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Bovine Rumen Metabolome Database



Showing metabocard for L-Glutamine (RMDB00641)

Legend: metabolite field enzyme field

Version 1.0
Creation Date 2005-11-16 15:48:42
Update Date 2009-06-23 16:21:16
Accession Number RMDB00641
Common Name L-Glutamine
Description Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code. Its side chain is an amide; it is formed by replacing a side-chain hydroxyl of glutamic acid with an amine functional group. glutamine is found in foods high in proteins, such as fish, red meat, beans, and dairy products. glutamine is a supplement that is used in weightlifting, bodybuilding, endurance and other sports, as well as by those who suffer from muscular cramps or pain particularly elderly people. The main use of glutamine within the diet of either group is as a means of replenishing the body's stores of amino acids that have been used during exercise or everyday activities. Studies which are looking into problems with excessive consumption of glutamine thus far have proved inconclusive. However, normal supplementation is healthy mainly because glutamine is supposed to be supplemented after prolonged periods of exercise (for example, a workout or exercise in which amino acids are required for use) and replenishes amino acid stores; this being the main reason glutamine is recommended during fasting or for people who suffer from physical trauma, immune deficiencies, or cancer. There is a significant body of evidence that links glutamine-enriched diets with intestinal effects; aiding maintenance of gut barrier function, intestinal cell proliferation and differentiation, as well as generally reducing septic morbidity and the symptoms of Irritable Bowel Syndrome. The reason for such "cleansing" properties is thought to stem from the fact that the intestinal extraction rate of glutamine is higher than that for other amino acids, and is therefore thought to be the most viable option when attempting to alleviate conditions relating to the gastrointestinal tract. These conditions were discovered after comparing plasma concentration within the gut between glutamine-enriched and non glutamine-enriched diets. However, even though glutamine is thought to have "cleansing" properties and effects, it is unknown to what extent glutamine has clinical benefits, due to the varied concentrations of glutamine in varieties of food. It is also known that glutamine has various effects in reducing healing time after operations. Hospital waiting times after abdominal surgery are reduced by providing parenteral nutrition regimens containing amounts of glutamine to patients. Clinical trials have revealed that patients on supplementation regimes containing glutamine have improved nitrogen balances, generation of cysteinyl-leukotrienes from polymorphonuclear neutrophil granulocytes and improved lymphocyte recovery and intestinal permeability (in postoperative patients) - in comparison to those who had no glutamine within their dietary regime; all without any side-effects. (http://en.wikipedia.org/wiki/glutamine)
Synonyms
  1. (2S)-2,5-diamino-5-oxopentanoic acid
  2. (2S)-2-amino-4-carbamoylbutanoic acid
  3. (S)-2,5-Diamino-5-oxopentanoic acid
  4. 2-Aminoglutaramic acid
  5. Cebrogen
  6. Glavamin
  7. Glumin
  8. Glutamic acid 5-amide
  9. Glutamic acid amide
  10. Glutamine
  11. L-(+)-glutamine
  12. L-2-Aminoglutaramic acid
  13. L-2-Aminoglutaramidic acid
  14. L-Glutamic acid 5-amide
  15. L-Glutaminsaeure-5-amid
  16. L-glutamic acid gamma-amide
  17. L-glutamid
  18. L-glutamide
  19. L-glutamin
  20. L-glutamine
  21. Levoglutamid
  22. Levoglutamida
  23. Levoglutamide
  24. Levoglutamidum
  25. Levoglutamina
  26. Polyglutamine
  27. Stimulina
  28. gamma-glutamine
  29. (2S)-2,5-diamino-5-oxopentanoate
  30. (2S)-2-amino-4-carbamoylbutanoate
  31. (S)-2,5-Diamino-5-oxopentanoate
Chemical IUPAC Name (2S)-2-amino-4-carbamoyl-butanoic acid
Chemical Formula C5H10N2O3
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Amino acids and Amino Acid conjugates
Class
  • Amino Acids
Sub Class
  • NA
Family
  • Mammalian_Metabolite
Species
  • primary amine; primary aliphatic amine (alkylamine); carboxylic acid; primary carboxylic acid amide; alpha-aminoacid
Biofunction
  • Essential amino acid; Energy source; Non-essential amino acid; RNA component; Component of Alanine and aspartate metabolism; Component of Aminoacyl-tRNA biosynthesis; Component of Aminosugars metabolism; Component of D-Glutamine and D-glutamate metabolism; Component of Glutamate metabolism; Component of Nitrogen metabolism; Component of Peptidoglycan biosynthesis; Component of Purine metabolism
Application
Source
  • Endogenous
Average Molecular Weight 146.145
Monoisotopic Molecular Weight 146.069138
Isomeric SMILES N[C@@H](CCC(N)=O)C(O)=O
Canonical SMILES NC(CCC(N)=O)C(O)=O
KEGG Compound ID C00064 Link Image
BioCyc ID GLN Link Image
BiGG ID 33714 Link Image
Wikipedia Link L-Glutamine Link Image
METLIN ID 5614 Link Image
PubChem Compound 5961 Link Image
PubChem Substance 10527678 Link Image
ChEBI ID 18050 Link Image
CAS Registry Number 56-85-9
InChI Identifier InChI=1/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
Synthesis Reference Jiao, Qingcai; Qian, Shaosong; Chen, Ran; Wu, Xiaoyan. Synthesis of L-glutamine. Faming Zhuanli Shenqing Gongkai Shuomingshu (2005), 7 pp.
Melting Point (Experimental) 185 oC
Experimental Water Solubility 41.3 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]; 41.3 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)] Source: PhysProp
Predicted Water Solubility 97.799995 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 0
State Solid
Experimental LogP/Hydrophobicity -3.64 [CHMELIK,J ET AL. (1991)] Source: PhysProp
Predicted LogP/Hydrophobicity -3.32 [Predicted by ALOGPS]; -4.1 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show Link Image
SDF File Show Link Image
PDB File Show Link Image
2D Structure
3D Structure
Experimental PDB ID 1CT9 Link Image
Experimental PDB File Show
Experimental PDB Structure
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum
Low Energy
Download File
Show Experimental Conditions Link Image
Medium Energy
Download File
Show Experimental Conditions Link Image
High Energy
Download File
Show Experimental Conditions Link Image
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Cytoplasm (Predicted from LogP)
  • Extracellular
  • mitochondria
Biofluid Location
  • Blood
  • Rumen
Tissue Location
Concentrations (Normal)
Biofluid Rumen
Value 830.5 +/- 251.38 uM
Age 4-5 years old
Sex Female (lactating)
Condition Normal (0% barley grain in dry matter (DM) basis)
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Concentrations (Abnormal)
Biofluid Rumen
Value 946 +/- 239 uM
Age 4-5 years old
Sex Female (lactating)
Condition 15% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 994 +/- 358 uM
Age 4-5 years old
Sex Female (lactating)
Condition 30% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Biofluid Rumen
Value 907.6 +/- 255.2 uM
Age 4-5 years old
Sex Female (lactating)
Condition 45% barley grain in dry matter (DM) basis
Breed Holstein-Friesian
Experimental Condition Rumen fluid for the analysis was collected 15-20 minutes before the morning feeding on days 12 and 21 of each experimental period. Cows were fed once daily at 0800.
