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Bovine Rumen Metabolome Database



Showing metabocard for Ornithine (RMDB00214)

Legend: metabolite field enzyme field

Version 1.0
Creation Date 2005-11-16 15:48:42
Update Date 2009-07-24 13:56:54
Accession Number RMDB00214
Common Name Ornithine
Description Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is also a precursor of citrulline and arginine. In order for ornithine produced in the cytosol to be converted to citrulline, it must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by ornithine transcarbamylase. This transfer is mediated by the mitochondrial ornithine transporter (SLC25A15; AF112968; ORNT1). Mutations in the mitochondrial ornithine transporter result in hyperammonemia, hyperornithinemia, homocitrullinuria (HHH) syndrome, a disorder of the urea cycle. (PMID 16256388) The pathophysiology of the disease may involve diminished ornithine transport into mitochondria, resulting in ornithine accumulation in the cytoplasm and reduced ability to clear carbamoyl phosphate and ammonia loads. (OMIM 838970)
Synonyms
  1. (+)-S-Ornithine
  2. (S)-2,5-Diaminopentanoate
  3. (S)-2,5-Diaminopentanoic acid
  4. (S)-Ornithine
  5. (S)-a,d-Diaminovalerate
  6. (S)-a,d-Diaminovaleric acid
  7. 5-amino-L-Norvaline
  8. L-(-)-Ornithine
  9. L-Ornithine
Chemical IUPAC Name 2,5-diaminopentanoic acid
Chemical Formula C5H12N2O2
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Amino acids and Amino Acid conjugates
Class
  • Amino Acids
Sub Class
  • NA
Family
  • Mammalian_Metabolite
Species
  • primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid
Biofunction
  • Component of Arginine and proline metabolism; Component of Glycine, serine and threonine metabolism
Application
Source
  • Endogenous
Average Molecular Weight 132.161
Monoisotopic Molecular Weight 132.089874
Isomeric SMILES NCCC[C@H](N)C(O)=O
Canonical SMILES NCCCC(N)C(O)=O
KEGG Compound ID C00077 Link Image
BioCyc ID L-ORNITHINE Link Image
BiGG ID 37976 Link Image
Wikipedia Link Ornithine Link Image
METLIN ID 27 Link Image
PubChem Compound 6262 Link Image
PubChem Substance 3134135 Link Image
ChEBI ID Not Available
CAS Registry Number 70-26-8
InChI Identifier InChI=1/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1
Synthesis Reference Zhang, Peng; Zhang, Shurong; Liu, Chunqiao; Yang, Yuhong. Method for preparing L-ornithine by enzymatic conversion. Faming Zhuanli Shenqing Gongkai Shuomingshu (2007), 8pp.
Melting Point (Experimental) 140 oC
Experimental Water Solubility 620 mg/mL [HMP experimental] Source: PhysProp
Predicted Water Solubility 1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 172.0 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 1
State Solid
Experimental LogP/Hydrophobicity -4.22 [SANGSTER (1994)] Source: PhysProp
Predicted LogP/Hydrophobicity -3.64 [Predicted by ALOGPS]; -3.3 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show Link Image
SDF File Show Link Image
PDB File Show Link Image
2D Structure
3D Structure
Experimental PDB ID 1DSR Link Image
Experimental PDB File Show
Experimental PDB Structure
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum
Low Energy
Download File
Show Experimental Conditions Link Image
Medium Energy
Download File
Show Experimental Conditions Link Image
High Energy
Download File
Show Experimental Conditions Link Image
