAATTCAGTCTCTGCTGGATGAACCGAATCCAAATAGT
CCAGCCAATAGTCAGGCAGCACAGCTTTATCAGGAAAACAAACGAGAATATGAGAAAAGA
GTTTCGGCCATTGTTGAACAAAGCTGGAATGATTCATAA
Enzyme 24 GenBank Gene ID BC108202 Link Image
Enzyme 24 GeneCard ID UBE2B Link Image
Enzyme 24 GenAtlas ID Not Available
Enzyme 24 HGNC ID Not Available
Enzyme 24 Chromosome Location Chromosome:5
Enzyme 24 Locus 5q23-q31
Enzyme 24 SNPs SNPJam Report Link Image
Enzyme 24 General References Not Available
Enzyme 24 Metabolite References Not Available
Enzyme 25 [top]
Enzyme 25 ID 978
Enzyme 25 Name Ubiquitin-conjugating enzyme E2 D2
Enzyme 25 Synonyms
  1. Ubiquitin-protein ligase D2
  2. Ubiquitin carrier protein D2
Enzyme 25 Gene Name UBE2D2
Enzyme 25 Protein Sequence >Ubiquitin-conjugating enzyme E2 D2
MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV
PEIARIYKTDREKYNRIAREWTQKYAM
Enzyme 25 Number of Residues 147
Enzyme 25 Molecular Weight 16735.1
Enzyme 25 Theoretical pI 7.96
Enzyme 25 GO Classification
Function
Process
Component
Enzyme 25 General Function Involved in ATP binding
Enzyme 25 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53
Enzyme 25 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 25 Reactions Not Available
Enzyme 25 Pfam Domain Function
Enzyme 25 Signals
  • None
Enzyme 25 Transmembrane Regions
  • None
Enzyme 25 Essentiality Not Available
Enzyme 25 GenBank ID Protein 92096687 Link Image
Enzyme 25 UniProtKB/Swiss-Prot ID Q1RMX2 Link Image
Enzyme 25 UniProtKB/Swiss-Prot Entry Name UB2D2_BOVIN Link Image
Enzyme 25 PDB ID 1UR6 Link Image
Enzyme 25 PDB File Show
Enzyme 25 3D Structure
Enzyme 25 Cellular Location Not Available
Enzyme 25 Gene Sequence >444 bp
ATGGCTCTGAAGAGAATCCATAAGGAATTGAATGACCTGGCACGGGACCCCCCAGCACAG
TGTTCAGCAGGTCCCGTTGGAGATGATATGTTCCATTGGCAAGCTACAATAATGGGGCCA
AATGACAGTCCCTATCAGGGTGGAGTATTTTTCTTGACAATTCATTTCCCAACAGATTAC
CCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGT
AATGGCAGCATTTGTCTTGATATTCTACGGTCACAGTGGTCTCCAGCACTAACTATTTCA
AAAGTACTTTTGTCCATCTGTTCTCTGTTGTGTGATCCCAATCCAGATGATCCTTTAGTG
CCTGAGATTGCTCGGATCTACAAAACAGATAGAGAAAAGTACAACAGAATAGCTCGGGAA
TGGACTCAGAAGTATGCGATGTAA
Enzyme 25 GenBank Gene ID BC114654 Link Image
Enzyme 25 GeneCard ID UBE2D2 Link Image
Enzyme 25 GenAtlas ID Not Available
Enzyme 25 HGNC ID Not Available
Enzyme 25 Chromosome Location Chromosome:5
Enzyme 25 Locus 5q31.2
Enzyme 25 SNPs SNPJam Report Link Image
Enzyme 25 General References Not Available
Enzyme 25 Metabolite References Not Available
Enzyme 26 [top]
Enzyme 26 ID 979