Comments Not Available
References
  • The rumen metabolome (in preparation)
Pathway Names Not Available
HMDB Pathways Not Available
KEGG Pathways Not Available
SimCell Pathways Not Available
General References
  1. Wikipedia Link Image
Metabolic Enzymes
  1. Glutamine synthetase
  2. Asparagine synthetase [glutamine-hydrolyzing]
  3. Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2
  4. Glutamyl-tRNA(Gln) amidotransferase subunit A homolog
  5. Protein-glutamine gamma-glutamyltransferase 2
  6. Glutamine-dependent NAD(+) synthetase
  7. Glutaminyl-tRNA synthetase
  8. Coagulation factor XIII A chain
Enzyme 1 [top]
Enzyme 1 ID 148
Enzyme 1 Name Glutamine synthetase
Enzyme 1 Synonyms
  1. GS
  2. Glutamate--ammonia ligase
Enzyme 1 Gene Name GLUL
Enzyme 1 Protein Sequence >Glutamine synthetase
MATSASSHLNKGIKQVYMALPQGDKVQAMYIWIDGTGEGLRCKTRTLDSEPKCIEELPEW
NFDGSSTFQSEGSNSDMYLVPAAMFRDPFRKDPNKLVFCEVFKYNRKPAETNLRHTCKRI
MDMVSNQRPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHY
RACLYAGIKIGGTNAEVMPAQWEFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPFAVTEALIRTCL
LNETGDEPFQYKN
Enzyme 1 Number of Residues 373
Enzyme 1 Molecular Weight 42031.2
Enzyme 1 Theoretical pI 6.83
Enzyme 1 GO Classification
Function
Process
Component
Enzyme 1 General Function Amino acid transport and metabolism
Enzyme 1 Specific Function Essential for proliferation of fetal skin fibroblasts
Enzyme 1 Pathways Not Available
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 73586743 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID P15103 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name GLNA_BOVIN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >1122 bp
ATGGCCACCTCGGCGAGCTCCCACTTGAACAAAGGCATCAAGCAGGTGTACATGGCCCTA
CCTCAGGGTGATAAAGTCCAAGCTATGTACATCTGGATCGACGGTACTGGAGAAGGACTG
CGCTGCAAGACCCGAACCTTGGATTCTGAACCCAAGTGTATAGAAGAGTTGCCCGAGTGG
AATTTTGATGGCTCTAGTACTTTTCAGTCTGAAGGCTCCAACAGTGACATGTATCTTGTC
CCCGCTGCCATGTTTCGGGACCCTTTCCGCAAGGACCCCAACAAGCTGGTGTTCTGTGAA
GTCTTCAAGTACAACCGAAAGCCTGCAGAGACCAATTTAAGGCACACCTGTAAACGGATA
ATGGACATGGTGAGCAACCAGCGCCCCTGGTTTGGAATGGAGCAGGAATATACCCTCATG
GGCACTGATGGGCACCCCTTTGGTTGGCCTTCCAATGGCTTTCCTGGGCCCCAAGGTCCC
TACTACTGTGGTGTGGGAGCGGACAAGGCCTACGGCAGGGATATTGTGGAGGCTCACTAC
AGGGCCTGCTTGTACGCCGGCATCAAGATCGGGGGCACGAATGCCGAGGTCATGCCTGCA
CAGTGGGAATTCCAGATAGGACCCTGTGAAGGAATCGACATGGGCGATCATCTCTGGGTG
GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTCGGAGTGATCGCCACCTTTGATCCT
AAGCCCATTCCTGGAAACTGGAATGGTGCTGGCTGCCACACCAACTTTAGCACCAAGGCC
ATGCGAGAGGAGAATGGTCTGAAGTACATTGAGGAGGCCATTGAGAAGCTAAGCAAGCGC
CACCAGTACCACATCCGAGCCTACGATCCCAAGGGGGGCCTGGACAACGCCCGGCGCCTA
ACTGGGTTCCACGAAACCTCCAACATCAACGACTTCTCTGCCGGCGTGGCCAACCGTGGT
GCTAGCATCCGCATCCCCCGGACTGTTGGCCAGGAGAAGAAGGGCTACTTCGAAGACCGT
CGCCCATCTGCCAACTGTGACCCCTTCGCCGTGACCGAAGCCCTCATCCGCACATGTCTT
CTGAACGAAACTGGCGACGAGCCCTTCCAGTACAAGAACTAA
Enzyme 1 GenBank Gene ID BC103099 Link Image
Enzyme 1 GeneCard ID GLUL Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Chromosome:1
Enzyme 1 Locus 1q31
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References
  1. [PubMed Link Image]
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 563
Enzyme 2 Name Asparagine synthetase [glutamine-hydrolyzing]
Enzyme 2 Synonyms
  1. Glutamine-dependent asparagine synthetase
Enzyme 2 Gene Name ASNS
Enzyme 2 Protein Sequence >Asparagine synthetase [glutamine-hydrolyzing]
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDQLFGMQ
PIRVKKYPYLWLCYNGEIYNHKKLQHHFEFEYQTKVDGEIILHLYDKGGIEQTVCMLDGV
FAFILLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVNLKHSMTPFLKVEPF
LPGHYEVLDLKPNGKVASVEMVKHHHCRDEPLHALYDGVEKLFPGFEIETVKSNLRILFD
NAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR
KVANHIGSEHHEVLFNSEEGIQVLDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVV
IFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPF
LDHRFSSYYLSLPPDMRVPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNS
WFRILQDYIEHQVDDAAMASAAQKFPINTPKTKEGYYYRQIFENHYPGRADWLPHYWMPR
WTNATDPSARTLTHYKAAAKA
Enzyme 2 Number of Residues 561
Enzyme 2 Molecular Weight 64219.1
