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Bovine Rumen Metabolome Database



Showing metabocard for Succinic acid (RMDB00254)

Legend: metabolite field enzyme field

Version 1.0
Creation Date 2005-11-16 15:48:42
Update Date 2009-08-10 14:41:22
Accession Number RMDB00254
Common Name Succinic acid
Description Succinic acid is a dicarboxylic acid. The anion, succinate, is a component of the citric acid cycle capable of donating electrons to the electron transfer chain. Succinate dehydrogenase (SDH) plays an important role in the mitochondria, being both part of the respiratory chain and the Krebs cycle. SDH with a covalently attached FAD prosthetic group, binds enzyme substrates (succinate and fumarate) and physiological regulators (oxaloacetate and ATP). Oxidizing succinate links SDH to the fast-cycling Krebs cycle portion where it participates in the breakdown of acetyl-CoA throughout the whole Krebs cycle. The succinate can readily be imported into the mitochondrial matrix by the n-butylmalonate- (or phenylsuccinate-) sensitive dicarboxylate carrier in exchange with inorganic phosphate or another organic acid, e. g. malate. (PMID 16143825) Mutations in the four genes encoding the subunits of the mitochondrial respiratory chain succinate dehydrogenase are associated with a wide spectrum of clinical presentations (i.e.: Huntington's disease. (PMID 11803021)
Synonyms
  1. 1,2-Ethanedicarboxylate
  2. 1,2-Ethanedicarboxylic acid
  3. 1,4-Butanedioate
  4. 1,4-Butanedioic acid
  5. Amber acid
  6. Asuccin
  7. Dihydrofumarate
  8. Dihydrofumaric acid
  9. Katasuccin
  10. Succinate
  11. Wormwood acid
Chemical IUPAC Name Butanedioic acid
Chemical Formula C4H6O4
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Organic acids
Class
  • Dicarboxylic Acids
Sub Class
  • Short chain dicarboxylic acids
Family
  • Mammalian_Metabolite
Species
  • carboxylic acid
Biofunction
  • DNA component; Component of Arginine and proline metabolism; Component of Butanoate metabolism; Component of C5-Branched dibasic acid metabolism; Component of Glutamate metabolism; Component of Propanoate metabolism
Application
Source
  • Endogenous
Average Molecular Weight 118.088
Monoisotopic Molecular Weight 118.026611
Isomeric SMILES OC(=O)CCC(O)=O
Canonical SMILES OC(=O)CCC(O)=O
KEGG Compound ID C00042 Link Image
BioCyc ID SUC Link Image
BiGG ID 33633 Link Image
Wikipedia Link Succinic acid Link Image
METLIN ID 114 Link Image
PubChem Compound 1110 Link Image
PubChem Substance 8138088 Link Image
ChEBI ID 15741 Link Image
CAS Registry Number 110-15-6
InChI Identifier InChI=1/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
Synthesis Reference Berglund, Kris Arvid; Andersson, Christian; Rova, Ulrika. Process for the production of succinic acid. PCT Int. Appl. (2007), 30pp.
Melting Point (Experimental) 185-188 oC
Experimental Water Solubility 83.2 mg/mL [YALKOWSKY,SH & HE,Y (2003)] Source: PhysProp
Predicted Water Solubility 210.99998 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge -2
State Solid
Experimental LogP/Hydrophobicity -0.59 [HANSCH,C ET AL. (1995)] Source: PhysProp
Predicted LogP/Hydrophobicity -0.53 [Predicted by ALOGPS]; -0.7 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show Link Image
SDF File Show Link Image
PDB File Show Link Image
2D Structure
3D Structure
Experimental PDB ID 1ABZ Link Image
Experimental PDB File Show
Experimental PDB Structure
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum
Low Energy
Download File
Show Experimental Conditions Link Image
Medium Energy
Download File
Show Experimental Conditions Link Image
High Energy
Download File
Show Experimental Conditions Link Image
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Cytoplasm (Predicted from LogP)
  • endoplasmic reticulum
  • Extracellular
  • mitochondria
  • peroxisome
Biofluid Location
  • Cow_Milk
  • Rumen
Tissue Location
Concentrations (Normal)
Biofluid Rumen
Value 123.5 +/- 21.1 uM
Age 4-5 years old
Sex Female (lactating)
Condition Normal (0% barley grain in dry matter (DM) basis)
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 83.3 +/- 1.8 uM
Age N/A
Sex Female
Condition Normal
Breed Not Available
Experimental Condition Not Available
Comments Not Available
References
  • Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows. Burim N. Ametaj, Qendrim Zebeli, Fozia Saleem, Nikolaos Psychogios, Michael J. Lewis, Suzanna M. Dunn, Jianguo Xia and David S. Wishart Metabolomics 2010;6(4):583-594
Concentrations (Abnormal)
Biofluid Rumen
Value 147 +/- 35 uM
Age 4-5 years old
Sex Female (lactating)
Condition 15% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 178 +/- 65 uM
Age 4-5 years old
Sex Female (lactating)
Condition 30% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 118 +/- 52 uM
Age 4-5 years old
Sex Female (lactating)
Condition 45% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Pathway Names Not Available
HMDB Pathways Not Available
KEGG Pathways Not Available
SimCell Pathways Not Available
General References
  1. Wikipedia Link Image
Metabolic Enzymes
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  2. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
  3. Aspartyl/asparaginyl beta-hydroxylase
  4. Trimethyllysine dioxygenase, mitochondrial
  5. Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