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Cytoplasm (Predicted from LogP)
  • Extracellular
  • mitochondria
Biofluid Location
  • Blood
  • Cow_Milk
  • Rumen
Tissue Location
Concentrations (Normal)
Biofluid Rumen
Value 18.95 +/- 11.75 uM
Age 4-5 years old
Sex Female (lactating)
Condition Normal (0% barley grain in dry matter (DM) basis)
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Concentrations (Abnormal)
Biofluid Rumen
Value 17 +/- 7 uM
Age 4-5 years old
Sex Female (lactating)
Condition 15% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 25 +/- 12 uM
Age 4-5 years old
Sex Female (lactating)
Condition 30% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 38 +/- 13 uM
Age 4-5 years old
Sex Female (lactating)
Condition 45% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Pathway Names Not Available
HMDB Pathways Not Available
KEGG Pathways Not Available
SimCell Pathways Not Available
General References
  1. Wikipedia Link Image
Metabolic Enzymes
  1. Arginase-1
  2. Glycine amidinotransferase, mitochondrial
  3. Arginase-2, mitochondrial
  4. Ornithine decarboxylase
  5. Ornithine decarboxylase
  6. Ornithine carbamoyltransferase, mitochondrial
  7. Ornithine decarboxylase antizyme
  8. Ornithine aminotransferase, mitochondrial
Enzyme 1 [top]
Enzyme 1 ID 553
Enzyme 1 Name Arginase-1
Enzyme 1 Synonyms
  1. Type I arginase
  2. Liver-type arginase
Enzyme 1 Gene Name ARG1
Enzyme 1 Protein Sequence >Arginase-1
MSSKPQSIGVIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKELECDVKDYGDLSFADNLD
DSPFQIVKNPRCVGKASEKLADVVAEVKKTGRISLVLGGDHSLAIGSISGHARVHPDLCV
IWVDAHTDINTPLTTKTGNLHGQPVSFLLKELKEKMPEVPGFYWVAPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVQGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTTVAIT
MACFGVAREGNHKPIDYLSPPK
Enzyme 1 Number of Residues 322
Enzyme 1 Molecular Weight 35009.0
Enzyme 1 Theoretical pI 6.51
Enzyme 1 GO Classification
Function
Process
Component
Enzyme 1 General Function Amino acid transport and metabolism
Enzyme 1 Specific Function L-arginine + H(2)O = L-ornithine + urea
Enzyme 1 Pathways
  • Nitrogen metabolism
  • urea cycle
  • L-ornithine and urea from L-arginine:step 1/1
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 86824019 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q2KJ64 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name ARGI1_BOVIN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >969 bp
ATGAGTTCCAAGCCACAGTCCATCGGGGTCATTGGAGCTCCCTTCTCAAAGGGCCAGCCA
CGAGGAGGGGTGGAAGAAGGCCCTACAGTACTTAGAAAGGCTGGTCTGCTTGAGAAACTT
AAAGAACTAGAGTGTGATGTGAAAGATTATGGGGACCTGTCCTTTGCTGATAATCTTGAT
GACAGTCCCTTTCAAATTGTGAAGAATCCAAGGTGTGTGGGAAAAGCAAGTGAAAAGCTG
GCTGATGTGGTGGCAGAAGTCAAGAAGACTGGAAGGATCAGCCTTGTCCTGGGCGGAGAC
CACAGTTTGGCGATCGGCAGCATCTCTGGCCATGCCAGGGTCCACCCAGACCTCTGTGTC
ATTTGGGTGGATGCTCACACGGACATCAACACTCCACTGACAACCAAAACCGGGAACTTG
CATGGACAACCTGTGTCTTTCCTTCTGAAGGAACTAAAGGAAAAGATGCCTGAGGTCCCA
GGATTCTACTGGGTGGCTCCCTGCATATCTGCCAAAGACATTGTGTATATTGGTCTGAGA
GATGTGGACCCTGGGGAACACTATATTTTGAAAACTCTGGGAATTAAATACTTTTCAATG
ACTGAAGTGGATAAACTGGGAATTGGCAAGGTGATGGAAGAAACATTCAGCTATCTACTA
GGAAGAAAGAAAAGGCCAATTCATTTGAGCTTTGATGTTGATGGACTGGACCCATCTTTC
ACGCCAGCTACTGGCACACCAGTCCAGGGAGGTCTGACTTACAGAGAAGGTCTCTACATC
ACAGAAGAAATTTACAAAACAGGTTTACTCTCAGGATTAGATATAATGGAAGTGAATCCG
TCTCTGGGGAAGACACCAGAAGAAGTGACTCGAACAGTGAACACAACAGTAGCAATAACC
