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Bovine Rumen Metabolome Database



Showing metabocard for L-Arginine (RMDB00517)

Legend: metabolite field enzyme field

Version 1.0
Creation Date 2005-11-16 15:48:42
Update Date 2009-08-07 15:25:07
Accession Number RMDB00517
Common Name L-Arginine
Description Arginine is an essential amino acid that is physiologically active in the L-form. In mammals, arginine is formally classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. Infants are unable to effectively synthesize arginine, making it nutritionally essential for infants. Adults, however, are able to synthesize arginine in the urea cycle. Arginine can be considered to be a basic amino acid as the part of the side chain nearest to the backbone is long, carbon-containing and hydrophobic, whereas the end of the side chain is a complex guanidinium group. With a pKa of 12.48, the guanidinium group is positively charged in neutral, acidic and even most basic environments. Because of the conjugation between the double bond and the nitrogen lone pairs, the positive charge is delocalized. This group is able to form multiple H-bonds. L-arginine is an amino acid that has numerous functions in the body. It helps dispose of ammonia, is used to make compounds such as nitric oxide, creatine, L-glutamate, L-proline, and it can be converted to glucose and glycogen if needed. In large doses, L-arginine also stimulates the release of hormones growth hormone and prolactin. It is found in plant and animal proteins, such as dairy products, meat, poultry, fish, and nuts. The ratio of L-arginine to lysine is also important - soy and other plant proteins have more L-arginine than animal sources of protein. Detoxargin Argamine Argivene Levargin Minophagen A
Synonyms
  1. (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate
  2. (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid
  3. 2-amino-5-guanidinovalerate
  4. 2-amino-5-guanidinovaleric acid
  5. 5-[(aminoiminomethyl)amino]-L-Norvaline
  6. Arginine
  7. L-(+)-Arginine
  8. L-a-Amino-d-guanidinovalerate
  9. L-a-Amino-d-guanidinovaleric acid
  10. N5-(aminoiminomethyl)-L-Ornithine
  11. L-alpha-Amino-delta-guanidinovalerate
  12. L-alpha-Amino-delta-guanidinovaleric acid
  13. (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoic acid
  14. (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoate
Chemical IUPAC Name (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid
Chemical Formula C6H14N4O2
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Amino acids and Amino Acid conjugates
Class
  • Amino Acids
Sub Class
  • NA
Family
  • Mammalian_Metabolite
Species
  • primary amine; primary aliphatic amine (alkylamine); carboxylic acid; guanidine; alpha-aminoacid
Biofunction
  • Essential amino acids; semi-essential amino acids; Essential amino acid; Component of Alanine and aspartate metabolism; Component of Aminoacyl-tRNA biosynthesis; Component of Arginine and proline metabolism; Component of Glycine, serine and threonine metabolism
Application
Source
  • Exogenous
Average Molecular Weight 174.201
Monoisotopic Molecular Weight 174.111679
Isomeric SMILES N[C@@H](CCCN=C(N)N)C(O)=O
Canonical SMILES NC(CCCN=C(N)N)C(O)=O
KEGG Compound ID C00062 Link Image
BioCyc ID ARG Link Image
BiGG ID 33707 Link Image
Wikipedia Link L-Arginine Link Image
METLIN ID 5502 Link Image
PubChem Compound 6322 Link Image
PubChem Substance 10318557 Link Image
ChEBI ID 16467 Link Image
CAS Registry Number 74-79-3
InChI Identifier InChI=1/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
Synthesis Reference Meyer, Helmut E.; Swiderek, Kristine; Hoffmann-Posorske, Edeltraut; Korte, Horst; Heilmeyer, Ludwig M. G., Jr. Quantitative determination of phosphoserine by high-performance liquid chromatography as the phenylthiocarbamyl-S-ethylcysteine. Application to
Melting Point (Experimental) 222 oC
Experimental Water Solubility 182 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]; 182.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)] Source: PhysProp
Predicted Water Solubility 7.59 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 1
State Solid
Experimental LogP/Hydrophobicity -4.20 [HANSCH,C ET AL. (1995)] Source: PhysProp
Predicted LogP/Hydrophobicity -3.6 [Predicted by PubChem via XLOGP]; -3.87 [Predicted by ALOGPS] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show Link Image
SDF File Show Link Image
PDB File Show Link Image
2D Structure
3D Structure
Experimental PDB ID 1FOL Link Image
Experimental PDB File Show
Experimental PDB Structure
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum
Low Energy
Download File
Show Experimental Conditions Link Image
Medium Energy
Download File
Show Experimental Conditions Link Image
High Energy
Download File
Show Experimental Conditions Link Image
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Cytoplasm
  • Extracellular
  • mitochondria
Biofluid Location
  • Blood
  • Cow_Milk
  • Rumen
Tissue Location
Concentrations (Normal)
Biofluid Rumen
Value 18.84 +/- 14.13 uM
Age 4-5 years old
Sex Female (lactating)
Condition Normal (0% barley grain in dry matter (DM) basis)
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 160.5 +/- 4.9 uM
Age N/A
Sex Female
Condition Normal
Breed Not Available
Experimental Condition Not Available
Comments Not Available
References
  • Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows. Burim N. Ametaj, Qendrim Zebeli, Fozia Saleem, Nikolaos Psychogios, Michael J. Lewis, Suzanna M. Dunn, Jianguo Xia and David S. Wishart Metabolomics 2010;6(4):583-594
Concentrations (Abnormal)
Biofluid Rumen
Value 14 +/- 7. uM
Age 4-5 years old
Sex Female (lactating)
Condition 15% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 20 +/- 10 uM
Age 4-5 years old
Sex Female (lactating)
Condition 30% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 44.5 +/- 35.6 uM
Age 4-5 years old
Sex Female (lactating)
Condition 45% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Pathway Names Not Available
HMDB Pathways Not Available