Enzyme 26 Name Ubiquitin-conjugating enzyme E2 J2
Enzyme 26 Synonyms Not Available
Enzyme 26 Gene Name UBE2J2
Enzyme 26 Protein Sequence >Ubiquitin-conjugating enzyme E2 J2
MSSNSVKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGY
YHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLS
FMVEKGPTLGSIETSDFTKRQLAAQSLVFNLKDKVFCELFPEVVEEIKQKQKAQDELSSR
PQALPLPDVVPDGETHHGQHGLPLLNGHAPGAGPHLAGLQQANRHHGLLGGALANLFVIV
GFAAFAYTVKYVLRSIAQE
Enzyme 26 Number of Residues 259
Enzyme 26 Molecular Weight 28848.0
Enzyme 26 Theoretical pI 8.60
Enzyme 26 GO Classification
Function
Process
Component
Enzyme 26 General Function Involved in ATP binding
Enzyme 26 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum
Enzyme 26 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 26 Reactions Not Available
Enzyme 26 Pfam Domain Function
Enzyme 26 Signals
  • None
Enzyme 26 Transmembrane Regions
  • 227-247
Enzyme 26 Essentiality Not Available
Enzyme 26 GenBank ID Protein 83405348 Link Image
Enzyme 26 UniProtKB/Swiss-Prot ID Q2TA03 Link Image
Enzyme 26 UniProtKB/Swiss-Prot Entry Name UB2J2_BOVIN Link Image
Enzyme 26 PDB ID Not Available
Enzyme 26 Cellular Location Not Available
Enzyme 26 Gene Sequence >780 bp
ATGAGCAGCAACAGCGTTAAGAGAGCACCGACGACAGCGACCCAGCGCCTGAAGCAGGAC
TATCTCCGGATTAAGAAAGACCCCGTGCCTTACATCTGTGCCGAGCCCCTCCCTTCCAAC
ATCCTTGAGTGGCACTATGTGGTCCGAGGCCCTGAGATGACTCCCTATGAAGGTGGCTAT
TACCACGGAAAACTAATTTTTCCCAGAGAATTTCCTTTTAAACCTCCTAGTATTTATATG
ATAACTCCCAATGGAAGATTTAAGTGCAATACAAGGCTGTGTCTTTCTATCACGGATTTC
CACCCAGACACGTGGAACCCGGCCTGGTCCGTCTCCACCATCCTGACGGGGCTCCTGAGC
TTTATGGTGGAGAAGGGCCCCACCCTGGGCAGCATCGAGACATCGGACTTCACGAAAAGA
CAACTGGCTGCACAAAGTTTAGTGTTTAATTTAAAAGACAAAGTGTTCTGTGAATTATTT
CCTGAAGTTGTGGAGGAAATTAAACAAAAACAGAAAGCACAAGACGAACTCAGTAGCAGA
CCCCAGGCTCTCCCCTTACCGGACGTGGTTCCAGACGGGGAGACGCACCACGGCCAGCAC
GGGCTCCCGCTCCTCAATGGGCACGCGCCGGGGGCCGGGCCGCACCTGGCGGGGCTCCAG
CAGGCCAACCGGCACCATGGACTTCTGGGCGGGGCCCTGGCGAACTTGTTTGTTATAGTT
GGTTTTGCGGCCTTCGCCTACACGGTCAAGTACGTGCTGAGGAGCATAGCGCAGGAGTGA
Enzyme 26 GenBank Gene ID BC111185 Link Image
Enzyme 26 GeneCard ID UBE2J2 Link Image
Enzyme 26 GenAtlas ID Not Available
Enzyme 26 HGNC ID Not Available
Enzyme 26 Chromosome Location Chromosome:1
Enzyme 26 Locus 1p36.33
Enzyme 26 SNPs SNPJam Report Link Image
Enzyme 26 General References Not Available
Enzyme 26 Metabolite References Not Available
Enzyme 27 [top]
Enzyme 27 ID 980
Enzyme 27 Name Lysyl-tRNA synthetase
Enzyme 27 Synonyms Not Available
Enzyme 27 Gene Name KARS