Enzyme 2 Theoretical pI 6.77
Enzyme 2 GO Classification
Function
Process
Component
Enzyme 2 General Function Amino acid transport and metabolism
Enzyme 2 Specific Function ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
Enzyme 2 Pathways
  • Amino-acid biosynthesis
  • L-asparagine biosynthesis
  • L- asparagine from L-aspartate (L-Gln route):step 1/1
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 94534952 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q1LZA3 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name ASNS_BOVIN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1686 bp
ATGTGTGGCATTTGGGCGCTCTTTGGCAGCGATGACTGCCTTTCTGTTCAGTGTCTGAGT
GCTATGAAGATTGCACACAGGGGTCCGGATGCATTCCGTTTTGAAAATGTTAATGGGTAC
ACCAATTGCTGCTTTGGATTTCACCGGTTGGCGGTAGTTGACCAGCTGTTTGGAATGCAG
CCAATTCGAGTGAAGAAATATCCTTACTTGTGGCTCTGTTACAACGGTGAAATCTACAAC
CACAAGAAGCTGCAACACCATTTTGAATTTGAATACCAGACCAAAGTGGATGGTGAAATA
ATCCTTCATCTTTATGACAAAGGAGGAATTGAACAAACAGTTTGTATGTTGGATGGAGTA
TTTGCATTTATTTTACTGGATACTGCCAATAAGAAAGTGTTCTTGGGCAGAGATACCTAT
GGAGTGAGACCTTTGTTTAAAGCCATGACAGAAGATGGATTTTTGGCCGTGTGTTCAGAA
GCTAAAGGACTGGTTAACTTGAAGCACTCCATGACTCCTTTTTTAAAAGTGGAGCCTTTT
CTGCCAGGACATTATGAAGTTTTGGACCTAAAGCCAAATGGCAAAGTGGCGTCGGTGGAA
ATGGTGAAGCACCATCACTGTAGAGACGAGCCTCTGCATGCCCTGTATGACGGCGTGGAG
AAACTCTTCCCAGGTTTTGAGATAGAAACTGTGAAGAGCAACCTCCGGATTCTTTTTGAC
AATGCCGTTAAGAAACGTTTGATGACGGACAGAAGGATTGGCTGCCTTTTATCAGGTGGC
TTGGATTCCAGTTTGGTTGCTGCCACTCTGTTGAAGCAGCTAAAAGAGGCCCAAGTTCAG
TACCCTCTCCAGACATTTGCGATTGGCATGGAAGACAGTCCCGATTTACTAGCTGCTAGA
AAGGTGGCAAATCATATTGGGAGCGAACACCATGAAGTCCTCTTTAACTCTGAGGAAGGC
ATTCAGGTCCTGGATGAAGTCATATTTTCCTTGGAAACTTATGATATTACAACAGTCCGT
GCTTCAGTAGGTATGTACTTAATTTCTAAGTACATTCGGAAGAACACAGATAGCGTGGTG
ATCTTCTCTGGAGAAGGTTCAGATGAACTTACGCAGGGTTATATATATTTTCACAAGGCT
CCTTCCCCGGAGAAAGCTGAGGAGGAGAGTGAGCGGCTTCTAAGGGAACTCTACTTGTTT
GATGTTCTCCGAGCAGATCGAACTACTGCAGCCCATGGCCTTGAATTGAGAGTCCCTTTC
TTGGATCATCGCTTTTCTTCCTACTACTTGTCTCTGCCACCAGATATGAGAGTTCCCAAG
AATGGGATAGAAAAGCATCTCCTGAGAGAGACATTTGAGGACTCCAATCTGATACCTAAA
GAGATTCTCTGGCGACCAAAAGAAGCCTTCAGTGATGGAATAACCTCAGTTAAAAATTCC
TGGTTTAGGATTTTACAGGACTATATTGAACATCAGGTTGATGATGCAGCGATGGCAAGC
GCAGCCCAGAAATTTCCCATCAATACCCCCAAAACAAAAGAAGGCTATTACTACCGTCAG
ATCTTTGAAAACCACTACCCAGGCCGTGCCGACTGGCTGCCCCATTACTGGATGCCCAGG
TGGACCAACGCCACGGACCCTTCTGCCCGCACTCTGACCCATTACAAGGCCGCTGCCAAA
GCTTAG
Enzyme 2 GenBank Gene ID BC116123 Link Image
Enzyme 2 GeneCard ID ASNS Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Chromosome:7
Enzyme 2 Locus 7q21.3
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References Not Available
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 827
Enzyme 3 Name Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Enzyme 3 Synonyms
  1. Glutamine:fructose 6 phosphate amidotransferase 2
  2. GFAT 2
  3. GFAT2
  4. D-fructose-6-phosphate amidotransferase 2
  5. Hexosephosphate aminotransferase 2
Enzyme 3 Gene Name GFPT2
Enzyme 3 Protein Sequence >Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2
MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNNEVKERHIQLVKKR
GNVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHN
GIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEG
AFALVFKSIHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPVLYRTRNIENVKNICKTRMK
RLDSSTCLHAVGNKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRLAS
DDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDH
LKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFF
ISQSGETADTLLALRYCKDRRALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYT
SQFISLVMFGLMMSEDRISLQNRRREIIHGLKSLPELIKEVLSLDEKIHDLALELYTQRS
LLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALIDKQMPVIMVIMKDPCF
AKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFH
LAVLRGYDVDFPRNLAKSVTVE
Enzyme 3 Number of Residues 682
Enzyme 3 Molecular Weight 77080.1
Enzyme 3 Theoretical pI 7.72
Enzyme 3 GO Classification
Function
Process
Component
Enzyme 3 General Function Cell wall/membrane/envelope biogenesis
Enzyme 3 Specific Function Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins
Enzyme 3 Pathways
  • Nucleotide-sugar biosynthesis
  • UDP-N-acetyl-alpha-D- glucosamine biosynthesis
  • alpha-D-glucosamine 6-phosphate from D- fructose 6-phosphate:step 1/1
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 115304901 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID Q08DQ2 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name GFPT2_BOVIN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >2049 bp
ATGTGCGGAATCTTTGCCTACATGAATTACAGAGTCCCCCGGACAAGGAAGGAGATTTTT
GAAACCCTCATCAAGGGCCTGCAGCGGCTTGAGTACAGAGGCTATGACTCAGCAGGTGTG
GCAATTGATGGAAATAATAATGAAGTCAAAGAAAGGCATATCCAGCTCGTCAAGAAAAGA
GGAAATGTCAAAGCTCTTGATGAAGAACTTTACAAACAAGACAGCATGGACTTAAAAGTG
GAGTTTGAGACCCACTTTGGCATTGCCCACACACGGTGGGCCACTCACGGGGTCCCCAGT
GCTGTCAACAGCCACCCGCAGCGCTCAGACAAGGGCAACGAATTCGTTGTCATCCATAAT
GGGATCATCACAAATTACAAAGACCTGAGGAAATTTCTGGAAAGCAAAGGCTATGAGTTT
GAGTCAGAAACAGATACAGAAACCATTGCCAAGCTGATTAAATATGTGTTCGACAACAGA
GAAACCGAGGACATTACATTTTCAACACTGGTGGAGAGAGTCATTCAGCAGCTGGAAGGC
GCATTTGCCTTGGTTTTCAAGAGCATCCACTACCCTGGAGAAGCCGTGGCCACAAGGAGA
GGCAGTCCCCTACTCATCGGAGTAAGGAGCAAATACAAACTCTCCACAGAACAGATCCCC
GTCTTATATAGGACACGCAATATTGAGAATGTGAAGAATATCTGTAAAACAAGGATGAAG
AGGCTGGACAGCTCGACCTGCCTTCACGCTGTGGGCAATAAAGCAGTGGAATTCTTTTTT
GCTTCTGATGCAAGTGCTATCATAGAGCACACCAACCGGGTCATCTTCCTTGAGGATGAT
GACATTGCCGCAGTGGCTGATGGGAAACTCTCTATTCACCGGGTCAAGCGTTTGGCTAGT
GATGACCCATCTCGAGCCATCCAGACCTTGCAGATGGAATTGCAGCAAATCATGAAAGGT
AACTTCAGTGCATTTATGCAAAAGGAGATATTTGAACAGCCAGAATCCGTTTTCAATACC
ATGAGAGGTCGAGTGAATTTTGAGACCAACACAGTGCTCCTGGGTGGCTTGAAAGACCAC
TTGAAGGAGATCAGACGATGCCGACGGCTCATTGTGATTGGCTGTGGGACCAGCTACCAC
GCCGCTGTGGCCACGCGGCAAGTTTTGGAGGAACTGACCGAGCTCCCCGTGATGGTTGAA
CTTGCTAGTGATTTTCTGGACAGGAACACACCTGTGTTCAGGGATGACGTTTGCTTTTTC
ATAAGCCAGTCAGGGGAGACTGCAGACACCCTCCTGGCACTGCGCTACTGCAAGGACCGC
CGAGCTCTGACCGTGGGCGTCACCAACACCGTGGGCAGCTCCATCTCCCGCGAGACGGAC
TGCGGCGTCCACATCAACGCAGGGCCGGAGATCGGTGTGGCCAGCACCAAGGCTTACACC
AGTCAGTTCATCTCCTTGGTGATGTTTGGTTTGATGATGTCTGAAGACCGCATTTCACTG
CAAAACAGAAGGCGAGAGATCATCCATGGCCTGAAATCTCTACCCGAGCTGATCAAGGAG
GTGCTGTCCCTGGATGAGAAGATCCACGACCTGGCCCTGGAGCTCTACACACAAAGGTCA
CTTCTGGTCATGGGGCGAGGCTACAACTATGCCACATGCCTGGAAGGAGCCCTGAAAATT
AAAGAGATAACCTACATGCACTCAGAAGGCATCCTGGCTGGAGAGTTGAAGCACGGCCCC
CTGGCGCTGATTGATAAGCAGATGCCTGTCATCATGGTCATCATGAAGGATCCTTGCTTT
GCCAAATGCCAGAACGCCCTGCAGCAGGTCACAGCGCGCCAGGGTCGCCCGATTATACTG
TGCTCCAAGGACGACACTGAAAGCTCCAAGTTTGCATATAAAACGATCGAGCTGCCCCAC
ACCGTAGACTGCCTGCAGGGCATCCTGAGTGTGATTCCACTGCAGCTCCTCTCCTTCCAC
CTGGCTGTACTCCGAGGATATGACGTTGACTTCCCCAGAAATCTGGCCAAGTCTGTAACC
GTGGAATGA
Enzyme 3 GenBank Gene ID BC123624 Link Image
Enzyme 3 GeneCard ID GFPT2 Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Chromosome:5
Enzyme 3 Locus 5q34-q35
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References Not Available
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 850
Enzyme 4 Name Glutamyl-tRNA(Gln) amidotransferase subunit A homolog
Enzyme 4 Synonyms
  1. Glutaminyl-tRNA synthase-like protein 1
Enzyme 4 Gene Name QRSL1
Enzyme 4 Protein Sequence >Glutamyl-tRNA(Gln) amidotransferase subunit A homolog
MLGRTLREVSVELKQGQITPTELCQRCLSLIKKTKFLNAYITVSEEVALKQAEESEKRYK
KGHSLGDLDGIPIAVKDNFSTSGIETTCASNMLKGYVPPYNATVVQKLLDQGALLMGKTN
LDEFAMGSGSTDGIFGPVKNPWSYSKQYREKRKQNSHSENEDSNWLITGGSSGGSAAAVS
AFTCFAALGSDTGGSTRNPAAHCGVVGLKPSYGLVSRHGLIPLVNSMDVPGILTRCVDDA
ATVLGVLAGHDPKDSTTIQDPVKPFTLPSLTDVSKLCIGIPKEYLTPELSSEVQSLWSKA
ANLFESEGAKVTEVSLPHTSYSIVCYHVLCTSEVASNMARFDGLEYGHRCDSDVSTEAMY
AATRREGFNDVVRGRILSGNFFLLKENYENYFVKAQKVRRLIANDFVNVFNSGVDVLLTP
TTLSEAVPYTEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSVPVALSSQGLPIGLQFIGRA
FCDQQLLIVAKWFEKQVQFPVIQLQELMDDCSSVFENEKLASVSLK
Enzyme 4 Number of Residues 526
Enzyme 4 Molecular Weight 57299.6
Enzyme 4 Theoretical pI 5.72
Enzyme 4 GO Classification
Function
Process
Component
Enzyme 4 General Function Translation, ribosomal structure and biogenesis
Enzyme 4 Specific Function ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • None