  6. Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
  7. Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
  8. Prolyl 4-hydroxylase subunit alpha-1
  9. Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
  10. Phytanoyl-CoA dioxygenase, peroxisomal
  11. Prolyl 4-hydroxylase subunit alpha-3
Enzyme 1 [top]
Enzyme 1 ID 297
Enzyme 1 Name Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Enzyme 1 Synonyms
  1. Iron-sulfur subunit of complex II
  2. IP
Enzyme 1 Gene Name SDHB
Enzyme 1 Protein Sequence >Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
MAAVVALSLRRRFPAAALGGARLQACRGAQTAAAAAPRIKKFAIYRWDPDKTGDKPHMQT
YEIDLNNCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN
LSKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQGGKEQYLQSIEDREKL
DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL
YRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKQASA
Enzyme 1 Number of Residues 280
Enzyme 1 Molecular Weight 31518.1
Enzyme 1 Theoretical pI 8.72
Enzyme 1 GO Classification
Function
Process
Component
Enzyme 1 General Function Energy production and conversion
Enzyme 1 Specific Function Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Enzyme 1 Pathways
  • Carbohydrate metabolism
  • tricarboxylic acid cycle
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function Not Available
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 74267982 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q3T189 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name DHSB_BOVIN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >843 bp
ATGGCGGCAGTGGTCGCGCTCTCCTTGAGGCGCCGGTTCCCGGCCGCCGCCCTCGGCGGG
GCCCGCCTGCAGGCCTGCCGTGGGGCTCAGACAGCTGCAGCCGCAGCACCCCGAATCAAG
AAATTTGCCATCTATCGATGGGACCCGGACAAGACTGGAGACAAACCTCACATGCAAACT
TATGAGATTGATTTGAATAACTGTGGTCCTATGGTGCTGGATGCTCTAATCAAGATTAAG
AATGAAATTGATTCCACCCTGACCTTCCGGAGATCATGCAGAGAAGGCATCTGCGGCTCC
TGTGCCATGAACATCAACGGAGGCAACACTCTGGCGTGCACCCGCAGGATCGACACCAAC
CTCAGCAAAGTTTCCAAAATCTACCCTCTGCCACACATGTATGTGATAAAGGACCTTGTT
CCTGATTTGAGCAACTTCTATGCTCAGTACAAGTCCATCGAGCCTTACTTAAAGAAGAAG
GATGAGTCCCAGGGAGGCAAGGAGCAGTATCTGCAGTCCATAGAAGACCGTGAGAAACTG
GACGGGCTCTATGAGTGTATCCTCTGCGCCTGCTGCAGCACCAGCTGCCCGAGCTACTGG
TGGAACGGAGACAAGTACCTGGGCCCCGCCGTGCTCATGCAGGCCTATCGCTGGATGATC
GACTCCAGAGACGACTTCACGGAGGAGCGCCTGGCCAAGCTGCAGGACCCCTTCTCTCTC
TACCGCTGCCACACCATCATGAACTGCACGCAGACCTGCCCCAAGGGGCTGAATCCTGGG
AAAGCTATTGCTGAAATCAAGAAGATGATGGCAACCTATAAAGAGAAGCAGGCTTCTGCT
TAA
Enzyme 1 GenBank Gene ID BC102067 Link Image
Enzyme 1 GeneCard ID SDHB Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Chromosome:1
Enzyme 1 Locus 1p36.1-p35
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References Not Available
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 339
Enzyme 2 Name Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Enzyme 2 Synonyms
  1. Flavoprotein subunit of complex II
  2. Fp
Enzyme 2 Gene Name SDHA
Enzyme 2 Protein Sequence >Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
MSGVAAVSRLWRARRLALTCTKWSAAWQTGTRSFHFTVDGNKRSSAKVSDAISAQYPVVD
HEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNW
RWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGKIYQRAFGGQSLK
FGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMESGECRGVIALCI
EDGSIHRIRARNTVIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTG
IYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGP
EKDHVYLQLHHLPPAQLAMRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKG
QVLRHVNGQDQGVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGD
KVPSIKPNAGEESVMNLDKLRFANGSIRTSELRLNMQKSMQSHAAVFRVGSVLQEGCEKI
SSLYGDLRHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGGPRREDFKE
RVDEYDYSKPIQGQQKKPFEQHWRKHTLSYVDIKTGKVTLEYRPVIDRTLNETDCATVPP
AIGSY
Enzyme 2 Number of Residues 665
Enzyme 2 Molecular Weight 72943.1
Enzyme 2 Theoretical pI 7.63
Enzyme 2 GO Classification
Function
Process
Component
Enzyme 2 General Function Energy production and conversion
Enzyme 2 Specific Function Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Enzyme 2 Pathways
  • Carbohydrate metabolism
  • tricarboxylic acid cycle
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 387584 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID P31039 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name DHSA_BOVIN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1998 bp
ATGTCGGGGGTTGCCGCTGTGTCGCGCTTGTGGCGCGCCCGGCGCCTGGCGCTGACCTGC
ACGAAGTGGTCGGCAGCATGGCAGACAGGAACCCGCAGTTTTCACTTCACCGTTGATGGC
AATAAGAGGTCGTCCGCTAAAGTTTCAGATGCGATTTCTGCGCAGTATCCAGTTGTGGAC
CATGAGTTTGATGCCGTGGTGGTTGGTGCCGGGGGGGCAGGCCTGCGGGCCGCGTTCGGC
CTCTCTGAAGCAGGTTTCAACACGGCCTGCGTCACGAAGCTCTTCCCCACCAGATCCCAC
ACTGTCGCGGCCCAGGGAGGGATCAATGCCGCCCTGGGGAACATGGAGGAGGACAACTGG
CGGTGGCACTTCTACGACACCGTGAAAGGCTCCGACTGGCTGGGGGACCAGGACGCCATC
CATTACATGACCGAGCAGGCCCCCGCCTCTGTGGTGGAGCTGGAGAATTACGGCATGCCC
TTTAGCAGAACTGAAGATGGCAAGATCTACCAGCGTGCCTTTGGCGGACAGAGCCTCAAG
TTCGGGAAGGGTGGGCAGGCCCATCGCTGCTGCTGCGTGGCCGACCGCACGGGCCACTCG
CTGCTGCACACGTTGTATGGAAGGTCTCTGCGCTATGACACCAGCTACTTTGTGGAGTAC
TTTGCTCTGGACCTCCTGATGGAGAGCGGGGAGTGCCGCGGTGTGATCGCTCTGTGCATA
GAAGAACGGGTCCATCCACCGCATCAGGGCCAGGAACACTGTCATCGCCACCGGAGCTAC
GGGCGCACCTACTTCAGCTGCACGTCCGCCCACACCAGCACCGGGGACGGCACTGCCATG
GTGACCAGGGCTGGCCTGCCCTGCCAGGACCTGGAGTTCGTGCAGTTCCACCCCACAGGC
ATATATGGCGCTGGCTGTCTCATCACAGAGGGCTGTCGTGGAGAGGGGGGCATCCTCATC