Enzyme 27 Protein Sequence >Lysyl-tRNA synthetase
MLVQAAARLVRGSLRQTSWAQWGQREPRLCQLAPFTTIHKDKALSDKRSELKRRLKAEKK
IAEKEAKQKELSEKQLSQAAASNHSAEDGVAAEEESLDPNQYFKIRSQAIHQLKVNGEDP
YPHKFHVDISLTHFIQEYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKL
QVMANSRNYKSEEEFIRINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLP
HLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNII
PGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPE
FTTCEFYMAYADYHDLMEITEKMISGMVKHITGSYKVTYHPDGSEGQAYEIDFTPPFRKI
SMVEELEKALGMKLPETNLFETEETRRILDDICVAKDVECPPPRTTARLLDKLVGEFLEV
TCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPVRQRQLFEE
QAKAKAAGDDEAMFIDETFCTALEYGLPPTGGWGMGIDRVTMFLTDSNNIKEVLLFPAMK
PEDKKENVATKDIPESTAPGTSV
Enzyme 27 Number of Residues 623
Enzyme 27 Molecular Weight 71320.3
Enzyme 27 Theoretical pI 6.77
Enzyme 27 GO Classification
Function
Process
Component
Enzyme 27 General Function Translation, ribosomal structure and biogenesis
Enzyme 27 Specific Function ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
Enzyme 27 Pathways Not Available
Enzyme 27 Reactions Not Available
Enzyme 27 Pfam Domain Function
Enzyme 27 Signals
  • None
Enzyme 27 Transmembrane Regions
  • None
Enzyme 27 Essentiality Not Available
Enzyme 27 GenBank ID Protein 74354788 Link Image
Enzyme 27 UniProtKB/Swiss-Prot ID Q3T0N2 Link Image
Enzyme 27 UniProtKB/Swiss-Prot Entry Name Q3T0N2_BOVIN Link Image
Enzyme 27 PDB ID Not Available
Enzyme 27 Cellular Location Not Available
Enzyme 27 Gene Sequence >1872 bp
ATGTTGGTGCAAGCCGCTGCAAGGCTTGTTAGGGGGTCCCTGCGCCAAACCTCCTGGGCA
CAGTGGGGGCAGAGGGAGCCGCGCCTGTGTCAACTTGCGCCTTTCACAACGATTCACAAG
GACAAGGCACTTTCTGATAAAAGAAGTGAGCTAAAGAGACGCCTGAAAGCTGAGAAGAAA
ATAGCGGAGAAGGAGGCCAAGCAGAAGGAGCTCAGTGAGAAACAGCTGAGTCAGGCCGCC
GCCAGCAATCACAGTGCTGAAGATGGCGTGGCTGCGGAGGAGGAGAGCTTGGACCCAAAT
CAATACTTCAAAATCCGAAGCCAAGCAATCCACCAGCTGAAGGTCAATGGGGAAGATCCA
TACCCACACAAGTTCCATGTGGACATCTCGCTCACTCACTTCATCCAAGAGTACAGTCAC
CTGCAGCCTGGGGACCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCC
AAAAGAGCTTCTGGAGGAAAGCTCATCTTCTATGACCTTCGAGGAGAGGGGGTCAAGTTG
CAAGTCATGGCCAATTCCAGGAATTACAAATCTGAAGAAGAATTTATTCGTATTAACAAC
AAACTGCGCCGGGGAGACATAATTGGAGTCCAGGGCAATCCTGGGAAAACCAAGAAGGGC
GAGCTAAGCATCATCCCCTATGAAATCACACTGCTGTCTCCTTGCCTGCACATGTTACCT
CATCTTCACTTCGGCCTCAAAGACAAGGAAACACGGTATCGTCAGAGATACTTGGACTTG
ATTCTGAATGACTTTGTGAGGCAGAAGTTTATCATCCGCTCTAAGATCATCACGTATATA
AGAAGTTTCTTGGATGAATTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATC
CCAGGGGGAGCTGTGGCCAAGCCTTTTATCACCTACCACAATGAGCTGGACATGAATTTA