KEGG Pathways Not Available
SimCell Pathways Not Available
General References
  1. Wikipedia Link Image
Metabolic Enzymes
  1. Nitric oxide synthase, endothelial
  2. Nitric oxide synthase, inducible
  3. 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
  4. [Protein ADP-ribosylarginine] hydrolase
  5. Argininosuccinate lyase
  6. Carboxypeptidase E
  7. Arginase-1
  8. Carboxypeptidase B
  9. Probable arginyl-tRNA synthetase, mitochondrial
  10. Glycine amidinotransferase, mitochondrial
  11. Inducible nitric oxid synthase
  12. Arginase-2, mitochondrial
Enzyme 1 [top]
Enzyme 1 ID 22
Enzyme 1 Name Nitric oxide synthase, endothelial
Enzyme 1 Synonyms
  1. Endothelial NOS
  2. eNOS
  3. EC-NOS
  4. NOS type III
  5. NOSIII
  6. Constitutive NOS
  7. cNOS
Enzyme 1 Gene Name NOS3
Enzyme 1 Protein Sequence >Nitric oxide synthase, endothelial
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPT
LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRCCLGSLVLPRKLQTRPSPGPP
PAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR
GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE
APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM
STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV
DHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD
PWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA
AAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT
ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG
GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR
RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVA
VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI
APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS
REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME
LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP
DTPGP
Enzyme 1 Number of Residues 1205
Enzyme 1 Molecular Weight 133285.5
Enzyme 1 Theoretical pI 6.92
Enzyme 1 GO Classification
Function
Process
Component
Enzyme 1 General Function Inorganic ion transport and metabolism
Enzyme 1 Specific Function Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets
Enzyme 1 Pathways Not Available
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 163422 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID P29473 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name NOS3_BOVIN Link Image
Enzyme 1 PDB ID 1FOL Link Image
Enzyme 1 PDB File Show
Enzyme 1 3D Structure
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >3618 bp
ATGGGCAACTTGAAGAGTGTGGGCCAGGAGCCCGGGCCCCCCTGCGGCCTGGGGCTGGGG
CTGGGCCTCGGGCTATGCGGCAAGCAGGGCCCAGCCTCCCCGGCACCTGAGCCCAGCCGG
GCCCCCGCACCCGCCACCCCGCACGCGCCAGACCACAGCCCAGCTCCCAACAGCCCCACG
CTGACCCGGCCTCCGGAGGGGCCCAAGTTCCCTCGCGTGAAGAACTGGGAGCTGGGGAGC
ATCACCTACGACACTCTGTGCGCGCAGTCCCAACAGGACGGGCCCTGCACTCCCAGGTGC
TGCCTGGGCTCCCTGGTGTTGCCCCGGAAACTGCAGACCCGGCCCTCCCCGGGACCTCCA
CCCGCTGAGCAGCTGCTGAGCCAGGCCAGGGACTTCATCAACCAGTACTACAGCTCCATC
AAGAGGAGCGGCTCCCAGGCTCACGAGGAGCGGCTTCAGGAGGTGGAGGCCGAGGTGGCA
TCCACGGGCACCTACCACCTCCGAGAGAGCGAGCTGGTGTTCGGGGCCAAGCAGGCCTGG
CGCAACGCACCCCGCTGCGTGGGCCGCATCCAGTGGGGGAAGCTGCAGGTGTTTGATGCC
CGGGACTGCAGCTCAGCACAGGAGATGTTCACCTACATCTGCAACCACATCAAGTACGCC
ACCAACCGCGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCGCCCCGGGCCGC
GGAGACTTCCGGATCTGGAACAGCCAGCTGGTGCGCTACGCAGGCTACAGACAGCAGGAT
GGCTCTGTGCGTGGGGACCCAGCCAATGTGGAGATCACGGAGCTCTGCATCCAGCACGGC
TGGACCCCCGGAAACGGCCGCTTCGACGTGCTGCCCCTGCTGCTCCAGGCCCCAGACGAG
GCTCCAGAGCTCTTTGTTCTGCCCCCCGAGCTGGTCCTTGAAGTGCCCCTGGAGCACCCC
ACACTGGAGTGGTTCGCGGCCCTGGGCCTGCGATGGTATGCCCTCCCGGCCGTGTCCAAC
ATGCTGCTGGAAATCGGGGGTCTGGAGTTCTCCGCGGCCCCCTTCAGCGGCTGGTACATG
AGCACGGAGATTGGCACGCGGAACCTGTGTGACCCTCACCGCTACAATATCCTGGAGGAT
GTGGCCGTCTGCATGGACCTCGACACGCGGACCACCTCGTCCCTGTGGAAGGACAAGGCG
GCCGTGGAGATCAACCTGGCTGTGCTGCACAGCTTTCAGCTCGCCAAGGTGACCATCGTG
GACCACCACGCCGCCACGGTGTCCTTCATGAAGCACCTGGACAACGAGCAGAAGGCCAGG
GGGGGCTGCCCCGCCGACTGGGCCTGGATCGTGCCCCCCATCTCAGGCAGCCTCACGCCC
GTCTTCCACCAGGAGATGGTCAACTACATCCTGTCCCCTGCCTTCCGCTACCAGCCAGAC
CCCTGGAAAGGGAGCGCGACCAAGGGCGCAGGCATCACCAGGAAGAAGACCTTTAAGGAA
GTGGCCAACGCGGTGAAGATCTCTGCCTCACTCATGGGCACCCTGATGGCCAAGCGAGTG
AAAGCAACCATCCTGTACGCCTCTGAGACCGGCCGGGCCCAGAGCTACGCTCAGCAGCTG
GGGAGGCTCTTCCGGAAGGCCTTCGATCCCCGGGTCCTGTGCATGGATGAGTATGACGTG
GTGTCCCTGGAGCACGAGGCGCTGGTACTGGTGGTGACCAGCACCTTTGGGAATGGCGAT
CCCCCGGAGAATGGAGAGAGTTTTGCAGCTGCCCTGATGGAGATGTCGGGGCCCTACAAC
AGCTCCCCGCGGCCGGAACAGCACAAGAGTTACAAGATCCGCTTCAACAGCGTCTCCTGC
TCAGACCCGCTGGTGTCCTCCTGGCGGCGGAAGAGAAAGGAGTCCAGCAACACAGACAGT
GCGGGGGCCCTGGGGACCCTCAGGTTCTGTGTGTTCGGACTGGGCTCCCGGGCATACCCC
CACTTCTGCGCCTTCGCGCGAGCGGTGGACACCCGGCTGGAAGAGCTTGGAGGGGAGCGG
CTGCTGCAGCTGGGCCAGGGCGATGAGCTCTGCGGCCAGGAAGAGGCCTTCCGTGGTTGG
GCAAAGGCGGCCTTCCAGGCCTCCTGTGAGACCTTCTGCGTTGGGGAGGAGGCCAAGGCC
GCCGCCCAGGACATCTTCAGCCCCAAACGGAGCTGGAAACGCCAGAGGTACCGGCTGAGC
ACCCAGGCCGAGGGCCTCCAGCTGCTGCCAGGCCTGATCCACGTGCACAGACGGAAGATG
TTTCAGGCCACAGTCCTCTCGGTGGAAAATCTGCAAAGCAGCAAGTCCACCCGGGCCACC
ATCCTGGTGCGCCTGGACACTGCAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCAC
ATAGGCATCTGCCCGCCCAACCGGCCGGGCCTGGTGGAGGCGCTGCTGAGCCGCGTGGAG
GACCCGCCACCGCCCACCGAGTCTGTGGCTGTGGAGCAGCTGGAGAAAGGCAGCCCAGGC
GGCCCTCCTCCCAGCTGGGTGCGGGACCCACGGCTGCCCCCGTGCACGCTGCGCCAGGCT
CTCACCTTCTTCCTGGACATCACCTCCCCACCCAGCCCCCGGCTTCTCCGACTGCTCAGC
ACCCTGGCCGAAGAACCCAGCGAGCAGCAGGAGCTTGAGACCCTCAGTCAGGACCCCCGG
CGCTACGAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTC
CCGTCCGTGGCGCTGCCCGCCCCGCTGCTCCTCACCCAGCTGCCCCTGCTGCAGCCCCGG
TACTACTCTGTCAGCTCGGCCCCCAACGCCCACCCCGGAGAGGTCCACCTCACAGTGGCC
GTGCTGGCGTACAGGACCCAAGATGGGCTGGGCCCCCTACACTACGGGGTCTGCTCCACA
TGGCTGAGCCAGCTCAAGACTGGAGACCCCGTGCCCTGCTTCATCAGGGGGGCTCCCTCC
TTCCGGCTGCCGCCTGACCCCTACGTGCCCTGCATCCTCGTGGGCCCTGGCACTGGCATC
GCCCCCTTCCGGGGATTTTGGCAGGAGAGGCTGCATGACATTGAGAGCAAAGGGCTGCAG
CCCGCCCCCATGACCCTGGTGTTCGGCTGCCGCTGCTCCCAACTCGACCATCTCTACCGC
GACGAGGTGCAGGACGCCCAGGAGCGCGGGGTGTTTGGCCGCGTCCTCACCGCCTTCTCC
CGGGAACCTGACAGCCCCAAGACCTACGTACAGGACATCCTGAGAACCGAGCTGGCTGCC
GAGGTGCACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTCACT
ATGGCAACCAGCGTCCTGCAGACGGTGCAGCGCATCTTGGCGACAGAGGGCGACATGGAG
CTGGACGAGGCGGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTATCACGAGGAC
ATTTTCGGCCTCACGCTGCGCACCCAGGAGGTGACAAGCCGTATACGTACCCAGAGCTTT
TCCCTGCAGGAGCGGCATCTGCGGGGCGCGGTGCCCTGGGCCTTCGACCCGCCCGGCCCA
GACACCCCCGGCCCCTGA
Enzyme 1 GenBank Gene ID M99057 Link Image
Enzyme 1 GeneCard ID NOS3 Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Chromosome:7
Enzyme 1 Locus 7q36
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References
  1. [PubMed Link Image]
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 69
Enzyme 2 Name Nitric oxide synthase, inducible
Enzyme 2 Synonyms
  1. Inducible NO synthase
  2. Inducible NOS
  3. iNOS
  4. NOS type II
  5. NOSII
Enzyme 2 Gene Name NOS2
Enzyme 2 Protein Sequence >Nitric oxide synthase, inducible
MACPWQFLFKIKSQKVDLATELDINNNVGKFYQPPSSPVTQDDPKRHSPGKHGNESPQPL
TGTVKTSPESLSKLDAPPSACPRHVRIKNWGSGVTFQDTLHQKAKGDLSCKSKSCLASIM
NPKSLTIGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAQEMFEHICRHVRYATNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVLPLVLQADGRDPELFEIPPDLVLEVPMEHPRYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEVGVRDFCDAQRYNILEEVGRRMGLETHKVASLWKDRAVVEINV
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPISGSITPVFHQEM
LNYVLSPFYYYQVEPWKTHVWQDERRRPQRREIRFKVLVKAVFFASVLMHKAMASRVRAT
ILFATETGRSETLAQDLGALFSCAFNPKVLCMDQYQLSHLEEEQLLLVVTSTFGNGDSPG
NGEKLKKSLLMLKELTNTFRYAVFGLGSSMYPQFCAFAHDIDQKLSQLGASQLAPTGEGD
ELSGQEEAFRSWAVQTFKAACETFDVSGKHHIEIPKLYTSNVTWDPQHYRLVQDSEPLDL
NKALSSMHAKHVFTMRLKSQQNLQSPKSSRTTLLVELSCEGSQAPSYLPGEHLGVFPCNQ
PALVQGILERVVDGPAPHQPVRLETLCENGSYWVKDKRLPPCSLSQALTYFLDITTPPTQ
LLLRKLAQLATEEAEKQRLETLCQPSDYNKWKFTNSPTFLEVLEEFPSLRVSASFLLSQL
PILKPRYYSISSSRDLTPTEIHLTVAVLTYRTRDGQGPLHHGVCSTWLSSLKPQDPVPCF
VRSASGFQLPEDRSRPCILIGPGTGIAPFRSFWQQRLHEAEHKGLQGGRMTLVFGCRRPE
EDHLYWEEMLEMARKGVLHEVHTAYSRLPDQPKVYVQDILRQRLAGEVLRVLHEEQGHLY
VCGDVRMARDVARTLKQLMATALSLNEEQVEDYFFQLKNQKRYHEDIFGAVFPYEVKKDG
AAGLPSNPRAPGAHRS
Enzyme 2 Number of Residues 1156
Enzyme 2 Molecular Weight 131206.8
Enzyme 2 Theoretical pI 7.42
Enzyme 2 GO Classification
Function
Process
Component
Enzyme 2 General Function Inorganic ion transport and metabolism
Enzyme 2 Specific Function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions
Enzyme 2 Pathways Not Available
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 110468061 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q27995 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name NOS2_BOVIN Link Image
Enzyme 2 PDB ID 2NSI Link Image
Enzyme 2 PDB File Show
Enzyme 2 3D Structure
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >3471 bp
ATGGCCTGTCCCTGGCAGTTTCTGTTCAAAATCAAATCCCAAAAGGTGGACTTGGCTACG
GAACTGGACATCAACAACAATGTGGGAAAATTCTACCAGCCCCCGTCCAGTCCAGTGACA
CAGGATGACCCCAAACGTCACAGCCCGGGCAAGCACGGGAATGAGTCTCCCCAGCCCCTC
ACGGGGACAGTAAAGACGTCTCCAGAATCCCTGAGCAAGCTGGACGCGCCCCCGTCAGCC
TGTCCACGGCATGTGAGGATCAAAAACTGGGGCAGCGGAGTGACTTTCCAAGACACGCTT
CACCAGAAGGCCAAAGGGGATCTCTCTTGCAAGTCCAAGTCTTGCCTGGCATCCATCATG
AACCCCAAAAGTTTGACCATAGGACCCCGGGACAAGCCAACCCCCCCAGACGAGCTTCTA
CCTCAAGCTATCGAATTTGTCAACCAGTATTACGGCTCCTTCAAAGAGGCAAAAATAGAG
GAACATCTGGCCAGGGTGGAAGCAGTAACAAAGGAGATAGAAACAACAGGAACCTACCAG
CTGACGGGAGATGAGCTCATCTTCGCCACCAAGCAGGCCTGGCGCAACGCCCCCCGCTGC
ATCGGAAGGATCCAGTGGTCGAACCTGCAGGTCTTTGACGCCCGGAGCTGTTCCACGGCC
CAGGAAATGTTCGAACACATCTGCAGACACGTGCGTTATGCCACCAACAACGGCAACATC
AGGTCGGCCATCACTGTGTTCCCCCAGCGGAGCGATGGGAAGCATGACTTCCGGGTCTGG
AACGCCCAGCTCATCCGCTATGCCGGCTACCAGATGCCAGATGGCAGCATCAGAGGGGAC
CCCGCCAACGTGGAGTTCACACAGCTGTGCATCGACCTGGGCTGGAAGCCCAAGTACGGC
CGCTTCGACGTGTTGCCTCTAGTCCTGCAGGCTGACGGCCGTGACCCAGAGCTCTTCGAA
ATCCCCCCTGACCTTGTTCTCGAGGTGCCCATGGAACATCCCAGGTACGAATGGTTCCGG
GAGCTGGAGCTCAAGTGGTACGCCCTGCCAGCCGTGGCCAACATGCTGCTTGAGGTGGGC
GGCCTCGAGTTCCCAGGGTGCCCCTTCAACGGGTGGTACATGGGCACAGAAGTTGGAGTC
CGGGACTTCTGCGACGCCCAGCGATACAACATCCTGGAGGAAGTGGGCAGAAGGATGGGC
CTGGAAACGCACAAGGTGGCCTCACTCTGGAAGGACCGGGCTGTCGTTGAGATCAACGTC
GCTGTGCTCCACAGTTTCCAGAAGCAGAACGTGACCATCATGGACCACCACTCCGCTGCA
GAGTCCTTCATGAAGTACATGCAGAATGAGTACCGCTCCCGAGGGGGCTGCCCAGCTGAC
TGGATTTGGCTGGTCCCCCCGATCTCTGGAAGCATCACCCCCGTGTTCCACCAGGAGATG
TTAAATTACGTCCTGTCCCCTTTCTACTACTACCAGGTGGAGCCCTGGAAAACCCACGTC
TGGCAGGACGAGAGGCGGAGACCCCAGAGAAGAGAAATTCGATTCAAAGTCTTGGTCAAA
GCCGTGTTCTTCGCCTCGGTGCTGATGCATAAGGCCATGGCATCCCGGGTCAGAGCCACG
ATCCTCTTTGCAACAGAGACGGGGAGATCGGAAACGCTGGCCCAGGACCTGGGGGCTTTG
TTCAGCTGTGCCTTCAACCCCAAGGTTCTCTGCATGGATCAGTACCAGCTGAGCCATCTG
GAGGAGGARCAGCTGCTGCTGGTGGTGACCAGCACTTTTGGCAACGGAGACTCCCCTGGC
AACGGAGAGAAACTGAAGAAGTCCCTCTTGATGCTGAAAGAACTCACCAACACGTTCCGG
TACGCCGTGTTTGGCCTTGGCTCCAGCATGTACCCTCAGTTCTGCGCTTTTGCTCATGAC
ATTGACCAGAAGTTGTCCCAGCTGGGGGCTTCTCAGCTTGCCCCAACCGGGGAAGGGGAC
GAACTCAGCGGGCAGGAGGAGGCCTTTCGCAGCTGGGCCGTGCAAACCTTCAAGGCAGCC
TGTGAGACATTCGATGTCAGCGGCAAGCACCACATTGAGATCCCCAAGCTCTACACTTCC
AATGTGACCTGGGACCCGCAGCACTACAGGCTCGTGCAGGACTCAGAGCCTCTGGACCTC
AACAAAGCCCTGAGCAGTATGCACGCCAAGCATGTGTTCACCATGAGGCTCAAATCGCAG
CAGAATCTGCAGAGTCCGAAATCCAGCCGCACCACCCTCCTGGTGGAACTCTCCTGTGAG
GGCAGCCAAGCTCCAAGCTACCTGCCGGGAGAGCACCTCGGAGTTTTCCCATGCAACCAG
CCGGCCCTGGTTCAAGGCATCCTTGAGCGAGTGGTGGATGGCCCTGCCCCGCACCAGCCT
GTGCGCCTGGAGACCCTCTGTGAGAATGGCAGCTATTGGGTCAAGGATAAGCGGCTGCCA
CCTTGCTCACTCAGCCAGGCTCTCACCTATTTCCTGGACATCACCACCCCGCCAACCCAG
CTGCTGCTCCGAAAGCTGGCCCAGCTGGCCACAGAAGAGGCTGAGAAGCAGAGGCTGGAG
ACCCTATGCCAGCCCTCAGATTACAACAAGTGGAAGTTCACCAACAGCCCCACATTTCTG
GAGGTGCTGGAGGAGTTCCCGTCCCTGCGGGTGTCTGCCAGCTTCCTGCTCTCCCAGCTC
CCTATTCTGAAGCCCCGGTACTACTCCATCAGCTCCTCCAGGGACCTCACACCCACGGAG
ATCCACCTCACTGTGGCCGTGCTCACGTACCGCACCCGAGATGGCCAAGGTCCCCTGCAC
CATGGTGTCTGCAGCACGTGGCTCAGCAGCTTGAAGCCCCAAGACCCGGTGCCCTGCTTT
GTGCGAAGTGCCAGYGGCTTCCAGCTTCCCGAGGACCGCTCCCGTCCTTGCATCCTCATT
GGGCCCGGCACGGGCATCGCCCCCTTCCGCAGTTTCTGGCAGCAGCGGCTCCATGAGGCT
GAGCACAAAGGGCTCCAGGGCGGCCGCATGACCCTGGTTTTCGGGTGCCGCCGCCCAGAA
GAGGACCACCTCTACTGGGAGGAGATGCTGGAGATGGCCCGCAAGGGGGTGCTGCACGAG
GTGCACACCGCCTATTCCCGCCTGCCTGACCAGCCCAAGGTCTATGTTCAAGACATCCTG
CGGCAGCGGCTGGCGGGCGAGGTGCTTCGCGTGCTCCATGAGGAGCAAGGTCACCTCTAT
GTCTGTGGGGATGTGCGCATGGCCCGGGACGTGGCCCGCACCCTGAAGCAGCTGATGGCT
ACTGCGCTGAGCCTGAACGAGGAACAGGTGGAGGACTATTTCTTCCAGCTCAAGAACCAG
AAGCGCTATCATGAAGACATCTTTGGTGCTGTATTTCCCTATGAGGTGAAAAAGGATGGG
GCAGCAGGGCTGCCCAGCAATCCCAGAGCTCCAGGCGCCCACAGAAGTTAA
Enzyme 2 GenBank Gene ID DQ676956 Link Image