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 88954303 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q29RP9 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name QRSL1_BOVIN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >1581 bp
ATGTTGGGCCGGACCCTGCGAGAAGTTTCTGTGGAACTGAAACAAGGCCAGATCACGCCA
ACTGAGCTCTGTCAAAGATGTCTCTCCCTTATCAAGAAGACTAAGTTTCTAAATGCATAC
ATTACTGTATCAGAAGAAGTGGCCTTAAAGCAAGCTGAAGAATCAGAGAAAAGATATAAG
AAAGGTCACTCACTGGGAGATTTAGATGGAATTCCTATTGCAGTAAAAGATAACTTTAGT
ACATCCGGCATTGAGACAACCTGTGCATCAAACATGCTGAAAGGTTATGTACCACCTTAT
AATGCCACAGTAGTTCAGAAGTTGTTGGATCAGGGAGCTCTGCTAATGGGAAAAACAAAC
TTAGATGAGTTTGCTATGGGATCTGGAAGCACAGATGGCATATTTGGACCAGTTAAAAAC
CCGTGGAGTTATTCAAAACAATATAGAGAAAAGAGGAAGCAAAACTCTCACAGTGAGAAT
GAGGATTCAAATTGGCTTATAACCGGAGGAAGCTCAGGAGGAAGTGCAGCGGCCGTGTCA
GCGTTCACGTGCTTTGCGGCTTTAGGATCAGATACGGGAGGATCAACCAGAAATCCAGCT
GCCCACTGCGGGGTTGTTGGTTTAAAACCAAGCTATGGCCTAGTTTCTCGTCATGGTCTC
ATTCCCCTGGTGAATTCAATGGATGTGCCAGGAATCTTAACCAGATGTGTGGATGATGCA
GCCACTGTGTTGGGTGTACTAGCTGGGCATGATCCCAAAGATTCTACCACAATTCAAGAT
CCTGTTAAACCATTTACGCTTCCCAGTTTGACAGATGTGAGCAAACTATGTATAGGAATT
CCAAAGGAGTATCTTACGCCAGAATTGTCAAGTGAAGTACAATCTCTTTGGTCCAAAGCT
GCTAATCTCTTTGAGTCTGAGGGGGCCAAAGTAACTGAAGTCTCCCTGCCCCATACCAGC
TACTCAATTGTGTGCTACCACGTATTGTGCACGTCGGAAGTGGCATCGAATATGGCCAGA
TTTGATGGGCTAGAATATGGTCACAGATGTGATAGTGATGTGTCTACTGAAGCCATGTAT
GCTGCAACCAGGCGAGAAGGGTTCAATGATGTGGTGAGAGGGAGAATCCTCTCAGGAAAC
TTTTTCCTATTAAAAGAAAATTATGAGAATTATTTTGTCAAAGCACAGAAAGTGAGACGG
CTCATTGCTAATGATTTTGTTAATGTTTTTAACTCTGGAGTGGACGTGCTGCTAACTCCC
ACGACCTTGAGTGAGGCAGTGCCGTACACAGAGTTCATCAAGGAAGACAACAGGACGCGC
AGCGCCCAAGACGACATCTTTACACAGGCCGTGAATATGGCAGGACTGCCAGCAGTGAGT
GTCCCTGTGGCCCTCTCAAGCCAAGGGTTGCCAATAGGACTGCAGTTTATTGGACGTGCA
TTTTGTGACCAGCAGCTTCTTATAGTTGCCAAATGGTTTGAAAAACAAGTCCAGTTTCCT
GTTATTCAACTTCAAGAACTAATGGATGATTGTTCATCAGTCTTTGAAAATGAAAAGTTG
GCTTCTGTTTCTCTAAAATAG
Enzyme 4 GenBank Gene ID BC114078 Link Image
Enzyme 4 GeneCard ID QRSL1 Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Chromosome:6
Enzyme 4 Locus 6q21
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 851
Enzyme 5 Name Protein-glutamine gamma-glutamyltransferase 2
Enzyme 5 Synonyms
  1. Tissue transglutaminase
  2. TGase C
  3. TGC
  4. TG(C)
  5. Transglutaminase-2
Enzyme 5 Gene Name TGM2
Enzyme 5 Protein Sequence >Protein-glutamine gamma-glutamyltransferase 2
MAEELVLERCDLELEANGRDHHTADLCRERLVVRRGQPFWLTLHFEGRNYEASVDSLTFC
AVTGPDPSEEAGTKALFRLSDATEEGAWAAVAADQRDSTLSLHLSTPANAPVGHYRLSLE
ASTGYQGSSFMLGQFTLLFNSWCPADAVYLDSDEERQEYVLTQQGFIYQGSAKFIKNIPW
NFGQFEEGILDICLMLLDVNPKFLRNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR
WDNNYADGISPMSWIGSVDILRRWKRDGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGEIQSDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT
PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIRQDDGSLHKSINHSL
VVGLKISTKCVGRDDREDITHSYKYPEGSPEEREAFTRANHLNKLVNKEETGVAMRIRVG
EGMNRGCDFDVFAHITNSTPEEHTGRLLLCARTVSYNGILGPECGTKDLLSLSLEPYSEK
SIPLRILYEKYCDCLTESNLIKVRGLLIEPAANSYLLAERDIYLENPEIKIRILGEPKQN
RKLVAEISLQNPLTVALSGCTFTVEGAGLIEEQKTVDVPDPVEAGEEVKVRVDLLPLYVG
RHKLVVNFESDRLKAVKGFRNVIVGPS
Enzyme 5 Number of Residues 687
Enzyme 5 Molecular Weight 77111.5
Enzyme 5 Theoretical pI 4.91
Enzyme 5 GO Classification
Function
Process
Component
Enzyme 5 General Function Involved in acyltransferase activity
Enzyme 5 Specific Function Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins
Enzyme 5 Pathways Not Available
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 818 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID P51176 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name TGM2_BOVIN Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >2064 bp
ATGGCCGAGGAGCTGGTCCTGGAGAGATGTGACCTGGAGCTGGAGGCCAATGGCCGTGAC
CACCACACAGCTGACCTGTGCAGGGAAAGGCTGGTAGTGCGGCGGGGCCAGCCCTTCTGG
CTGACTCTGCACTTTGAGGGCCGGAACTATGAGGCCAGCGTGGACAGCCTCACCTTTTGT
GCTGTGACTGGCCCAGACCCCAGTGAGGAGGCCGGGACCAAGGCCCTCTTCAGGCTGTCC
GATGCTACGGAGGAGGGGGCCTGGGCAGCGGTGGCAGCGGACCAGCGAGACAGCACCCTC
TCGCTGCACCTCAGCACCCCGGCCAATGCCCCCGTTGGCCATTACCGCCTCAGCTTGGAG
GCCTCCACTGGCTACCAGGGCTCCAGTTTCATGCTGGGTCAGTTCACCCTGCTCTTCAAC
AGCTGGTGTCCAGCGGATGCTGTGTACCTGGACTCAGATGAGGAGCGGCAAGAATACGTC