TATATGAGAATTGCTCCGGAACTCTACCATAAGATGCTGGTGGTTGGTGGCATCGACCGG
GTTTATGAAATTGGACGCCAGTTCCGGAATGAAGGAATTGATTTGACTCACAATCCTGAG
TTCACCACCTGTGAATTCTACATGGCCTATGCCGACTATCATGATCTTATGGAAATCACA
GAGAAGATGATTTCAGGGATGGTGAAACACATTACAGGCAGTTACAAGGTCACCTACCAT
CCAGATGGCTCAGAAGGCCAAGCCTATGAGATTGACTTCACCCCGCCCTTCCGGAAAATC
AGCATGGTAGAAGAGCTTGAGAAAGCCCTGGGCATGAAACTGCCAGAAACGAACCTCTTT
GAAACTGAAGAAACTCGCAGAATCCTTGATGATATCTGTGTGGCAAAAGATGTCGAGTGC
CCTCCACCCCGGACCACTGCCAGGCTCCTTGATAAGCTTGTCGGGGAGTTCCTGGAAGTG
ACGTGCATCAATCCTACCTTCATCTGTGATCACCCACAGATAATGAGCCCTCTGGCCAAA
TGGCACCGCTCTAAAGAGGGTCTGACTGAGCGTTTTGAGCTGTTTGTCATGAAGAAGGAA
ATATGCAATGCCTACACTGAGCTGAATGACCCTGTGCGACAGCGGCAGCTCTTTGAAGAA
CAGGCCAAGGCCAAGGCCGCTGGCGACGATGAGGCCATGTTCATAGATGAAACCTTCTGC
ACCGCCCTGGAGTACGGACTGCCCCCCACGGGGGGCTGGGGCATGGGCATCGACCGCGTC
ACCATGTTTCTCACAGACTCCAATAACATCAAGGAGGTGCTTTTGTTTCCTGCCATGAAA
CCTGAAGACAAGAAGGAGAATGTAGCCACCAAGGATATCCCGGAAAGCACAGCTCCTGGC
ACTTCTGTCTAG
Enzyme 27 GenBank Gene ID BC102322 Link Image
Enzyme 27 GeneCard ID KARS Link Image
Enzyme 27 GenAtlas ID Not Available
Enzyme 27 HGNC ID Not Available
Enzyme 27 Chromosome Location Chromosome:1
Enzyme 27 Locus 16q23-q24
Enzyme 27 SNPs SNPJam Report Link Image
Enzyme 27 General References Not Available
Enzyme 27 Metabolite References Not Available
Enzyme 28 [top]
Enzyme 28 ID 981
Enzyme 28 Name Ubiquitin-conjugating enzyme E2 G2
Enzyme 28 Synonyms
  1. Ubiquitin-protein ligase G2
  2. Ubiquitin carrier protein G2
Enzyme 28 Gene Name UBE2G2
Enzyme 28 Protein Sequence >Ubiquitin-conjugating enzyme E2 G2
MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSF
PLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKIL
LSVVSMLAEPNDESGANVDASKMWRDDREQFYKVAKQIVQKSLGL
Enzyme 28 Number of Residues 165
Enzyme 28 Molecular Weight 18552.1
Enzyme 28 Theoretical pI 4.34
Enzyme 28 GO Classification
Function
Process
Component
Enzyme 28 General Function Involved in ATP binding
Enzyme 28 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Involved in endoplasmic reticulum-associated degradation (ERAD)
Enzyme 28 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 28 Reactions Not Available
Enzyme 28 Pfam Domain Function
Enzyme 28 Signals
  • None
Enzyme 28 Transmembrane Regions
  • None
Enzyme 28 Essentiality Not Available
Enzyme 28 GenBank ID Protein 110331753 Link Image
Enzyme 28 UniProtKB/Swiss-Prot ID Q17QG5 Link Image
Enzyme 28 UniProtKB/Swiss-Prot Entry Name UB2G2_BOVIN Link Image
Enzyme 28 PDB ID Not Available