Enzyme 2 GeneCard ID NOS2 Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Chromosome:1
Enzyme 2 Locus 17q11.2-q12
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 76
Enzyme 3 Name 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Enzyme 3 Synonyms
  1. Phosphoinositide phospholipase C
  2. Phospholipase C-gamma-1
  3. PLC-gamma-1
  4. PLC-II
  5. PLC-148
Enzyme 3 Gene Name PLCG1
Enzyme 3 Protein Sequence >1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
MAGAASPCANGCGPSAPSDAEVVHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIRGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRTSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSIWNSQLDEVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAVRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSVMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEGL
ELASLLVKIDVFPAKQENGDLSPFGGASLRERSCDASGPLFHGRAREGSFEARYQQPFED
FRISQEHLADHFDGRDRRTPRRTRVNGDNRL
Enzyme 3 Number of Residues 1291
Enzyme 3 Molecular Weight 148311.6
Enzyme 3 Theoretical pI 5.85
Enzyme 3 GO Classification
Function
Process
Component
Enzyme 3 General Function Involved in calcium ion binding
Enzyme 3 Specific Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 639 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID P08487 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name PLCG1_BOVIN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >3876 bp
ATGGCGGGCGCCGCGTCCCCCTGCGCCAACGGCTGCGGGCCCAGTGCGCCCTCGGACGCC
GAGGTGGTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCC
AAGAAGTCGCAGCGGCCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGGCAGATC
ACGTGGAGCCGAGGCGCCGACAAGATAGAGGGGGCCATTGACATTCGTGAAATCAAGGAG
ATCCGCCCAGGGAAGACCTCACGGGACTTCGATCGCTACCAAGAGGATCCTGCTTTTCGA
CCGGACCAGTCCCACTGCTTCGTCATCCTGTATGGAATGGAATTCCGCCTGAAGACCCTG
AGCCTCCAAGCCACGTCTGAGGACGAAGTGAACATGTGGATCAGGGGCCTGACTTGGCTG
ATGGAGGACACGTTGCAGGCAGCCACACCCCTGCAGATTGAGAGGTGGCTGCGGAAGCAG
TTCTACTCAGTGGACCGGAACCGTGAGGACCGGATATCGGCCAAGGACCTGAAGAACATG
CTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGGGAGCGGCTGACGGAC
CTGGAGCAGCGCACCAGTGACATCACCTACGGGCAGTTTGCACAGCTGTACCGCAGCCTC
ATGTACAGCGCCCAGAAGACGATGGACCTTCCTTTCCTGGAAGCCAGCGCCCTGAGGGCG
GGGGAGCGGCCGGAGCTGTGCCGGGTGTCCCTTCCTGAGTTCCAGCAGTTCCTCCTCGAG
TACCAAGGGGAGCTGTGGGCGGTGGACCGGCTCCAGGTGCAGGAGTTCATGCTCAGCTTC
CTCCGAGACCCCTTGCGAGAGATTGAGGAGCCTTACTTCTTCCTGGACGAGTTCGTCACC
TTCCTGTTCTCCAAGGAGAACAGCATATGGAACTCGCAGCTAGACGAGGTGTGCCCCGAC
ACCATGAACAACCCCCTGTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACC
GGGGACCAGTTCTCCAGCGAGTCCTCCCTGGAAGCCTACGCTCGCTGCCTGCGGATGGGC
TGCCGTTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATGCCGGTCATTTACCAT
GGACACACTCTGACCACCAAGATCAAGTTCTCAGACGTCCTGCACACCATCAAGGAGCAC
GCCTTTGTGGCCTCAGAGTACCCGGTCATCCTGTCCATCGAGGACCACTGCAGCATTGCC
CAGCAGAGGAACATGGCCCAGTATTTCAAAAAGGTGCTTGGGGACACACTCCTCACCAAG
CCCGTGGATATTGCAGCCGACGGGCTCCCCTCCCCCAACCAGCTCAAGAGGAAGATCCTT
ATCAAGCACAAGAAGTTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCAACATCGGTGATG
TACTCTGAGAACGACATCAGCAACTCCATCAAGAATGGCATCCTCTACCTGGAAGACCCT
GTGAACCATGAGTGGTACCCCCACTACTTCGTCCTGACCAGCAGCAAGATCTACTACTCG
GAGGAGACCAGCAGCGACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGCCAGTGGC
AGCACAGAGCTGCACTCCAACGAGAAGTGGTTCCACGGGAAGCTTGGGGCGGGCCGGGAT
GGGCGGCACATCGCCGAGCGCCTGCTCACGGAGTACTGCATTGAGACCGGGGCCCCCGAC
GGCTCCTTCCTTGTGCGCGAGAGCGAGACCTTTGTGGGCGACTACACTCTGTCCTTCTGG
CGGAATGGCAAAGTGCAGCACTGCCGGATCCACTCCCGGCAGGACGCAGGCACCCCCAAG
TTCTTCCTGACGGACAACCTCGTCTTCGACTCCCTCTATGACCTCATCACGCACTACCAG
CAGGTGCCCCTGCGCTGCAACGAATTTGAGATGCGCCTCTCAGAGCCGGTCCCGCAGACC
AACGCGCACGAGAGCAAAGAGTGGTACCACGCCAGCCTGACCAGAGCGCAGGCCGAGCAC
ATGCTGATGCGTGTACCCAGGGACGGGGCCTTCCTGGTGCGGAAACGGAACGAGCCCAAC
TCCTACGCCATCTCCTTCCGGGCTGAGGGCAAGATCAAGCACTGCCGCGTCCAGCAGGAG
GGCCAGACCGTGATGCTGGGCAACTCAGAGTTTGACAGCCTTGTCGACCTCATCAGCTAC
TACGAGAAGCACCCACTGTACCGCAAGATGAAGCTGCGCTACCCCATCAACGAGGAGGCT
CTGGAGAAGATCGGCACAGCTGAGCCTGACTACGGCGCGCTGTACGAGGGCCGCAACCCT
GGCTTCTATGTGGAGGCGAACCCCATGCCCACGTTCAAGTGCGCCGTCAAAGCTCTCTTC
GACTACAAAGCGCAGCGGGAGGACGAGCTGACATTCACCAAGAGTGCCATCATCCAGAAC
GTGGAGAAGCAGGAGGGAGGCTGGTGGCGGGGTGACTACGGCGGGAAGAAGCAGCTGTGG
TTCCCTTCAAACTATGTGGAGGAAATGGTCAGCCCGGCGGCCCTGGAGCCCGAGAGGGAG
CACTTGGACGAGAACAGCCCACTCGGGGACTTGCTCCGGGGGGTCCTGGATGTGCCAGCT
TGTCAGATAGCCGTCCGTCCCGAGGGCAAGAACAACCGGCTGTTCGTCTTCTCCATCAGC
ATGGCCTCGGTGGCACACTGGTCCCTGGATGTGGCTGCCGACTCGCAGGAAGAGCTGCAG
GACTGGGTGAAGAAGATCCGGGAGGTGGCGCAGACAGCGGATGCCAGGCTCACCGAGGGC
AAGATGATGGAGCGGAGGAAGAAGATCGCCCTAGAGCTCTCAGAGCTCGTCGTCTACTGC
CGGCCTGTCCCTTTCGACGAAGAGAAGATTGGCACCGAACGGGCCTGCTACCGCGACATG
TCGTCCTTCCCGGAGACCAAGGCCGAGAAGTACGTGAACAAGGCCAAAGGCAAGAAGTTC
CTCCAGTACAACCGCCTGCAGCTCTCCCGCATCTACCCTAAGGGCCAGCGGCTGGACTCC
TCCAATTACGACCCCCTGCCCATGTGGATCTGCGGCAGCCAGCTTGTGGCCCTCAACTTC
CAGACCCCAGACAAACCCATGCAGATGAACCAGGCCCTGTTCCTGGCCGGCGGGCACTGT
GGCTATGTGCTGCAGCCCAGCGTCATGCGCGATGAGGCCTTCGATCCCTTTGACAAGAGC
AGCCTCCGCGGGCTGGAGCCGTGCGCCATCTGCATCGAGGTGCTGGGGGCCCGGCACCTG
CCGAAGAACGGCCGAGGCATCGTGTGTCCTTTTGTGGAGATCGAGGTGGCCGGAGCCGAG
TATGACAGCATCAAGCAGAAGACAGAGTTTGTGGTGGACAATGGACTGAACCCCGTGTGG
CCAGCCAAGCCCTTCCACTTCCAGATTAGTAACCCCGAGTTCGCCTTCCTGCGCTTCGTG
GTCTATGAGGAGGACATGTTTAGTGACCAGAACTTCCTAGCTCAGGCTACCTTCCCAGTG
AAGGGTCTGAAGACAGGCTACAGAGCGGTGCCTCTGAAGAACAACTACAGTGAGGGCCTG
GAGCTGGCCTCCCTGCTCGTCAAGATTGACGTGTTCCCTGCCAAGCAGGAGAACGGCGAC
CTCAGCCCCTTCGGGGGTGCGTCCCTGCGGGAGCGGAGCTGTGACGCCTCGGGCCCGCTG
TTCCACGGCCGGGCCCGGGAGGGCTCCTTTGAAGCTCGCTACCAGCAGCCCTTTGAGGAC
TTCCGCATCTCCCAGGAGCATCTCGCAGACCATTTTGACGGTCGGGATCGCAGGACCCCA
CGCAGGACTCGGGTCAACGGAGACAACCGCCTGTAG
Enzyme 3 GenBank Gene ID Y00301 Link Image
Enzyme 3 GeneCard ID PLCG1 Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Chromosome:2
Enzyme 3 Locus 20q12-q13.1
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 134
Enzyme 4 Name [Protein ADP-ribosylarginine] hydrolase
Enzyme 4 Synonyms
  1. ADP-ribosylarginine hydrolase
  2. ADP-ribose-L-arginine cleaving enzyme
Enzyme 4 Gene Name ADPRH
Enzyme 4 Protein Sequence >[Protein ADP-ribosylarginine] hydrolase
MCGALMERYVAAMVLSAAGDALGYFNGKWEFLQNGEKIHRQLAQLGGLDAIDVERWRVSD
DTVMHLATAEALLEAGKVSDLTHLYSLLAKHYQDCMGDMDGRAPGGASVQNAMLLEPDKA