CTTACCCAGCAAGGCTTCATCTACCAGGGCTCAGCCAAGTTCATCAAGAACATACCTTGG
AATTTTGGGCAGTTTGAAGAAGGGATCCTAGACATCTGCCTGATGCTCCTGGATGTCAAC
CCCAAGTTCCTGAGGAATGCCGGCCGAGACTGCTCCCGCCGCAGTAGTCCGGTCTATGTG
GGCCGGGTGGTGAGCGGCATGGTCAACTGCAACGATGACCAGGGCGTGCTGCTGGGGCGC
TGGGACAACAACTACGCAGACGGCATCAGCCCCATGTCCTGGATCGGCAGCGTGGACATC
CTGCGGCGCTGGAAGAGAGATGGCTGCCAGCGCGTCAAGTACGGCCAGTGCTGGGTGTTC
GCGGCTGTGGCCTGCACCGTGCTGCGGTGCCTTGGCATCCCTACCCGAGTCGTGACCAAC
TATAACTCAGCCCATGACCAGAACAGCAACCTGCTCATCGAGTACTTCCGCAATGAGTTC
GGGGAGATCCAGAGTGACAAGAGCGAGATGATCTGGAACTTCCACTGCTGGGTGGAGTCG
TGGATGACCAGGCCAGACCTGCAGCCGGGGTACGAGGGGTGGCAGGCCCTCGACCCCACG
CCCCAGGAGAAGAGCGAAGGGACTTACTGCTGTGGCCCGGTTCCCGTTCGTGCCATCAAG
GAGGGTGACCTGAGCACCAAATACGACGCCCCTTTCGTCTTTGCCGAAGTCAACGCTGAC
GTGGTGGACTGGATCCGGCAGGACGATGGGTCTCTGCACAAATCCATCAACCACTCCCTG
GTGGTGGGGCTGAAGATCAGCACAAAGTGTGTGGGCAGAGATGATCGGGAGGACATCACC
CACAGCTACAAGTACCCGGAGGGGTCCCCAGAGGAAAGGGAAGCCTTCACAAGAGCCAAC
CATCTGAACAAACTGGTTAACAAAGAGGAGACAGGGGTGGCCATGCGGATCCGTGTGGGC
GAGGGCATGAACAGAGGCTGCGACTTCGACGTCTTTGCCCACATCACCAACAGCACCCCT
GAGGAGCACACTGGCCGCCTCCTGCTCTGTGCCCGCACTGTCAGCTACAATGGGATCCTG
GGACCTGAGTGCGGCACCAAGGATCTGCTCAGCCTTTCCCTGGAGCCCTACTCTGAGAAG
AGCATTCCCCTTCGAATCCTCTACGAAAAGTACTGTGATTGCCTGACCGAATCGAACCTT
ATCAAGGTGCGGGGCCTCCTTATTGAGCCAGCTGCCAATAGCTACCTGCTGGCCGAGAGG
GACATCTACCTGGAGAACCCAGAAATCAAGATCCGGATCCTGGGAGAGCCCAAGCAGAAC
CGCAAGCTGGTGGCTGAGATATCTCTGCAGAACCCGCTCACTGTGGCGCTGTCGGGCTGC
ACCTTCACTGTGGAGGGAGCAGGCCTGATTGAGGAGCAGAAGACTGTGGACGTCCCAGAC
CCCGTGGAAGCAGGGGAGGAAGTCAAGGTGAGGGTGGACCTGCTGCCTCTGTACGTGGGC
CGCCACAAGCTGGTGGTGAACTTCGAGAGCGACAGGCTGAAGGCCGTGAAGGGCTTTAGG
AACGTCATCGTTGGCCCCTCCTAA
Enzyme 5 GenBank Gene ID X60686 Link Image
Enzyme 5 GeneCard ID TGM2 Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Chromosome:2
Enzyme 5 Locus 20q12
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References
  1. [PubMed Link Image]
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 852
Enzyme 6 Name Glutamine-dependent NAD(+) synthetase
Enzyme 6 Synonyms
  1. NAD(+) synthase [glutamine-hydrolyzing]
  2. NAD(+) synthetase 1
Enzyme 6 Gene Name NADSYN1
Enzyme 6 Protein Sequence >Glutamine-dependent NAD(+) synthetase
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKHRGARYRLGPELEICGYGCWDHYYES
DTLLHSLQVLAALLESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRQTEEYFLPRMLQDLTKQETVPFGDAVLSTWDTCIGSEVCEELWT
PHSPHVDMGLDGVEIFTNASGSHHVLRKAHARVDLVTMATTKNGGIYLLANQKGCDGDRL
YYDGCALIAMNGSIFAQGSQFSLDDVEVLTATLDLEDIRSYRAEISSRNLAASRVSPYPR
VKVDFALSCHEDLLEPVSEPIEWKYHSPAEEISLGPACWLWDFLRRSRQAGFFLPLSGGV
DSAATACLVYSMCHQVCEAVKRGNLEVLADVRTIVNQLSYTPQDPRELCGRVLTTCYMAS
ENSSQETCDRARELAQQIGSHHIGLHIDPVVKALVGLFSLVTGASPRFAVHGGSDRENLA
LQNVQARVRMVIAYLFAQLSLWSRGAPGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQLCVERFQLPALQSILAAPATAELEPLAHGRVSQTDEEDMGMTYAELSV
YGRLRKVAKTGPYSMFCKLLDMWRDTCSPRQVADKVKCFFSKYSMNRHKMTTLTPAYHAE
SYSPDDNRFDLRPFLYNTRWPWQFRCIENQVLQLEGRQRQELDGVD
Enzyme 6 Number of Residues 706
Enzyme 6 Molecular Weight 79398.9
Enzyme 6 Theoretical pI 6.46
Enzyme 6 GO Classification
Function
Process
Component
Enzyme 6 General Function Coenzyme transport and metabolism
Enzyme 6 Specific Function ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate
Enzyme 6 Pathways
  • Cofactor biosynthesis
  • NAD(+) biosynthesis
  • NAD(+) from deamido-NAD(+) (L-Gln route):step 1/1
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 73587273 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID Q3ZBF0 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name NADE1_BOVIN Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >2121 bp
ATGGGGCGAAAGGTGACCGTGGCCACCTGTGCGCTCAACCAGTGGGCCCTGGACTTTGAG
GGCAATTTGCAAAGGATTTTAAAAAGTATTGAAATTGCCAAACACAGAGGAGCAAGATAC
AGGCTTGGACCAGAACTGGAAATCTGTGGCTACGGCTGTTGGGATCATTATTACGAGTCG
GACACCCTCCTGCATTCGCTCCAGGTCCTGGCGGCCCTTTTGGAGTCTCCGGTCACTCAG
GATATCATCTGCGACGTGGGGATGCCCGTGATGCACCGAAACGTCCGCTATAACTGCAGG
GTGATATTCCTCAACAGGAAGATCCTGCTCATCAGACCCAAGATGGCCTTGGCGAATGAG
GGCAACTACCGAGAGTTGCGCTGGTTCACGCCATGGTCCAGGAGCCGGCAAACAGAGGAG
TATTTTCTCCCCCGGATGTTACAGGACCTGACGAAGCAGGAAACTGTGCCCTTTGGGGAT