Enzyme 28 Cellular Location Not Available
Enzyme 28 Gene Sequence >498 bp
ATGGCGGGGACGGCACTCAAGAGGCTGATGGCCGAGTACAAACAACTAACGCTGAATCCT
CCAGAAGGAATTGTGGCAGGCCCCATGAATGAAGAGAATTTTTTTGAATGGGAGGCATTG
ATCATGGGCCCAGAAGACACCTGTTTTGAGTTTGGGGTGTTTCCTGCCATCCTGAGTTTC
CCACTTGATTACCCGTTAAGTCCCCCAAAGATGAGATTTACCTGCGAGATGTTTCACCCC
AACATCTACCCAGATGGCAGAGTCTGCATCTCCATCCTGCACGCTCCTGGCGACGACCCC
ATGGGCTACGAGAGCAGCGCCGAGCGCTGGAGCCCCGTGCAGAGCGTGGAGAAGATCCTC
CTGTCGGTGGTGAGCATGCTGGCAGAGCCCAATGACGAGAGCGGCGCCAACGTGGACGCC
TCCAAGATGTGGCGGGACGACCGGGAGCAGTTCTACAAGGTCGCCAAGCAGATTGTGCAG
AAGTCGCTGGGGCTCTGA
Enzyme 28 GenBank Gene ID BT026143 Link Image
Enzyme 28 GeneCard ID UBE2G2 Link Image
Enzyme 28 GenAtlas ID Not Available
Enzyme 28 HGNC ID Not Available
Enzyme 28 Chromosome Location Chromosome:2
Enzyme 28 Locus 21q22.3
Enzyme 28 SNPs SNPJam Report Link Image
Enzyme 28 General References
  1. [PubMed Link Image]
Enzyme 28 Metabolite References Not Available
Enzyme 29 [top]
Enzyme 29 ID 982
Enzyme 29 Name Ubiquitin-conjugating enzyme E2 D1
Enzyme 29 Synonyms
  1. Ubiquitin-protein ligase D1
  2. Ubiquitin carrier protein D1
Enzyme 29 Gene Name UBE2D1
Enzyme 29 Protein Sequence >Ubiquitin-conjugating enzyme E2 D1
MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDY
PFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLV
PDIAQIYKSDKEKYNRHAREWTQKYAM
Enzyme 29 Number of Residues 147
Enzyme 29 Molecular Weight 16601.9
Enzyme 29 Theoretical pI 7.50
Enzyme 29 GO Classification
Function
Process
Component
Enzyme 29 General Function Involved in ATP binding
Enzyme 29 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53
Enzyme 29 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 29 Reactions Not Available
Enzyme 29 Pfam Domain Function
Enzyme 29 Signals
  • None
Enzyme 29 Transmembrane Regions
  • None
Enzyme 29 Essentiality Not Available
Enzyme 29 GenBank ID Protein 83405380 Link Image
Enzyme 29 UniProtKB/Swiss-Prot ID Q2TA10 Link Image
Enzyme 29 UniProtKB/Swiss-Prot Entry Name UB2D1_BOVIN Link Image
Enzyme 29 PDB ID 1Z2U Link Image
Enzyme 29 PDB File Show
Enzyme 29 3D Structure
Enzyme 29 Cellular Location Not Available
Enzyme 29 Gene Sequence >444 bp
ATGGCGCTGAAGCGGATTCAGAAAGAGTTAAGTGATCTACAACGTGACCCACCTGCTCAC
TGTTCGGCTGGACCTGTGGGAGATGACTTGTTCCACTGGCAAGCAACTATTATGGGGCCT
CCTGATAGCGCATATCAAGGTGGAGTCTTCTTTCTCACTGTACATTTTCCGACAGACTAT
CCTTTTAAACCACCAAAGATTGCTTTCACAACAAAAATTTACCATCCAAACATAAACAGT
AATGGAAGTATTTGTCTTGATATCCTGAGGTCACAATGGTCACCAGCTCTGACTGTGTCA