AACAGCCAGGGTGAGAGGTTCATGGAGCGCTACGCCCCCGTCGCTAAGGACCTGGCGTCC
AGGGATGTCGTGTCCCGGTCCATGACCCTGGAAATCCGCGAGGGAAGAGGCTGTGGGCCC
GAGAAGGACCATGTGTACCTGCAGCTGCACCACCTGCCCCCAGCACAGCTGGCTATGCGC
CTGCCTGGCATCTCAGAGACGGCCATGATCTTCGCGGGCGTGGACGTCACCAAGGAGCCC
ATCCCCGTGCTTCCCACCGTGCACTACAACATGGGTGGCATCCCCACCAACTACAAGGGG
CAGGTTCTGAGGCACGTGAATGGCCAGGACCAGGGTGTGCCTGGCCTGTACGCATGCGGG
GAGGCTGCCTGCGCCTCGGTGCATGGTGCCAACCGTCTGGGTGCAAACTCGCTCCTGGAC
CTGGTTGTCTTCGGCCGGGCGTGCGCCCTGAGCATCGCAGAGTCCTGCAGACCCGGAGAT
AAAGTTCCCTCGATTAAACCAAATGCTGGGGAAGAATCTGTCATGAATCTTGACAAATTG
AGATTTGCCAATGGAAGCATAAGGACATCGGAACTGCGACTCAACATGCAGAAGTCGATG
CAGAGCCATGCCGCGGTGTTCCGTGTGGGGAGTGTGCTGCAGGAAGGCTGTGAGAAGATC
AGCAGCCTCTACGGAGACCTGCGGCATCTGAAGACGTTCGACAGGGGAATGGTCTGGAAC
ACTGACCTGGTGGAGACCCTGGAGCTGCAGAACCTGATGCTTTGTGCTCTGCAGACCATC
TACGGAGCGGAGGCCCGGAAGGAGTCGCGCGGCGGCCCACGCAGGGAGGACTTCAAGGAG
AGGGTTGACGAGTACGATTACTCCAAGCCCATCCAGGGGCAGCAGAAGAAGCCCTTTGAG
CAGCACTGGAGGAAGCACACGCTCTCCTACGTTGACATCAAGACTGGGAAGGTCACCCTG
GAGTACAGACCTGTAATCGACAGAACTTTGAACGAGACTGACTGCGCCACTGTTCCCCCA
GCCATCGGCTCCTACTGA
Enzyme 2 GenBank Gene ID M60879 Link Image
Enzyme 2 GeneCard ID SDHA Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Chromosome:5
Enzyme 2 Locus 5p15
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 568
Enzyme 3 Name Aspartyl/asparaginyl beta-hydroxylase
Enzyme 3 Synonyms
  1. Aspartate beta-hydroxylase
  2. ASP beta-hydroxylase
  3. Peptide-aspartate beta-dioxygenase
Enzyme 3 Gene Name ASPH
Enzyme 3 Protein Sequence >Aspartyl/asparaginyl beta-hydroxylase
MAPRKNAKGGGGNSSSSSSGSPTGCTSGGSSSPGARRETKQGGLKNGRKGGLSGSSFFTW
FMVIALLGVWTSVAVVWFDLVDYEEVLAKAKDFRYNLSEVLQGKLGIYDADGDGDFDVDD
AKVLLGLKEKPAPKPTVPPEEADMYPWLEDQVLESPGRQNIEDEVYEQVQSLDETVYSEP
GENLPQEPEGPAEELQPDDHVFVGSDADDRYEPMGTGAVHEETEDSYHIEETASPAYSQD
MEDMMYEQENPDSSEPVVVDDAERTYQETDDVTYRDYDEQDHAVDNSNTILEEPHMPPAE
EQQEVPPETNKKADEPGKKGKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAF
EELVRKYPQSPGARYGKAQCEDDLAEKRRSNEILRRAIETYQEAASLPDAPTDLVKLSLK
RRSDRQQFLGHMRGSLLTLQKLVQLFPDDTALKNDLGVGYLLIGDNDSAKKVYEEVLSVT
PNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAY
RWYELGHQRGHFASVWQRSLYNVQGLKAQPWWTPKETGYTELVKSLERNWKLIRDEGLAA
MDRTHGLFLPEDENLREKGDWSQFTLWQQGRKNENACKGAPKTCSLLDKFPETTGCRRGQ
IKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETRTWEEGKVLIFDDSFE
HEVWQDAASFRLIFIVDVWHPELTPHQRRSLPAI
Enzyme 3 Number of Residues 754
Enzyme 3 Molecular Weight 84998.2
Enzyme 3 Theoretical pI 4.81
Enzyme 3 GO Classification
Function
Process
Component
Enzyme 3 General Function Posttranslational modification, protein turnover, chaperones
Enzyme 3 Specific Function Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • 57-77
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 162694 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q28056 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name ASPH_BOVIN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >2265 bp
ATGGCCCCGCGCAAGAATGCCAAGGGCGGCGGCGGCAACAGCAGCAGCAGCAGCTCTGGC
AGTCCGACCGGCTGCACCAGCGGCGGCAGCAGCAGCCCCGGGGCCCGGAGAGAGACGAAA
CAGGGAGGACTCAAGAATGGGAGGAAAGGAGGACTTTCTGGAAGTTCATTTTTCACATGG
TTTATGGTCATTGCACTGCTCGGAGTCTGGACATCAGTAGCTGTGGTCTGGTTTGATCTT
GTTGATTATGAAGAAGTGTTAGCCAAAGCAAAGGACTTCCGTTATAACTTGTCAGAGGTA
CTTCAAGGAAAACTTGGAATCTATGATGCTGATGGTGATGGAGATTTTGATGTGGATGAT
GCCAAAGTTTTATTAGGCCTTAAAGAAAAACCTGCTCCAAAGCCAACAGTGCCACCAGAA
GAGGCAGACATGTACCCTTGGCTGGAAGATCAGGTTCTGGAGAGCCCAGGACGTCAGAAT
ATTGAAGATGAAGTATATGAACAAGTTCAGTCACTTGATGAAACAGTATACTCAGAACCT
GGAGAGAACCTGCCCCAAGAACCAGAAGGACCAGCAGAAGAGCTGCAGCCCGACGACCAT
GTCTTTGTAGGAAGTGATGCAGATGACAGATACGAACCCATGGGAACTGGAGCCGTTCAT
GAAGAAACTGAAGATAGCTACCATATAGAAGAGACAGCTTCGCCAGCCTACAGTCAAGAT
ATGGAAGACATGATGTATGAGCAGGAAAATCCAGATTCCAGTGAACCAGTAGTAGTAGAT
GATGCTGAAAGAACATACCAAGAAACAGATGATGTCACCTACCGAGACTATGATGAACAA
GATCATGCTGTAGATAATTCAAACACAATTTTAGAAGAACCGCACATGCCCCCTGCAGAG
GAACAGCAAGAAGTACCACCAGAAACAAATAAGAAAGCAGATGAGCCAGGAAAAAAAGGA
AAAGTGAAGAAAAAGAAGCCTAAACTATTAAATAAATTTGATAAGACTATTAAAGCTGAG
CTCGATGCTGCAGAAAAACTCCGTAAAAGGGGAAAAATTGAGGAAGCAGTGAATGCATTT
GAAGAACTGGTTCGCAAGTACCCTCAGAGTCCAGGAGCTCGGTATGGGAAAGCACAGTGT
GAAGATGATTTGGCTGAGAAGAGAAGGAGCAATGAGATCCTGCGCAGGGCCATCGAGACC
TACCAGGAGGCGGCCAGTCTGCCTGATGCCCCCACAGACTTGGTGAAGCTGAGCCTGAAG
CGGAGGTCAGACAGACAGCAGTTTCTAGGTCACATGAGAGGATCCTTGCTTACTCTTCAG
AAATTAGTTCAACTATTTCCTGATGATACTGCCTTAAAGAATGACCTTGGAGTTGGATAC
CTCTTGATAGGTGACAATGACAGTGCCAAGAAGGTCTATGAAGAGGTTCTGAGCGTGACA
CCCAATGATGGTTTTGCTAAAGTGCATTATGGCTTTATCCTGAAGGCACAGAACAAGATT
GCTGAGAGCATCCCCTATCTGAAGGAAGGAATAGAATCTGGGGATCCTGGTACTGATGAT
GGGAGATTTTATTTTCACCTGGGGGACGCCATGCAGAGAGTTGGAAACAAAGAGGCATAT
CGGTGGTACGAGCTGGGGCACCAGAGGGGCCACTTTGCCTCCGTGTGGCAGCGCTCACTG
TACAACGTGCAGGGATTGAAAGCCCAGCCGTGGTGGACCCCCAAAGAGACCGGCTACACC
GAGTTAGTGAAGTCCTTAGAAAGAAACTGGAAGTTAATCAGAGATGAAGGCCTTGCAGCA
ATGGATAGAACCCATGGCCTCTTCCTGCCTGAAGATGAGAACCTGAGGGAAAAGGGTGAC
TGGAGTCAGTTTACGCTGTGGCAGCAAGGAAGAAAAAATGAAAATGCCTGTAAAGGAGCT
CCTAAGACCTGTTCTTTACTAGATAAATTCCCTGAGACAACAGGATGCCGAAGAGGACAG
ATCAAATATTCCATCATGCACCCGGGAACCCACGTGTGGCCGCACACGGGACCCACGAAC
TGTAGGCTCCGAATGCACCTGGGCTTGGTGATTCCCAAGGAAGGCTGCAAGATCCGATGC
GCCAACGAGACCAGGACGTGGGAAGAAGGCAAGGTGCTCATCTTTGACGACTCCTTTGAA
CACGAGGTGTGGCAGGATGCCGCGTCTTTCCGGCTCATCTTCATTGTGGATGTGTGGCAC
CCTGAGCTGACACCCCATCAGAGACGCAGCCTTCCTGCAATTTAG
Enzyme 3 GenBank Gene ID M91213 Link Image
Enzyme 3 GeneCard ID ASPH Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Chromosome:8