DGWRIPFNSHEGGCGAAMRAMCIGLRFPHSSQLDSLIQVSIESGRMTHHHPTGYLGALVS
ALFTAYAVNGKPPQQWGRGLMEVLPEAKKYIVQSGFFVEQNLQHWSYFQDQWEKYLKLRG
IWDGKSAPTFPKPFDVKERDQFYSSVSYSGWGGSSGHDAPMIAYDAILAAGDSWKELAHR
AFFHGGDSDSTAAIAGCWWGVMYGFKGVSPSNYEKLEYRNRLEETARALYSLR
Enzyme 4 Number of Residues 353
Enzyme 4 Molecular Weight 39152.0
Enzyme 4 Theoretical pI 6.45
Enzyme 4 GO Classification
Function
Process
Component
Enzyme 4 General Function Posttranslational modification, protein turnover, chaperones
Enzyme 4 Specific Function Catalyzes the reverse reaction of mono-ADP-ribosylation
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 81673929 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q32KR8 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name ADPRH_BOVIN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >1062 bp
ATGTGTGGGGCCCTGATGGAGAGGTATGTGGCAGCCATGGTGCTGAGTGCAGCTGGAGAT
GCCTTGGGATACTTCAATGGAAAGTGGGAGTTCCTCCAGAATGGGGAGAAAATTCACAGG
CAGCTGGCCCAGCTTGGTGGCTTGGATGCCATAGATGTGGAGAGGTGGAGAGTCAGCGAT
GACACCGTGATGCACCTGGCCACAGCAGAAGCACTCCTGGAAGCTGGCAAAGTCTCAGAC
TTGACTCACTTGTATTCCCTCCTTGCTAAGCATTACCAGGACTGCATGGGAGACATGGAT
GGCCGGGCACCAGGGGGTGCCTCAGTGCAGAACGCCATGCTGCTGGAGCCAGACAAAGCC
GATGGCTGGAGGATTCCCTTTAACAGTCATGAGGGTGGCTGCGGGGCCGCCATGAGGGCC
ATGTGCATTGGTCTCCGGTTCCCTCACAGCAGTCAGCTGGACTCACTGATCCAGGTGAGC
ATCGAGAGCGGCCGGATGACCCATCACCATCCCACAGGCTACCTGGGAGCCCTTGTGTCT
GCTCTTTTTACAGCCTATGCTGTGAACGGCAAGCCTCCCCAGCAGTGGGGAAGAGGACTG
ATGGAGGTACTTCCGGAAGCTAAAAAGTACATTGTCCAATCAGGCTTCTTTGTGGAGCAG
AATCTTCAACACTGGTCTTACTTCCAAGACCAGTGGGAAAAGTACCTAAAACTCAGAGGA
ATTTGGGATGGCAAATCAGCCCCTACCTTCCCCAAGCCCTTTGATGTGAAGGAAAGGGAT
CAGTTCTACAGTTCTGTGAGCTACTCTGGCTGGGGCGGCAGCAGTGGACACGATGCCCCC
ATGATTGCCTATGATGCCATCCTGGCTGCAGGAGACTCCTGGAAGGAGCTTGCCCACCGA
GCATTTTTCCACGGTGGAGACAGTGATTCTACCGCTGCAATTGCTGGCTGTTGGTGGGGA
GTGATGTATGGTTTTAAAGGAGTAAGTCCCTCCAACTATGAGAAGCTAGAATACAGAAAC
CGGCTGGAAGAGACAGCTAGGGCTTTGTATTCTCTTAGGTAA
Enzyme 4 GenBank Gene ID BC109957 Link Image
Enzyme 4 GeneCard ID ADPRH Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Chromosome:3
Enzyme 4 Locus 3q13.31-q13.33
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 238
Enzyme 5 Name Argininosuccinate lyase
Enzyme 5 Synonyms
  1. ASAL
  2. Arginosuccinase
Enzyme 5 Gene Name ASL
Enzyme 5 Protein Sequence >Argininosuccinate lyase
MASESGKLWGGRFVGTVDPIMEKFNSSITYDRHLWEADVQGSKAYSRGLEKAGLLTKAEM
DQILHGLDKVAEEWAQGTFKLNPNDEDIHTANERRLKELIGETAGKLHTGRSRNDQVVTD
LRLWMRQNCSMLSALLCELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVAL
TRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELDFGAITLNSMDATSERDFVA
EFLFWASLCMTHLSRMAEDLILYGTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKA
GRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHRENM
GRALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLF
SGDVSHVWDYGHSVEQYEALGGTARSSVDWQIGQLRALLRAQQTESPPHASPK
Enzyme 5 Number of Residues 473
Enzyme 5 Molecular Weight 52742.6
Enzyme 5 Theoretical pI 6.46
Enzyme 5 GO Classification
Function
Process
Component
Enzyme 5 General Function Amino acid transport and metabolism
Enzyme 5 Specific Function 2-(N(omega)-L-arginino)succinate = fumarate + L-arginine
Enzyme 5 Pathways
  • Nitrogen metabolism
  • urea cycle
  • L-arginine and fumarate from (N(omega)-L-arginino)succinate:step 1/1
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 74354042 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q3SZJ0 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name ARLY_BOVIN Link Image
Enzyme 5 PDB ID 1K62 Link Image
Enzyme 5 PDB File Show
Enzyme 5 3D Structure
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >1422 bp
ATGGCATCGGAGAGCGGGAAGCTATGGGGTGGCCGGTTTGTGGGCACAGTGGACCCCATC
ATGGAAAAGTTCAACTCGTCCATCACGTACGACCGGCACCTCTGGGAGGCGGACGTGCAG
GGCAGCAAAGCCTACAGCCGGGGCCTGGAGAAGGCGGGGCTCCTCACCAAAGCCGAGATG
GACCAGATACTCCATGGCCTGGACAAGGTAGCTGAGGAGTGGGCTCAGGGCACCTTCAAA
CTAAACCCCAATGATGAGGACATCCATACGGCCAATGAGCGGCGTCTGAAGGAGCTCATT
GGTGAAACCGCGGGGAAGCTGCACACGGGACGAAGTCGGAACGACCAGGTGGTCACTGAC
CTCAGGCTGTGGATGCGGCAGAATTGCTCCATGCTCTCAGCCCTCCTCTGCGAACTCATC
AGAACCATGGTGGATCGGGCAGAGGCGGAACGTGATGTCCTCTTCCCAGGGTACACACAC
CTGCAGAGGGCTCAGCCGATCCGCTGGAGCCACTGGATCCTGAGCCATGCGGTGGCTCTG
ACCAGAGACTCTGAAAGGCTGCTGGAGGTGCGGAAGCGGATCAACGTCCTGCCCCTGGGG
AGCGGGGCCATCGCAGGCAACCCCCTGGGTGTGGACCGGGAACTGCTCCGAGCAGAACTG
GACTTTGGGGCCATCACTCTCAACAGCATGGATGCCACCAGTGAGCGAGACTTTGTGGCC
GAGTTCCTATTCTGGGCTTCGCTGTGCATGACCCACCTCAGCAGGATGGCTGAGGATCTC
ATCCTCTATGGCACCAAGGAGTTCAGCTTCGTGCAGCTCTCAGATGCCTACAGCACCGGA
AGCAGTCTGATGCCCCAGAAGAAAAACCCAGACAGCCTGGAGCTGATCCGGAGCAAGGCG
GGGCGAGTGTTTGGGCGGTGTGCTGGGCTCCTGATGACACTCAAGGGACTTCCGAGCACC
TACAACAAGGACTTACAGGAAGACAAGGAAGCCGTGTTTGAAGTGTCCGACACCATGAGC
GCTGTCCTCCAAGTGGCCACTGGTGTCATCTCTACCCTGCAGATTCACCGTGAGAACATG
GGACGGGCTCTGAGTCCTGACATGCTAGCCACTGACCTCGCCTACTACCTGGTCCGAAAA
GGGATGCCATTCCGCCAGGCCCACGAGGCCTCCGGGAAAGCCGTGTTCATGGCTGAGACC
AAGGGGGTCGCCCTCAATCAGCTGTCACTGCAGGAGCTGCAGACCATCAGCCCCCTGTTC
TCGGGCGACGTGAGCCACGTGTGGGACTACGGACACAGCGTGGAGCAGTACGAGGCCCTG
GGAGGCACCGCGCGCTCCAGCGTTGACTGGCAGATCGGCCAGCTGCGAGCTCTCCTCCGG
GCACAGCAGACCGAGAGCCCTCCCCACGCCTCTCCCAAATAA
Enzyme 5 GenBank Gene ID BC102831 Link Image
Enzyme 5 GeneCard ID ASL Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Chromosome:7
Enzyme 5 Locus 7cen-q11.2
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References Not Available
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 552
Enzyme 6 Name Carboxypeptidase E
Enzyme 6 Synonyms
  1. CPE
  2. Carboxypeptidase H
  3. CPH
  4. Enkephalin convertase
  5. Prohormone-processing carboxypeptidase
Enzyme 6 Gene Name CPE
Enzyme 6 Protein Sequence >Carboxypeptidase E
MARRGGCALLVLCGSLAACAWLLGAEARGPGGPVAGARRRRRPQEDGISFEYHRYPELRE
ALVSVWLQCAAVSRIYTVGRSFEGRELLVLELSDNPGVHEPGEPEFKYIGNMHGNEAVGR
ELLIFLAQYLCNEYQKGNETIVQLIHNTRIHIMPSLNPDGFEKAASQLGELKDWFVGRSN
AQGIDLNRNFPDLDRIVYINEKEGGPNNHLLKNLKKIVDQNTKLAPETKAVIHWIMDIPF
VLSANLHGGDLVANYPYDETRSGSAHEYSSCPDDDIFQSLARAYSSFNPPMSDPDRPPCR
KNDDDSSFVEGTTNGAAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKNYWEDN
KNSLISYIQQIHRGVKGFVRDLQGNPIANATLSVEGIDHDVTSAKDGDYWRLLVPGNYKL
TASAPGYLAIAKKVAVPYSPAVRVDFELESFSERKEEEKEELMEWWKMMSETLNF