AAAGTTTTATTGTCCATATGTTCTCTGCTTTGTGACCCTAATCCAGATGATCCCTTAGTA
CCAGATATTGCTCAAATCTATAAATCAGACAAAGAAAAATACAACAGACACGCAAGAGAA
TGGACTCAGAAATATGCAATGTAA
Enzyme 29 GenBank Gene ID BC111175 Link Image
Enzyme 29 GeneCard ID UBE2D1 Link Image
Enzyme 29 GenAtlas ID Not Available
Enzyme 29 HGNC ID Not Available
Enzyme 29 Chromosome Location Chromosome:1
Enzyme 29 Locus 10q11.2-q21
Enzyme 29 SNPs SNPJam Report Link Image
Enzyme 29 General References Not Available
Enzyme 29 Metabolite References Not Available
Enzyme 30 [top]
Enzyme 30 ID 983
Enzyme 30 Name Ubiquitin-conjugating enzyme E2 T
Enzyme 30 Synonyms
  1. Ubiquitin-protein ligase T
  2. Ubiquitin carrier protein T
Enzyme 30 Gene Name UBE2T
Enzyme 30 Protein Sequence >Ubiquitin-conjugating enzyme E2 T
MQRTSRLKRELSLLAAEPPPGITCWQDGDRMEDLRAQILGGANTPYEKGVFKLEVHIPER
YPFEPPQIRFLTPIYHPNIDSAGRICLDVLKLPPKGAWRPSLNIATLLTCIQQLMAEPNP
DDPLMADISSEFKYNKPVFFKNARQWTEKHARQKTDEEGMPGSLPEVGGSEGPSAAQKRK
AGQLSSGGKRFCPDV
Enzyme 30 Number of Residues 195
Enzyme 30 Molecular Weight 21780.8
Enzyme 30 Theoretical pI 8.32
Enzyme 30 GO Classification
Function
Process
Component
Enzyme 30 General Function Involved in ATP binding
Enzyme 30 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins
Enzyme 30 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 30 Reactions Not Available
Enzyme 30 Pfam Domain Function
Enzyme 30 Signals
  • None
Enzyme 30 Transmembrane Regions
  • None
Enzyme 30 Essentiality Not Available
Enzyme 30 GenBank ID Protein 81674581 Link Image
Enzyme 30 UniProtKB/Swiss-Prot ID Q32LD2 Link Image
Enzyme 30 UniProtKB/Swiss-Prot Entry Name UBE2T_BOVIN Link Image
Enzyme 30 PDB ID Not Available
Enzyme 30 Cellular Location Not Available
Enzyme 30 Gene Sequence >588 bp
ATGCAGAGAACATCGCGTCTGAAGCGAGAGCTGAGCCTGCTGGCCGCGGAGCCGCCCCCG
GGCATCACGTGCTGGCAGGATGGGGATCGGATGGAAGACCTGCGAGCGCAGATTCTAGGT
GGAGCCAACACACCTTATGAAAAAGGTGTTTTCAAGCTGGAAGTTCACATTCCAGAGAGG
TACCCATTTGAACCTCCTCAGATCCGATTTCTGACTCCCATCTATCACCCCAACATCGAC
TCTGCGGGACGGATTTGTCTAGATGTTCTCAAGTTGCCACCAAAAGGTGCCTGGAGACCA
TCCCTCAACATCGCAACCCTGCTGACTTGCATTCAGCAGCTCATGGCCGAGCCCAACCCG
GACGACCCGCTCATGGCTGACATCTCCTCAGAGTTTAAATACAACAAGCCAGTCTTCTTC
AAGAACGCCAGGCAGTGGACAGAGAAGCACGCACGGCAGAAGACAGACGAGGAAGGGATG
CCTGGCAGCCTCCCCGAGGTGGGCGGCTCAGAGGGACCCAGCGCCGCACAGAAGAGGAAA
GCTGGGCAGCTGAGCAGCGGTGGAAAGAGGTTTTGCCCTGACGTTTAG
Enzyme 30 GenBank Gene ID BC109637 Link Image
Enzyme 30 GeneCard ID UBE2T Link Image
Enzyme 30 GenAtlas ID Not Available
Enzyme 30 HGNC ID Not Available