Enzyme 3 Locus 8q12.1
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 622
Enzyme 4 Name Trimethyllysine dioxygenase, mitochondrial
Enzyme 4 Synonyms
  1. Epsilon-trimethyllysine 2-oxoglutarate dioxygenase
  2. TML-alpha-ketoglutarate dioxygenase
  3. TML dioxygenase
  4. TMLD
  5. TML hydroxylase
Enzyme 4 Gene Name TMLHE
Enzyme 4 Protein Sequence >Trimethyllysine dioxygenase, mitochondrial
MWCHRLSHLQSRLQDLLRGRVTRWALQQSNFKSLFPLAIYWHHTASKSLNCVWQQHEDHF
ELQYANNVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIQPQTIHLDETTLFFTW
PDGHVTRYDLDWLMKNSYEGQKQKVIQPRILWNAEIYQQAQVPAVDFQTFLETKEGLKNF
LQNFLLYGIAFVENVPPTQKHTEKLAERISLIRETIYGRMWFFTSDFSRGDTAYTKLALD
RHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLQKAPEEFELLSKVPLKHE
YIENVGECQNHMIGVGPVLNIYPWNKELYLIRYNNYDRAVINTVPYDVVHRWYTAHRTLT
RELRRPENEFWVKLKPGKVLFIDNWRVLHGRESFTGYRQLCGCYLTRDDVLNTARLLGLQ
A
Enzyme 4 Number of Residues 421
Enzyme 4 Molecular Weight 49836.4
Enzyme 4 Theoretical pI 7.97
Enzyme 4 GO Classification
Function
Process
Component
Enzyme 4 General Function Secondary metabolites biosynthesis, transport and catabolism
Enzyme 4 Specific Function Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML)
Enzyme 4 Pathways
  • Amine and polyamine biosynthesis
  • carnitine biosynthesis
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 111305234 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q0VC74 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name TMLH_BOVIN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >1266 bp
ATGTGGTGTCACAGGTTGTCCCACCTACAAAGCAGGCTCCAGGACCTGCTGAGGGGACGG
GTCACACGTTGGGCCCTTCAACAGTCCAACTTCAAAAGCTTATTTCCACTAGCCATCTAT
TGGCACCATACAGCCTCCAAGTCTCTGAATTGTGTTTGGCAGCAACATGAAGATCATTTT
GAACTGCAATATGCTAACAATGTGATGCGCTTTGATTATGTCTGGCTTCGAGACCACTGC
CGCTCAGCATCTTGCTACAACTCTAAGACTCACCAGCGCAGCCTAGACACTGCCAGCGTG
GATTTATGTATCCAGCCACAGACCATTCATCTGGATGAGACCACACTCTTTTTCACTTGG
CCAGATGGTCATGTGACTAGATATGATTTGGATTGGCTCATGAAAAACAGCTATGAAGGG
CAGAAACAAAAGGTCATCCAGCCTAGAATCTTATGGAATGCTGAAATCTACCAGCAAGCC
CAAGTTCCAGCTGTAGATTTCCAGACGTTCTTAGAAACCAAGGAGGGACTGAAGAACTTT
CTGCAGAACTTTCTGCTCTATGGAATTGCTTTTGTGGAAAATGTCCCTCCTACTCAGAAA
CACACAGAGAAGCTGGCAGAAAGGATCAGCTTGATCAGAGAAACCATCTATGGAAGGATG
TGGTTTTTCACTTCAGACTTCTCCAGAGGTGACACTGCATACACCAAGCTAGCTCTGGAT
CGGCACACTGACACCACCTATTTTCAAGAGCCCTGTGGCATTCAAGTGTTTCACTGTCTT
AAGCATGAAGGAACAGGTGGCAGGACACTGCTAGTTGATGGATTCTATGCAGCAGAACAA
GTACTTCAAAAGGCACCTGAGGAATTTGAACTCCTCAGTAAAGTGCCATTGAAGCATGAA
TATATTGAAAATGTTGGAGAATGTCAAAACCACATGATTGGGGTTGGGCCAGTCTTAAAT
ATCTACCCATGGAATAAAGAGCTCTATTTGATCAGGTACAACAACTATGACCGGGCTGTC
ATAAATACTGTACCTTATGATGTTGTCCATCGTTGGTATACAGCACACCGGACTCTAACC
AGAGAGTTGAGGAGGCCTGAGAATGAGTTTTGGGTCAAACTCAAGCCTGGCAAGGTACTA
TTTATAGACAACTGGCGTGTCCTACATGGCAGGGAATCCTTCACAGGCTACCGCCAACTC
TGTGGCTGCTATTTAACAAGGGATGATGTATTAAACACTGCTCGTCTCTTGGGCCTTCAG
GCTTAA
Enzyme 4 GenBank Gene ID BC120318 Link Image
Enzyme 4 GeneCard ID TMLHE Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Not Available
Enzyme 4 Locus Xq28
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 625
Enzyme 5 Name Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
Enzyme 5 Synonyms
  1. Succinyl-CoA synthetase beta-A chain
  2. SCS-betaA
  3. ATP-specific succinyl-CoA synthetase subunit beta
Enzyme 5 Gene Name SUCLA2
Enzyme 5 Protein Sequence >Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
MAASVFYSRLLAAATLRSHRPRTALPAAAQVLGSSGLFNNHGVQIQHQQQRNLSLHEYLS
MELLQEAGVSIPKGHVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVK
IVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERRYPRREYYFAITMERSFQGP
VLIGSSHGGVNIEDVAAETPEAIVKEPIDIVEGIKKEQAVRLAQKMGFPASIVDSAAENM
IKLYDPFLKYDATMVEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDER
DKDAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEA
FKLITSDKKVLSILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPIVVRLQGTRVDDAKALI
ADSGLKILACDDLDEAAKMVVKLSEIVTLAKQAQVDVKFQLPI
Enzyme 5 Number of Residues 463
Enzyme 5 Molecular Weight 50129.6
Enzyme 5 Theoretical pI 7.21
Enzyme 5 GO Classification
Function
Process
Component
Enzyme 5 General Function Energy production and conversion
Enzyme 5 Specific Function ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Enzyme 5 Pathways
  • Carbohydrate metabolism
  • tricarboxylic acid cycle
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 109939816 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q148D5 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name SUCB1_BOVIN Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >1392 bp
ATGGCGGCCTCCGTGTTCTACAGCCGGCTCTTGGCTGCCGCCACCCTGAGGAGCCACCGA
CCCCGAACGGCGCTGCCGGCCGCCGCCCAGGTCCTGGGAAGCTCTGGATTGTTTAACAAC
CATGGAGTCCAAATACAGCATCAACAGCAAAGGAATCTCTCGCTGCATGAATACCTGAGT
ATGGAATTGTTGCAGGAAGCTGGCGTCTCCATTCCCAAAGGACATGTGGCTAAGTCACCA
GATGAAGCTTATGCGATTGCCAAAAAATTAGGTTCAAAAGATGTTGTGATAAAGGCGCAA
GTTTTGGCTGGTGGCAGAGGAAAAGGAACATTTGAAAGTGGCCTCAAAGGAGGAGTGAAG
ATAGTTTTCTCTCCAGAAGAAGCAAAAGCTGTTTCCTCACAAATGATTGGGAAAAAGTTG
TTTACCAAGCAAACAGGAGAAAAGGGCAGGATATGCAATCAAGTATTGGTTTGTGAACGA
AGATATCCCAGGAGAGAATACTACTTTGCAATCACAATGGAAAGGTCATTTCAAGGTCCT
GTATTAATAGGAAGTTCTCACGGTGGTGTCAACATTGAAGATGTTGCTGCTGAGACTCCC
GAGGCCATAGTTAAAGAGCCTATCGATATCGTAGAAGGCATCAAAAAGGAACAAGCTGTC
CGGCTTGCACAGAAGATGGGATTTCCAGCCAGTATTGTGGATTCTGCAGCAGAAAACATG
ATCAAGCTTTATGACCCTTTTCTGAAATACGATGCAACCATGGTAGAAATAAATCCAATG
GTAGAGGATTCAGATGGAGCTGTGCTGTGTATGGATGCAAAGATCAATTTTGATTCTAAT