Enzyme 6 Number of Residues 475
Enzyme 6 Molecular Weight 53308.5
Enzyme 6 Theoretical pI 4.94
Enzyme 6 GO Classification
Function
Process
Component
Enzyme 6 General Function Amino acid transport and metabolism
Enzyme 6 Specific Function Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing
Enzyme 6 Pathways Not Available
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • 1-27
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 148743816 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID P04836 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name CBPE_BOVIN Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >1428 bp
ATGGCCCGGCGAGGGGGCTGCGCGCTGCTGGTGCTGTGCGGCTCGCTGGCCGCCTGTGCC
TGGCTGCTGGGCGCCGAGGCCCGGGGGCCTGGGGGCCCTGTGGCGGGCGCAAGGCGGCGC
CGGCGGCCCCAGGAGGACGGCATCTCCTTTGAGTACCACCGCTACCCAGAGCTTCGTGAA
GCGCTCGTGTCCGTGTGGCTGCAGTGCGCCGCGGTCAGCAGGATCTACACGGTGGGGCGC
AGCTTCGAGGGCCGCGAGCTGCTGGTGCTCGAGCTGTCCGACAACCCCGGCGTCCACGAG
CCGGGTGAGCCTGAATTTAAATACATCGGGAATATGCATGGCAATGAAGCTGTCGGACGG
GAGCTGCTCATTTTTCTGGCCCAGTACCTGTGCAATGAGTACCAAAAAGGGAATGAGACA
ATTGTCCAGCTGATCCACAACACCCGAATCCACATCATGCCTTCTCTGAACCCTGATGGC
TTTGAAAAGGCAGCATCTCAGCTTGGTGAGCTGAAGGACTGGTTCGTGGGTCGAAGCAAT
GCCCAGGGAATAGATCTGAACCGGAACTTTCCCGACCTGGACAGAATAGTTTATATTAAT
GAGAAAGAAGGTGGTCCAAATAATCATCTGTTGAAAAATCTGAAGAAAATTGTGGATCAA
AACACAAAGCTTGCTCCTGAGACGAAGGCTGTCATTCATTGGATTATGGATATTCCTTTT
GTGCTCTCTGCCAATCTTCACGGAGGAGACCTTGTGGCCAATTATCCATATGATGAGACG
AGGAGTGGTAGTGCTCATGAATACAGCTCCTGCCCAGATGACGACATCTTCCAAAGCTTA
GCTCGGGCATACTCATCCTTCAACCCCCCAATGTCGGACCCAGATCGGCCCCCATGTCGC
AAGAATGATGATGACAGCAGCTTTGTAGAAGGAACGACCAATGGTGCTGCATGGTACAGC
GTGCCTGGAGGAATGCAAGATTTCAATTACCTCAGCAGCAACTGCTTTGAGATTACTGTG
GAGCTTAGCTGTGAAAAGTTTCCACCTGAAGAGACTTTGAAGAACTACTGGGAGGATAAC
AAAAACTCCCTCATTAGCTACATTCAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGA
GATCTTCAGGGTAACCCAATTGCTAATGCCACCCTCTCTGTGGAAGGAATAGACCATGAT
GTCACATCTGCAAAGGATGGTGATTACTGGAGATTGCTCGTCCCTGGAAACTATAAACTT
ACAGCCTCAGCACCGGGCTATCTGGCAATAGCAAAGAAAGTGGCAGTTCCTTATAGCCCT
GCTGTCAGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAAGAAGAAGAGAAGGAA
GAATTAATGGAATGGTGGAAGATGATGTCAGAAACTTTAAACTTTTAA
Enzyme 6 GenBank Gene ID BC142181 Link Image
Enzyme 6 GeneCard ID CPE Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Chromosome:4
Enzyme 6 Locus 4q32.3
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References
  1. [PubMed Link Image]
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 553
Enzyme 7 Name Arginase-1
Enzyme 7 Synonyms
  1. Type I arginase
  2. Liver-type arginase
Enzyme 7 Gene Name ARG1
Enzyme 7 Protein Sequence >Arginase-1
MSSKPQSIGVIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKELECDVKDYGDLSFADNLD
DSPFQIVKNPRCVGKASEKLADVVAEVKKTGRISLVLGGDHSLAIGSISGHARVHPDLCV
IWVDAHTDINTPLTTKTGNLHGQPVSFLLKELKEKMPEVPGFYWVAPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVQGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTTVAIT
MACFGVAREGNHKPIDYLSPPK
Enzyme 7 Number of Residues 322
Enzyme 7 Molecular Weight 35009.0
Enzyme 7 Theoretical pI 6.51
Enzyme 7 GO Classification
Function
Process
Component
Enzyme 7 General Function Amino acid transport and metabolism
Enzyme 7 Specific Function L-arginine + H(2)O = L-ornithine + urea
Enzyme 7 Pathways
  • Nitrogen metabolism
  • urea cycle
  • L-ornithine and urea from L-arginine:step 1/1
Enzyme 7 Reactions Not Available
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • None
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein 86824019 Link Image
Enzyme 7 UniProtKB/Swiss-Prot ID Q2KJ64 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name ARGI1_BOVIN Link Image
Enzyme 7 PDB ID Not Available
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence >969 bp
ATGAGTTCCAAGCCACAGTCCATCGGGGTCATTGGAGCTCCCTTCTCAAAGGGCCAGCCA
CGAGGAGGGGTGGAAGAAGGCCCTACAGTACTTAGAAAGGCTGGTCTGCTTGAGAAACTT
AAAGAACTAGAGTGTGATGTGAAAGATTATGGGGACCTGTCCTTTGCTGATAATCTTGAT
GACAGTCCCTTTCAAATTGTGAAGAATCCAAGGTGTGTGGGAAAAGCAAGTGAAAAGCTG
GCTGATGTGGTGGCAGAAGTCAAGAAGACTGGAAGGATCAGCCTTGTCCTGGGCGGAGAC
CACAGTTTGGCGATCGGCAGCATCTCTGGCCATGCCAGGGTCCACCCAGACCTCTGTGTC
ATTTGGGTGGATGCTCACACGGACATCAACACTCCACTGACAACCAAAACCGGGAACTTG
CATGGACAACCTGTGTCTTTCCTTCTGAAGGAACTAAAGGAAAAGATGCCTGAGGTCCCA
GGATTCTACTGGGTGGCTCCCTGCATATCTGCCAAAGACATTGTGTATATTGGTCTGAGA
GATGTGGACCCTGGGGAACACTATATTTTGAAAACTCTGGGAATTAAATACTTTTCAATG
ACTGAAGTGGATAAACTGGGAATTGGCAAGGTGATGGAAGAAACATTCAGCTATCTACTA
GGAAGAAAGAAAAGGCCAATTCATTTGAGCTTTGATGTTGATGGACTGGACCCATCTTTC
ACGCCAGCTACTGGCACACCAGTCCAGGGAGGTCTGACTTACAGAGAAGGTCTCTACATC
ACAGAAGAAATTTACAAAACAGGTTTACTCTCAGGATTAGATATAATGGAAGTGAATCCG
TCTCTGGGGAAGACACCAGAAGAAGTGACTCGAACAGTGAACACAACAGTAGCAATAACC
ATGGCTTGCTTTGGGGTTGCTCGAGAGGGTAACCATAAACCTATTGATTACCTTAGCCCA
CCAAAGTAA
Enzyme 7 GenBank Gene ID BC105497 Link Image
Enzyme 7 GeneCard ID ARG1 Link Image
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Chromosome:6
Enzyme 7 Locus 6q23
Enzyme 7 SNPs SNPJam Report Link Image
Enzyme 7 General References Not Available
Enzyme 7 Metabolite References Not Available
Enzyme 8 [top]
Enzyme 8 ID 554
Enzyme 8 Name Carboxypeptidase B
Enzyme 8 Synonyms Not Available
Enzyme 8 Gene Name CPB1
Enzyme 8 Protein Sequence >Carboxypeptidase B
MLAFLILVTVTLASAHHSGEHFEGDKVFRVHVEDENHISLLHELASTRQMDFWKPDSVTQ
VKPHSTVDFRVKAEDTVAVEDFLGQNGLRYEVLISNLRSMLEAQFDSRVRTTGHSYEKYN
NWETIEAWTEQVASENPDLISRSAIGTTFLGNTIYLLKVGKPGSNKPAVFMDCGFHAREW
ISPAFCQWFVREAVRTYGREIHMTEFLDKLDFYVLPVVNIDGYIYTWTTNRMWRKTRSTR
AGSSCTGTDLNRNFDAGWCSIGASNNPCSETYCGSAAESEKESKAVADFIRNHLSSIKAY
LTIHSYSQMMLYPYSYDYKLPKNNVELNTLAKGAVKKLASLHGTTYTYGPGASTIYPASG
GSDDWAYDQGIKYSFTFELRDKGRYGFVLPESQIQPTCEETMLAIKYVTSYVLEHLY
Enzyme 8 Number of Residues 417
Enzyme 8 Molecular Weight 47347.9
Enzyme 8 Theoretical pI 6.39
Enzyme 8 GO Classification
Function
Process
Component
Enzyme 8 General Function Amino acid transport and metabolism
Enzyme 8 Specific Function Preferential release of a C-terminal lysine or arginine amino acid
Enzyme 8 Pathways Not Available
Enzyme 8 Reactions Not Available
Enzyme 8 Pfam Domain Function
Enzyme 8 Signals
  • 1-16
Enzyme 8 Transmembrane Regions
  • None
Enzyme 8 Essentiality Not Available