Enzyme 30 Chromosome Location Chromosome:1
Enzyme 30 Locus 1q32.1
Enzyme 30 SNPs SNPJam Report Link Image
Enzyme 30 General References Not Available
Enzyme 30 Metabolite References Not Available
Enzyme 31 [top]
Enzyme 31 ID 984
Enzyme 31 Name Ubiquitin-conjugating enzyme E2 K
Enzyme 31 Synonyms
  1. Ubiquitin-conjugating enzyme E2-25 kDa
  2. E2(25K)
  3. E2-25K
  4. Ubiquitin-protein ligase
  5. Ubiquitin carrier protein
  6. Huntingtin-interacting protein 2
  7. HIP-2
Enzyme 31 Gene Name UBE2K
Enzyme 31 Protein Sequence >Ubiquitin-conjugating enzyme E2 K
MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI
KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA
EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI
VALSSKSWDVETATELLLSN
Enzyme 31 Number of Residues 200
Enzyme 31 Molecular Weight 22406.4
Enzyme 31 Theoretical pI 5.10
Enzyme 31 GO Classification
Function
Process
Component
Enzyme 31 General Function Involved in ATP binding
Enzyme 31 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53
Enzyme 31 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 31 Reactions Not Available
Enzyme 31 Pfam Domain Function
Enzyme 31 Signals
  • None
Enzyme 31 Transmembrane Regions
  • None
Enzyme 31 Essentiality Not Available
Enzyme 31 GenBank ID Protein 233966 Link Image
Enzyme 31 UniProtKB/Swiss-Prot ID P61085 Link Image
Enzyme 31 UniProtKB/Swiss-Prot Entry Name UBE2K_BOVIN Link Image
Enzyme 31 PDB ID 1YLA Link Image
Enzyme 31 PDB File Show
Enzyme 31 3D Structure
Enzyme 31 Cellular Location Not Available
Enzyme 31 Gene Sequence >603 bp
ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAG
GAGACGACGAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGA
GGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATATCAACTAGAGATT
AAAATACCAGAAACATATCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGG
CATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGG
GCAGCAGCAATGACTCTGCGCACGGTATTGTTGTCATTACAAGCTCTGCTGGCAGCTGCA
GAACCGGATGATCCACAAGATGCAGTAGTAGCAAATCAGTACAAACAAAATCCTGAAATG
TTCAAACAGACAGCTCGACTTTGGGCACATGTGTATGCTGGAGCACCAGTTTCTAGTCCA
GAGTACACCAAAAAAATAGAAAACCTATGTGCTATGGGCTTTGATAGGAATGCGGTAATA
GTGGCCTTGTCTTCAAAATCATGGGATGTAGAGACTGCAACAGAATTGCTTCTGAGTAAC
TGA
Enzyme 31 GenBank Gene ID S51016 Link Image
Enzyme 31 GeneCard ID UBE2K Link Image
Enzyme 31 GenAtlas ID Not Available
Enzyme 31 HGNC ID Not Available
Enzyme 31 Chromosome Location Chromosome:4
Enzyme 31 Locus 4p14
Enzyme 31 SNPs SNPJam Report Link Image
Enzyme 31 General References