TCAGCTTATCGTCAGAAGAAAATCTTTGACCTGCAGGACTGGACCCAGGAAGATGAAAGG
GACAAAGATGCAGCTAAGGCAGATCTCAACTACATTGGCCTTGACGGAAATATCGGCTGT
CTAGTGAATGGTGCTGGTTTGGCTATGGCTACAATGGATATAATAAAACTCCATGGAGGG
ACTCCAGCCAACTTTCTTGATGTTGGTGGTGGTGCCACAGTCCATCAAGTAACAGAAGCG
TTTAAACTTATCACTTCAGATAAAAAGGTACTATCTATTTTGGTCAACATTTTTGGAGGA
ATCATGCGGTGTGACGTTATTGCACAGGGTATAGTCATGGCAGTAAAGGATTTGGAAATT
AAAATACCTATTGTGGTACGGTTACAAGGTACACGAGTTGATGATGCTAAGGCACTGATA
GCGGACAGTGGACTTAAAATCCTTGCTTGTGATGACTTGGATGAAGCTGCTAAAATGGTT
GTAAAGCTCTCTGAGATAGTGACCTTAGCCAAGCAAGCCCAGGTGGATGTGAAATTTCAG
TTGCCAATCTGA
Enzyme 5 GenBank Gene ID BC118443 Link Image
Enzyme 5 GeneCard ID SUCLA2 Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Chromosome:1
Enzyme 5 Locus 13q12.2-q13.3
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References Not Available
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 626
Enzyme 6 Name Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
Enzyme 6 Synonyms
  1. Succinyl-CoA synthetase subunit alpha
  2. SCS-alpha
Enzyme 6 Gene Name SUCLG1
Enzyme 6 Protein Sequence >Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
MTAALAAARAAATMASGSSGLAAARLLSRAFLLQQNGIRHCSYTTSRKHLYVDRNTKIIC
QGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGKTHLGLPVFNTVKEAKEQTGATASVIYV
PPPFAVAAIDEAIEAEVSLVVCITEGIPQQDMVRVKHKLLRQGKTRLVGPNCPGVINPGE
CKIGIMPGHIHKKGRVGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFTDCL
EIFLNDPATEGIILIGEIGGNAEENAAEFLKQHNSGPKAKPVVSFIAGLTAPPGRRMGHA
GAIIAGGKGGAKEKIAALQSAGVVVSMSPAQLGTTMYKEFEKRKML
Enzyme 6 Number of Residues 346
Enzyme 6 Molecular Weight 36166.6
Enzyme 6 Theoretical pI 9.83
Enzyme 6 GO Classification
Function
Process
Component
Enzyme 6 General Function Energy production and conversion
Enzyme 6 Specific Function GTP + succinate + CoA = GDP + phosphate + succinyl-CoA
Enzyme 6 Pathways
  • Carbohydrate metabolism
  • tricarboxylic acid cycle
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 61553261 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID Q58DR8 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name SUCA_BOVIN Link Image
Enzyme 6 PDB ID 1EUC Link Image
Enzyme 6 PDB File Show
Enzyme 6 3D Structure
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >1041 bp
ATGACCGCAGCCCTCGCTGCTGCCCGTGCCGCTGCGACCATGGCCTCTGGCAGCAGCGGC
CTCGCCGCCGCCCGCCTCCTGTCCCGCGCCTTCCTCTTGCAACAGAATGGAATTCGGCAT
TGCTCTTATACAACTTCCAGGAAGCATCTCTATGTTGATAGAAATACGAAGATTATTTGC
CAGGGTTTCACTGGTAAGCAGGGCACCTTTCATAGCCAGCAGGCACTGGAATATGGCACC
AAACTAGTTGGAGGAACCACTCCAGGGAAAGGAGGAAAGACGCACCTGGGCTTACCAGTC
TTTAACACTGTGAAGGAGGCCAAAGAACAGACTGGGGCGACAGCATCTGTCATTTATGTC
CCTCCTCCCTTTGCTGTTGCTGCCATTGATGAAGCTATCGAGGCGGAAGTGTCCCTGGTC
GTGTGCATCACCGAAGGTATCCCGCAGCAGGACATGGTGCGGGTCAAGCACAAACTGCTG
CGACAGGGAAAGACCAGGCTGGTCGGGCCGAACTGCCCTGGAGTCATCAATCCTGGAGAA
TGCAAAATTGGCATCATGCCTGGCCATATTCACAAGAAAGGAAGAGTCGGTATCGTGTCT
AGATCCGGCACCCTGACTTACGAAGCGGTTCACCAGACAACACAAGTTGGATTGGGGCAG
TCTTTGTGTGTTGGCATTGGAGGCGATCCTTTCAATGGAACAGACTTTACAGACTGCCTT
GAAATCTTTCTGAATGATCCGGCCACAGAAGGCATCATATTGATTGGTGAAATTGGTGGT
AATGCCGAAGAAAATGCTGCAGAATTTTTGAAGCAACATAATTCAGGTCCCAAGGCCAAG
CCTGTGGTGTCCTTCATTGCTGGTTTAACTGCTCCTCCCGGCAGAAGAATGGGTCACGCA
GGGGCAATCATTGCTGGAGGAAAAGGTGGAGCTAAAGAGAAGATCGCAGCCCTGCAGAGT
GCTGGGGTTGTGGTCAGCATGTCCCCAGCACAGCTGGGAACCACCATGTACAAGGAGTTT
GAAAAGAGGAAGATGCTCTGA
Enzyme 6 GenBank Gene ID BT021529 Link Image
Enzyme 6 GeneCard ID SUCLG1 Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Chromosome:2
Enzyme 6 Locus 2p11.2
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References
  1. [PubMed Link Image]
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 627
Enzyme 7 Name Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
Enzyme 7 Synonyms
  1. GTP-specific succinyl-CoA synthetase subunit beta
  2. Succinyl-CoA synthetase beta-G chain
  3. SCS-betaG
Enzyme 7 Gene Name SUCLG2
Enzyme 7 Protein Sequence >Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
MAAPVGAQARKLLRDLVLRPPLLAARSQVVQLTSRRWLNLQEYQSKKLMSDNGVKVQRFF
VADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFSSGLKGGVHLTKDPKVVGQLAKQM
IGYNLATKQTPKEGVKVKKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEV
AASNPELIFKEQIDIIEGIKDSQAQRMAENLGFLGPLKNQAADQIKKLYNLFLKIDATQV
EVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAARYDLKYIGLD
GNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKESQVYQAFKLLTADPKVEAILV
NIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVHEAQNILSNSGLPITSAVDLED
AAKKAVASVAKK
Enzyme 7 Number of Residues 432
Enzyme 7 Molecular Weight 46690.6
Enzyme 7 Theoretical pI 7.76
Enzyme 7 GO Classification
Function
Process
Component
Enzyme 7 General Function Energy production and conversion
Enzyme 7 Specific Function GTP + succinate + CoA = GDP + phosphate + succinyl-CoA
Enzyme 7 Pathways
  • Carbohydrate metabolism
  • tricarboxylic acid cycle
Enzyme 7 Reactions Not Available
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • None
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein 75773452 Link Image
Enzyme 7 UniProtKB/Swiss-Prot ID Q3MHX5 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name SUCB2_BOVIN Link Image
Enzyme 7 PDB ID 1EUC Link Image
Enzyme 7 PDB File Show
Enzyme 7 3D Structure
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence >1299 bp
ATGGCGGCCCCCGTGGGAGCGCAGGCCCGGAAACTTCTGAGAGACCTGGTGCTCCGGCCC