GCCGTCCTCTCCACATGGGACACCTGTATCGGGAGTGAGGTCTGTGAGGAGCTCTGGACG
CCCCACAGCCCACACGTGGACATGGGCCTGGACGGCGTGGAGATCTTCACCAACGCCTCG
GGTAGCCATCACGTGCTGCGCAAAGCCCACGCCCGGGTGGACCTGGTGACCATGGCTACC
ACCAAGAACGGCGGGATCTACTTGCTGGCCAATCAGAAGGGCTGCGATGGGGACCGGCTG
TATTACGACGGCTGTGCTCTCATAGCCATGAACGGCAGCATCTTTGCCCAGGGGTCCCAG
TTCTCTCTGGATGACGTGGAAGTGCTCACTGCCACGTTGGATTTGGAGGACATCAGAAGC
TACAGGGCGGAGATTTCATCTCGAAACCTGGCGGCCAGCAGGGTGAGCCCCTACCCCCGC
GTGAAGGTGGATTTCGCCCTCTCCTGCCATGAAGACCTGCTGGAGCCTGTGTCTGAGCCT
ATCGAGTGGAAATACCACAGTCCCGCCGAGGAGATCAGCCTGGGACCCGCGTGCTGGCTC
TGGGACTTCTTAAGACGCAGCCGACAGGCAGGGTTCTTCCTTCCCCTGAGCGGCGGGGTG
GACAGCGCGGCCACCGCCTGCCTGGTCTACTCCATGTGCCACCAGGTCTGCGAGGCTGTG
AAGCGTGGAAATCTGGAGGTGCTGGCTGATGTCCGAACCATCGTGAACCAGCTCAGCTAC
ACCCCCCAGGACCCCCGGGAGCTCTGCGGCCGCGTCCTGACCACCTGCTACATGGCCAGC
GAGAACTCCTCCCAGGAGACCTGCGACAGGGCCCGAGAGCTGGCCCAGCAGATTGGAAGC
CACCACATCGGTCTCCACATCGACCCAGTGGTCAAGGCCCTCGTGGGCCTCTTCAGCCTG
GTGACGGGTGCGAGCCCTCGGTTTGCGGTTCACGGAGGGAGCGACCGGGAGAACCTGGCT
CTGCAGAACGTCCAGGCGCGGGTGAGGATGGTCATCGCCTACCTCTTCGCTCAGCTGAGC
CTCTGGTCTCGCGGTGCCCCCGGCGGGCTTCTCGTGCTCGGATCCGCCAATGTGGACGAG
AGCCTCCTTGGCTACCTGACCAAGTACGACTGCTCCAGCGCTGACATCAACCCCATCGGC
GGGATCAGCAAGACGGACCTGAGAGCCTTCGTCCAGCTCTGCGTGGAGCGCTTCCAGCTT
CCTGCCCTGCAGAGCATCCTGGCAGCACCGGCCACAGCTGAGCTGGAGCCCCTGGCCCAC
GGACGGGTGTCCCAGACCGATGAGGAAGACATGGGGATGACATATGCGGAGCTGTCCGTC
TACGGGAGGCTCCGGAAGGTCGCCAAGACAGGCCCCTACAGCATGTTCTGCAAACTCCTC
GACATGTGGAGGGATACCTGCTCGCCCCGACAGGTGGCTGACAAAGTGAAGTGCTTTTTC
TCCAAGTATTCCATGAACAGACACAAGATGACCACACTGACCCCCGCATACCACGCCGAG
AGCTACAGCCCGGACGACAACAGGTTCGACCTGCGGCCATTTCTGTATAACACCCGCTGG
CCCTGGCAGTTCCGCTGCATCGAAAACCAGGTCCTCCAGCTGGAGGGGAGACAGCGGCAG
GAGCTAGACGGCGTGGACTGA
Enzyme 6 GenBank Gene ID BC103388 Link Image
Enzyme 6 GeneCard ID NADSYN1 Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Chromosome:1
Enzyme 6 Locus 11q13.4
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References Not Available
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 853
Enzyme 7 Name Glutaminyl-tRNA synthetase
Enzyme 7 Synonyms
  1. Glutamine--tRNA ligase
  2. GlnRS
Enzyme 7 Gene Name QARS
Enzyme 7 Protein Sequence >Glutaminyl-tRNA synthetase
MAALDSLSLFTGLGLSEQKARETLKNTVLSAQLREAATQAQQTLGSSIDKATGTLLYGLA
SRLRDPRRLSFLVSYITSRKIHTETQLSAALEYVRSHPLDPINTEDFEQECGVGVVVTPE
QIEEAVEAAINRHRAKLLVERYHFSMGLLMGEARAALKWADGKMIKHEVDMQVLHLLGPK
TETDLEKKPKVAKARPEETDQRTAKDVVENGEVVVQTLSLMEQLRGEALKFHKPGENYKT
PGYVTTPHTMDLLKQHLDITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFL
RFDDTNPEKEEAKFFTAIYDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRDQAYVCHQ
RGEELKGHNPLPSPWRDRPIEESLLLFEAMRKGKFAEGEATLRMKLVMEDGKMDPVAYRV
KYTPHHRTGDTWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPV
QWEYGRLNLHYAVVSKRKILQLVAAGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVG
VTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLEPLQVVITNFPATKALDIQVPNFPADET
KGFHQVPFGSTVFIERMDFKEEPEPGYKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVES
LKVTCRRADAGEKPKAFIHWVSQPLTCEIRLYERLFQHKNPEDPAEVPGGFLSDLNPASL
QVVEAALVDCSVALAKPFDKFQFERLGYFSVDPDSNQGQLVFNRTVTLKEDPGKV
Enzyme 7 Number of Residues 775
Enzyme 7 Molecular Weight 87642.5
Enzyme 7 Theoretical pI 6.89
Enzyme 7 GO Classification
Function
Process
Component
Enzyme 7 General Function Translation, ribosomal structure and biogenesis
Enzyme 7 Specific Function ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)
Enzyme 7 Pathways Not Available
Enzyme 7 Reactions Not Available
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • None
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein 95769540 Link Image
Enzyme 7 UniProtKB/Swiss-Prot ID Q3MHH4 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name SYQ_BOVIN Link Image
Enzyme 7 PDB ID Not Available
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence >2328 bp
ATGGCGGCTTTGGACTCCTTGTCGCTCTTCACTGGCCTCGGCCTGAGCGAGCAGAAGGCC
CGCGAAACGCTCAAGAACACGGTTCTGAGCGCGCAGCTACGCGAGGCGGCGACCCAGGCG
CAGCAGACTCTGGGCTCCTCCATCGACAAGGCTACCGGGACCCTGCTCTATGGATTGGCC
TCCCGACTCCGGGATCCTCGGCGCCTTTCTTTCCTCGTGAGCTACATAACCAGTAGGAAG