  1. [PubMed Link Image]
Enzyme 31 Metabolite References Not Available
Enzyme 32 [top]
Enzyme 32 ID 985
Enzyme 32 Name Ubiquitin-conjugating enzyme E2 S
Enzyme 32 Synonyms
  1. Ubiquitin-protein ligase S
  2. Ubiquitin carrier protein S
Enzyme 32 Gene Name UBE2S
Enzyme 32 Protein Sequence >Ubiquitin-conjugating enzyme E2 S
MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQVTIEGPEGTPYAGGLF
RMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRDWTAELGIRHVLLTIKCLL
IHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGAGGPSGGRPEPGRATASGAAAST
ADPTATGGPAGAEGPMAKKHAGERDKKLAAKKKTDKKRALRRL
Enzyme 32 Number of Residues 223
Enzyme 32 Molecular Weight 23900.1
Enzyme 32 Theoretical pI 9.05
Enzyme 32 GO Classification
Function
Process
Component
Enzyme 32 General Function Involved in ATP binding
Enzyme 32 Specific Function Catalyzes the covalent attachment of ubiquitin to other proteins
Enzyme 32 Pathways
  • Protein modification
  • protein ubiquitination
Enzyme 32 Reactions Not Available
Enzyme 32 Pfam Domain Function
Enzyme 32 Signals
  • None
Enzyme 32 Transmembrane Regions
  • None
Enzyme 32 Essentiality Not Available
Enzyme 32 GenBank ID Protein 92097559 Link Image
Enzyme 32 UniProtKB/Swiss-Prot ID Q1RML1 Link Image
Enzyme 32 UniProtKB/Swiss-Prot Entry Name UBE2S_BOVIN Link Image
Enzyme 32 PDB ID 1ZDN Link Image
Enzyme 32 PDB File Show
Enzyme 32 3D Structure
Enzyme 32 Cellular Location Not Available
Enzyme 32 Gene Sequence >672 bp
ATGAACTCCAACGTGGAGAACCTGCCCCCCCACATCATCCGCCTGGTGTACAAGGAGGTG
ACGACGCTGACCGCTGACCCACCTGATGGCATCAAGGTCTTTCCCAACGAGGAAGACCTT
ACCGACCTGCAGGTCACCATTGAGGGCCCTGAGGGGACCCCGTATGCCGGAGGCCTCTTC
CGCATGAAACTCCTGCTGGGGAAGGACTTTCCGGCCTCCCCACCCAAGGGCTACTTCCTG
ACGAAGATCTTCCACCCGAATGTGGGCGCCAATGGCGAGATCTGCGTCAATGTGCTCAAG
AGGGACTGGACCGCTGAGCTGGGCATCCGGCACGTGCTTCTGACCATCAAGTGCCTGCTG
ATCCACCCCAACCCCGAGTCGGCCCTCAACGAGGAGGCGGGCCGCCTGCTGCTGGAGAAC
TACGAGGAGTACGCAGCCCGCGCGCGCCTGCTCACTGAGATCCACGGCGGCGCCGGCGGG
CCCAGCGGTGGGAGGCCCGAGCCCGGCCGGGCCACTGCCAGTGGGGCGGCGGCCTCCACT
GCTGACCCCACAGCCACTGGGGGCCCAGCAGGGGCTGAGGGGCCCATGGCCAAGAAGCAC
GCGGGCGAGCGCGACAAGAAGCTGGCAGCCAAGAAAAAGACGGACAAGAAGCGGGCACTG
CGGCGCCTGTAG
Enzyme 32 GenBank Gene ID BC114838 Link Image
Enzyme 32 GeneCard ID UBE2S Link Image
Enzyme 32 GenAtlas ID Not Available
Enzyme 32 HGNC ID Not Available
Enzyme 32 Chromosome Location Chromosome:1
Enzyme 32 Locus 19q13.43
Enzyme 32 SNPs SNPJam Report Link Image
Enzyme 32 General References Not Available
Enzyme 32 Metabolite References Not Available