CCGCTCCTGGCGGCCAGGTCCCAGGTGGTTCAATTAACATCCAGAAGATGGCTGAACCTG
CAGGAATACCAGAGTAAGAAATTAATGTCTGACAACGGAGTGAAAGTTCAAAGATTCTTT
GTTGCCGACACTGCCAATGAAGCTCTGGAGGCTGCTAAGAGACTAAATGCAAAAGAAATT
GTTTTAAAAGCCCAGATCTTAGCTGGCGGAAGAGGAAAAGGTGTCTTCAGTAGCGGTTTG
AAAGGAGGCGTTCATTTAACAAAAGACCCTAAAGTTGTGGGACAGCTGGCTAAACAGATG
ATTGGATATAATCTAGCAACAAAACAAACTCCAAAAGAAGGTGTGAAAGTTAAAAAGGTG
ATGGTTGCTGAAGCCCTGGACATTTCCAGGGAAACCTACTTGGCCATTCTGATGGACCGG
TCCTGCAATGGCCCTGTGCTGGTGGGCAGCCCTCAGGGGGGCGTTGACATTGAAGAGGTG
GCAGCTTCGAATCCAGAACTTATTTTTAAGGAGCAAATTGACATTATTGAAGGGATAAAG
GACAGCCAAGCTCAGCGGATGGCGGAAAATCTAGGCTTCCTTGGGCCTTTGAAAAACCAG
GCTGCAGATCAAATTAAGAAGCTGTACAATCTCTTCCTGAAAATTGATGCTACTCAGGTG
GAAGTGAATCCCTTTGGTGAAACTCCAGAAGGACAAGTTGTCTGTTTTGATGCCAAGATA
AACTTTGATGACAACGCAGAATTCCGACAAAAGGATATATTTGCTATGGATGACAAATCA
GAGAATGAGCCCATTGAAAATGAAGCTGCCAGATATGATCTAAAATACATAGGACTGGAT
GGGAACATTGCCTGTTTTGTTAATGGTGCTGGACTCGCCATGGCTACCTGTGACATCATT
TTCCTGAATGGTGGGAAGCCAGCCAACTTTTTGGATCTTGGTGGTGGTGTAAAGGAATCT
CAAGTATATCAAGCATTCAAATTACTCACAGCTGATCCTAAGGTTGAAGCCATCCTAGTC
AATATTTTTGGTGGAATTGTCAACTGTGCCATCATTGCCAATGGGATCACCAAAGCCTGC
CGGGAGCTGGAGCTCAAGGTGCCACTGGTGGTCCGGCTTGAAGGAACCAACGTCCACGAG
GCCCAGAACATTCTCAGTAACAGCGGACTCCCCATCACTTCAGCTGTCGACCTGGAGGAT
GCAGCCAAGAAAGCTGTTGCCAGTGTGGCTAAGAAGTGA
Enzyme 7 GenBank Gene ID BC104559 Link Image
Enzyme 7 GeneCard ID SUCLG2 Link Image
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Chromosome:3
Enzyme 7 Locus 3p14.1
Enzyme 7 SNPs SNPJam Report Link Image
Enzyme 7 General References Not Available
Enzyme 7 Metabolite References Not Available
Enzyme 8 [top]
Enzyme 8 ID 668
Enzyme 8 Name Prolyl 4-hydroxylase subunit alpha-1
Enzyme 8 Synonyms
  1. 4-PH alpha-1
  2. Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
Enzyme 8 Gene Name P4HA1
Enzyme 8 Protein Sequence >Prolyl 4-hydroxylase subunit alpha-1
MIWYILVVGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
FPNDEDQVGAAKALLRLQDTYNLDTDTISKGDLPGVKHKSFLTVEDCFELGKVAYTEADY
YHTELWMEQALRQLDEGEVSTVDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
ANGNLKYFEYIMAKEKDANKSSSDDQSDQKTTLKKKGAAVDYLPERQKYEMLCRGEGIKM
TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEVVKDLAKPRL
RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY
GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVLAGGATVFPEVGASVWPKKG
TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
Enzyme 8 Number of Residues 534
Enzyme 8 Molecular Weight 61009.7
Enzyme 8 Theoretical pI 5.70
Enzyme 8 GO Classification
Function
Process
Component
Enzyme 8 General Function Involved in iron ion binding
Enzyme 8 Specific Function Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins
Enzyme 8 Pathways Not Available
Enzyme 8 Reactions Not Available
Enzyme 8 Pfam Domain Function
Enzyme 8 Signals
  • 1-17
Enzyme 8 Transmembrane Regions
  • None
Enzyme 8 Essentiality Not Available
Enzyme 8 GenBank ID Protein 92097479 Link Image
Enzyme 8 UniProtKB/Swiss-Prot ID Q1RMU3 Link Image
Enzyme 8 UniProtKB/Swiss-Prot Entry Name P4HA1_BOVIN Link Image
Enzyme 8 PDB ID 1TJC Link Image
Enzyme 8 PDB File Show
Enzyme 8 3D Structure
Enzyme 8 Cellular Location Not Available
Enzyme 8 Gene Sequence >1605 bp
ATGATCTGGTATATTTTAGTTGTAGGGATTCTACTTCCCCAGTCTTTGGCCCATCCAGGC
TTTTTTACTTCTATTGGTCAGATGACTGATTTGATTCATACTGAAAAAGATCTGGTGACT
TCCCTGAAAGACTATATAAAGGCAGAAGAGGACAAATTAGAACAAATAAAAAAATGGGCA
GAGAAATTAGATCGATTAACCAGCACAGCGACAAAAGATCCAGAAGGATTTGTTGGACAC
CCTGTAAATGCATTCAAATTAATGAAACGTCTGAACACTGAGTGGAGTGAGTTGGAGAAT
CTGGTCCTTAAGGATATGTCAGATGGTTTTATCTCTAACCTAACCATTCAGAGACAGTAC
TTCCCTAATGATGAAGATCAGGTTGGGGCAGCCAAAGCTCTGTTGCGTCTACAGGACACC
TACAATTTGGATACAGATACCATCTCAAAGGGTGATCTTCCAGGAGTAAAACACAAATCT
TTTCTAACAGTTGAGGACTGTTTTGAGTTGGGCAAAGTGGCCTACACAGAAGCAGATTAT
TACCATACAGAGCTGTGGATGGAACAAGCACTGAGGCAGCTGGATGAAGGCGAGGTTTCT
ACCGTTGATAAAGTCTCTGTTCTGGATTATTTGAGCTATGCAGTATACCAGCAGGGAGAC
CTGGATAAGGCGCTTTTGCTCACAAAGAAGCTTCTTGAACTAGATCCTGAACATCAGAGA
GCTAACGGTAACTTAAAATACTTTGAGTATATAATGGCTAAAGAAAAAGATGCCAATAAG
TCTTCTTCAGATGACCAATCTGATCAGAAAACCACACTGAAGAAGAAAGGTGCTGCTGTG
GATTACCTGCCAGAGAGACAGAAGTACGAAATGCTGTGCCGTGGGGAGGGTATCAAAATG
ACTCCTCGGAGACAGAAAAAACTCTTCTGTCGCTACCATGATGGAAACCGGAATCCTAAA
TTTATCCTGGCTCCAGCCAAACAGGAGGATGAGTGGGACAAGCCTCGTATTATCCGCTTC
CATGATATTATTTCTGATGCAGAAATTGAAGTCGTTAAAGATCTAGCAAAACCAAGGCTG
AGGCGAGCCACCATTTCAAACCCAATAACAGGAGACTTGGAGACGGTACATTACAGAATT
AGCAAAAGTGCCTGGCTGTCTGGCTATGAAAACCCTGTGGTGTCACGAATTAATATGAGA
ATCCAAGATCTGACAGGACTAGATGTCTCCACAGCAGAGGAATTACAGGTAGCAAATTAT
GGAGTTGGAGGACAGTATGAACCCCATTTTGATTTTGCACGGAAAGATGAGCCAGATGCT
TTCAAAGAGCTGGGGACAGGAAATAGAATTGCTACATGGCTGTTTTATATGAGTGATGTG
TTAGCAGGAGGAGCCACTGTTTTTCCTGAAGTAGGAGCTAGTGTTTGGCCCAAAAAGGGA
ACTGCTGTTTTCTGGTATAATCTGTTTGCCAGTGGAGAAGGAGATTATAGTACACGGCAT
GCAGCCTGTCCAGTGCTGGTTGGAAACAAATGGGTATCCAATAAATGGCTCCATGAACGT
GGACAGGAATTTCGAAGACCATGCACCTTGTCAGAATTGGAATGA
Enzyme 8 GenBank Gene ID BC114708 Link Image
Enzyme 8 GeneCard ID P4HA1 Link Image
Enzyme 8 GenAtlas ID Not Available
Enzyme 8 HGNC ID Not Available
Enzyme 8 Chromosome Location Chromosome:1
Enzyme 8 Locus 10q21.3-q23.1
Enzyme 8 SNPs SNPJam Report Link Image
Enzyme 8 General References Not Available
Enzyme 8 Metabolite References Not Available
Enzyme 9 [top]
Enzyme 9 ID 682
Enzyme 9 Name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Enzyme 9 Synonyms
  1. Lysyl hydroxylase 1
  2. LH1
Enzyme 9 Gene Name PLOD1
Enzyme 9 Protein Sequence >Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
MRLLLLLAPLGWLLLAETKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGL
GEDWPGEAMLAGGGLKVRLLKKALEKHADKENLVILFTDSYDVVFASGPRELLKKFRQAR
SQVVFSAEELIYPDRRLEAKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQL
FYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEVVLKFEMGQVRARNLAYDTLPVLIH
GNGPTKLQLNYLGNYIPRFWTFETGCAVCDEGLRSLKGIGDEALPAVLVGVFIEQPTPFL
SLFFQRLLRLHYPQKRLRLFIHNHEQHHKAQVEQFLAEHGDEYQSVKLVGPEVRVANADA
RNMGADLCRQDRGCTYYFSVDADVALTEPKTLRLLIEQNKNVIAPLMTRHGRLWSNFWGA
LSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRAELQETDLFHHSKLDPDM
AFCANIRQQDVFMFLTNRHSFGHLLSLDSYQTTHLHNDLWEVFSNPEDWKEKYIHENYTK
ALAGKMVEMPCPDVYWFPIFTETACDELVEEMEHYGQWSLGDNKDNRIQGGYENVPTIDI
HMNQINFEREWHKFLVEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLVPHHDAST
FTINIALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTKGTRYIA
VSFVDP
Enzyme 9 Number of Residues 726
Enzyme 9 Molecular Weight 83486.6
Enzyme 9 Theoretical pI 6.61
Enzyme 9 GO Classification
Function
Process
Component
Enzyme 9 General Function Involved in iron ion binding
Enzyme 9 Specific Function Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links
Enzyme 9 Pathways Not Available
Enzyme 9 Reactions Not Available
Enzyme 9 Pfam Domain Function
Enzyme 9 Signals
  • 1-18
Enzyme 9 Transmembrane Regions
  • None
Enzyme 9 Essentiality Not Available
Enzyme 9 GenBank ID Protein 3283055 Link Image
Enzyme 9 UniProtKB/Swiss-Prot ID O77588 Link Image
Enzyme 9 UniProtKB/Swiss-Prot Entry Name PLOD1_BOVIN Link Image
Enzyme 9 PDB ID Not Available
Enzyme 9 Cellular Location Not Available
Enzyme 9 Gene Sequence >2181 bp
ATGCGGCTCCTGCTGCTCCTGGCCCCGTTGGGCTGGCTGCTTCTAGCCGAAACGAAGGGT
GACGCCAAGCCGGAGGACAACCTTTTGGTCCTCACTGTGGCTACGAAGGAGACCGAGGGG
TTCCGACGCTTTAAGCGCTCAGCTCAGTTCTTCAACTACAAGATCCAGGCGCTGGGGCTG
GGGGAGGACTGGCCTGGGGAGGCGATGTTGGCAGGCGGTGGGCTGAAGGTCCGGCTATTG
AAGAAAGCCCTGGAGAAGCACGCCGACAAGGAGAACCTGGTCATTCTCTTCACAGACAGC
TATGATGTGGTATTTGCCTCGGGGCCCCGAGAGCTCCTGAAGAAGTTCCGGCAGGCCAGG
AGCCAGGTGGTCTTCTCGGCCGAGGAGCTCATCTACCCGGACCGCAGGCTGGAGGCCAAT
TACCCGGTGGTGTCCGACGGCAAGAGGTTCCTGGGCTCTGGAGGCTTCATCGGTTATGCT
CCCAACCTTATCAAACTGGTGGCAGAGTGGGAAGGCCAGGACAGCGACAGCGATCAGCTC
TTTTACACCAAGATCTTCTTGGACCCAGAGAAGAGGGAGCAGATCAATATCACCCTGGAC
CACCGTTGCCGAATCTTCCAGAATTTCCATGGAGCCTTGGATGAGGTCGTGCTCAAGTTT
GAAATGGGCCAAGTGAGAGCGAGGAACCTGGCCTACGACACCCTCCCAGTCCTGATTCAT
GGCAACGGGCCCACCAAGCTGCAGCTGAACTACTTGGGCAACTACATCCCGCGCTTCTGG
ACCTTCGAGACGGGGTGCGCTGTGTGTGACGAGGGCCTGCGCAGCCTCAAGGGCATCGGG
GATGAAGCTCTGCCTGCTGTTCTGGTCGGCGTGTTCATCGAACAGCCCACCCCGTTCCTG
TCCCTGTTCTTCCAGCGGCTCTTGCTCCTCCACTACCCCCAAAAACGGTTCAGGCTTTTC
ATTCACAACCACGAGCAGCACCACAAGGCTCAGGTGGAGCAGTTCCTGGCAGAGCACGGC
GATGAGTACCAGTCTGTGAAACTGGTGGGCCCCGAGGTGCGGGTGGCCAACGCAGACGCC
AGGAACATGGGCGCGGACTTGTGCCGGCAGGACCGTGGCTGCACTTACTACTTCAGCGTG
GATGCCGACGTGGCCCTGACTGAGCCCAAAACCCTGCGGCTGCTGATCGAGCAGAACAAG
AACGTTATCACCCCATTGATGACCCGCCATGGGAGGCTGTGGTCGAACTTCTGGGGGGCA
CTGAGTGCAGATGGCTACTACGCCCGCTCCGAGGACTACGTGGACATCGTGCAGGGGCGG
CGTGTGGGTGTCTGGAATGTACCCTACATCTCAAACATCTACCTGATCAAGGGTAGCGCC
CTGCGGGCTGAGTTGCAGGAGACAGACCTGTTCCACCACAGCAAGCTGGACCCCGACATG
GCCTTCTGTGCCAACATCCGGCAGCAGGATGTGTTCATGTTCCTGACCAACCGGCACTCC
TTTGGCCACCTGCTCTCCCTGGACAGCTACCAGACCACCCACCTCCACAACGACCTCTGG
GAGGTGTTCAGCAACCCCGAGGACTGGAAGGAGAAATACATCCATGAGAACTACACCAAG
GCCTTGGCGGGGAAGATGGTGGAGATGCCTTGCCCGGACGTCTACTGGTTCCCCATCTTC
ACGGAGACGGCCTGTGATGAGCTGGTGGAAGAGATGGAGCACTACGGCCAGTGGTCCCTG
GGAGATAACAAGGACAACCGCATCCAGGGTGGCTACGAAAACGTGCCAACCATCGACATC
CACATGAACCAGATCAACTATGAGCGGGAGTGGCACAAGTTCCTGGTGGAGTACATCGCC
CCCATGACGGAGAAACTCTACCCGGGCTACTACACCAGGGCCCAATTCGACCTGGCCTTT
GTCGTCCGCTACAAGCCTGATGAGCAGCCCTCGCTGGTGCCACACCACGACGCCTCCACC
TTCACCATCAACATCGGCCTGAACCGGGTTGGAGTGGATTATGAGGGCGGGGGGTGTCGG
TTCCTGCGCTACAACTGCTCCATCCGAGCCCCACGGAAGGGCTGGACCCTGATGCACCCC
GGGCGACTCACGCACTACCACGAGGGGGTCCCCACCACCAAAGGCACCCGCTACATCGCA
GTCTCCTTCGTCGATCCCTAA
Enzyme 9 GenBank Gene ID AF054274 Link Image
Enzyme 9 GeneCard ID PLOD1 Link Image
Enzyme 9 GenAtlas ID Not Available
Enzyme 9 HGNC ID Not Available
Enzyme 9 Chromosome Location Chromosome:1
Enzyme 9 Locus 1p36.22
Enzyme 9 SNPs SNPJam Report Link Image
Enzyme 9 General References
  1. [PubMed Link Image]
Enzyme 9 Metabolite References Not Available
Enzyme 10 [top]
Enzyme 10 ID 688
Enzyme 10 Name Phytanoyl-CoA dioxygenase, peroxisomal
Enzyme 10 Synonyms
  1. Phytanoyl-CoA alpha-hydroxylase
  2. PhyH
  3. Phytanic acid oxidase
Enzyme 10 Gene Name PHYH
Enzyme 10 Protein Sequence >Phytanoyl-CoA dioxygenase, peroxisomal
MDRNRASARLTVLLRHLGCRSAGTIIAHHTSGVGSLASFHPQQFQYTRENNVLSLEQRKF
YEENGFLVIKNLVSDADIQRFRNEFERICRKEVKPLGLSVMRDVTITKSEYVPSEKVVSK
VQDFQEDEELFRYCTLPEILKYVECFTGPNIMAMHTMLINKPPDSGKKTSRHPLHQDLHY
FPFRPSNSIVCAWTAMEHIDRNNGCLVVLPGTHKGPLQPHDYPQWEGGVNIMFHGIQDYD
KNNARVHLVMEKGDTVFFHPLLIHGSGRNKSQGFRKAISCHFADANCHYIDVEGTSQENI
EKEVVDIVRKKYGFKDVTLKDVWTFRGRVVKGERINL
Enzyme 10 Number of Residues 337
Enzyme 10 Molecular Weight 38770.1
Enzyme 10 Theoretical pI 8.56
Enzyme 10 GO Classification
Function
Process
Component
Enzyme 10 General Function Involved in iron ion binding
Enzyme 10 Specific Function Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA
Enzyme 10 Pathways
  • Lipid metabolism
  • fatty acid metabolism
Enzyme 10 Reactions Not Available
Enzyme 10 Pfam Domain Function
Enzyme 10 Signals
  • None
Enzyme 10 Transmembrane Regions
  • None
Enzyme 10 Essentiality Not Available