ATGGCTTGCTTTGGGGTTGCTCGAGAGGGTAACCATAAACCTATTGATTACCTTAGCCCA
CCAAAGTAA
Enzyme 1 GenBank Gene ID BC105497 Link Image
Enzyme 1 GeneCard ID ARG1 Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Chromosome:6
Enzyme 1 Locus 6q23
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References Not Available
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 556
Enzyme 2 Name Glycine amidinotransferase, mitochondrial
Enzyme 2 Synonyms
  1. L-arginine:glycine amidinotransferase
  2. Transamidinase
  3. AT
Enzyme 2 Gene Name GATM
Enzyme 2 Protein Sequence >Glycine amidinotransferase, mitochondrial
MLRVRCLRGGSRGAEALHYIGSRLGRTVTGWVQRTFQSTQAATASSRNSCAADDKATDPL
PKDCPVSSFNEWDPLEEVIVGRAENACVPPFTVEVKANTYDKHWPFYQKYGGSYFPKDHL
QKAVAEIEEMCNILKMEGVTVRRPDPIDWSLKYKTPDFESTGLYGAMPRDILIVVGNEII
EAPMAWRARFFEYRAYRTIIKDYFRRGAKWTTAPKPTMADELYDQDYPIHSVEDRHKLAA
QGKFVTTEFEPCFDAADFIRAGRDIFVQRSQVTNYMGIEWMRKHLAPDYRVHIVSFKDPN
PMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPIIPDDHPLWMSSKWLSM
NVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVSIRNANSLGGGFHCWTCDVRRRGTLQS
YFD
Enzyme 2 Number of Residues 423
Enzyme 2 Molecular Weight 48357.0
Enzyme 2 Theoretical pI 7.97
Enzyme 2 GO Classification
Function
Process
Component
Enzyme 2 General Function Amino acid transport and metabolism
Enzyme 2 Specific Function L-arginine + glycine = L-ornithine + guanidinoacetate
Enzyme 2 Pathways
  • Amine and polyamine biosynthesis
  • creatine biosynthesis
  • creatine from L-arginine and glycine:step 1/2
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 87578309 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q2HJ74 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name GATM_BOVIN Link Image
Enzyme 2 PDB ID 3JDW Link Image
Enzyme 2 PDB File Show
Enzyme 2 3D Structure
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1272 bp
ATGCTGCGGGTGCGGTGTCTGCGCGGCGGGAGCCGCGGTGCCGAAGCGCTGCACTACATC
GGGTCTCGGCTTGGAAGAACTGTAACGGGATGGGTGCAGCGAACTTTCCAGAGCACCCAG
GCAGCTACGGCTTCCTCCCGGAATTCCTGTGCAGCTGATGACAAGGCCACTGATCCTCTG
CCCAAGGACTGCCCTGTCTCCTCTTTCAACGAATGGGACCCCTTAGAGGAAGTGATCGTG
GGCAGAGCAGAAAATGCCTGTGTTCCACCGTTCACTGTGGAGGTGAAGGCCAACACATAT
GACAAGCACTGGCCTTTTTACCAAAAGTATGGGGGCAGTTATTTTCCCAAAGATCATTTG
CAAAAGGCTGTTGCTGAAATTGAAGAAATGTGCAATATTTTAAAAATGGAAGGAGTGACA
GTGAGGAGGCCTGACCCCATTGACTGGTCACTGAAGTATAAAACTCCTGATTTTGAGTCT
ACGGGTTTATATGGCGCGATGCCTCGAGACATCCTGATAGTTGTGGGAAATGAGATTATC
GAGGCTCCCATGGCCTGGCGCGCTCGCTTCTTTGAGTACCGTGCATACAGAACAATTATC
AAAGACTACTTCCGCCGTGGGGCCAAGTGGACAACGGCTCCTAAGCCCACAATGGCTGAT
GAGCTTTATGACCAAGATTACCCCATCCATTCTGTAGAAGACAGACACAAATTGGCTGCT
CAGGGAAAGTTTGTGACAACTGAGTTTGAGCCATGCTTTGATGCTGCTGATTTCATTCGA
GCTGGAAGAGATATCTTCGTACAAAGAAGCCAGGTTACAAACTACATGGGCATTGAATGG
ATGCGTAAGCATCTGGCTCCAGACTACAGAGTGCACATTGTTTCCTTTAAAGACCCCAAT
CCAATGCACATTGATGCCACCTTCAATATCATTGGGCCTGGTCTTGTGCTTTCCAACCCT
GACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACCATAGTTACTCCT
CCAACACCAATCATCCCAGATGATCACCCACTCTGGATGTCCTCCAAATGGCTTTCCATG
AATGTCTTAATGCTAGATGAAAAGCGTGTTATGGTGGATGCCAACGAGGTCCCAATTCAG
AAGATGTTTGAAAAGCTGGGTATCAGTACCATTAAGGTTAGCATTCGTAACGCCAATTCC
CTGGGAGGAGGCTTCCACTGCTGGACCTGCGATGTCCGTCGCCGGGGCACCCTGCAGTCC
TACTTTGACTGA
Enzyme 2 GenBank Gene ID BC113272 Link Image
Enzyme 2 GeneCard ID GATM Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Chromosome:1
Enzyme 2 Locus 15q21.1
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References Not Available