ATCCACACTGAGACCCAGCTGAGCGCTGCCCTTGAGTATGTGCGGAGTCATCCCTTGGAT
CCCATCAACACTGAGGACTTCGAGCAGGAATGCGGTGTGGGCGTTGTGGTGACCCCAGAA
CAGATTGAAGAGGCCGTGGAGGCTGCCATAAATCGCCACCGAGCCAAGCTCCTGGTAGAG
CGTTACCATTTCAGCATGGGGCTGCTGATGGGAGAGGCTCGGGCTGCACTCAAGTGGGCA
GATGGCAAAATGATCAAGCATGAAGTAGACATGCAGGTCCTCCATCTTCTGGGTCCCAAG
ACAGAGACTGATCTGGAGAAGAAGCCCAAGGTGGCAAAGGCTCGGCCAGAAGAGACAGAC
CAAAGGACAGCAAAGGATGTGGTGGAGAATGGTGAGGTTGTTGTTCAGACCCTGTCTCTG
ATGGAGCAGCTCCGAGGCGAGGCACTTAAGTTCCACAAACCTGGTGAGAACTACAAGACC
CCGGGCTATGTGACCACTCCTCATACCATGGATCTACTGAAGCAGCACCTGGACATCACC
GGAGGACAGGTTCGTACCCGGTTCCCGCCAGAACCCAATGGAATCCTGCACATTGGACAT
GCCAAAGCAATCAATTTCAATTTTGGCTATGCCAAGGCCAACAATGGGATCTGTTTCCTG
CGCTTTGATGACACCAACCCTGAGAAAGAGGAAGCAAAGTTCTTCACTGCCATATACGAC
ATGGTGGCCTGGCTGGGTTACACCCCTTACAAGGTGACATATGCCTCCGATTATTTTGAC
CAGCTGTATGCCTGGGCTGTGGAGCTTATCCGCAGGGATCAGGCCTACGTGTGCCACCAG
CGAGGAGAGGAGCTCAAAGGCCACAACCCACTGCCCTCACCCTGGAGAGACCGTCCCATA
GAGGAGTCGCTGCTGCTCTTCGAGGCAATGCGCAAGGGCAAGTTTGCTGAGGGTGAGGCC
ACATTGCGGATGAAGCTGGTGATGGAGGATGGCAAGATGGACCCCGTGGCCTACCGCGTC
AAGTACACGCCGCACCACCGCACAGGGGACACCTGGTGCATCTACCCCACCTATGACTAC
ACGCACTGCCTCTGTGACTCCATCGAGCACATCACCCACTCACTCTGCACCAAGGAATTC
CAGGCCCGACGCTCCTCCTACTTCTGGCTGTGCAATGCGCTGGACGTCTACTGTCCCGTG
CAGTGGGAGTACGGCCGCCTCAATCTGCACTATGCTGTCGTCTCCAAGAGGAAGATTCTC
CAGCTTGTGGCGGCTGGCGCTGTGCGGGATTGGGACGATCCCCGGCTCTTCACGCTCACA
GCCTTACGACGCCGGGGCTTTCCGCCCGAGGCCATCAACAACTTCTGTGCTCGGGTGGGA
GTGACAGTGGCACAGACCACAATGGAACCACATCTGCTAGAAGCCTGTGTGCGTGATGTG
CTGAATGACACAGCCCCTCGGGCCATGGCTGTGCTGGAGCCGTTACAGGTGGTCATCACC
AATTTTCCTGCCACCAAGGCCTTGGACATCCAGGTGCCCAACTTCCCAGCTGATGAGACC
AAGGGCTTCCATCAGGTTCCTTTTGGATCCACTGTTTTCATTGAAAGGATGGACTTCAAA
GAGGAGCCAGAGCCAGGCTATAAGCGCCTGGCATGGGGCCAGCCCGTGGGCCTGAGGCAT
ACAGGCTACGTCATCGAGCTGCAGCATGTTGTCAAGGGCCCCAGTGGCTGTGTGGAAAGC
CTCAAGGTGACCTGCAGGCGCGCAGATGCTGGTGAAAAGCCCAAGGCATTTATTCACTGG
GTATCACAGCCTCTGACATGTGAGATCCGCCTCTATGAGCGACTATTTCAGCACAAGAAC
CCCGAGGATCCTGCTGAGGTGCCTGGTGGATTCTTAAGTGACCTGAACCCGGCCTCGCTA
CAAGTGGTGGAGGCTGCATTAGTGGACTGTTCTGTGGCCCTGGCAAAGCCCTTCGACAAG
TTCCAATTTGAGCGCCTTGGTTACTTTTCCGTGGATCCAGACAGCAACCAGGGACAGCTT
GTCTTCAACCGAACCGTCACACTGAAGGAGGACCCAGGAAAAGTGTGA
Enzyme 7 GenBank Gene ID BT025487 Link Image
Enzyme 7 GeneCard ID QARS Link Image
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Chromosome:3
Enzyme 7 Locus 3p21.3-p21.1
Enzyme 7 SNPs SNPJam Report Link Image
Enzyme 7 General References
  1. [PubMed Link Image]
Enzyme 7 Metabolite References Not Available
Enzyme 8 [top]
Enzyme 8 ID 854
Enzyme 8 Name Coagulation factor XIII A chain
Enzyme 8 Synonyms
  1. Coagulation factor XIIIa
  2. Protein-glutamine gamma-glutamyltransferase A chain
  3. Transglutaminase A chain
  4. Fragment
Enzyme 8 Gene Name F13A1
Enzyme 8 Protein Sequence >Coagulation factor XIII A chain
MSESSGTAFGGRRAIPPNTSNAAENDPPTVELQGLVPRGFNPQDYLNVTNVHLFKERWDS
NKVDHHTDKYSNDKLIVRRGQSFYIQIDFNRPYDPTRDLFRVEYVIGLYPQENKGTYIPV
PLVSELQSGKWGAKVVMREDRSVRLSVQSSADCIVGKFRMYVAVWTPYGVIRTSRNPETD
TYILFNPWCEEDAVYLEN
Enzyme 8 Number of Residues 198
Enzyme 8 Molecular Weight 22744.4
Enzyme 8 Theoretical pI 6.27
Enzyme 8 GO Classification
Function
Process
Component
Enzyme 8 General Function Involved in acyltransferase activity
Enzyme 8 Specific Function Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin
Enzyme 8 Pathways Not Available
Enzyme 8 Reactions Not Available
Enzyme 8 Pfam Domain Function
Enzyme 8 Signals
  • None
Enzyme 8 Transmembrane Regions
  • None
Enzyme 8 Essentiality Not Available
Enzyme 8 GenBank ID Protein 95767504 Link Image
Enzyme 8 UniProtKB/Swiss-Prot ID P12260 Link Image
Enzyme 8 UniProtKB/Swiss-Prot Entry Name F13A_BOVIN Link Image
Enzyme 8 PDB ID Not Available
Enzyme 8 Cellular Location Not Available
Enzyme 8 Gene Sequence Not Available
Enzyme 8 GenBank Gene ID BT025350 Link Image
Enzyme 8 GeneCard ID F13A1 Link Image
Enzyme 8 GenAtlas ID Not Available
Enzyme 8 HGNC ID Not Available
Enzyme 8 Chromosome Location Chromosome:6
Enzyme 8 Locus 6p25.3-p24.3
Enzyme 8 SNPs SNPJam Report Link Image
Enzyme 8 General References
  1. [PubMed Link Image]
Enzyme 8 Metabolite References Not Available