Enzyme 10 GenBank ID Protein 2307006 Link Image
Enzyme 10 UniProtKB/Swiss-Prot ID O18778 Link Image
Enzyme 10 UniProtKB/Swiss-Prot Entry Name PAHX_BOVIN Link Image
Enzyme 10 PDB ID Not Available
Enzyme 10 Cellular Location Not Available
Enzyme 10 Gene Sequence >1014 bp
ATGGACCGAAACCGANCTTCCGCGCGCTTGACTGTCTTGCTGCGACACCTCGGTTGCCGC
TCGGCCGGGACCATTATAGCTCACCACACTTCGGGGGTTGGTTCTCTTGCCAGTTTCCAT
CCTCAACAATTCCAGTATACCCGGGAGAATAATGTTCTAAGCCTAGAACAGAGAAAATTT
TATGAAGAAAATGGATTTCTTGTCATTAAAAATTTGGTGTCTGATGCTGATATTCAACGC
TTTAGGAATGAGTTTGAAAGAATCTGCAGAAAGGAGGTGAAACCATTGGGATTGTCGGTG
ATGAGAGATGTCACCATCACAAAATCAGAATATGTGCCAAGTGAGAAAGTGGTTTCCAAG
GTCCAGGATTTCCAAGAAGATGAGGAACTCTTCAGATACTGCACCCTCCCTGAGATTCTG
AAATATGTGGAGTGCTTCACTGGACCCAATATTATGGCCATGCATACAATSCTGATAAAC
AAACCTCCAGATTCTSGAAAGAAGACATCCCGTCATCCCTTGCACCAGGATCTGCACTAT
TTCCCCTTCAGGCCCAGCAATAGCATCGTTTGTGCCTGGACAGCCATGGAGCACATTGAC
CGGAACAATGGCTGTCTGGTTGTGCTCCCAGGGACACACAAAGGCCCCTTGCAACCCCAT
GATTATCCCCAGTGGGAGGGAGGAGTCAACATCATGTTCCACGGGATCCAGGACTATGAC
AAAAACAATGCCCGTGTGCACTTGGTGATGGAGAAGGGAGACACCGTCTTCTTTCACCCT
TTGCTCATCCATGGATCTGGTCGGAACAAAAGTCAAGGATTCCGGAAGGCAATTTCCTGC
CATTTTGCGGATGCCAACTGTCACTACATAGATGTGGAGGGCACCAGTCAAGAAAACATT
GAAAAGGAAGTTGTTGATATAGTCAGGAAAAAGTATGGATTTAAAGACGTCACTCTGAAG
GATGTTTGGACATTTCGAGGGCGTGTTGTGAAAGGAGAAAGAATCAACCTTTGA
Enzyme 10 GenBank Gene ID AF011925 Link Image
Enzyme 10 GeneCard ID PHYH Link Image
Enzyme 10 GenAtlas ID Not Available
Enzyme 10 HGNC ID Not Available
Enzyme 10 Chromosome Location Chromosome:1
Enzyme 10 Locus 10p13
Enzyme 10 SNPs SNPJam Report Link Image
Enzyme 10 General References Not Available
Enzyme 10 Metabolite References Not Available
Enzyme 11 [top]
Enzyme 11 ID 691
Enzyme 11 Name Prolyl 4-hydroxylase subunit alpha-3
Enzyme 11 Synonyms
  1. 4-PH alpha-3
  2. Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3
Enzyme 11 Gene Name P4HA3
Enzyme 11 Protein Sequence >Prolyl 4-hydroxylase subunit alpha-3
MGPAARLAALLAVLAFRAGDPAEVAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEA
RLRDLTRFYHKVLSLHEDSATPVSNPLLAFTLIKRLQSDWKNVVHSLEASENIRALKDGY
ERVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAVTDLYSPRRLFSLT
GDDCFQVGKVAYDMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFQA
GNVLCALNLSREFLLYSPDNKRVARNVLKYEKLLAESPNQAVAETVMQRPNVPHLQTRDT
YEGLCQTLGSQPTHYRIPSLYCSYETSSSPYLLLQPVRKEVIHLEPYVVLYHDFVSDAEA
QTIRGLAEPWLQRSVVASGEKQLPVEYRISKSAWLKDTVDPVLVTLDHRIAALTGLDVQP
PYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMNSGNRVATFMIYLSSVEAGGATAFIY
GNFSVPVVKNAALFWWNLHRSGEGDGDTLHAACPVLVGDKWVANKWIHEYGQEFRRPCSS
RPED
Enzyme 11 Number of Residues 544
Enzyme 11 Molecular Weight 61022.6
Enzyme 11 Theoretical pI 6.31
Enzyme 11 GO Classification
Function
Process
Component
Enzyme 11 General Function Involved in iron ion binding
Enzyme 11 Specific Function Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins
Enzyme 11 Pathways Not Available
Enzyme 11 Reactions Not Available
Enzyme 11 Pfam Domain Function
Enzyme 11 Signals
  • 1-19
Enzyme 11 Transmembrane Regions
  • None
Enzyme 11 Essentiality Not Available
Enzyme 11 GenBank ID Protein 47115494 Link Image
Enzyme 11 UniProtKB/Swiss-Prot ID Q75UG4 Link Image
Enzyme 11 UniProtKB/Swiss-Prot Entry Name P4HA3_BOVIN Link Image
Enzyme 11 PDB ID Not Available
Enzyme 11 Cellular Location Not Available
Enzyme 11 Gene Sequence >1635 bp
ATGGGCCCCGCAGCGCGGCTGGCGGCGCTGTTGGCGGTGCTGGCGTTCCGGGCAGGGGAC
CCAGCCGAGGTCGCGGCGCGCGGGGACACGTTCTCGGCGCTGACCAGTGTGGCGCGCGCC
CTGGCGCCCGAGCGCCGGCTGCTGGGACTGCTGCGGCGCTACCTGCGCGGGGAGGAGGCG
CGGCTGCGGGACCTGACCAGATTCTATCACAAGGTGCTATCTTTACATGAAGATTCAGCA
ACCCCTGTGTCTAACCCTCTGCTTGCATTTACTCTCATCAAACGCCTACAGTCTGACTGG
AAGAATGTGGTACATAGTCTGGAGGCCAGTGAGAACATCCGAGCTCTCAAGGATGGTTAT
GAGAGGGTGGAGCAGGACCTGCCAGCCTTTGAGGACCTCGAGGGAGCAGCAAGGGCCCTG
ATGCGGCTGCAGGACGTGTACATGCTCAATGTGAAGGGACTTGCCCGAGGCGTCTTCCAG
AGAGTCACAGGCTCTGCTGTCACTGACTTGTATAGTCCCAGGCGACTTTTCTCCCTCACC
GGGGATGACTGCTTCCAAGTTGGCAAGGTGGCCTATGACATGGGGGATTACTACCATGCC
ATTCCATGGCTGGAGGAGGCCGTCAGTCTCTTCCGAGGCTCTTATGGAGAATGGAAGACA
GAGGATGAGGCAAGTCTTGAGGATGCCTTGGATCACCTGGCCTTCGCCTATTTCCAGGCA
GGAAATGTTTTGTGTGCCCTCAACCTTTCCCGGGAGTTTCTTCTGTACAGCCCAGATAAT
AAAAGGGTGGCCAGAAATGTCTTGAAGTATGAAAAGCTCTTGGCAGAGAGCCCTAACCAG
GCTGTAGCAGAGACTGTCATGCAGAGACCCAATGTGCCCCACCTGCAGACCAGGGACACC
TACGAGGGGTTATGTCAGACCCTGGGTTCCCAGCCTACTCACTACCGGATCCCCAGCCTC
TACTGCTCCTATGAGACCAGTTCCAGTCCTTACCTGCTGCTCCAGCCTGTGCGGAAGGAG
GTCATCCACCTGGAGCCCTATGTTGTTCTCTACCATGACTTTGTCAGTGACGCCGAGGCT
CAGACGATCAGAGGGCTTGCGGAACCATGGTTACAGAGATCCGTGGTGGCGTCAGGTGAA
AAGCAGTTACCAGTGGAGTACCGCATCAGCAAGAGTGCCTGGCTGAAGGACACTGTTGAC
CCAGTGCTGGTGACCCTTGACCATCGCATTGCTGCCCTCACGGGCCTTGATGTCCAGCCT
CCCTACGCAGAGTATCTCCAGGTGGTGAACTATGGAATTGGAGGGCACTATGAGCCTCAC
TTTGACCATGCTACGTCACCAAGCAGCCCACTGTACAGAATGAACTCTGGGAACCGGGTC
GCAACATTTATGATCTATTTGAGCTCGGTGGAAGCCGGAGGAGCCACAGCCTTCATCTAC
GGCAACTTCAGCGTTCCTGTGGTCAAGAATGCAGCACTCTTTTGGTGGAACCTGCATAGG
AGTGGTGAAGGGGATGGTGACACACTTCATGCTGCCTGCCCTGTCCTGGTAGGAGATAAA
TGGGTGGCCAACAAGTGGATACACGAGTATGGACAGGAATTCCGCAGACCCTGCAGCTCG
AGACCTGAAGACTAA
Enzyme 11 GenBank Gene ID AB126035 Link Image
Enzyme 11 GeneCard ID P4HA3 Link Image
Enzyme 11 GenAtlas ID Not Available
Enzyme 11 HGNC ID Not Available
Enzyme 11 Chromosome Location Chromosome:1
Enzyme 11 Locus 11q13.4
Enzyme 11 SNPs SNPJam Report Link Image
Enzyme 11 General References Not Available
Enzyme 11 Metabolite References Not Available