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 558
Enzyme 3 Name Arginase-2, mitochondrial
Enzyme 3 Synonyms
  1. Arginase II
Enzyme 3 Gene Name ARG2
Enzyme 3 Protein Sequence >Arginase-2, mitochondrial
MSLRSHLSRLLRTQVHSVRKKSVHSVAVIGAPFSQGQKRKGVEYGPAAVRXAGLMKRLSD
LGCHLKDFGDLNFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSGGYSCVTVGGDH
SLAIGTISGHARHCPDLGVIWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSPSIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMEQTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGIYITEEIHSTGLLSALDLVEVNPR
LAVSEEEAKATASLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESESEERVRI
Enzyme 3 Number of Residues 354
Enzyme 3 Molecular Weight 38561.5
Enzyme 3 Theoretical pI 6.45
Enzyme 3 GO Classification
Function
Process
Component
Enzyme 3 General Function Amino acid transport and metabolism
Enzyme 3 Specific Function May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis
Enzyme 3 Pathways
  • Nitrogen metabolism
  • urea cycle
  • L-ornithine and urea from L-arginine:step 1/1
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 61553631 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q58DL1 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name ARGI2_BOVIN Link Image
Enzyme 3 PDB ID 1PQ3 Link Image
Enzyme 3 PDB File Show
Enzyme 3 3D Structure
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1065 bp
ATGTCCCTGAGGAGCCACCTCTCGCGTCTCCTCCGGACGCAAGTGCACTCCGTCCGGAAG
AAGTCTGTCCACTCCGTGGCTGTCATTGGAGCCCCATTCTCCCAGGGACAGAAAAGAAAA
GGAGTGGAATATGGTCCTGCTGCTGTAAGANAAGCTGGCTTGATGAAAAGGCTCTCGGAT
CTGGGCTGCCACCTTAAAGACTTCGGAGATTTGAATTTTACTCCAGTTCCCAAAGATGAT
CTCTATAACAACTTGATAGTGAATCCTCGCTCAGTGGGCCTGGCCAACCAGGAACTAGCG
GAGGTGGTTAGCCGAGCTGTGTCAGGTGGCTACAGCTGTGTCACGGTGGGAGGAGACCAC
AGCCTGGCAATCGGTACCATCAGTGGCCACGCCCGACACTGCCCAGACCTTGGTGTGATC
TGGGTTGATGCCCATGCTGACATCAATACACCCCTCACCACTTCATCTGGAAATCTACAT
GGACAGCCAGTTTCGTTTCTCCTCAGAGAACTACAGGACAAGGTACCACAGCTCCCAGGA
TTTTCCTGGATCAAACCTTGTATCTCTTCTCCAAGTATTGTATATATTGGACTAAGAGAC
GTGGACCCTCCTGAACATTTTATTTTAAAGAATTATGATATCCAGTATTTTTCCATGAGA
GACATAGATCGACTTGGTATCCAGAAGGTCATGGAACAGACATTCGATCTGCTGATTGGC
AAAAGACAAAGGCCAATCCATCTGAGTTTCGATATTGATGCATTTGACCCTACACTGGCT
CCAGCCACAGGAACCCCTGTTGTAGGGGGACTGACCTATCGAGAAGGCATATATATTACT
GAGGAAATACACAGTACAGGGTTGCTCTCGGCCCTGGACCTCGTTGAAGTCAATCCTCGG
TTGGCCGTGTCAGAGGAGGAGGCCAAGGCTACAGCCAGCCTGGCAGTGGACGTCATTGCT
TCGAGTTTCGGGCAGACGAGGGAGGGAGGGCATATTGTCTACGACCAACTTCCAACTCCC
AGCTCACCAGATGAATCAGAGAGTGAAGAACGTGTAAGAATTTAG
Enzyme 3 GenBank Gene ID BT021586 Link Image
Enzyme 3 GeneCard ID ARG2 Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Chromosome:1
Enzyme 3 Locus 14q24.1-q24.3
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 922
Enzyme 4 Name Ornithine decarboxylase
Enzyme 4 Synonyms
  1. ODC
Enzyme 4 Gene Name ODC1
Enzyme 4 Protein Sequence >Ornithine decarboxylase
MNSFSNEEFDCHFLDEGFTAKDILDQKINEVSYSDDKDAFYVADLGDILKKHLRWLKALP
RVTPFYAVKCNDSRTIVKTLAAIGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI
KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLL
LERAKELDIDVIGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFNMYLLDIGGGFPG
SEDVKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKLVLKEQ
TGSDDEEESTDRTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC
DGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPTWQLMQQI
RTQDFPPGVEEPDVGPLPVSCAWESGMKRHSAACASTRINV
Enzyme 4 Number of Residues 461
Enzyme 4 Molecular Weight 51345.1
Enzyme 4 Theoretical pI 5.12
Enzyme 4 GO Classification
Function
Process
Component
Enzyme 4 General Function Amino acid transport and metabolism
Enzyme 4 Specific Function L-ornithine = putrescine + CO(2)
Enzyme 4 Pathways
  • Amine and polyamine biosynthesis
  • putrescine biosynthesis via L-ornithine pathway
  • putrescine from L-ornithine:step 1/1
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 163449 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID P27117 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name DCOR_BOVIN Link Image
Enzyme 4 PDB ID 1D7K Link Image
Enzyme 4 PDB File Show
Enzyme 4 3D Structure
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >1386 bp
ATGAACAGCTTTAGCAATGAAGAGTTTGACTGCCATTTCTTGGATGAAGGCTTTACTGCC
AAGGATATTCTGGACCAAAAAATTAATGAAGTTTCTTATTCTGATGATAAGGATGCCTTC
TATGTTGCGGACCTGGGAGACATTCTGAAGAAACATCTGAGATGGTTGAAAGCTCTTCCT
CGGGTCACCCCCTTTTATGCCGTCAAATGCAATGATAGCAGAACCATAGTGAAGACACTC
GCTGCCATTGGGACAGGATTTGACTGTGCCAGCAAGACTGAAATACAATTGGTGCAGAGT
CTCGGGGTGCCCCCAGAGAGGATTATCTATGCAAATCCATGTAAACAAGTGTCTCAGATT
AAGTATGCTGCCAATAACGGAGTCCAGATGATGACTTTTGATAGTGAAGTTGAGCTGATG
AAAGTTGCCAGGGCACATCCAAAGGCCAAGTTGGTTTTACGGATCGCCACTGATGATTCC
AAAGCAGTCTGTCGCCTCAGTGTCAAATTTGGTGCCACACTCAAAACCAGCAGGCTTCTT
TTGGAACGGGCGAAAGAGCTAGATATTGATGTCATTGGTGTCAGCTTCCACGTGGGAAGT
GGCTGTACTGATCCTGAGACCTTTGTGCAGGCCATCTCTGATGCCCGCTGTGTCTTTGAC
ATGGGCGCTGAGGTTGGTTTCAACATGTATCTGCTTGATATTGGTGGTGGCTTTCCTGGA
TCAGAGGATGTAAAGCTTAAATTTGAAGAGATCACCAGTGTAATCAACCCAGCACTGGAC
AAGTATTTTCCATCAGACTCTGGAGTGAGAATCATAGCTGAGCCAGGCAGATACTATGTT
GCATCAGCTTTCACGCTCGCAGTTAATATTATTGCCAAAAAACTTGTATTAAAGGAACAG
ACAGGCTCTGATGATGAAGAGGAGTCAACTGATCGGACATTTATGTATTATGTGAACGAT
GGAGTATATGGGTCATTCAACTGCATCCTTTATGATCACGCACACGTGAAGCCTCTTCTG
CAGAAGAGACCCAAACCAGATGAGAAGTATTATTCATCCAGCATCTGGGGACCGACCTGT
GACGGCCTGGACCGCATTGTTGAGCGCTGTAACCTGCCTGAGATGCATGTGGGTGATTGG
ATGCTCTTTGAGAACATGGGTGCTTACACTGTTGCTGCTGCTTCTACCTTCAATGGATTC
CAGAGACCCACCATCTACTATGTGATGTCAGGGCCAACGTGGCAACTGATGCAGCAGATC
CGGACCCAGGACTTCCCGCCTGGAGTGGAGGAGCCGGACGTCGGTCCCCTGCCCGTGTCC
TGTGCCTGGGAGAGCGGCATGAAGCGGCACTCGGCAGCCTGCGCTTCCACGCGTATTAAC
GTGTAG
Enzyme 4 GenBank Gene ID M92441 Link Image
Enzyme 4 GeneCard ID ODC1 Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Chromosome:2
Enzyme 4 Locus 2p25
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References
  1. [PubMed Link Image]
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 923
Enzyme 5 Name Ornithine decarboxylase
Enzyme 5 Synonyms Not Available
Enzyme 5 Gene Name ADC
Enzyme 5 Protein Sequence >Ornithine decarboxylase
MAGYLRETDFVMVEEGFSTRDLLEELTLGASQATTEEVAAFFVADLGAVVRKHFCFLKCL
PRVRSFYAVKCNSSPGVLKVLAELGLGFSCANKAEMELVQHIGVPASKIIYANPCKQIAH
IKYAAKHGVRLLSFDNEMELAKVVKSHPSAKMVLCVATEDSHSLSRLSLKFGASLKSCRH
LLENAKRDHVEVVGVSFHIGSDCPDPQAYAQSIADARVVFEMGAELGHRMHILDLGGGFP
GVEDAKVRFEEIASVINSALDLYFPEGCGVDILAKLGRYYVTSAFTLAVSIIAKKEVLLD
QPGREEETSSSPKSVVYHLGEGVYGVFNSVLFDSACPAPILQKKPSTEQPLYSSSLWGPV
ASGCDCVAEGLWLPQLHVGDWLVFENMGAYTVGVGSLLRGAQTCRITYAMSRVAWEALQG
QLLPAEQDEDAEGMCKPLSCGWEITDTLCMGPVFTPASIMCIPETLASGTSQVEQTTPRT
SLPAPRSRVGSALVLGEVLAGI
Enzyme 5 Number of Residues 502
Enzyme 5 Molecular Weight 54146.8
Enzyme 5 Theoretical pI 5.46
Enzyme 5 GO Classification
Function
Process
Component
Enzyme 5 General Function Amino acid transport and metabolism