Enzyme 8 GenBank ID Protein Not Available
Enzyme 8 UniProtKB/Swiss-Prot ID P00732 Link Image
Enzyme 8 UniProtKB/Swiss-Prot Entry Name CBPB1_BOVIN Link Image
Enzyme 8 PDB ID Not Available
Enzyme 8 Cellular Location Not Available
Enzyme 8 Gene Sequence Not Available
Enzyme 8 GenBank Gene ID Not Available
Enzyme 8 GeneCard ID CPB1 Link Image
Enzyme 8 GenAtlas ID Not Available
Enzyme 8 HGNC ID Not Available
Enzyme 8 Chromosome Location Chromosome:3
Enzyme 8 Locus 3q24
Enzyme 8 SNPs SNPJam Report Link Image
Enzyme 8 General References
  1. [PubMed Link Image]
Enzyme 8 Metabolite References Not Available
Enzyme 9 [top]
Enzyme 9 ID 555
Enzyme 9 Name Probable arginyl-tRNA synthetase, mitochondrial
Enzyme 9 Synonyms
  1. Arginine--tRNA ligase
  2. ArgRS
  3. Arginyl-tRNA synthetase-like
Enzyme 9 Gene Name RARS2
Enzyme 9 Protein Sequence >Probable arginyl-tRNA synthetase, mitochondrial
MACGFRRSIASQLSRVLDLPPENLIKSISAVPISRKEEVADFQLSVDSLLENNNDHSRPD
IQIQAMRLAEKLKCDTVVSEISTGQGTVNFKINRELLTKTVLQQVIEDGSKYGLKSELFS
GLPKKRIVVEFSSPNVAKKFHVGHLRSTIIGNFIANLKEALGHQVTRINYLGDWGMQFGL
LGTGFQLFGYEEKLQSSPLQHLFEVYVQVNKEAADDKNVAKSAHEFFQRLELGDMQALAL
WQKFRDLSIDEYMRIYQRLGVHFDEYSGESFYREKSQEVLKLLDSKGLLQKTLKGTAVVD
LSGNGDPSSVCTVMRSDGTSLYATRDLAAAIDRMEKYNFDKMIYVTDKGQKKHFQQVFQI
LQIMGYDWAERCQHVPFGVVQGMKTRRGDVTFLEDVLNEIRLRMLQNMASIKTTKELENP
EETAEQVGLAALIIQDFRGFLLSDYQFSWDRVFQSRGDTGVFLQYTHARLHSLEETFGCG
YLNDFNTACLQEPQSVSILQHLLRFDEVLYRSSQDLQPRHIVSYLLTLSHLAAVAHRTLH
VRNSPPEVAGARLHLFRAVRSVLANGMKLLGITPVCRM
Enzyme 9 Number of Residues 578
Enzyme 9 Molecular Weight 65630.7
Enzyme 9 Theoretical pI 7.67
Enzyme 9 GO Classification
Function
Process
Component
Enzyme 9 General Function Translation, ribosomal structure and biogenesis
Enzyme 9 Specific Function ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
Enzyme 9 Pathways Not Available
Enzyme 9 Reactions Not Available
Enzyme 9 Pfam Domain Function
Enzyme 9 Signals
  • None
Enzyme 9 Transmembrane Regions
  • None
Enzyme 9 Essentiality Not Available
Enzyme 9 GenBank ID Protein 112362204 Link Image
Enzyme 9 UniProtKB/Swiss-Prot ID Q0P5H7 Link Image
Enzyme 9 UniProtKB/Swiss-Prot Entry Name SYRM_BOVIN Link Image
Enzyme 9 PDB ID Not Available
Enzyme 9 Cellular Location Not Available
Enzyme 9 Gene Sequence >1737 bp
ATGGCGTGCGGTTTCCGCAGGTCCATCGCCAGTCAGCTTTCCAGAGTGTTGGATCTTCCA
CCAGAAAACTTGATCAAGTCAATATCTGCAGTTCCGATTTCCAGAAAAGAAGAGGTAGCT
GACTTCCAGCTTTCTGTGGATTCTCTATTGGAAAACAACAATGACCATTCAAGACCAGAT
ATTCAAATTCAAGCCATGAGACTGGCAGAGAAGCTAAAATGTGACACAGTGGTGAGTGAA
ATCAGCACTGGTCAAGGGACTGTAAATTTCAAAATCAACAGAGAACTGTTAACAAAGACA
GTACTGCAACAGGTGATTGAAGATGGCTCAAAATATGGATTAAAAAGTGAACTTTTTTCT
GGCCTCCCCAAGAAGAGGATCGTGGTTGAATTCAGTTCACCTAATGTTGCCAAAAAATTT
CACGTTGGACATTTGCGTTCTACCATCATAGGAAATTTTATAGCAAATCTCAAAGAAGCT
TTAGGACATCAAGTAACAAGAATAAATTATCTTGGCGATTGGGGCATGCAGTTTGGTCTT
CTGGGAACTGGCTTCCAGCTGTTTGGCTATGAAGAAAAACTGCAGTCCAGTCCTTTACAG
CATCTCTTTGAAGTTTATGTACAAGTTAATAAAGAAGCAGCAGACGATAAAAACGTAGCA
AAATCAGCACATGAGTTCTTCCAGCGACTGGAACTAGGCGACATGCAAGCACTTGCCCTA
TGGCAGAAATTTCGGGACTTGAGCATAGATGAGTACATGCGGATTTACCAGCGTCTAGGA
GTACACTTTGATGAATATTCAGGAGAATCGTTTTACCGTGAAAAATCTCAAGAAGTCTTA
AAGTTGCTGGACAGTAAAGGACTCCTACAGAAAACACTAAAAGGCACTGCTGTAGTAGAT
CTTTCAGGGAATGGTGACCCCTCCTCAGTTTGTACTGTAATGCGAAGTGACGGGACGTCT
CTGTATGCAACCAGAGATCTTGCAGCTGCTATAGATCGAATGGAAAAGTATAATTTTGAT
AAAATGATCTATGTGACAGATAAAGGGCAAAAAAAGCATTTTCAGCAAGTGTTCCAGATA
CTGCAGATCATGGGATATGACTGGGCAGAAAGGTGCCAGCACGTGCCCTTTGGGGTAGTG
CAGGGAATGAAAACTCGGAGAGGAGATGTTACTTTTCTGGAAGATGTTCTAAATGAGATT
CGATTGAGGATGCTGCAGAACATGGCTTCTATTAAGACAACCAAAGAGCTGGAGAATCCC
GAGGAGACAGCAGAGCAGGTGGGACTTGCAGCCCTCATCATTCAGGACTTCAGAGGTTTC
CTGCTGTCTGACTATCAGTTCAGCTGGGATCGTGTTTTCCAGAGCCGCGGGGACACGGGC
GTCTTCCTGCAGTACACACACGCCCGCCTCCACAGTCTGGAAGAGACTTTTGGATGCGGT
TATCTCAATGACTTCAATACCGCCTGCTTACAGGAGCCACAATCTGTTTCCATTCTCCAG
CATCTTCTCAGGTTCGACGAGGTACTTTATAGGTCATCTCAAGACCTTCAGCCCAGGCAC
ATTGTCAGCTACCTTCTAACTCTAAGTCACCTCGCTGCGGTGGCACACAGAACACTGCAC
GTCAGAAACAGTCCTCCTGAGGTGGCCGGGGCCAGACTTCACCTTTTCAGAGCTGTCCGC
TCAGTCCTAGCCAACGGAATGAAACTTCTTGGAATAACACCTGTATGTAGAATGTAA
Enzyme 9 GenBank Gene ID BC120020 Link Image
Enzyme 9 GeneCard ID RARS2 Link Image
Enzyme 9 GenAtlas ID Not Available
Enzyme 9 HGNC ID Not Available
Enzyme 9 Chromosome Location Chromosome:6
Enzyme 9 Locus 6q16.1
Enzyme 9 SNPs SNPJam Report Link Image
Enzyme 9 General References Not Available
Enzyme 9 Metabolite References Not Available
Enzyme 10 [top]
Enzyme 10 ID 556
Enzyme 10 Name Glycine amidinotransferase, mitochondrial
Enzyme 10 Synonyms
  1. L-arginine:glycine amidinotransferase
  2. Transamidinase
  3. AT
Enzyme 10 Gene Name GATM
Enzyme 10 Protein Sequence >Glycine amidinotransferase, mitochondrial
MLRVRCLRGGSRGAEALHYIGSRLGRTVTGWVQRTFQSTQAATASSRNSCAADDKATDPL
PKDCPVSSFNEWDPLEEVIVGRAENACVPPFTVEVKANTYDKHWPFYQKYGGSYFPKDHL
QKAVAEIEEMCNILKMEGVTVRRPDPIDWSLKYKTPDFESTGLYGAMPRDILIVVGNEII
EAPMAWRARFFEYRAYRTIIKDYFRRGAKWTTAPKPTMADELYDQDYPIHSVEDRHKLAA
QGKFVTTEFEPCFDAADFIRAGRDIFVQRSQVTNYMGIEWMRKHLAPDYRVHIVSFKDPN
PMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPIIPDDHPLWMSSKWLSM
NVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVSIRNANSLGGGFHCWTCDVRRRGTLQS
YFD
Enzyme 10 Number of Residues 423
Enzyme 10 Molecular Weight 48357.0
Enzyme 10 Theoretical pI 7.97
Enzyme 10 GO Classification
Function
Process
Component
Enzyme 10 General Function Amino acid transport and metabolism
Enzyme 10 Specific Function L-arginine + glycine = L-ornithine + guanidinoacetate
Enzyme 10 Pathways
  • Amine and polyamine biosynthesis
  • creatine biosynthesis
  • creatine from L-arginine and glycine:step 1/2
Enzyme 10 Reactions Not Available
Enzyme 10 Pfam Domain Function
Enzyme 10 Signals
  • None
Enzyme 10 Transmembrane Regions
  • None
Enzyme 10 Essentiality Not Available
Enzyme 10 GenBank ID Protein 87578309 Link Image
Enzyme 10 UniProtKB/Swiss-Prot ID Q2HJ74 Link Image
Enzyme 10 UniProtKB/Swiss-Prot Entry Name GATM_BOVIN Link Image
Enzyme 10 PDB ID 3JDW Link Image
Enzyme 10 PDB File Show
Enzyme 10 3D Structure
Enzyme 10 Cellular Location Not Available
Enzyme 10 Gene Sequence >1272 bp
ATGCTGCGGGTGCGGTGTCTGCGCGGCGGGAGCCGCGGTGCCGAAGCGCTGCACTACATC