Enzyme 5 Specific Function L-ornithine = putrescine + CO(2)
Enzyme 5 Pathways
  • Amine and polyamine biosynthesis
  • putrescine biosynthesis via L-ornithine pathway
  • putrescine from L-ornithine:step 1/1
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 83638748 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q2TBX3 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name Q2TBX3_BOVIN Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >1509 bp
ATGGCTGGCTACCTGAGAGAAACGGACTTTGTGATGGTGGAGGAGGGTTTCAGCACCCGA
GACCTGCTGGAGGAGCTCACTCTGGGGGCCTCACAGGCCACCACGGAAGAGGTTGCTGCC
TTCTTCGTGGCCGACCTGGGTGCCGTGGTGAGGAAGCACTTCTGCTTTCTGAAGTGCCTG
CCTCGAGTCCGATCCTTTTACGCTGTCAAGTGCAACAGCAGCCCGGGCGTGCTGAAGGTC
CTGGCCGAGCTGGGGCTGGGCTTCAGCTGTGCCAACAAGGCAGAGATGGAGTTGGTCCAG
CATATTGGTGTCCCTGCCAGTAAGATCATCTATGCCAATCCCTGTAAGCAAATTGCACAC
ATCAAGTATGCTGCCAAGCACGGGGTCCGGCTGCTGAGCTTTGACAACGAGATGGAGCTG
GCAAAGGTGGTGAAAAGCCACCCCAGTGCCAAGATGGTTCTGTGCGTTGCCACGGAGGAC
TCCCACTCTCTGAGCCGCCTGAGCCTCAAGTTCGGAGCCTCGCTGAAATCTTGCCGACAC
CTGCTTGAGAATGCCAAGAGGGACCATGTAGAGGTGGTAGGTGTGAGTTTTCACATTGGC
AGTGACTGTCCTGACCCTCAGGCCTACGCTCAGTCCATTGCGGACGCCCGGGTTGTGTTC
GAAATGGGTGCTGAGCTGGGCCACAGGATGCACATCCTGGACCTTGGTGGCGGCTTCCCC
GGAGTGGAGGACGCCAAAGTGAGATTCGAGGAGATTGCTTCTGTGATCAACTCAGCCTTG
GACCTATACTTCCCGGAGGGCTGCGGTGTGGACATCCTTGCCAAGCTGGGGCGCTACTAC
GTGACCTCGGCCTTCACCTTGGCAGTCAGCATCATTGCCAAGAAGGAGGTTCTTCTGGAT
CAGCCAGGCAGGGAGGAGGAAACCAGTTCCTCCCCCAAGAGCGTTGTGTACCACCTTGGC
GAGGGCGTGTATGGAGTCTTCAACTCAGTCCTGTTTGACAGCGCCTGCCCCGCCCCCATC
CTGCAGAAGAAACCATCCACGGAACAGCCCCTGTACAGCAGCAGCCTGTGGGGCCCGGTG
GCCAGTGGCTGTGACTGCGTAGCTGAGGGCTTGTGGCTGCCGCAACTACACGTAGGGGAC
TGGCTGGTCTTTGAGAACATGGGCGCCTACACCGTGGGCGTGGGTTCCCTCCTCAGGGGT
GCCCAGACCTGCCGCATCACCTATGCCATGTCCCGGGTGGCCTGGGAAGCCCTGCAAGGG
CAGCTGCTGCCTGCAGAACAGGACGAGGACGCCGAGGGCATGTGCAAGCCTCTGTCCTGT
GGCTGGGAGATCACGGACACCTTGTGCATGGGCCCCGTCTTCACCCCGGCGAGCATCATG
TGTATTCCAGAGACACTTGCTTCAGGGACTTCTCAGGTGGAGCAAACCACCCCGAGGACG
TCCCTCCCCGCTCCGAGGAGTCGCGTGGGAAGCGCGCTAGTCCTCGGAGAGGTTCTCGCT
GGAATATGA
Enzyme 5 GenBank Gene ID BC109524 Link Image
Enzyme 5 GeneCard ID ADC Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Chromosome:1
Enzyme 5 Locus 1p33-p34.3
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References Not Available
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 953
Enzyme 6 Name Ornithine carbamoyltransferase, mitochondrial
Enzyme 6 Synonyms
  1. Ornithine transcarbamylase
  2. OTCase
Enzyme 6 Gene Name OTC
Enzyme 6 Protein Sequence >Ornithine carbamoyltransferase, mitochondrial
MLFHLRTLLNNAALRNGHNFVVRNFRCGQPLQDKVQLKGRDLLTLKNFTGEEIKYMLWLS
ADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTDDIHLGV
NESLTDTARVLSSMTDAVLARVYKQSDLDLLAKEASIPIVNGLSDLYHPIQILADYLTLQ
EHYGSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQVATPKGYEPDPSITKMAEQYAKEN
GTKLSLTNDPLEAACGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAAPDWTF
LHCLPRKPEEVDDEVFYSPRSLVSPEAENRKWTIMAVMVSLLTDYSPQLQKPKF
Enzyme 6 Number of Residues 354
Enzyme 6 Molecular Weight 39841.7
Enzyme 6 Theoretical pI 8.30
Enzyme 6 GO Classification
Function
Process
Component
Enzyme 6 General Function Amino acid transport and metabolism
Enzyme 6 Specific Function Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
Enzyme 6 Pathways
  • Nitrogen metabolism
  • urea cycle
  • L-citrulline from L- ornithine and carbamoyl phosphate:step 1/1
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 7381141 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID Q9N1U7 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name OTC_BOVIN Link Image
Enzyme 6 PDB ID 1FVO Link Image
Enzyme 6 PDB File Show
Enzyme 6 3D Structure
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >1065 bp
ATGCTGTTTCATCTAAGGACCCTGTTGAACAATGCAGCTCTTAGAAATGGTCACAATTTC
GTGGTTCGAAATTTTCGATGTGGGCAACCACTACAGGATAAAGTACAGCTGAAGGGCCGT
GACCTCCTCACTCTAAAGAACTTTACAGGAGAAGAAATTAAGTATATGCTATGGCTATCA
GCAGATCTGAAATTCAGGATAAAACAGAAAGGAGAGTATTTGCCTTTACTGCAAGGGAAG
TCCTTAGGCATGATTTTTGAAAAAAGAAGTACTCGAACAAGATTGTCCACAGAAACAGGC
TTTGCACTTCTGGGAGGACACCCTTGTTTTCTTACTACGGACGATATTCATTTGGGTGTG
AATGAAAGTCTCACAGATACAGCCCGTGTGTTGTCTAGCATGACAGATGCCGTGCTGGCG
CGAGTGTACAAACAATCAGATCTGGACCTCCTGGCTAAAGAAGCTTCCATCCCAATTGTC
AATGGGCTGTCGGATTTGTACCACCCTATCCAGATCCTGGCTGATTACCTCACGCTCCAG
GAACACTACGGCTCTCTGAAAGGCCTTACCCTCAGCTGGATTGGGGATGGGAATAACATC
CTGCACTCCATCATGATGAGTGCGGCTAAATTCGGGATGCACCTTCAGGTGGCTACCCCA
AAGGGTTATGAGCCGGATCCCAGTATAACCAAGATGGCAGAGCAGTATGCCAAGGAGAAC
GGTACCAAGCTGTCGCTGACAAATGATCCATTGGAAGCAGCTTGTGGAGGCAATGTATTA
ATTACAGACACTTGGATAAGCATGGGACAAGAAGAGGAGAAGAAAAAGCGGCTCCAGGCT
TTCCAAGGTTACCAGGTTACAATGAAGACTGCTAAAGTTGCTGCCCCTGACTGGACATTT
TTACACTGCTTGCCCAGAAAGCCAGAAGAAGTGGACGATGAAGTGTTTTATTCTCCACGA
TCTCTTGTATCCCCAGAGGCCGAAAACAGAAAGTGGACAATCATGGCTGTCATGGTATCC
CTGCTGACAGATTATTCGCCTCAGCTCCAGAAGCCAAAGTTTTGA
Enzyme 6 GenBank Gene ID AF134841 Link Image
Enzyme 6 GeneCard ID OTC Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Not Available
Enzyme 6 Locus Xp21.1
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References Not Available
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 1140
Enzyme 7 Name Ornithine decarboxylase antizyme
Enzyme 7 Synonyms
  1. ODC-Az
Enzyme 7 Gene Name OAZ1
Enzyme 7 Protein Sequence >Ornithine decarboxylase antizyme
MVKSSLQRILNSHCFAREKEGDKPSATVHATRTMPLLSLHSRGGRSSESSRVSINCCSNL
GPGPRWCSDVPHPPLKIPGGRGNSQRDHNLSANLFYSDNRLNVTEELTSNNKTRIFNVQS
RLTEAKHINWRAVLSNSCLYVEIPGGALPEGSKDSFAVLLEFAEEQLHVDHVFICFHKNR
DDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEE
Enzyme 7 Number of Residues 227
Enzyme 7 Molecular Weight 25447.4
Enzyme 7 Theoretical pI 8.09
Enzyme 7 GO Classification
Function
Process
Component
Enzyme 7 General Function Involved in ornithine decarboxylase inhibitor activity
Enzyme 7 Specific Function Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter
Enzyme 7 Pathways Not Available
Enzyme 7 Reactions Not Available
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • None
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein 58760346 Link Image
Enzyme 7 UniProtKB/Swiss-Prot ID Q56K12 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name OAZ1_BOVIN Link Image
Enzyme 7 PDB ID Not Available
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence >207 bp
ATGGTGAAATCCTCCCTGCAGCGGATCCTCAACAGCCACTGCTTCGCCAGAGAGAAGGAA
GGGGATAAACCCAGCGCCACCGTCCACGCCACCCGCACCATGCCGCTCCTTAGCCTGCAC
AGCCGCGGAGGCCGCAGCAGTGAGAGTTCCAGGGTCTCCATCAACTGCTGTAGTAACCTG
GGTCCAGGGCCTCGGTGGTGCTCCTGA
Enzyme 7 GenBank Gene ID AY911315 Link Image
Enzyme 7 GeneCard ID OAZ1 Link Image
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Chromosome:1
Enzyme 7 Locus 19p13.3
Enzyme 7 SNPs SNPJam Report Link Image
Enzyme 7 General References Not Available
Enzyme 7 Metabolite References Not Available
Enzyme 8 [top]