GGGTCTCGGCTTGGAAGAACTGTAACGGGATGGGTGCAGCGAACTTTCCAGAGCACCCAG
GCAGCTACGGCTTCCTCCCGGAATTCCTGTGCAGCTGATGACAAGGCCACTGATCCTCTG
CCCAAGGACTGCCCTGTCTCCTCTTTCAACGAATGGGACCCCTTAGAGGAAGTGATCGTG
GGCAGAGCAGAAAATGCCTGTGTTCCACCGTTCACTGTGGAGGTGAAGGCCAACACATAT
GACAAGCACTGGCCTTTTTACCAAAAGTATGGGGGCAGTTATTTTCCCAAAGATCATTTG
CAAAAGGCTGTTGCTGAAATTGAAGAAATGTGCAATATTTTAAAAATGGAAGGAGTGACA
GTGAGGAGGCCTGACCCCATTGACTGGTCACTGAAGTATAAAACTCCTGATTTTGAGTCT
ACGGGTTTATATGGCGCGATGCCTCGAGACATCCTGATAGTTGTGGGAAATGAGATTATC
GAGGCTCCCATGGCCTGGCGCGCTCGCTTCTTTGAGTACCGTGCATACAGAACAATTATC
AAAGACTACTTCCGCCGTGGGGCCAAGTGGACAACGGCTCCTAAGCCCACAATGGCTGAT
GAGCTTTATGACCAAGATTACCCCATCCATTCTGTAGAAGACAGACACAAATTGGCTGCT
CAGGGAAAGTTTGTGACAACTGAGTTTGAGCCATGCTTTGATGCTGCTGATTTCATTCGA
GCTGGAAGAGATATCTTCGTACAAAGAAGCCAGGTTACAAACTACATGGGCATTGAATGG
ATGCGTAAGCATCTGGCTCCAGACTACAGAGTGCACATTGTTTCCTTTAAAGACCCCAAT
CCAATGCACATTGATGCCACCTTCAATATCATTGGGCCTGGTCTTGTGCTTTCCAACCCT
GACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACCATAGTTACTCCT
CCAACACCAATCATCCCAGATGATCACCCACTCTGGATGTCCTCCAAATGGCTTTCCATG
AATGTCTTAATGCTAGATGAAAAGCGTGTTATGGTGGATGCCAACGAGGTCCCAATTCAG
AAGATGTTTGAAAAGCTGGGTATCAGTACCATTAAGGTTAGCATTCGTAACGCCAATTCC
CTGGGAGGAGGCTTCCACTGCTGGACCTGCGATGTCCGTCGCCGGGGCACCCTGCAGTCC
TACTTTGACTGA
Enzyme 10 GenBank Gene ID BC113272 Link Image
Enzyme 10 GeneCard ID GATM Link Image
Enzyme 10 GenAtlas ID Not Available
Enzyme 10 HGNC ID Not Available
Enzyme 10 Chromosome Location Chromosome:1
Enzyme 10 Locus 15q21.1
Enzyme 10 SNPs SNPJam Report Link Image
Enzyme 10 General References Not Available
Enzyme 10 Metabolite References Not Available
Enzyme 11 [top]
Enzyme 11 ID 557
Enzyme 11 Name Inducible nitric oxid synthase
Enzyme 11 Synonyms Not Available
Enzyme 11 Gene Name iNOS
Enzyme 11 Protein Sequence >Inducible nitric oxid synthase
TYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAQEMFEHICRHVRYATNN
GNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPA
Enzyme 11 Number of Residues 105
Enzyme 11 Molecular Weight 12092.5
Enzyme 11 Theoretical pI 9.28
Enzyme 11 GO Classification
Function
Process
Component
Enzyme 11 General Function Involved in arginine binding
Enzyme 11 Specific Function Not Available
Enzyme 11 Pathways Not Available
Enzyme 11 Reactions Not Available
Enzyme 11 Pfam Domain Function
Enzyme 11 Signals
  • None
Enzyme 11 Transmembrane Regions
  • None
Enzyme 11 Essentiality Not Available
Enzyme 11 GenBank ID Protein 47057289 Link Image
Enzyme 11 UniProtKB/Swiss-Prot ID Q6ZXD5 Link Image
Enzyme 11 UniProtKB/Swiss-Prot Entry Name Q6ZXD5_BOVIN Link Image
Enzyme 11 PDB ID 4NOS Link Image
Enzyme 11 PDB File Show
Enzyme 11 3D Structure
Enzyme 11 Cellular Location Not Available
Enzyme 11 Gene Sequence Not Available
Enzyme 11 GenBank Gene ID AJ699400 Link Image
Enzyme 11 GeneCard ID iNOS Link Image
Enzyme 11 GenAtlas ID Not Available
Enzyme 11 HGNC ID Not Available
Enzyme 11 Chromosome Location Not Available
Enzyme 11 Locus Not Available
Enzyme 11 SNPs SNPJam Report Link Image
Enzyme 11 General References
  1. [PubMed Link Image]
Enzyme 11 Metabolite References Not Available
Enzyme 12 [top]
Enzyme 12 ID 558
Enzyme 12 Name Arginase-2, mitochondrial
Enzyme 12 Synonyms
  1. Arginase II
Enzyme 12 Gene Name ARG2
Enzyme 12 Protein Sequence >Arginase-2, mitochondrial
MSLRSHLSRLLRTQVHSVRKKSVHSVAVIGAPFSQGQKRKGVEYGPAAVRXAGLMKRLSD
LGCHLKDFGDLNFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSGGYSCVTVGGDH
SLAIGTISGHARHCPDLGVIWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSPSIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMEQTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGIYITEEIHSTGLLSALDLVEVNPR
LAVSEEEAKATASLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESESEERVRI
Enzyme 12 Number of Residues 354
Enzyme 12 Molecular Weight 38561.5
Enzyme 12 Theoretical pI 6.45
Enzyme 12 GO Classification
Function
Process
Component
Enzyme 12 General Function Amino acid transport and metabolism
Enzyme 12 Specific Function May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis
Enzyme 12 Pathways
  • Nitrogen metabolism
  • urea cycle
  • L-ornithine and urea from L-arginine:step 1/1
Enzyme 12 Reactions Not Available
Enzyme 12 Pfam Domain Function
Enzyme 12 Signals
  • None
Enzyme 12 Transmembrane Regions
  • None
Enzyme 12 Essentiality Not Available
Enzyme 12 GenBank ID Protein 61553631 Link Image
Enzyme 12 UniProtKB/Swiss-Prot ID Q58DL1 Link Image
Enzyme 12 UniProtKB/Swiss-Prot Entry Name ARGI2_BOVIN Link Image
Enzyme 12 PDB ID 1PQ3 Link Image
Enzyme 12 PDB File Show
Enzyme 12 3D Structure
Enzyme 12 Cellular Location Not Available
Enzyme 12 Gene Sequence >1065 bp
ATGTCCCTGAGGAGCCACCTCTCGCGTCTCCTCCGGACGCAAGTGCACTCCGTCCGGAAG
AAGTCTGTCCACTCCGTGGCTGTCATTGGAGCCCCATTCTCCCAGGGACAGAAAAGAAAA
GGAGTGGAATATGGTCCTGCTGCTGTAAGANAAGCTGGCTTGATGAAAAGGCTCTCGGAT
CTGGGCTGCCACCTTAAAGACTTCGGAGATTTGAATTTTACTCCAGTTCCCAAAGATGAT
CTCTATAACAACTTGATAGTGAATCCTCGCTCAGTGGGCCTGGCCAACCAGGAACTAGCG
GAGGTGGTTAGCCGAGCTGTGTCAGGTGGCTACAGCTGTGTCACGGTGGGAGGAGACCAC
AGCCTGGCAATCGGTACCATCAGTGGCCACGCCCGACACTGCCCAGACCTTGGTGTGATC
TGGGTTGATGCCCATGCTGACATCAATACACCCCTCACCACTTCATCTGGAAATCTACAT
GGACAGCCAGTTTCGTTTCTCCTCAGAGAACTACAGGACAAGGTACCACAGCTCCCAGGA
TTTTCCTGGATCAAACCTTGTATCTCTTCTCCAAGTATTGTATATATTGGACTAAGAGAC
GTGGACCCTCCTGAACATTTTATTTTAAAGAATTATGATATCCAGTATTTTTCCATGAGA
GACATAGATCGACTTGGTATCCAGAAGGTCATGGAACAGACATTCGATCTGCTGATTGGC
AAAAGACAAAGGCCAATCCATCTGAGTTTCGATATTGATGCATTTGACCCTACACTGGCT
CCAGCCACAGGAACCCCTGTTGTAGGGGGACTGACCTATCGAGAAGGCATATATATTACT
GAGGAAATACACAGTACAGGGTTGCTCTCGGCCCTGGACCTCGTTGAAGTCAATCCTCGG
TTGGCCGTGTCAGAGGAGGAGGCCAAGGCTACAGCCAGCCTGGCAGTGGACGTCATTGCT
TCGAGTTTCGGGCAGACGAGGGAGGGAGGGCATATTGTCTACGACCAACTTCCAACTCCC
AGCTCACCAGATGAATCAGAGAGTGAAGAACGTGTAAGAATTTAG
Enzyme 12 GenBank Gene ID BT021586 Link Image
Enzyme 12 GeneCard ID ARG2 Link Image
Enzyme 12 GenAtlas ID Not Available
Enzyme 12 HGNC ID Not Available
Enzyme 12 Chromosome Location Chromosome:1
Enzyme 12 Locus 14q24.1-q24.3
Enzyme 12 SNPs SNPJam Report Link Image
Enzyme 12 General References
  1. [PubMed Link Image]
Enzyme 12 Metabolite References Not Available