Enzyme 8 ID 1327
Enzyme 8 Name Ornithine aminotransferase, mitochondrial
Enzyme 8 Synonyms
  1. Ornithine--oxo-acid aminotransferase
Enzyme 8 Gene Name OAT
Enzyme 8 Protein Sequence >Ornithine aminotransferase, mitochondrial
MLSKLARLQTVAGLGLGVHSSVASATSVATKKTVQGPPSSDYIFERESKYGAHNYHPLPV
ALERGKGIYVWDVEGRKYFDFLSAYSAVNQGHCHPKIVDALKSQVDKLTLTSRAFYNNVL
GEYEEYVTKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIPKYKAKIVFAAGNFWGR
TLSAISSSTDPTSYDGFGPFMPGFEIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV
PDPGYLVGVRELCTQHQVLFIADEIQTGLARTGRWLAIDHENVRPDIVLLGKALSGGLYP
VSAVLCDDEIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENAEKMGIILRNEL
MKLPSDVVTTVRGKGLLNAIVIRETKDCDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI
KEDEILEAVEIINKTILSF
Enzyme 8 Number of Residues 439
Enzyme 8 Molecular Weight 48075.0
Enzyme 8 Theoretical pI 6.51
Enzyme 8 GO Classification
Function
Process
Component
Enzyme 8 General Function Amino acid transport and metabolism
Enzyme 8 Specific Function L-ornithine + a 2-oxo acid = L-glutamate 5- semialdehyde + an L-amino acid
Enzyme 8 Pathways
  • Amino-acid biosynthesis
  • L-proline biosynthesis
  • L- glutamate 5-semialdehyde from L-ornithine:step 1/1
Enzyme 8 Reactions Not Available
Enzyme 8 Pfam Domain Function
Enzyme 8 Signals
  • None
Enzyme 8 Transmembrane Regions
  • None
Enzyme 8 Essentiality Not Available
Enzyme 8 GenBank ID Protein 73586966 Link Image
Enzyme 8 UniProtKB/Swiss-Prot ID Q3ZCF5 Link Image
Enzyme 8 UniProtKB/Swiss-Prot Entry Name OAT_BOVIN Link Image
Enzyme 8 PDB ID 1OAT Link Image
Enzyme 8 PDB File Show
Enzyme 8 3D Structure
Enzyme 8 Cellular Location Not Available
Enzyme 8 Gene Sequence >1320 bp
ATGCTTTCCAAACTAGCGCGTTTGCAGACTGTTGCTGGCCTTGGTCTTGGAGTTCATTCT
TCAGTGGCTTCTGCTACATCTGTTGCAACTAAAAAAACCGTTCAAGGCCCTCCGTCCTCT
GATTACATTTTTGAACGGGAATCTAAATATGGTGCCCACAACTACCATCCTTTACCTGTA
GCCCTGGAGAGAGGGAAGGGCATTTACGTATGGGATGTTGAAGGCAGAAAATATTTTGAC
TTTCTGAGTGCTTACAGTGCTGTCAACCAGGGGCATTGTCATCCAAAGATTGTGGATGCT
TTGAAAAGTCAAGTGGACAAGTTGACCTTAACATCTAGGGCTTTCTACAATAACGTGCTT
GGTGAATATGAAGAGTATGTTACTAAACTTTTCAACTACCACAAAGTTCTTCCTATGAAT
ACAGGAGTGGAGGCTGGAGAGACTGCTTGCAAGCTTGCTCGTAAATGGGGGTATACTGTC
AAGGGGATCCCGAAATACAAAGCAAAGATTGTTTTTGCAGCTGGGAACTTCTGGGGTAGG
ACATTGTCTGCTATCTCCAGCTCCACTGACCCAACCAGTTACGATGGTTTTGGACCATTT
ATGCCGGGTTTTGAAATCATTCCGTATAATGATCTGCCTGCCCTTGAGCGTGCGCTTCAG
GACCCAAACGTTGCCGCGTTCATGGTGGAACCAATCCAGGGTGAAGCGGGCGTTGTTGTT
CCGGATCCAGGCTACCTCGTGGGCGTCCGCGAGCTCTGCACCCAGCACCAGGTTCTGTTT
ATTGCTGATGAAATCCAGACAGGCTTGGCCAGAACTGGGAGATGGCTGGCTATTGACCAC
GAAAATGTCCGACCTGATATTGTCCTTCTAGGAAAGGCACTTTCTGGTGGTTTATACCCC
GTGTCCGCAGTGTTGTGTGATGATGAAATAATGCTGACCATTAAGCCAGGGGAACATGGT
TCTACGTATGGAGGCAATCCGCTGGGCTGCCGAGTGGCTATCGCAGCCCTGGAGGTTTTG
GAAGAAGAAAACCTTGCTGAAAATGCAGAGAAAATGGGTATCATCTTGAGAAATGAACTC
ATGAAGCTGCCTTCTGATGTTGTAACGACTGTAAGAGGAAAAGGATTACTAAATGCTATT
GTTATCAGAGAAACCAAAGATTGTGATGCTTGGAAGGTGTGTCTGCGACTGCGAGATAAT
GGACTTCTGGCCAAGCCAACCCACGGCGACATCATTAGGTTTGCGCCCCCGCTTGTGATC
AAGGAGGATGAGATTCTAGAGGCGGTGGAGATCATTAACAAGACCATCCTGTCTTTCTGA
Enzyme 8 GenBank Gene ID BC102427 Link Image
Enzyme 8 GeneCard ID OAT Link Image
Enzyme 8 GenAtlas ID Not Available
Enzyme 8 HGNC ID Not Available
Enzyme 8 Chromosome Location Chromosome:1
Enzyme 8 Locus 10q26
Enzyme 8 SNPs SNPJam Report Link Image
Enzyme 8 General References Not Available
Enzyme 8 Metabolite References Not Available